Review
Surgery
George Fotakopoulos, Hugo Andrade-Barazarte, Juri Kivelev, Mardjono Tjahjadi, Felix Goehre, Juha Hernesniemi
Summary: This study conducted a systematic review and meta-analysis on the therapeutic strategies for brainstem cavernous malformations. The findings suggest that there is no superiority between microsurgical resection and stereotactic radiosurgery in terms of mortality, rebleeding rate, and permanent neurological deficits.
FRONTIERS IN SURGERY
(2022)
Article
Neurosciences
Cormac G. Gavin, Matthias W. R. Radatz
Summary: The optimal management of cavernous malformations (CMs) is controversial, but stereotactic radiosurgery (SRS) has gained acceptance in managing CMs, especially in high-risk cases. However, the long-term benefits of SRS and the reduced rehemorrhage rate may just reflect natural history. Adverse radiation effects (AREs) have been a concern but have been reduced with lower dose treatment protocols. Recent studies suggest higher hemorrhage rates and neurological sequelae in untreated brainstem and thalamic CMs, supporting the use of early proactive SRS in symptomatic deep-seated CMs.
Article
Clinical Neurology
Chloe Dumot, Georgios Mantziaris, Stylianos Pikis, Sam Dayawansa, Zhiyuan Xu, Yavuz Samanci, Gokce D. Ardor, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Ahmed H. Elazzazi, Nuria Martinez Moreno, Roberto Martinez alvarez, Roman Liscak, Jaromir May, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Akshay Rajput, Narendra Kumar, Rupinder Kaur, Piero Picozzi, Andrea Franzini, Herwin Speckter, Wenceslao Hernandez, Anderson Brito, Ronald E. Warnick, Juan Alzate, Douglas Kondziolka, Greg N. Bowden, Samir Patel, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) has been proposed as an alternative to resection for epilepsy control in patients with cerebral cavernous malformations (CCM) located in critical areas. This multicentric, retrospective study evaluated seizure control in patients with a solitary CCM and a history of at least one seizure prior to SRS. 47.7% of patients achieved Engel class I at the last follow-up.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: Treating brainstem cavernous malformations with microsurgery or radiosurgery has shown to be effective in reducing the rehemorrhage rate. The neurosurgery cohort had lower incidence of symptomatic intracranial hemorrhage, while the radiosurgery cohort had lower incidence of persistent focal neurological deficit.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Meng-Wu Chung, Chi-Cheng Chuang, Chun-Chieh Wang, Hsien-Chih Chen, Peng-Wei Hsu
Summary: This study evaluated prognostic factors for post-radiosurgical rebleeding and focal edematous changes in patients with CCM. The results showed that higher dose and earlier treatment were associated with a lower rebleeding rate. The study demonstrated the efficacy of LINAC SRS in preventing CCM rebleeding.
Article
Medicine, General & Internal
Matthieu Peyre, Danielle Miyagishima, Franck Bielle, Francoise Chapon, Michael Sierant, Quitterie Venot, Julie Lerond, Pauline Marijon, Samiya Abi-Jaoude, Tuan Le Van, Karim Labreche, Richard Houlston, Maxime Faisant, Stephane Clemenceau, Anne-Laure Boch, Aurelien Nouet, Alexandre Carpentier, Julien Boetto, Angeliki Louvi, Michel Kalamarides
Summary: Researchers initially aimed to create a meningioma model but unexpectedly observed the development of cerebral cavernous malformations in engineered mice, leading them to test the implicated genes in patients with these malformations. Somatic mutations in PIK3CA were found to be more prevalent in tissue samples from sporadic CCMs compared to mutations in other genes, with a relatively small contribution from genes causing familial CCMs.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Clinical Neurology
Mihir D. Shanker, Rebecca Webber, Mark B. Pinkham, Michael Huo, Sarah Olson, Bruce Hall, Rumal Jayalath, Trevor Watkins, Matthew C. Foote
Summary: Gamma Knife stereotactic radiosurgery is effective in reducing the annual hemorrhage rate for intracranial cavernous malformations, particularly in the first two years post-treatment. The overall risk of treatment-related morbidity is low.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Claudio Maderna, Federica Pisati, Claudio Tripodo, Elisabetta Dejana, Matteo Malinverno
Summary: Cavernomas are vascular malformations that form in the brain and spinal cord, causing symptoms such as hemorrhage and epileptic seizures. Current murine models have limitations in reproducing the characteristics of the human disease. A newly characterized murine model recapitulates features of human cavernomas, providing a preclinical model for developing drugs to treat acute hemorrhage.
