Article
Neurosciences
Fenghui Ye, Ya Hua, Richard F. Keep, Guohua Xi, Hugh J. L. Garton
Summary: Blocking CD47 in the hematoma accelerated hematoma clearance and alleviated hemolysis and hydrocephalus development after intraventricular hemorrhage, suggesting CD47 might be valuable in the future treatment for IVH. Erythrophagocytosis was observed as soon as 4 h after IVH and was enhanced on day 3. CD47 blockade also upregulated intra-hematoma infiltration of CD68, heme oxygenase-1 and ferritin positive phagocytes by day 3.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Clinical Neurology
Eun-Kyung Park, Ja-Yoon Kim, Dong-Seok Kim, Kyu-Won Shim
Summary: Post-hemorrhagic hydrocephalus (PHH) in preterm infants is common and life-threatening, resulting in bad developmental outcomes. Ventriculoperitoneal (VP) shunt is used as the ultimate treatment for PHH. The most important prognostic factor for VP shunting is age, but low birth weight and low gestational age also contribute to worse prognosis. Early and aggressive intervention can effectively control intraventricular hemorrhage and intracranial pressures, reducing the risk of infection and brain damage. Allowing PHH infants to mature and gain weight before undergoing VP shunt is crucial to reduce shunt-related complications.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Clinical Neurology
Yi Cao, Chang Liu, Gaowei Li, Weina Gao, Hui Tang, Shuanmin Fan, Xin Tang, Long Zhao, Haoxiang Wang, Aijun Peng, Chao You, Aiping Tong, Liangxue Zhou
Summary: Metformin has been found to attenuate neuroinflammation and subsequent fibrosis after intraventricular hemorrhage, thereby reducing the occurrence of delayed hydrocephalus. It exerts its effects through regulating the AMPK/SIRT1/NF-kappa B pathways.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Sruthi Ramagiri, Shelei Pan, Dakota DeFreitas, Peter H. Yang, Dhvanii K. Raval, David F. Wozniak, Prabagaran Esakky, Jennifer M. Strahle
Summary: Posthemorrhagic hydrocephalus is a common complication of intraventricular hemorrhage in infants. This study develops an animal model of intraventricular hemorrhage and demonstrates that administration of the iron chelator deferoxamine at the time of hemorrhage can prevent hydrocephalus and reduce iron levels in the choroid plexus. This treatment strategy may be clinically relevant for preventing neurological sequelae after intraventricular hemorrhage.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pediatrics
Emilie Groulx-Boivin, Mariane Paquette, May Khairy, Marc Beltempo, Roy Dudley, Amaryllis Ferrand, Mireille Guillot, Victoria Bizgu, Jarred Garfinkle
Summary: This study investigated the temporal evolution of post-hemorrhagic ventricular dilatation (PHVD) and compared neurodevelopmental impairments in newborns with different outcomes. The results showed that newborns with persistent PHVD without resolution are at higher risk for neurodevelopmental impairments, which may be due to larger ventricular dilatation.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Miriam Zamorano, Scott D. Olson, Candice Haase, Juan J. Herrera, Shuning Huang, David J. Sequeira, Charles S. Cox Jr, Brandon A. Miller
Summary: Inflammation and white matter injury are consequences of neonatal intraventricular hemorrhage (IVH). The effects of IVH occurring at different developmental time points in the same model have not been examined. Understanding how the timing of IVH affects outcome may provide important insights into both IVH pathophysiology and innate immune development.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Medicine, General & Internal
Taek Min Nam, Ji Hwan Jang, Seung Hwan Kim, Kyu Hong Kim, Young Zoon Kim
Summary: This study found that spontaneous thalamic hemorrhage patients with intraventricular hemorrhage have higher mortality rates and lower rates of good functional recovery. Additionally, treatment involving external ventricular drainage may lead to a higher incidence of delayed normal pressure hydrocephalus in these patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Editorial Material
