Article
Clinical Neurology
Christina Devoto, Rany Vorn, Sara Mithani, Timothy B. Meier, Chen Lai, Steven P. Broglio, Thomas Mcallister, Christopher C. Giza, Daniel Huber, Jaroslaw Harezlak, Kenneth L. Cameron, Gerald Mcginty, Jonathan Jackson, Kevin Guskiewicz, Jason P. Mihalik, Alison Brooks, Stefan Duma, Steven Rowson, Lindsay D. Nelson, Paul Pasquina, Christine Turtzo, Lawrence Latour, Michael A. Mccrea, Jessica M. Gill, CARE Consortium Investigators
Summary: This study aimed to investigate plasma phosphorylated tau (p-tau181) protein in mild traumatic brain injury (mTBI) patients and concussed athletes. The study found that plasma p-tau181 concentrations were significantly elevated within 48 hours of injury in both groups, with the highest levels observed in patients with neuroimaging evidence of injury. These findings suggest that plasma p-tau181 concentrations may be related to brain injury and could potentially serve as an early diagnostic biomarker for mTBI/concussions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Etienne Gaudette, Seth A. Seabury, Nancy Temkin, Jason Barber, Anthony M. DiGiorgio, Amy J. Markowitz, Geoffrey T. Manley
Summary: This study assessed the employment and economic outcomes for working-age adults with mild traumatic brain injury (mTBI) in the 12 months after injury. It also explored the association between returning to work and employer assistance.
Article
Critical Care Medicine
Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Antti Korvenoja, Kaisa Maki, Taina Nybo, Rahul Raj, Susanna Melkas
Summary: This prospective cohort study found that patients with traumatic microbleeds (TMBs) in mild traumatic brain injury (mTBI) did not experience more post-concussion symptoms or worse overall recovery compared to patients without TMBs. TMBs do not seem to be a significant prognostic factor of return to work (RTW) in mTBI patients.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Rehabilitation
Noah D. Silverberg, Grant L. Iverson, Alison Cogan, Kristen Dams-O-Connor, Richard Delmonico, Min Jeong P. Graf, Mary Alexis Iaccarino, Maria Kajankova, Joshua Kamins, Karen L. McCulloch, Gary McKinney, Drew Nagele, William J. Panenka, Amanda R. Rabinowitz, Nick Reed, Jennifer Wethe, Victoria Whitehair, Vicki Anderson, David B. Arciniegas, Mark T. Bayley, Jeffery J. Bazarian, Kathleen R. Bell, Steven P. Broglio, David Cifu, Gavin A. Davis, Jiri Dvorak, Ruben J. Echemendia, Gerard A. Gioia, Christopher C. Giza, Sidney R. Hinds II, Douglas I. Katz, Brad G. Kurowski, John J. Leddy, Natalie Le Sage, Angela Lumba-Brown, Andrew I. R. Maas, Geoffrey T. Manley, Michael McCrea, David K. Menon, Jennie Ponsford, Margot Putukian, Stacy J. Suskauer, Joukje van der Naalt, William C. Walker, Keith Owen Yeates, Ross Zafonte, Nathan D. Zasler, Roger Zemek
Summary: This study aims to develop new diagnostic criteria for mild traumatic brain injury (TBI) that are appropriate for use across the lifespan and in sports, civilian trauma, and military settings. Through a rapid evidence review and Delphi method, a 90.7% agreement on the diagnostic criteria was reached, which will improve the quality and consistency of mild TBI research and clinical care.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Neurosciences
Meaghan K. Race, Amanda E. Hahn-Ketter, Lisa A. A. Spielman, Enna Selmanovic, Karla L. Therese Sy, Robin Wellington, Kristen Dams-O'Connor
Summary: The study aimed to test the hypothesis that individuals with a history of traumatic brain injury (TBI) before the collegiate pre-season are at a higher risk for re-injury. The findings revealed that collegiate athletes with a lifetime history of TBI had a significantly higher risk of sustaining a subsequent concussion.
