Article
Clinical Neurology
Saeed Oraee-Yazdani, Roozbeh Tavanaei, Seyyed Saeed Rezaee-Naserabad, Samin Khannejad, Siamak Alizadeh Zendehrood, Kaveh Oraii Yazdani, Alireza Zali
Summary: This study evaluated the safety and potential efficacy of selective dorsal rhizotomy (SDR) in chronic spinal cord injury-induced spasticity. The results showed that SDR is a safe procedure and all secondary outcome measures improved significantly over the study period. However, larger and more authoritative clinical trials are needed to validate the findings regarding efficacy.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Katherine Belanger, William McKay, Joyce Oleszek, Sarah Graber, Corbett Wilkinson
Summary: This study reports two cases of spinal cord tethering after selective dorsal rhizotomy (SDR) below the conus, a previously unreported complication. It highlights the importance of recognizing this potential complication following SDR.
CHILDS NERVOUS SYSTEM
(2022)
Article
Clinical Neurology
Marc Sindou, Anthony Joud, George Georgoulis
Summary: Dorsal rhizotomy is the gold standard for treating spastic diplegia/quadriplegia in children with cerebral palsy, and the Keyhole Interlaminar modality offers tailored accuracy with a duration of 5 +/- 1 hours.
ACTA NEUROCHIRURGICA
(2021)
Review
Clinical Neurology
Mohit Agrawal, Raghu Samala, Ramesh Doddamani, Deepak Agrawal, Sarat P. Chandra
Summary: SDR has been proven effective in treating spasticity caused by cerebral palsy, with potential to be beneficial in post-traumatic cases as well, and has shown favorable outcomes in the literature.
NEUROSURGICAL REVIEW
(2021)
Review
Clinical Neurology
Hemant Kumar, Ankita Bhagwani, Manjeet Chopra
Summary: Traumatic spinal cord injury can result in long-lasting complications such as chronic neuropathic pain and spasticity, which significantly impact the daily activities of patients. Current medical treatments for SCI-related neuropathic pain are limited due to the complex mechanisms involved, but restoring inhibitory GABAergic tone and preventing excitotoxicity may provide neuroprotective and analgesic effects.
Review
Biochemistry & Molecular Biology
Ramiro Palazon-Garcia, Ana Maria Benavente-Valdepenas
Summary: Botulinum toxin, known for about three centuries, is considered one of the most powerful toxins but has found medical applications in the treatment of spasticity, particularly in strokes and cerebral palsy. Despite not being approved for use in spinal cord injury spasticity, it is being used in such cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Zackery J. Billington, Austin M. Henke, David R. Gater
Summary: Spasticity is a common comorbidity of spinal cord injury, with both beneficial and problematic effects. This manuscript discusses the anatomy and physiology of neuromuscular reflexes, the pathophysiology of post-SCI, assessment of spasticity, and management strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Tarik Alp Sargut, Hannes Haberl, Simone Wolter, Sascha Tafelski, Anne van Riesen, Maijana Linhard, Angela M. Kaindl, Ulrich-Wilhelm Thomale, Matthias Schulz
Summary: The study investigated the outcomes of children with cerebral palsy who underwent selective dorsal rhizotomy (SDR), showing improvements in spasticity, muscle strength, and overall function after the surgery. Results demonstrated a significant reduction in spasticity, increased muscle strength, and improved overall function in pediatric patients with bilateral spastic CP after SDR.
ACTA NEUROCHIRURGICA
(2021)
Article
Neurosciences
Mark L. Mcmulkin, Bruce A. Macwilliams, Elizabeth A. Nelson, Meghan E. Munger, Brian Po-Jung Chen, Tom F. Novacheck, Kristen L. Carroll, Alan K. Stotts, Lisa H. Carter, Shelley L. Mader, Brianna Hayes, Glen O. Baird, Michael H. Schwartz
Summary: This study analyzed the long-term effects of selective dorsal rhizotomy (SDR) on spasticity in children with cerebral palsy (CP) and found that aggressive spasticity management did not result in significant differences in gait kinematics compared to minimal spasticity management. Regardless of whether SDR was performed or not, both groups received the same orthopedic surgery treatment.
Article
Pediatrics
Megan Ryan, Marisa Flavin, Joyce Oleszek, Amy Bodkin, Anne-Marie Wilson, Corbett Wilkinson
Summary: This article reports a case of using selective dorsal rhizotomy (SDR) to treat spasticity caused by spinal lipoma. After surgery and rehabilitation, the patient's gait improved significantly.
JOURNAL OF PEDIATRIC REHABILITATION MEDICINE
(2022)
Article
Neurosciences
Peter Spazzapan, Roman Bosnjak, Zoran Rodi, Natasa Kos, Katja Groleger, Tomaz Velnar
Summary: Selective dorsal rhizotomy (SDR) can be used to improve the abnormal increase in muscle tone caused by spasticity, and postoperatively, patients show improvement in muscle tone and gait pattern, confirming the efficacy of SDR.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Pediatrics
Jawaria Shahid, Ayesha Kashif, Muhammad Kashif Shahid
Summary: Spasticity is common in children with bilateral spastic CP. SDR is a surgical procedure used to reduce lower limb rigidity, along with other treatment options such as intrathecal medication and DBS. The aim is to improve quality of life, and this article provides information for parents' counseling and treatment planning.
Review
Clinical Neurology
Pramath Kakodkar, Aria Fallah, Albert Tu
Summary: The study identified 129 publications from 1970 to 2019, with 12 publications meeting the inclusion criteria (total of 141 patients). Selective dorsal rhizotomy in adults showed improvements in ambulatory function, reduced spasticity, and alleviated muscle and joint pain, with positive effects on activities of daily life. However, post-surgery some patients may develop new lower limb paresthesia. Further follow-up is needed to confirm the durability of these outcomes.
CHILDS NERVOUS SYSTEM
(2021)
Review
Biochemistry & Molecular Biology
Liliana Elena Stanciu, Madalina Gabriela Iliescu, Liliana Vladareanu, Alexandra Ecaterina Ciota, Elena-Valentina Ionescu, Claudia Ileana Mihailov
Summary: This study aims to determine the importance and/or use of hydrotherapy in the therapeutic management of spinal cord injury patients. The analysis of several databases between 2000 and 2021 found only four scientific publications supporting the benefits of hydrotherapy for SCI patients, but the limited number of studies requires more standardized methodology to prove the improvements in lower limb functioning. Clinical trials in the future are necessary.