Clinical Neurology
Emanuele La Corte, Micol Babini, Mariella Lefosse, Francesca Nicolini, Mino Zucchelli
Summary: Intraventricular hemorrhage and subsequent post hemorrhagic hydrocephalus are serious complications in premature infants, leading to neurodevelopmental delay, epilepsy, and cognitive impairment. Temporary cerebrospinal fluid diversion procedures may be a therapeutic option for such infants.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Yingfeng Wan, Katherine G. Holste, Fenghui Ye, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage, especially accompanied by intraventricular hemorrhage (IVH), is common in the elderly and can lead to posthemorrhagic hydrocephalus and poor prognosis. This study used T2* magnetic resonance imaging (MRI) to detect periventricular iron deposition after IVH and investigated the effects of minocycline on hydrocephalus in an aged rat IVH model. The findings showed that IVH-induced hydrocephalus is associated with periventricular iron deposition, ependymal damage, and choroid plexus epiplexus cell activation in aged rats. Minocycline attenuated these effects and may be a potential treatment for posthemorrhagic hydrocephalus in the elderly.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Laura Ollegaard Johnsen, Kathrine Abildskov Friis, Helle Hasager Damkier
Summary: Intraventricular hemorrhage is a life-threatening condition with approximately 20% of patients developing posthemorrhagic hydrocephalus. Inflammatory components have been found to affect membrane transporters involved in cerebrospinal fluid secretion, primarily mediated by the activation of basolateral receptors in the choroid plexus, mainly facilitated by IL-6.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Review
Neurosciences
Katherine G. Holste, Fan Xia, Fenghui Ye, Richard F. Keep, Guohua Xi
Summary: Intraventricular hemorrhage (IVH) is a significant cause of morbidity and mortality in both neonatal and adult populations. The subsequent inflammation caused by IVH not only leads to additional brain injury and edema, but also places individuals at risk for white matter injury, seizures, and death. Understanding the mechanisms of neuroinflammation after IVH may highlight potential novel therapeutic targets for post-hemorrhagic hydrocephalus (PHH).
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Immunology
Zhaoqi Zhang, Qiang Tan, Peiwen Guo, Suna Huang, Zhengcai Jia, Xin Liu, Hua Feng, Yujie Chen
Summary: The NLRP3 inflammasome plays a crucial role in the pathogenesis of hydrocephalus after intracerebral hemorrhage. Inhibition of NLRP3 decreases CSF secretion and attenuates ventricular dilation and neurological deficits.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Ao Chen, JianXian Li, Hao Luo, Tao Sun, RenHui Zhou, Rong Xiang, ZhongChi Tong
Summary: This study aimed to determine whether EVD is beneficial in patients with mild IVH. Data from IVH patients treated conservatively or with EVD were analyzed retrospectively. The primary outcome was poor functional status at 90 days, and secondary outcomes included mRS score distribution, clot resolution time, and complications. No evidence supports that preventive EVD benefits patients with mild IVH.
NEUROSURGICAL REVIEW
(2023)
Article
Critical Care Medicine
Ying Li, Ding Nan, Ran Liu, Jieyu Li, Zhuangzhuang Zhang, Jianwen Deng, Yang Zhang, Ziguang Yan, Chao Hou, Ensheng Yao, Weiping Sun, Zhaoxia Wang, Yining Huang
Summary: This study investigated the role of Aquaporin 4 (AQP4) in hydrocephalus caused by iron overload after intraventricular hemorrhage (IVH). The results showed that iron overload contributed to the development of hydrocephalus, and AQP4 played an important role in this process.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Raywat Noiphithak, Thapakorn Phumichard, Warot Ratanavinitkul, Pataravit Rukskul
Summary: The diameter of posttreatment temporal horn and the degree of IVH reduction were significant predictors of shunt dependency in patients with IVH. Early conversion from EVD to ventriculoperitoneal shunt is safe and feasible.
WORLD NEUROSURGERY
(2023)