The molecular biology and novel treatments of vestibular schwannomas

Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2

(2011) V.-F. Mautner et al.   NEURO-ONCOLOGY

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Incidence and risk of significantly raised blood pressure in cancer patients treated with bevacizumab: an updated meta-analysis

(2010) Mao Mao An et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma

(2010) S. Ammoun et al.   NEURO-ONCOLOGY

True Incidence of Vestibular Schwannoma?

(2010) Sven-Eric Stangerup et al.   NEUROSURGERY

NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation

(2010) E E Bosco et al.   ONCOGENE

Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas

(2010) K D Hadfield et al.   ONCOGENE

Merlin Knockdown in Human Schwann Cells

(2010) Zana Ahmad et al.   OTOLOGY & NEUROTOLOGY

Erlotinib for Progressive Vestibular Schwannoma in Neurofibromatosis 2 Patients

(2010) Scott R. Plotkin et al.   OTOLOGY & NEUROTOLOGY

Predictors of Vestibular Schwannoma Growth and Clinical Implications

(2010) Yuri Agrawal et al.   OTOLOGY & NEUROTOLOGY

Deregulated Genes in Sporadic Vestibular Schwannomas

(2010) Per Cayé-Thomasen et al.   OTOLOGY & NEUROTOLOGY

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

(2009) Christine Flaiz et al.   EXPERIMENTAL NEUROLOGY

Molecular biology of familial and sporadic vestibular schwannomas: implications for novel therapeutics

(2009) Michael E. Sughrue et al.   JOURNAL OF NEUROSURGERY

Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitization

(2009) Andrea H. Yeung et al.   Neurosurgical Focus

Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2

(2009) Scott R. Plotkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex

(2009) Andrea I. McClatchey et al.   TRENDS IN CELL BIOLOGY

Altered Adhesive Structures and Their Relation to RhoGTPase Activation in Merlin-Deficient Schwannoma

(2008) Christine Flaiz et al.   BRAIN PATHOLOGY

Clinical pharmacokinetics of bevacizumab in patients with solid tumors

(2008) Jian-Feng Lu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases

(2008) P MEDINA et al.   CLINICAL THERAPEUTICS

Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells

(2008) C. Flaiz et al.   GLIA

Phase II Trial of Lapatinib for Brain Metastases in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

(2008) Nancy U. Lin et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain

(2008) B. Gril et al.   JNCI-Journal of the National Cancer Institute

Effects of ErbB2 Signaling on the Response of Vestibular Schwannoma Cells to ??-Irradiation

(2008) Marlan R. Hansen et al.   LARYNGOSCOPE

The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner

(2008) S. S. Houshmandi et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development

(2008) C. M. McCall et al.   MOLECULAR AND CELLULAR BIOLOGY

Vestibular Schwannoma

(2008) C. Arturo Solares et al.   OTOLOGY & NEUROTOLOGY

The ErbB Inhibitors Trastuzumab and Erlotinib Inhibit Growth of Vestibular Schwannoma Xenografts in Nude Mice

(2008) J. Jason Clark et al.   OTOLOGY & NEUROTOLOGY