Article
Clinical Neurology
Jeroen Hermanides, Young T. Hong, Monica Trivedi, Joanne Outtrim, Franklin Aigbirhio, Peter J. Nestor, Matthew Guilfoyle, Stefan Winzeck, Virginia F. J. Newcombe, Tilak Das, Marta M. Correia, Keri L. H. Carpenter, Peter J. A. Hutchinson, Arun K. Gupta, Tim D. Fryer, John D. Pickard, David K. Menon, Jonathan P. Coles
Summary: Metabolic derangements following traumatic brain injury were comprehensively characterized using a combination of PET techniques, revealing reduced glucose utilization in the brain of patients, with regional increases associated with reductions in glucose availability, blood flow, and oxygen metabolism in the absence of ischemia.
Article
Clinical Neurology
Audrey Lafrenaye, Stefania Mondello, John Povlishock, Karen Gorse, Susan Walker, Ronald Hayes, Kevin Wang, Patrick M. Kochanek
Summary: OBTT aims to improve the quality of preclinical studies and increase the translational potential of experimental TBI treatments by screening drugs and biomarkers. LEV was the most promising drug tested by OBTT, causing changes in circulating GFAP levels in pigs and alterations in the morphological properties of APP+ axonal swellings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Seokwon Yoon, Juyoung Lee, Yong Hoon Jun, Ga Won Jeon
Summary: The term shaken baby syndrome has been replaced by abusive head trauma (AHT) for its mechanism of injury. Diagnosis of AHT remains a challenge when parents do not report trauma in preverbal infants. Reasonable suspicion of abuse, in combination with thorough physical examination, neuroimaging, and skilled neuroradiologist, can improve diagnosis and help victims in a timely manner.
Article
Clinical Neurology
Joseph A. A. Falcone, Jefferson W. W. Chen
Summary: In this retrospective study, the authors summarized the importance of cerebral microdialysis in brain injury monitoring and described different methods for placing microdialysis catheters. The results of the study showed that with careful planning and thoughtful execution, microdialysis catheters can be successfully placed through various strategies to optimize and individualize brain monitoring in different clinical settings.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chisomo Zimphango, Farah C. Alimagham, Keri L. H. Carpenter, Peter J. Hutchinson, Tanya Hutter
Summary: Cerebral microdialysis technique provides useful information on brain metabolites for clinical decision making and medical treatment, but the limitations of hourly result retrieval exist. Recent focus has been on developing biosensing techniques for continuous online monitoring. Further research and future perspectives are still worth attention.
Article
Clinical Neurology
Moinay Kim, Suk Kyung Hong, Sang Ryong Jeon, Sung Woo Roh, Seungjoo Lee
Summary: The study aimed to evaluate DAI patients according to DAI stage and identify risk factors that may affect clinical outcome. The results showed a correlation between DAI stage, certain factors, and patient outcomes.
TURKISH NEUROSURGERY
(2022)
Article
Family Studies
Katelyn M. Even, Kent P. Hymel, Veronica Armijo-Garcia, Matthew Musick, Kerri Weeks, Suzanne B. Haney, Mark Marinello, Bruce E. Herman, Terra N. Frazier, Christopher L. Carroll, Menglu Liang, Ming Wang
Summary: The study found that subcortical injury is strongly associated with the diagnosis of abusive head trauma (AHT), historical inaccuracies concerning abuse, traumatic extracranial injuries, and increased severity of illness.
CHILD ABUSE & NEGLECT
(2022)
Article
Clinical Neurology
Ana M. Castano-Leon, Cristina Sanchez Carabias, Amaya Hilario, Ana Ramos, Blanca Navarro-Main, Igor Paredes, Pablo M. Munarriz, Irene Panero, Carla Eiriz Fernandez, Daniel Garcia-Perez, Luis Miguel Moreno-Gomez, Olga Esteban-Sinovas, Guillermo Garcia Posadas, Pedro A. Gomez, Alfonso Lagares
Summary: This study explores the potential role of serum biomarkers in assessing traumatic axonal injury (TAI). By extracting blood and performing imaging assessments on traumatic brain injury (TBI) patients, it was found that the concentrations of biomarkers were significantly higher in TBI patients compared to the control group. Among these biomarkers, UCH-L1 and NfL appear to be more specific markers for detecting TAI. Furthermore, the combination of NfL and the fractional anisotropy (FA) of the corpus callosum (CC) can help predict long-term outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
Abdelhakim Khellaf, Nuria Marco Garcia, Tamara Tajsic, Aftab Alam, Matthew G. Stovell, Monica J. Killen, Duncan J. Howe, Mathew R. Guilfoyle, Ibrahim Jalloh, Ivan Timofeev, Michael P. Murphy, T. Adrian Carpenter, David K. Menon, Ari Ercole, Peter J. Hutchinson, Keri L. H. Carpenter, Eric P. Thelin, Adel Helmy
Summary: The study found that cerebral mitochondrial dysfunction is common in TBI patients, and treatment with succinate can improve energy metabolism. The combination of microdialysis and nuclear magnetic resonance spectroscopy provides crucial monitoring and evidence support for this process.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Abhijith V. Matur, Laura B. Ngwenya, Charles J. Prestigiacomo
Summary: Motor vehicle collisions are a major cause of head injuries, but efforts to improve automobile design and promote helmet use have significantly reduced the number of serious head injuries. Neurosurgeons have played a crucial role in preventing head injuries and saving lives in MVCs through their recommendations and research efforts.
