Letter
Anesthesiology
Sean Coeckelenbergh, Maxime Soucy-Proulx, Finn Radtke
Summary: Mesenchymal stem cells can improve postoperative cognitive recovery in aging mice by inhibiting hippocampus ferroptosis through activating the SIRT1/Nrf2/HO-1 signaling pathway. Exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells can also ameliorate postoperative cognitive dysfunction in mice with diabetes.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Agriculture, Dairy & Animal Science
Claudia Interlandi, Simona Di Pietro, Giovanna L. Costa, Filippo Spadola, Nicola M. Iannelli, Daniele Macri, Vincenzo Ferrantelli, Francesco Macri
Summary: The addition of cisatracurium besylate to anesthesia protocols in dogs undergoing mastectomy surgery can result in a reduction in the dosage of anesthetic drugs used. This study demonstrated that cisatracurium provided good muscle relaxation without side effects and allowed for a decrease in the use of propofol and sevoflurane, resulting in a stable anesthetic plan.
Article
Anesthesiology
William K. Diprose, Michael T. M. Wang, Doug Campbell, James A. Sutcliffe, Andrew McFetridge, Daniel Chiou, Joshua Lai, P. Alan Barber
Summary: In ischemic stroke patients undergoing endovascular thrombectomy with general anesthesia, there may be a differential effect between intravenous propofol and volatile inhalational agents. Patients treated with propofol anesthesia showed improved functional independence at 3 months, suggesting the need for further research to explore these findings.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2021)
Article
Medicine, General & Internal
Zhiqi Hou, Dexing Luo, Huanhuan Luo, Qiang Hui, Yongqing Xu, Xiaofeng Lin, Zhibin Xu
Summary: This study aimed to establish a co-expression prognostic-related genes signature based on propofol and sevoflurane anesthesia in glioblastoma (GBM) patients. The findings showed that the anesthesia method in GBM patients was closely associated with gene expression, prognosis, and immune therapy response. Moreover, the methylation level of the MGMT promoter changed during the anesthesia process. Therefore, this model can serve as a new biomarker for predicting the prognosis of GBM patients.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Laura Jansen, Bente F. H. Dubois, Markus W. Hollmann
Summary: Every year, millions of patients are diagnosed with cancer and undergo surgical resection with anesthesia. However, a significant number of these patients experience recurrence or metastasis after surgery. The effect of different anesthesia techniques on postoperative outcomes in oncological surgery is still controversial and lacks substantial evidence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Soo Yeon Kim, Ji-Yoon Kim, Jonghae Kim, Seungcheol Yu, Kwang Hyun Lee, Hyeon Seok Lee, Min Seok Oh, Eugene Kim
Summary: The study compared the antinociceptive properties of sevoflurane and desflurane by measuring the pupillary dilation reflex (PDR). The results showed that there was no difference in the change of PDR amplitude, mean arterial pressure (MAP), and heart rate (HR) between the two anesthetics after a noxious stimulation. This suggests that sevoflurane and desflurane may have similar antinociceptive properties.
ANESTHESIA AND ANALGESIA
(2022)
Article
Biotechnology & Applied Microbiology
Shikun Zhang, Xiaoyan Du, Kun Zhang, Haiyan Wang
Summary: Sevoflurane treatment reduces the apoptosis of myocardial cells after hypoxia treatment, and improves the connectivity of myocardium.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Oncology
Panpan Fang, Jiaqi Zhou, Zhengyuan Xia, Yao Lu, Xuesheng Liu
Summary: Perioperative interventions can cause biological disturbances that are associated with the risk of cancer recurrence after surgery. The impact of anesthetic drugs on tumor microenvironment has been a topic of interest. It is still uncertain whether anesthetic drugs have positive or negative effects on cancer outcomes after surgery. This review focuses on the effects of propofol and sevoflurane, the most commonly used intravenous and inhaled anesthetics, on the prognosis of breast cancer. Preclinical studies have shown that sevoflurane may enhance the recurrence and metastasis of breast cancer, while propofol is more likely to reduce cancer cell activity through immune system modulation and direct anti-tumor effects. However, contradictory results have been found in retrospective clinical studies. More preclinical and randomized controlled studies are needed to guide the choice of anesthetics for breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Liu, Xiao Liu, Wen-Yu Zhou, Jun Gan, Jie Wang, Qi Zhang, Jun-Liang Li, Zhong-Shan Shen, Yue-Ying Zhang, Qiong-Yao Tang, Zhe Zhang
Summary: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state. In this study, the role of TMN GABAergic neurons in general anesthesia was investigated using chemogenetics and optogenetics strategies. The findings showed that activation of TMN GABAergic neurons decreased the effect of sevoflurane and propofol anesthesia, while inhibition of these neurons facilitated sevoflurane anesthesia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
G. M. Li, J. G. Li, M. Liu, B. You
Summary: The study found that the combination of sevoflurane and propofol anesthesia has a protective effect on cognitive function in elderly patients undergoing electro-prostatectomy. By increasing BDNF levels and reducing S100 protein levels, the negative effects on patients can be mitigated.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Neurosciences
Hongliang Liu, Bo Chen, Bianqin Guo, Xiaoyuan Deng, Bin Wang, Xiaoyun Dou
Summary: The study found that postconditioning with sevoflurane could reverse the cognitive deficits induced by neuroinflammation and provide reliable neuroprotection. On the other hand, postconditioning with propofol, while also anti-neuroinflammatory like sevoflurane, caused neurotoxicity leading to impairments in spatial recognition memory.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Anesthesiology
Thomas W. Schnider, Gertrude J. Nieuwenhuijs-Moeke, Beatrice Beck-Schimmer, Thomas M. Hemmerling
Summary: This article discusses the debate on whether all general anesthesia should be done using target-controlled propofol anesthesia guided by monitoring of depth of anesthesia. The Pro side argues that total intravenous anesthesia causes less postoperative nausea and higher patient satisfaction than anesthesia using volatile anesthetics. The Con side argues that volatile anesthetics might have advantages in certain situations such as ischemia and reperfusion injury or severe inflammation, and in times of drug shortages.
