Article
Endocrinology & Metabolism
Takako Araki, Yukiko Tone, Masaaki Yamamoto, Hiraku Kameda, Anat Ben-Shlomo, Shozo Yamada, Akira Takeshita, Masato Yamamoto, Yasuhiko Kawakami, Masahide Tone, Shlomo Melmed
Summary: A novel regulatory region near the intron 2/exon 3 junction in the human POMC gene functions as a second promoter and enhancer, regulated by methylation status in ACTH-secreting pituitary tumors, and potentially influencing the clinical phenotype of Cushing disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Nagihan Bestepe, Didem Ozdemir, Burcak Polat, Oya Topaloglu, Oktay Algin, Ercan Bal, Reyhan Ersoy, Bekir Cakir
Summary: BIPSS is an important diagnostic tool for identifying the source of ACTH secretion in CD patients without clear radiological evidence, showing a higher sensitivity and accuracy in localizing the pituitary lesion compared to MRI.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Takako Araki, Yukiko Tone, Masaaki Yamamoto, Hiraku Kameda, Anat Ben-Shlomo, Shozo Yamada, Akira Takeshita, Masato Yamamoto, Yasuhiko Kawakami, Masahide Tone, Shlomo Melmed
Summary: We identified a novel regulatory region near the intron 2/exon 3 junction in the POMC gene, serving as a second promoter and enhancer regulated by methylation status, with demethylation patterns correlating with Cushing disease clinical phenotypes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Yi Fang, He Wang, Ming Feng, Hongjie Chen, Wentai Zhang, Liangfeng Wei, Zhijie Pei, Renzhi Wang, Shousen Wang
Summary: In this study, a CNN model was used to assess cavernous sinus invasion (CSI) in pituitary adenoma (PA), and it showed a high proficiency in diagnosis compared to the traditional Knosp grading system.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Elzbieta Moszczynska, Elzbieta Marczak, Mieczyslaw Szalecki, Krzysztof Kadziolka, Marcin Roszkowski, Patrycja Zagata-Lesnicka
Summary: This study analyzed the diagnostic accuracy of BIPSS in pediatric patients with CD, showing that BIPSS has high accuracy in identifying the underlying cause and guiding surgical intervention, but limited value in tumor localization.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ning Ai Liu, Anat Ben-Shlomo, John D. Carmichael, Christina Wang, Ronald S. Swerdloff, Anthony P. Heaney, Garni Barkhoudarian, Daniel Kelly, Mazen Noureddin, Lin Lu, Manish Desai, Yana Stolyarov, Kevin Yuen, Adam N. Mamelak, James Mirocha, Mourad Tighiouart, Shlomo Melmed
Summary: Seliciclib may directly target pituitary corticotrophs in patients with Cushing's disease and reverse hypercortisolism. However, further research is needed regarding the liver toxicity associated with seliciclib.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Yi Fang, Zhijie Pei, Hongjie Chen, Renzhi Wang, Ming Feng, Liangfeng Wei, Jun Li, Heng Zhang, Shousen Wang
Summary: The study found that grades 2-4, 3-4, and 3B-4 of the Knosp grade had good discriminative abilities in predicting CSI, and modifying the KG improved its prognostic role in CSI and gross total resection. However, the reliability of the scale's middle grades (grades 2 and 3A) was weak, and therefore these grading systems cannot be used as a standard for invasive and non-invasive pituitary adenomas. It is recommended that future studies report KG as high, medium, and low to optimize the application of the scale.
Article
Clinical Neurology
Lukas Andereggen, Luigi Mariani, Juergen Beck, Robert H. Andres, Jan Gralla, Markus M. Luedi, Joachim Weis, Emanuel Christ
Summary: This study found that resection of one-third of the lateral pituitary gland based on IPSS predictions in CD patients without intraoperative adenoma identification resulted in low morbidity and long-term remission in 31% of patients, with some patients experiencing new pituitary hormone deficits. Long-term control of hypercortisolism was achieved in 77% of patients, but additional therapies were needed for 69% of them. Considering the small sample size, the decision to perform lateral one-third-gland resection should be carefully discussed with patients before surgery.
ACTA NEUROCHIRURGICA
(2021)
Article
Surgery
Ethan Harel, Giulia Cossu, Roy Thomas Daniel, Mahmoud Messerer
Summary: This study analyzed the surgical outcomes of L- and G-PAs based on factors such as tumor relationship with the diaphragm, invasion of CS, and invasion of the subarachnoid space. Results showed that most patients had grade 1 tumors and achieving GTR was linked to lower CS invasion rates. Radiological evaluation plays a crucial role in planning surgical strategy for L- and G-PAs.
