Article
Biotechnology & Applied Microbiology
Chaosheng Yu, Zhen Long, Qianhui Qiu, Fang Liu, Yiming Xu, Tao Zhang, Rui Guo, Wen Zhong, Shuixian Huang, Shuaijun Chen
Summary: A new type of nanomaterial was developed by a research team, using GE11-modified graphene quantum dots as drug carriers for targeting, imaging, and treating nasopharyngeal carcinoma. The nanoscale probe can monitor drug release processes and significantly inhibit tumor cell proliferation through the combination of chemotherapy drugs cisplatin and doxorubicin.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Chibueze D. Nwagwu, Amanda V. Immidisetti, Michael Y. Jiang, Oluwasegun Adeagbo, David C. Adamson, Anne-Marie Carbonell
Summary: This review discusses the potential of convection-enhanced delivery (CED) in treating high-grade gliomas by directly delivering homogeneous drug concentrations to the site of disease, which can significantly limit systemic toxicity and enhance therapeutic effectiveness.
Article
Clinical Neurology
Krystof S. Bankiewicz, Tomasz Pasterski, Daniel Kreatsoulas, Jakub Onikijuk, Krzysztof Mozgiel, Vikas Munjal, J. Bradley Elder, Russell R. Lonser, Miroslaw Zabek
Summary: The study demonstrates that the MRI-compatible frameless stereotactic ball-joint guide array is feasible, accurate, effective, and safe for cannula placement, infusion MRI monitoring, and cannula adjustment during convection-enhanced delivery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Nanoscience & Nanotechnology
Sauradip Chaudhuri, Martha J. Fowler, Cassandra Baker, Sylwia A. Stopka, Michael S. Regan, Lindsey Sablatura, Colton W. Broughton, Brandon E. Knight, Sarah E. Stabenfeldt, Nathalie Y. R. Agar, Rachael W. Sirianni
Summary: This research introduces a novel nanocarrier platform for encapsulating HDACi, improving drug delivery efficiency, and providing insights into the structural requirements for effective drug loading and self-assembly of nanoparticles. The optimized CDN nanoparticles show promising results in slowing tumor growth and increasing exposure of tumors to drugs, indicating a step forward in HDACi therapy for better disease treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Huanhuan Sun, Wenjie Ma, Shuangdi Duan, Jin Huang, Ruichen Jia, Hong Cheng, Biao Chen, Xiaoxiao He, Kemin Wang
Summary: The development of stimuli-responsive nanoplatforms for cancer theranostics is valuable. A nanocluster-bomb activated by endogenous legumain is created for enhanced tumor imaging and controlled gene/drug release. The disaggregation of the nanobomb triggered by legumain improves imaging contrast and enables efficient gene/chemo combination therapy.
Article
Mathematics, Applied
J. A. Ferreira, L. Pinto, R. F. Santos
Summary: Convection enhanced drug delivery is a technique that allows therapeutic agents to reach target sites more efficiently through a catheter, particularly useful for treating diseases of the central nervous system. Numerical analysis shows that the fully discrete finite element method proposed for simulating CED is effective and has second order convergence.
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS
(2022)
Review
Clinical Neurology
Amir H. Faraji, Sibi Rajendran, Andrea S. Jaquins-Gerstl, Hunter J. Hayes, R. Mark Richardson
Summary: This article focuses on the convection-enhanced delivery in stereotactic neurosurgery, highlighting the importance of understanding the biophysical properties of molecular transport in the extracellular space. By addressing current efforts and challenges, the article aims to further refine predictive models for advances in drug delivery techniques to the brain.
WORLD NEUROSURGERY
(2021)
Review
Pharmacology & Pharmacy
Pavan S. Upadhyayula, Eleonora F. Spinazzi, Michael G. Argenziano, Peter Canoll, Jeffrey N. Bruce
Summary: Convection enhanced delivery (CED) is a technique used for treating glioma by infusing treatments directly into the brain parenchyma. The manuscript describes the physical principles behind CED, common pitfalls, and optimization methods. The institutional experience using topotecan CED for malignant glioma treatment is highlighted.
