Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Sang-Soo Choi, Haeyoun Choi, In-Cheol Baek, Soon A. Park, Jae-Sung Park, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn
Summary: This case-control study evaluated the association between HLA polymorphism and the risk of glioblastoma development in Koreans. Findings suggest that certain HLA types may affect the development of glioblastoma in Koreans. Further research with larger sample sizes is needed to confirm the role of HLA polymorphisms in the pathogenesis of glioblastoma.
Article
Multidisciplinary Sciences
Mohammad Hazaymeh, Ronja Loeber-Handwerker, Katja Doering, Tammam Abboud, Dorothee Mielke, Veit Rohde, Vesna Malinova
Summary: Approximately 25% of glioblastomas show corpus callosum infiltration at diagnosis, which is associated with poor prognosis. The extent of corpus callosum involvement ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Haohao Huang, Songyang Zhang, Yuanyuan Li, Zhaodan Liu, Lanjuan Mi, Yan Cai, Xinzheng Wang, Lishu Chen, Haowen Ran, Dake Xiao, Fangye Li, Jiaqi Wu, Tingting Li, Qiuying Han, Liang Chen, Xin Pan, Huiyan Li, Tao Li, Kun He, Ailing Li, Xuemin Zhang, Tao Zhou, Qing Xia, Jianghong Man
Summary: Prohibitin regulates mitochondrial ROS production by stabilizing the peroxidase PRDX3, contributing to radiotherapy resistance in glioma stem-like cells.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Silvia Chiesa, Antonella Mangraviti, Maurizio Martini, Tonia Cenci, Ciro Mazzarella, Simona Gaudino, Serena Bracci, Antonella Martino, Giuseppe M. Della Pepa, Martina Offi, Marco Gessi, Rosellina Russo, Matia Martucci, Francesco Beghella Bartoli, Luigi M. Larocca, Liverana Lauretti, Alessandro Olivi, Roberto Pallini, Mario Balducci, Quintino Giorgio D'Alessandris
Summary: This study aimed to identify molecular predictive factors for response to regorafenib in recurrent IDH-wildtype glioblastoma patients and found that mutations in the MAPK pathway may predict poor response and shorter survival in patients treated with regorafenib.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
R. C. Cornelison, J. X. Yuan, K. M. Tate, A. Petrosky, G. F. Beeghly, M. Bloomfield, S. C. Schwager, A. L. Berr, C. A. Stine, D. Cimini, F. F. Bafakih, J. W. Mandell, B. W. Purow, B. J. Horton, J. M. Munson
Summary: In this study, a four-component 3D model of glioblastoma was created using patient-derived glioma stem cells and human glial cells. The model allowed examination of invasion, proliferation, and stemness in the context of glial cells, fluid forces, and chemotherapies. The findings suggest that interstitial flow promotes glioma cell proliferation and stemness, while glial cells affect invasion and stemness, potentially through CCL2 expression and differential activation.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Zili Tang, Ivana Dokic, Maximilian Knoll, Federica Ciamarone, Christian Schwager, Carmen Klein, Gina Cebulla, Dirk C. Hoffmann, Julian Schlegel, Philipp Seidel, Christiane Rutenberg, Stephan Brons, Christel Herold-Mende, Wolfgang Wick, Juergen Debus, Dieter Lemke, Amir Abdollahi
Summary: This study reveals that invasive tumor cells in glioblastoma exhibit high radioresistance and are closely associated with patient prognosis. Transcriptome analysis identifies the gene expression profile of invasive cells and validates the involvement of key pathways. Inhibition of specific signaling pathways and the use of carbon ion therapy can enhance the sensitivity of invasive cells to radiation treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Cell Biology
Anna Carrano, Juan Jose Juarez, Diego Incontri, Antonio Ibarra, Hugo Guerrero Cazares
Summary: Sex differences exist in brain tumors, with males having higher incidence and worse outcomes in GBM compared to females. Estrogen plays a protective role in GBM, while upregulation of androgen receptors and testosterone may have detrimental effects. Hormones and the immune system play important roles in the GBM microenvironment.