Review
Biochemistry & Molecular Biology
Maria Ascencion Globisch, Favour Chinyere Onyeogaziri, Ross Osborne Smith, Maximiliano Arce, Peetra Ulrica Magnusson
Summary: This review provides an overview of the latest molecular insights into CCM as a hemostatic disease, highlighting the crucial role of endothelial dysfunction in disease progression and severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zifeng Dai, Jingwei Li, Ying Li, Rui Wang, Huili Yan, Ziyu Xiong, Shiting Wu, Xi Yang, Dongbo Lu, Dongdong Zhang, Guofu Li, Yuwen Wang, Chunyang Men, Wenzhong Du, Xiangjian Zheng, Changbin Shi
Summary: Pericytes play a crucial role in the development of cerebral cavernous malformation (CCM), and fibronectin intervention could be a novel therapeutic target for this disease.
Article
Clinical Neurology
Dimitri Benner, Benjamin K. Hendricks, Arnau Benet, Christopher S. Graffeo, Lea Scherschinski, Visish M. Srinivasan, Joshua S. Catapano, Peter M. Lawrence, Mark Schornak, Michael T. Lawton
Summary: The authors present a system of anatomical triangles specifically for resection of brainstem cavernous malformations (BSCMs). Through analysis of patient's MRI and intraoperative photographs or videos, the most frequently used anatomical triangles were determined. The concept of triangles can increase the precision of surgery, optimize the surgical pathway, and potentially improve patient outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biology
Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A. Awad, Mark H. Ginsberg
Summary: Mosaic inactivation of CCM2 can lead to the formation of lethal multicavernous lesions in zebrafish embryos. The flow-regulated transcription factor KLF2 plays a crucial role in the formation of typical CCM in both fishes and mammals.
Article
Multidisciplinary Sciences
Nastasja Grdseloff, Gwenola Boulday, Claudia J. Roedel, Cecile Otten, Daphne Raphaelle Vannier, Cecile Cardoso, Eva Faurobert, Deepika Dogra, Elisabeth Tournier-Lasserve, Salim Abdelilah-Seyfried
Summary: The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells, leading to recurrent cerebral hemorrhages. Previous pharmacological suppression screens discovered that retinoic acid has a positive effect on CCM phenotypes. In this study, it was found that retinoic acid signaling is impaired in the CCM pathophysiology and modifying retinoic acid levels can alleviate CCM phenotypes.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Michael Paddock, Sarah Lanham, Kanwar Gill, Saurabh Sinha, Daniel J. A. Connolly
Summary: Cerebral cavernous malformations, the second most common vascular malformations in the central nervous system, can present with a variety of symptoms in children and can be diagnosed through imaging. The diagnosis, follow-up, and management of the condition are crucial for affected children and their families.
PEDIATRIC NEUROLOGY
(2021)
Review
Health Care Sciences & Services
Jessa E. Hoffman, Blake Wittenberg, Brent Morel, Zach Folzenlogen, David Case, Christopher Roark, Samy Youssef, Joshua Seinfeld
Summary: The diagnosis and treatment of cerebral cavernous malformations (CCMs) are constantly evolving with the availability of more data and treatment options. Intervention becomes necessary when a lesion causes symptomatic neurological deficits, seizures, or has a high risk of continued hemorrhage. Future medical treatments may focus on targeting the underlying pathogenesis of these lesions.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
William T. Millar, John W. Hopewell, Ian Paddick, Christer Lindquist, Hakan Nordstron, Par Lidberg, Jonas Garding
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2015)
Letter
Public, Environmental & Occupational Health
Bengt Karlsson, Christer Lindquist, Michael Soderman
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2011)
Review
Oncology
Bodo Lippitz, Christer Lindquist, Ian Paddick, David Peterson, Kevin O'Neill, Ronald Beaney
CANCER TREATMENT REVIEWS
(2014)
Article
Clinical Neurology
Bengt Karlsson, Patrick Hanssens, Robert Wolff, Michael Soderman, Christer Lindquist, Guus Beute
JOURNAL OF NEUROSURGERY
(2009)
Article
Clinical Neurology
Antonio Santacroce, Maja Walier, Jean Regis, Roman Liscak, Enrico Motti, Christer Lindquist, Andras Kemeny, Klaus Kitz, Bodo Lippitz, Roberto Martnez Alvarez, Paal-Henning Pedersen, Shoji Yomo, Francesco Lupidi, Karlheinz Dominikus, Philip Blackburn, Thomas Mindermann, Otto Bundschuh, A. T. C. J. van Eck, Rolf Fimmers, Gerhard A. Horstmann
Article
Clinical Neurology
Christer Lindquist, Ian Paddick
Article
Oncology
A Christopoulou, S Retsas, D Kingsley, I Paddick, C Lindquist
Article
Clinical Neurology
T Mathiesen, L Kihlström, B Karlsson, C Lindquist, LD Lunsford, RF Young, K Takakura, G Pendl
SURGICAL NEUROLOGY
(2003)
Article
Clinical Neurology
E Ulfarsson, C Lindquist, M Roberts, T Rähn, M Lindquist, M Thorén, B Lippitz
JOURNAL OF NEUROSURGERY
(2002)
Article
Clinical Neurology
ER Engström, L Hillered, R Flink, L Kihlström, C Lindquist, JX Nie, Y Olsson, HC Silander