Article
Chemistry, Multidisciplinary
Shih-Hsun Cheng, M. Reid Groseclose, Cindy Mininger, Mats Bergstrom, Lily Zhang, Stephen C. Lenhard, Tinamarie Skedzielewski, Zachary D. Kelley, Debra Comroe, Hyundae Hong, Haifeng Cui, Jennifer L. Hoover, Steve Rittenhouse, Stephen Castellino, Beat M. Jucker, Hasan Alsaid
Summary: This study developed a multimodal imaging approach to assess the distribution of an antibacterial drug delivered as a liposomal formulation in a mouse infection model. By combining positron emission tomography (PET) and matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS), the researchers observed an excellent correlation between the radiolabel signal detected by PET and the drug and lipid component signals detected by MALDI IMS.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Medicinal
Advait Badkar, Rajesh B. Gandhi, Shawn P. Davis, Michael J. LaBarre
Summary: Subcutaneous (SC) delivery of biologics has traditionally been limited to small volumes, but new technologies are emerging to enable the delivery of larger amounts of drug through the SC route, overcoming challenges related to high dosage and volume.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dimitri Hamzaoui, Sarah Montagne, Benjamin Granger, Alexandre Allera, Malek Ezziane, Anna Luzurier, Raphaelle Quint, Mehdi Kalai, Nicholas Ayache, Herve Delingette, Raphaele Renard Penna
Summary: In this study, the intra- and inter-rater variability of prostate volume estimation using manual planimetry and ellipsoid formulas were compared. The results showed that both methods provided highly reproducible measurements, but manual planimetry had the best inter-rater reproducibility, while the ellipsoid formula showed slight overestimation of prostate volume compared to manual planimetry.
EUROPEAN RADIOLOGY
(2022)
Article
Biophysics
Jason N. Mehta, Brianna E. Morales, Fang-Chi Hsu, John H. Rossmeisl, Christopher G. Rylander
Summary: This study investigates the use of constant pressure infusions and controlled catheter movement to increase volume dispersed in an agarose gel brain tissue phantom, and reveals the limitation of flow-driven infusions in achieving maximum infusion volume.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Nanoscience & Nanotechnology
Dong Zhang, Weifen Zhang, Xinghan Wu, Qian Li, Zhiyi Mu, Fengshuo Sun, Mogen Zhang, Guoyan Liu, Linlin Hu
Summary: A multifunctional drug delivery system was developed for melanoma treatment by incorporating drugs into manganese-doped mesoporous silica nanoparticles, coupled with MRI and photothermal imaging. The system showed excellent drug loading and release efficiency, imaging capability, photothermal heating ability, and demonstrated superior antitumor effect in both in vitro and in vivo experiments, highlighting its potential for melanoma therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biology
Michael Plaksin, Tiran Bercovici, Gabriella Gabi Sat Toltsis, Javier Grinfeld, Boaz Shapira, Yuval Zur, Rafi de Picciotto, Eyal Zadicario, Mustaffa Siddeeq, Anton Wohl, Zion Zibly, Yoav Levy, Zvi R. Cohen
Summary: Ultrasound in combination with microbubbles can effectively open the blood brain barrier, allowing the passage of therapeutic agents. A magnetic resonance imaging analysis based on Delta R-2* values can be used for real-time treatment management. The study demonstrates a successful correlation between Delta R-2* values and the concentrations of liposomes in different sizes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Yiyu Chou, Catie Chang, Samuel W. Remedios, John A. Butman, Leighton Chan, Dzung L. Pham
Summary: This paper proposes a deep learning algorithm based on a Siamese Network to classify functional resting state networks (RSNs) derived from Independent Component Analysis (ICA) decomposition. The method out-performs traditional convolutional neural network (CNN) and template matching methods in identifying subject-specific RSNs, achieving high accuracy on holdout and outside data sets. It is also robust to scan-rescan variation and reveals altered functional connectivity in a group analysis of traumatic brain injury (TBI).