Article
Multidisciplinary Sciences
Ping Zhu, Xianglin L. Du, Lu-yu Hwang, David Lairson, Ruosha Li, Yoshua Esquenazi, Jay-Jiguang Zhu
Summary: The optimal time to initiate adjuvant therapy (AT) in elderly patients with glioblastoma (GBM) remains uncertain. Two large-scale datasets from the United States were used to investigate the impact of timing on overall survival (OS) in elderly GBM populations. The study found that initiating AT with a modest delay (27-37 days) or a longer delay (>= 38 days) after craniotomy may be the preferred timing for elderly GBM patients.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Yifan Ma, Yue Wang, Chen Nie, Yongzhong Lin
Summary: Through a comprehensive meta-analysis, this study found that targeted therapy combined with radiotherapy and chemotherapy can improve the survival rate and progression-free survival of glioma patients to some extent.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Alessandro Salvalaggio, Lorenzo Pini, Matteo Gaiola, Aron Velco, Giulio Sansone, Mariagiulia Anglani, Lucius Fekonja, Franco Chioffi, Thomas Picht, Michel Thiebaut de Schotten, Vittorina Zagonel, Giuseppe Lombardi, Domenico D'Avella, Maurizio Corbetta
Summary: This study examined the association between white matter tracts affected by glioblastoma (GBM) and patients' overall survival (OS), using a new tract density index (TDI) as a predictor. The results showed that GBMs encompassing regions with low white matter tract density were associated with longer OS. The TDI was identified as a reliable presurgical outcome predictor that can be considered in clinical trials and clinical practice.
Article
Biochemistry & Molecular Biology
Parveen Kumar, Vivek Verma, Dheeraj Mohania, Surbhi Gupta, Avneet K. Babbar, Bhawna Rathi, Rakesh S. Dhanda, Manisha Yadav
Summary: The study revealed that RUNX1T1 is mutated in different cancers and associated with poor overall survival in glioma patients, possibly affecting glioma growth and development through HIF1α regulation. Experimental results showed that downregulation of RUNX1T1 may lead to degradation of HIF1α, reducing proliferation and invasiveness of glioblastoma cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Qu-Jing Gai, Zhen Fu, Jiang He, Min Mao, Xiao-Xue Yao, Yan Qin, Xi Lan, Lin Zhang, Jing-Ya Miao, Yan-Xia Wang, Jiang Zhu, Fei-Cheng Yang, Hui-Min Lu, Ze-Xuan Yan, Fang-Lin Chen, Yu Shi, Yi-Fang Ping, You-Hong Cui, Xia Zhang, Xindong Liu, Xiao-Hong Yao, Sheng-Qing Lv, Xiu-Wu Bian, Yan Wang
Summary: PDGFRA may not be necessary for PDGFA function. The study revealed EPHA2 as a potential receptor of PDGFA and identified that co-upregulation of PDGFA and EPHA2 led to worse patient prognosis and poorer therapeutic effects. Combination inhibitors targeting PDGFRA and EHA2 represent a promising therapeutic strategy for GBM treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Oncology
Annekatrin Seidlitz, Bettina Beuthien-Baumann, Steffen Loeck, Christina Jentsch, Ivan Platzek, Klaus Zoephel, Annett Linge, Joerg Kotzerke, Jan Petr, Joerg van den Hoff, Joerg Steinbach, Dietmar Krex, Gabriele Schmitz-Schackert, Monique Falk, Michael Baumann, Mechthild Krause
Summary: This study reveals that in patients with glioblastoma, those without increased tracer accumulation in postoperative MET-PET have longer time to recurrence, while residual tumors detected by MRI post-surgery affect time to recurrence. Significant multivariable predictors for time to recurrence include MET accumulation in pre-RCTPET, MRI positivity, and MGMT hypermethylation.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Cong Lyu, Yamei Niu, Weiyi Lai, Yu Wang, Yaning Wang, Peibin Dai, Chunhui Ma, Shaokun Chen, Yao Li, Guibin Jiang, Zhiyong Liang, Wenbin Ma, Zhengliang Gao, Wei-Min Tong, Hailin Wang
Summary: The entity of DNA N-6-methyladenine (6mA) in mammals remains elusive and its roles in diseases are poorly understood. In this study, a bacteria-free UHPLC-MS/MS assay was used to reassess DNA 6mA in human glioblastomas and it was found to be extremely rare. Further experiments revealed that the observed 6mA is solely generated by DNA polymerase-mediated misincorporation. The generation of misincorporated DNA 6mA is associated with the release of RNA N-6-methyladenine (m6A) nucleoside, which is inhibited by hypoxia milieu.