ANESTHESIA AND ANALGESIA
(2023)
Article
Medicine, General & Internal
Taina B. Oliveira, Cassia L. Braga, Denise Battaglini, Paolo Pelosi, Patricia R. M. Rocco, Pedro L. Silva, Fernanda F. Cruz
Summary: This study compared the effects of sevoflurane and propofol on immune responses and cytokine expression in rats with sepsis. The results showed that sevoflurane increased the expression of anti-inflammatory biomarkers in monocytes, enhanced their phagocytic capacity, and increased neutrophil migration. Sevoflurane also protected lung epithelial and endothelial cells. in contrast, propofol had less significant effects.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Jee-Eun Chang, Seong-Won Min, Hyerim Kim, Dongwook Won, Jung-Man Lee, Tae Kyong Kim, Chanho Kim, Jin-Young Hwang
Summary: This study compared the incidence of postoperative cognitive dysfunction (POD) after propofol- and sevoflurane-based anesthesia in elderly patients undergoing spine surgery. The findings showed that propofol-based anesthesia was associated with a lower incidence of POD compared to sevoflurane-based anesthesia.
GLOBAL SPINE JOURNAL
(2022)
Article
Anesthesiology
Jinpiao Zhu, Chang Chen, Jinfeng Wu, Mengying He, Shuang Li, Yuanyuan Fang, Yan Zhou, Haibo Xu, Saeed Sadigh-Eteghad, Anne Manyande, Feng Zheng, Ting Chen, Fuqiang Xu, Daqing Ma, Jie Wang, Zongze Zhang
Summary: This study investigated the changes in social and anxiety-related brain functional connectivity induced by sleep deprivation and the potential therapeutic effects of the general anesthetics propofol and sevoflurane. The results showed that propofol reduced sleep deprivation-induced anxiety behaviors and improved social preference, while sevoflurane did not have the same effects.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Ehab Farag, Chen Liang, Edward J. Mascha, Maged Y. Argalious, Jacob Ezell, Kamal Maheshwari, Wael Ali Sakr Esa, Christopher A. Troianos, Daniel I. Sessler
Article
Anesthesiology
Yize I. Wan, Akshaykumar Patel, Tom E. F. Abbott, Cheryl Achary, Neil MacDonald, Emmanuelle Duceppe, Daniel I. Sessler, Wojtek Szczeklik, Gareth L. Ackland, Philip J. Devereaux, Rupert M. Pearse
BRITISH JOURNAL OF ANAESTHESIA
(2020)
Review
Anesthesiology
Daniel I. Sessler
Summary: The esophagus and nasopharynx are ideal sites for temperature monitoring during general anesthesia, while alternatives for neuraxial anesthesia and postoperative care include oral and axillary temperatures, as well as zero-heat flux forehead temperature.
Article
Anesthesiology
Ryan M. Hijazi, Daniel I. Sessler, Chen Liang, Fabio A. Rodriguez-Patarroyo, Edward G. Soltesz, Andra E. Duncan
Summary: This study found no significant difference in mortality and cardiac complications between patients undergoing cardiac surgeries in the morning and afternoon. The timing of surgery did not alter postoperative risk according to the results.