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-Tung Wang, Ningzhi Li, Ioannis Papageorgiou, Leighton Chan, Dzung L. Pham, John A. Butman
Summary: The objective of this study was to evaluate the effectiveness of an accelerated 3D segmented echo planar imaging susceptibility-weighted imaging (segEPI SWI) in detecting cerebral microhemorrhages (CMBs) in traumatic brain injury (TBI). The results showed that segEPI SWI was comparable to the traditional 3D gradient echo SWI (GRE SWI) in CMB counts and diffuse axonal injury (DAI) diagnosis. Therefore, segEPI SWI has the potential to replace GRE SWI, especially in time-critical situations.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mihika Gangolli, Wen-Tung Wang, Neville D. Gai, Dzung L. Pham, John A. Butman
Summary: This study aimed to determine whether a diffusion gradient table can acquire data to estimate both dynamic and diffusion tensor imaging (DTI) metrics simultaneously. The results showed that using a nested cubes diffusion gradient table in a single acquisition can produce tensor-based and dynamic diffusion measurements.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
John D. Heiss
NEUROSURGERY CLINICS OF NORTH AMERICA
(2023)
Review
Medicine, General & Internal
Enver Bogdanov, Aisylu T. Faizutdinova, John D. Heiss
Summary: Patients with typical CM1 symptoms usually undergo MRI, and a TH of more than 5 mm is diagnosed as CM1, a TH between 3-5 mm is diagnosed as borderline CM1, and a TH of less than 3 mm with an associated cervical syrinx is diagnosed as CM0. However, patients are usually not diagnosed with CM if MRI shows less than 3-5 mm of TH and no syrinx. Recent MRI morphometric analysis has detected anatomical abnormalities that explain these symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Xueting Jin, Zied Abdullaev, John A. Butman, Sara K. Inati, Shareena A. Rahman, Kareem A. Zaghloul, Antonios Papanicolau-Sengos, Drew W. Pratt, Kenneth D. Aldape, Martha M. Quezado
Article
Engineering, Biomedical
Andrew K. Knutsen, Suhas Vidhate, Grace McIlvain, Josh Luster, Eric J. Galindo, Curtis L. Johnson, Dzung L. Pham, John A. Butman, Ricardo Mejia-Alvarez, Michaelann Tartis, Adam M. Willis
Summary: Traumatic brain injury (TBI) is a significant health concern with a gap in understanding the relationship between impulsive loadings and injury patterns. This study introduces the ANGUS phantom, a synthetic model that mimics the human brain, and compares its response to data from human subjects. The results suggest that the ANGUS phantom is suitable for reproducing the brain's response to linear impulses but requires improvement for rotational impacts.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Medicine, General & Internal
Hannah P. Famili, Christopher K. Zalewski, Alaaddin Ibrahimy, Jessica Mack, Fredric Cantor, John D. Heiss, Carmen C. Brewer
Summary: This study aimed to describe the audiovestibular phenotype in patients with CM1 and dizziness symptoms. Vestibular abnormalities, especially functional balance impairment, were common in these patients. Neck pain was negatively associated with somatosensory analysis score. Although isolated peripheral vestibulopathy was rare, vestibular/balance assessment is important for identifying patients who may benefit from specialized medical care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Dardo Tomasi, Peter Manza, Jean Logan, Ehsan Shokri-Kojori, Michele-Vera Yonga, Danielle Kroll, Dana Feldman, Katherine McPherson, Catherine Biesecker, Evan Dennis, Allison Johnson, Kai Yuan, Wen-Tung Wang, John A. Butman, Gene-Jack Wang, Nora D. Volkow