JOURNAL OF NEUROSURGERY
(2021)
Review
Pharmacology & Pharmacy
C. Batson, A. Gomez, A. S. Sainbhi, L. Froese, F. A. Zeiler
Summary: This review article summarizes the impact of age and biological sex on outcomes of moderate/severe TBI patients through high-frequency multi-modal monitoring. By reviewing a large body of literature, it discusses the relationship between various physiological parameters and patient age and sex, while also identifying current knowledge gaps in the field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Hans Kristian Moe, Turid Follestad, Nada Andelic, Asta Kristine Haberg, Anne-Mari Holte Flusund, Kjell Arne Kvistad, Elin Hildrum Saksvoll, Oystein Olsen, Sebastian Abel-Gruner, Oddrun Sandrod, Toril Skandsen, Anne Vik, Kent Goran Moen
Summary: This study aimed to investigate the relationship between MRI findings of traumatic axonal injury (TAI) and admission Glasgow Coma Scale (GCS) score and prolonged duration of posttraumatic amnesia (PTA) after traumatic brain injury (TBI). The results showed that the location and burden of TAI lesions were significantly associated with GCS score and duration of PTA. Specifically, bilateral TAI lesions in the thalamus and the total volume of TAI lesions on FLAIR were found to have the strongest predictive value for prolonged PTA.
JOURNAL OF NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Stephanie S. Sloley, Bevan S. Main, Charisse N. Winston, Alex C. Harvey, Alice Kaganovich, Holly T. Korthas, Adam P. Caccavano, David N. Zapple, Jian-young Wu, John G. Partridge, Mark R. Cookson, Stefano Vicini, Mark P. Burns
Summary: This study reveals that high frequency head impacts can cause chronic cognitive impairments in mice by altering brain function through synaptic adaptation, rather than traditional brain trauma pathology. Transcriptional profiling of both mouse and human chronic traumatic encephalopathy brain shows that synapses are significantly affected by head impacts, leading to cognitive dysfunction. Electrophysiological analysis demonstrates that high frequency head impacts chronically modify the AMPA/NMDA ratio in neurons, contributing to changes in cognition.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Patrick D. Kelly, Pious D. Patel, Aaron M. Yengo-Kahn, Daniel Wolfson, Fakhry Dawoud, Ranbir Ahluwalia, Oscar D. Guillamondegui, Christopher M. Bonfield
Summary: This study assessed the accuracy of the Baylor score among patients who survived the acute phase of hospitalization for gunshot wounds to the head, finding that while the score accurately predicted mortality and functional outcome, it tended to overestimate mortality and underestimate good functional outcome.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Dan Benjamini, Diego Iacono, Michal E. Komlosh, Daniel P. Perl, David L. Brody, Peter J. Basser
Summary: The study focused on investigating the changes in different MRI parameters related to DAI in traumatic brain injury, using a combination of MRI and histopathology. The results suggest that multidimensional MRI can effectively differentiate the severity of axonal injury and may serve as non-invasive biomarkers for DAI detection.
Review
Infectious Diseases
Ciro Ramos-Estebanez, Karlo J. Lizarraga, Amedeo Merenda
Article
Clinical Neurology
Amedeo Merenda, Michael DeGeorgia
CURRENT OPINION IN NEUROLOGY
(2010)
Article
Clinical Neurology
Zhengwen Zhou, Dong Sun, Joseph E. Levasseur, Amedeo Merenda, Robert J. Hamm, Jiepei Zhu, Bruce D. Spiess, M. Ross Bullock
Review
Critical Care Medicine
Nathan Mohney, Omar Alkhatib, Sebastian Koch, Kristine O'Phelan, Amedeo Merenda
NEUROCRITICAL CARE
(2020)
Review
Critical Care Medicine
Rami Algahtani, Amedeo Merenda
Summary: With the increasing prevalence of chronic diseases, managing multimorbid patients in neuro-ICUs presents unique challenges and risks. Perioperative optimization is crucial in preventing postoperative complications, requiring thorough risk assessment and personalized management strategies for high-risk neurosurgical patients.
NEUROCRITICAL CARE
(2021)
Review
Critical Care Medicine
Amedeo Merenda, Ross Bullock
CURRENT OPINION IN CRITICAL CARE
(2006)
Article
Clinical Neurology
Karlo J. Lizarraga, Lucien C. Alexandre, Ciro Ramos-Estebanez, Amedeo Merenda
CASE REPORTS IN NEUROLOGY
(2013)