Article
Rehabilitation
Toril Skandsen, Jonas Stenberg, Turid Follestad, Migle Karaliute, Simen B. Saksvik, Cathrine E. Einarsen, Hanna Lillehaug, Asta K. Haberg, Anne Vik, Alexander Olsen, Grant L. Iverson
Summary: Personal factors play an important role in predicting postconcussion symptoms in patients with mild traumatic brain injury (MTBI). Factors such as work status, preinjury health problems, and gender were found to be predictors of postconcussion symptoms. Intracranial abnormalities on CT scans were also identified as a risk factor for postconcussion symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Medicine, General & Internal
Valeska Hofmann, Christian Deininger, Stefan Doebele, Christian Konrads, Florian Wichlas
Summary: The number of fall-related hospitalizations among older adults has been on the rise in recent decades. One common reason for this is mild traumatic brain injury (mTBI) in older individuals taking anticoagulant medication. Research found that geriatric patients under anticoagulant medication do not necessarily require a second cCT scan if the initial scan shows no signs of intracranial bleeding and the patient is asymptomatic.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Anat Biegon
Summary: Published epidemiological studies show that the number of women with TBI is significantly higher than previously believed, with young women being more likely to die from TBI compared to men in the same age group, but this reverses in postmenopausal women. Studies also indicate that female athletes who sustain mild TBI are more likely to report more symptoms than males.
FRONTIERS IN NEUROLOGY
(2021)
Article
Orthopedics
Sarah A. Orban, Jeffery N. Epstein, Devon Carr, Kelsey Logan, Paul J. Gubanich, Craig Sidol, Gregory D. Myer
Summary: Patients with ADHD had higher parent-reported symptoms both before and after mTBI, while females exhibited higher fatigue and emotional symptoms pre-injury and higher symptoms in all domains post-mTBI compared to males. The study highlights the importance of assessing baseline symptoms and considering ADHD status and sex when evaluating mTBI symptom severity in clinical settings.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: This systematic review and meta-analysis found that nearly one in three adults with mild traumatic brain injury experience mild severity post-concussion symptoms 3-6 months later. However, controlling for attrition bias, the true prevalence may be one in six. This highlights the need for studies with representative samples and high retention rates.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Emergency Medicine
Frederique Beauchamp, Valerie Boucher, Xavier Neveu, Vincent Ouellet, Patrick Archambault, Simon Berthelot, Jean-Marc Chauny, Elaine de Guise, Marcel emond, Jerome Frenette, Eddy Lang, Jacques Lee, Eric Mercier, Lynne Moore, Marie-Christine Ouellet, Jeffrey Perry, Natalie Le Sage
Summary: The study found that patients who sustained sports-related mild TBI may be at lower risk of experiencing symptoms such as fatigue and dizziness 90 days post-injury compared to non-sports-related mild TBI patients.
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: Studies on the long-term symptoms and disability after mild traumatic brain injury (mTBI) have produced mixed results. This systematic review and meta-analysis aimed to determine the prevalence of self-reported post-concussion symptoms (PCS) and disability following mTBI. The findings suggest that approximately one in three adults with mTBI experience at least mild severity PCS 3-6 months after the injury, but controlling for attrition bias, the true prevalence may be one in six. Well-designed studies with representative samples and high retention rates are needed to further investigate this issue.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Debbie Y. Madhok, Robert M. Rodriguez, Jason Barber, Nancy R. Temkin, Amy J. Markowitz, Natalie Kreitzer, Geoffrey T. Manley
Summary: This study found that most patients with mild TBI, with a GCS score of 15 and a negative head CT scan, did not fully recover at 2 weeks and 6 months after the injury. Emergency department clinicians should recommend 2-week follow-up visits to identify patients with incomplete recovery and facilitate rehabilitation.