Article
Anesthesiology
Lukas Martin Mueller-Wirtz, Daniel Kiefer, Felix Maurer, Maximilian Alexander Floss, Jonas Doneit, Tobias Hueppe, Theodora Shopova, Beate Wolf, Daniel I. Sessler, Thomas Volk, Sascha Kreuer, Tobias Fink
Summary: Exhaled pentanal may serve as a potential biomarker for early detection of ventilator-induced lung injury in rats. Ventilation at high tidal volumes led to significantly increased exhaled pentanal concentrations, while short-term ventilation at high tidal volumes did not result in significant increases in white blood cell concentrations and cleaved caspase 3 in lung tissue.
ANESTHESIA AND ANALGESIA
(2021)
Letter
Anesthesiology
Daniel I. Sessler, Rod J. Nault
Letter
Anesthesiology
Kamal Maheshwari, Zhongping Jian, Daniel I. Sessler
Editorial Material
Anesthesiology
Donal J. Buggy, Bernhard Riedel, Daniel I. Sessler
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Shobana Rajan, Sanchit Ahuja, Barak Cohen, Adriana Martin, Amanda Pursell, Chen Liang, Guangmei Mao, Ryu Komatsu, Ehab Farag, Daniel I. Sessler
Summary: There was no significant difference in the risk of postoperative stroke after non-neurological, noncarotid, and noncardiac surgeries between patients who used ACEIs or ARBs for a long time and those who did not.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukas M. Muller-Wirtz, Daniel Kiefer, Joschua Knauf, Maximilian A. Floss, Jonas Doneit, Beate Wolf, Felix Maurer, Daniel I. Sessler, Thomas Volk, Sascha Kreuer, Tobias Fink
Summary: High inspired oxygen during mechanical ventilation can affect exhalation of breath biomarkers and induce systemic inflammation. Pentanal exhalation increases during ventilation, while hexanal shows a slight increase at high inspired oxygen levels.
Article
Anesthesiology
James S. Khan, Daniel I. Sessler, Matthew T. V. Chan, C. Y. Wang, Ignacio Garutti, Wojciech Szczeklik, Alparslan Turan, Jason W. Busse, D. Norman Buckley, James Paul, Michael McGillion, Carmen Fernandez-Riveira, Sadeesh K. Srinathan, Harsha Shanthanna, Ian Gilron, Michael Jacka, Paul Jackson, James Hankinson, Pilar Paniagua, Shirley Pettit, P. J. Devereaux
Summary: This study investigated the incidence, characteristics, impact, and risk factors associated with persistent incisional pain in patients aged 45 years and older who underwent major inpatient noncardiac surgery. The results showed that female sex, Asian ethnicity, history of chronic pain, specific types of surgery, and postoperative analgesia were associated with an increased risk of persistent pain. It was found that persistent incisional pain affected daily activities and led to increased analgesic consumption, indicating significant morbidity.
Article
Anesthesiology
Tetsuya Shimada, Edward J. Mascha, Dongsheng Yang, Mauro Bravo, Eva Rivas, Ilker Ince, Alparslan Turan, Daniel I. Sessler
Summary: This study aimed to evaluate whether intra-operative hypertension causes postoperative complications. The results showed that there was no clinically meaningful relationship between intra-operative systolic pressure and the composite of myocardial injury and mortality, or acute kidney injury, and there was no interaction with preoperative clinic blood pressure.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Article
Anesthesiology
Gausan Ratna Bajracharya, Wael Ali Sakr Esa, Guangmei Mao, Steve Leung, Barak Cohen, Kamal Maheshwari, Hermann P. Kessler, Emre Gorgun, Daniel I. Sessler, Alparslan Turan
Summary: This study investigated the effect of regional analgesia on postoperative infections in patients undergoing colorectal surgery. The results showed no significant difference in the occurrence of serious infections between patients with regional analgesia and patients with IV-PCA. Therefore, regional analgesia should not be chosen as a postoperative analgesic technique to reduce infections.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Mark D. Neuman, Rui Feng, Susan S. Ellenberg, Frederick Sieber, Daniel I. Sessler, Jay Magaziner, Nabil Elkassabany, Eric S. Schwenk, Derek Dillane, Edward R. Marcantonio, Diane Menio, Sabry Ayad, Manal Hassan, Trevor Stone, Steven Papp, Derek Donegan, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Ann Tierney, Lakisha J. Gaskins, Annamarie D. Horan, Trina Brown, James Dattilo, Jeffrey L. Carson
Summary: Results from the study showed that spinal anesthesia led to more severe pain in the first 24 hours after surgery and higher prescription analgesic use at 60 days compared to general anesthesia, but satisfaction was similar between the two groups.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Anesthesiology
Ryu Komatsu, Huseyin Oguz Yilmaz, Natalya Makarova, Alparslan Turan, Daniel I. Sessler, Shobana Rajan, Maged Argalious
Summary: Preoperative statin use in noncardiac surgical patients was associated with slightly reduced odds of postoperative respiratory, infectious, and cardiovascular complications. However, the number needed to treat was high.
ANESTHESIA AND ANALGESIA
(2021)