FRONTIERS IN SURGERY
(2022)
Review
Endocrinology & Metabolism
Dimin Zhu, Zongming Wang, Tian Tian, Xinyi Wu, Dongsheng He, Yonghong Zhu, Dawei Liu, Haijun Wang
Summary: Crooke's cell adenoma is a tumor subtype with obvious clinical aggressive behavior. Male patients are more common and often present with elevated adrenocorticotropic hormone levels. The tumor diameter is larger and invasive. Female patients dominate the reported cases and exhibit symptoms such as Cushing's syndrome and hormonal dysfunction. Tumors are more commonly macroadenomas and grow in the suprasellar region, with a high recurrence rate and a significant proportion progressing to pituitary carcinomas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Zhijie Pei, Jiaxing Wang, Shuwen Mu, Tianshun Feng, Meina Wang, Shentong Yu, Liangfeng Wei, Yi Fang, Shousen Wang
Summary: The study found that factors such as Knosp grade 3-4, a greater proportion of suprasellar tumor volume, and evidence of invasion of the cavernous sinus during surgery make it more difficult to completely remove giant pituitary adenomas.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
FuMing Yang, YunKe Bi, QiangYi Zhou, HongChan Li, YaJun Xue, QingWei Zhu, Jian Yin, ZhiYu Wang, MeiQing Lou
Summary: The study aimed to understand the characteristics and growth corridors of Knosp grade 4 pituitary adenomas (Knosp4PA) with cavernous sinus (CS) compartments penetration and intracranial extension. A case series of 120 Knosp4PA patients was reviewed, and a novel surgery-relevant grading system was proposed. The study found that the grading system can improve the total resection rate of Knosp4PA.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Heng Sun, Chunli Wu, Biao Hu, Genqing Xie
Summary: This study is the first to report a high prevalence of radiologic VFs in recently diagnosed CD patients. VFs may represent an early manifestation of CD and may be related to cortisol levels. Therefore, VF assessment should be included in the workup during CD diagnosis.
ANNALS OF MEDICINE
(2023)
Article
Oncology
Taohui Ouyang, Na Zhang, Shenhao Xie, Bin Tang, Junjun Li, Limin Xiao, Fabao Zhang, Bowen Wu, Dongwei Zhou, Meihua Li, Tao Hong
Summary: The study retrospectively analyzed outcomes and complications in 102 patients with Knosp grade 4 pituitary adenomas. It found that patients with complete resection of the entire tumor were more likely to have favorable endocrine and visual outcomes, and that recurrent tumors and firm consistency tumors were adverse factors for complete resection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Regin Jay Mallari, Jai Deep Thakur, Garni Barkhoudarian, Amy Eisenberg, Amanda Rodriguez, Sarah Rettinger, Pejman Cohan, Lynnette Nieman, Daniel F. Kelly
Summary: This study describes the predictive performance of preoperative biochemical and imaging data on postoperative remission and clinical characteristics in patients with presumed Cushing's disease. The use of strict biochemical thresholds can improve surgical remission rates and avoid recommending surgery to patients with equivocal biochemical data.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Letter
Clinical Neurology
Joshua M. Ammerman, Matthew D. Ammerman, Joshua J. Wind
JOURNAL OF NEUROSURGERY-SPINE
(2016)
Review
Clinical Neurology
Alan Siu, Joshua J. Wind, J. Bryan Iorgulescu, Timothy A. Chan, Yoshiya Yamada, Jonathan H. Sherman
ACTA NEUROCHIRURGICA
(2012)
Review
Clinical Neurology
Joshua J. Wind, Russell R. Lonser
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2011)
Article
Endocrinology & Metabolism
Russell R. Lonser, Joshua J. Wind, Lynnette K. Nieman, Robert J. Weil, Hetty L. DeVroom, Edward H. Oldfield
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Article
Endocrinology & Metabolism
Joshua J. Wind, Russell R. Lonser, Lynnette K. Nieman, Hetty L. DeVroom, Richard Chang, Edward H. Oldfield
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Article
Clinical Neurology
Joshua J. Wind, Kamran D. Bakhtian, Jennifer A. Sweet, Gautam U. Mehta, Jayesh P. Thawani, Ashok R. Asthagiri, Edward H. Oldfield, Russell R. Lonser
JOURNAL OF NEUROSURGERY
(2011)
Article
Clinical Neurology
Joshua J. Wind, John P. Leonetti, Michael J. M. Raffin, Marc T. Pisansky, Brian Herr, Justin D. Triemstra, Douglas E. Anderson
JOURNAL OF NEUROSURGERY
(2011)
Article
Clinical Neurology
Richard M. Young, Jonathan H. Sherman, Joshua J. Wind, Zachary Litvack, Joseph O'Brien
JOURNAL OF NEUROSURGERY-SPINE
(2014)
Article
Clinical Neurology
Richard M. Young, Vikram Prasad, Joshua J. Wind, Wayne Olan, Anthony J. Caputy
JOURNAL OF NEUROSURGERY-SPINE
(2014)
Article
Clinical Neurology
Joshua J. Wind, Richard Young, Ashima Saini, Jonathan H. Sherman
NEUROSURGERY CLINICS OF NORTH AMERICA
(2012)
Article
Clinical Neurology
Joshua J. Wind, Chima Ohaegbulam, Fabio M. Iwamoto, Peter M. Black, John K. Park
WORLD NEUROSURGERY
(2013)
Article
Public, Environmental & Occupational Health
Joshua M. Ammerman, Joshua J. Wind, Michael E. Goldsmith, Jason A. Inzana
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Review
Otorhinolaryngology
Fabio Roberti, Joshua J. Wind, Rosa Perez, Anthony J. Caputy
Summary: Surgical anatomy training and practical dissection courses are crucial for skull base surgeons, but transferring skills and knowledge from the lab to the operating room presents challenges. This study provides a detailed comparison of anatomical exposures in the lab and OR, discussing technical nuances and challenges encountered during surgery.
JOURNAL OF OTOLOGY
(2021)
Meeting Abstract
Clinical Neurology
Joshua J. Wind, Russell R. Lonser, Lynnette K. Nieman, Edward H. Oldfield
JOURNAL OF NEUROSURGERY
(2011)