Article
Surgery
Qiangqiang Pan, Zhenhui Zhang, Yanyu Zhu, Wentao Jiang, Kai Su, Peilin Liu, Yongsheng Kang, Zhe Shao, Wei Mei, Qingde Wang
Summary: This study proposed a zoning laminectomy to reduce the incidence of nerve injury during spinal surgery for thoracic ossification of the ligamentum flavum (TOLF). Retrospective analysis of 45 TOLF patients who underwent zoning laminectomy showed that it was a safe and effective surgical option.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Neurosciences
Venkata Vemula Ramesh Chandra, Bodapati C. M. Prasad, Paradesi Rajesh, Sudharsan Agarwal, Mohana Murali Krishna
Summary: This study identified age, associated trauma, OLF level, tuberous type OLF, intramedullary signal change on T2WI, preoperative severity of myelopathy, preoperative mJOA score, and Nurick grade as important predictors of surgical outcome in patients with T-OLF.
Review
Orthopedics
Alan H. Daniels, Christopher L. McDonald, Bryce A. Basques, Eren O. Kuris
Summary: Ossification of the ligamentum flavum (OLF) is a spinal condition that can potentially cause compression of the spinal canal and neurological damage. The exact cause is debated but is likely related to gene overexpression and signaling pathways. Progressive myelopathy is the most common symptom, and radiographic analysis can show ossification in different areas. Surgical treatment options exist but may result in complications and postoperative neurological deficits.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Clinical Neurology
Guanghui Chen, Zhongqiang Chen, Weishi Li, Yu Jiang, Xinhu Guo, Baoliang Zhang, Liyuan Tao, Chunli Song, Chuiguo Sun
Summary: Dural ossification (DO) is a common condition in patients with ossification of the ligamentum flavum (OLF), leading to dural tears. However, current methods for diagnosing DO are limited. This study proposed a novel CT-based imaging sign, called the Banner cloud sign (BCs), and investigated its clinical characteristics and correlations with DO.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
FuCheng Bian, Jian Zhang, GuangYu Bian, DaYong Wang, Bin Chen, YongSheng An
Summary: This study aimed to compare the short-term outcomes of PETD and PTL in treating thoracic ossification. The results showed that the PETD group had shorter operation time and less blood loss compared to the PTL group. The PETD group also had a higher recovery rate and fewer complications. In conclusion, PETD is an effective and feasible treatment option for thoracic ossification.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Pang Hung Wu, Brian Zhao Jie Chin, Hyeun Sung Kim, Seth Ian Sim, Il-Tae Jang
Summary: Endoscopic posterior decompression is a safe and effective technique for treating TOLF, with low rates of complications and improvement in pain and function.
WORLD NEUROSURGERY
(2023)
Article
Surgery
Feng-Kai Yang, Peng-Fei Li, Chen-Tao Dou, Rong-Bo Yu, Bin Chen
Summary: In patients with thoracic spinal stenosis caused by ossification of the ligamentum flavum, both percutaneous endoscopic thoracic decompression (PETD) and posterior thoracic laminectomy (PTL) achieved favorable outcomes and safety. PETD is minimally invasive and achieves similar postoperative symptom relief to PTL, making it an effective alternative to traditional open surgery for thoracic ossification of the ligamentum flavum in a single-segment lower thoracic spine.
Article
Surgery
Jia-lin He, Qian Du, Wan-dong Hu, Zhi-jun Xin, Xin-xin Shao, Wen-bo Liao
Summary: This study evaluated the efficacy of posterior percutaneous full-endoscopic technique for patients with thoracic myelopathy caused by ossification of ligamentum flavum (TOLF). The results showed that endoscopic surgery has a good clinical effect on TOLF, with minimal impact on the spinal structure.
Article
Orthopedics
Yue Deng, Mingzhi Yang, Chao Xia, Yong Chen, Zhong Xie
Summary: This study evaluated the efficacy and safety of unilateral biportal endoscopic decompression treatment in patients with thoracic ossification of the ligamentum flavum (OLF). The results showed that this treatment significantly improved the neurological status of the patients and had a low complication rate.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Orthopedics
Tsuyoshi Yamada, Shigeo Shindo, Toshitaka Yoshii, Shuta Ushio, Kazuo Kusano, Norihiko Miyake, Yoshiyasu Arai, Kazuyuki Otani, Atsushi Okawa, Osamu Nakai
Summary: This study evaluated the prevalence, distribution, and clinical characteristics of thoracic ossification of ligamentum flavum (T-OLF) in patients with lumbar spinal canal stenosis (LCS). The findings indicated that T-OLF was highly associated with other spinal disorders, and poor outcomes in T-OLF surgery could be due to age and concurrent LCS. Additional lumbar surgery effectively improved neurological findings in T-OLF patients with LCS.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, Research & Experimental
Kinshi Kato, Kenichi Otoshi, Michiyuki Hakozaki, Shin-Ichi Konno
Summary: This case study suggests that thoracic OLF may increase in size and become exacerbated in certain individuals, such as professional pitchers, who experience repeated, localized, mechanical stress on the thoracic spine, regardless of age.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kuankuan Liu, Li Shu, Ann Yehong Huang, Yanan Chang, Zhongqiang Chen, Chi Zhang
Summary: This study identified the increased expression of PTGR1 in thoracic ossification of the ligamentum flavum (TOLF) and demonstrated its involvement in cell proliferation, possibly through activating the expression of c-Myc and CyclinD1 via the JNK pathway.
Article
Clinical Neurology
Jialiang Lin, Fei Xu, Shuai Jiang, Longjie Wang, Zhuoran Sun, Zhongqiang Chen, Zhaoqing Guo, Qiang Qi, Yan Zeng, Chuiguo Sun, Weishi Li
Summary: The study investigates the relationship between BMI and thoracic ossification of the ligamentum flavum (TOLF), finding that BMI is a crucial risk factor for TOLF. Prompt detection and treatment of TOLF progression are necessary for asymptomatic TOLF patients with high BMI.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Masahiko Takahata, Tsutomu Endo, Yoshinao Koike, Kuniyoshi Abumi, Kota Suda, Ryo Fujita, Toshifumi Murakami, Hideki Sudo, Katsuhisa Yamada, Takashi Ohnishi, Katsuro Ura, Daisuke Ukeba, Norimasa Iwasaki
Summary: This retrospective observational study evaluated the long-term recurrence rates and functional status of patients with thoracic ossification of the posterior longitudinal ligament (OPLL) after decompression and posterior fusion surgery. The study found that while the surgery had stable long-term clinical outcomes, late neurological deterioration was observed in some patients outside of the primary operative lesion. Factors such as young age, high body mass index, and lumbar OPLL were associated with this deterioration.
GLOBAL SPINE JOURNAL
(2022)
Article
Medicine, General & Internal
Baoliang Zhang, Guanghui Chen, Xi Chen, Zhongqiang Chen, Chuiguo Sun
Summary: Diffuse idiopathic skeletal hyperostosis (DISH) is a disease associated with older males and diffuse-type thoracic ossification of the ligamentum flavum (TOLF). Although mild DISH may lead to suboptimal surgical outcomes, thoracic posterior decompression surgery can improve neurological function and relieve pain.