Summary: Combined PET imaging and mathematical simulations show that the rate of dopamine increase in the striatum is the basis for self-reports of drug high in response to oral and intravenous methylphenidate challenges. This study reveals that the speed of dopamine increases, in addition to its amplitude, plays a role in drug reward. The findings suggest that intravenous methylphenidate induces faster dopamine increases compared to oral methylphenidate, and the time-to-peak is associated with the intensity of the self-report of high.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Alaaddin Ibrahimy, Tianxia Wu, Jessica Mack, Gretchen C. Scott, Michaela X. Cortes, Fredric K. Cantor, Francis Loth, John D. Heiss
Summary: This study showed that patients with Chiari I malformation experienced enlargement of CSF areas and improvement in quality of life after craniocervical decompression surgery, with most changes occurring within the first year post-operation. Overall, a 1-year follow-up period seemed sufficient for evaluating surgical efficacy and postoperative imaging changes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Genetics & Heredity
Isabelle Roux, Cristina Fenollar-Ferrer, Hyun Jae Lee, Parna Chattaraj, Ivan A. Lopez, Kyungreem Han, Keiji Honda, Carmen C. Brewer, John A. Butman, Robert J. Morell, Donna M. Martin, Andrew J. Griffith
Summary: Enlargement of the endolymphatic sac, duct, and vestibular aqueduct (EVA) is a common inner ear malformation in patients with hearing loss, and is associated with pathogenic variants in SLC26A4. However, in European-Caucasian populations, around 50% of EVA patients have no pathogenic alleles of SLC26A4. This study found that CHD7 variants can cause EVA and nonsyndromic hearing loss, and suggest that CHD7 should be included in DNA sequence analyses for EVA patients.
Article
Medicine, General & Internal
Eric A. Kohut, Shantelle A. Graff, Samuel H. Wakelin, Martin Arhin, Govind Nair, John D. Heiss
Summary: Neurosurgeons use MRI scans to evaluate the reduction in syrinx size after surgical treatment. Manual measurement of syrinx volume is time-consuming and prone to errors. Developing convenient semiautomated methods for volumetric analysis can improve the monitoring of syringomyelia. This study compared two semiautomated methods (SCAT and 3DQI) with a manual method (CAV) and found that all methods detected a decrease in syrinx volume after surgery. The semiautomated methods showed efficient and accurate results for clinical decision-making and research studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ashish H. Shah, Robert Suter, Pavan Gudoor, Tara T. Doucet-O'Hare, Vasileios Stathias, Iahn Cajigas, Macarena de la Fuente, Vaidya Govindarajan, Alexis A. Morell, Daniel G. Eichberg, Evan Luther, Victor M. Lu, John Heiss, Ricardo J. Komotar, Michael E. Ivan, Stephan Schurer, Mark R. Gilbert, Nagi G. Ayad
Summary: This study utilized pharmacogenomic and tissue databases to investigate the correlation between reversing the disease signature of glioblastoma and drug efficacy, laying a crucial foundation for personalized treatment development.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Oncology
Yeshavanth Kumar Banasavadi-Siddegowda, Sriya Namagiri, Yoshihiro Otani, Hannah Sur, Sarah Rivas, Jean-Paul Bryant, Allison Shellbourn, Mitchell Rock, Ashis Chowdhury, Cole T. Lewis, Toshihiko Shimizu, Stuart Walbridge, Sivarajan Kumarasamy, Ashish H. Shah, Tae Jin Lee, Dragan Maric, Yuanqing Yan, Ji Young Yoo, Sangamesh G. Kumbar, John D. Heiss, Balveen Kaur
Summary: The study demonstrated that combined inhibition of PRMT5 and MEK synergistically inhibited glioblastoma in animal models, showing promising therapeutic potential.
NEURO-ONCOLOGY ADVANCES
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Krystof Bankiewicz, Matthew T. Rocco, Asad Akhter, Debra Ehrlich, Gretchen C. Scott, Codrin Lungu, Vikas Munjal, Anthony Aquino, Russell R. Lonser, Massimo S. Fiandaca, Mark Hallett, John D. Heiss