Article
Medicine, General & Internal
Won Pyo Hong, Ki Jeong Hong, Sang Do Shin, Kyoung Jun Song, Tae Han Kim, Jeong Ho Park, Young Sun Ro, Seung Chul Lee, Chu Hyun Kim, Joo Jeong
Summary: This study found that prehospital low-flow oxygen administration was associated with lower in-hospital mortality compared with the no-oxygen group, while high-flow oxygen administration was associated with higher mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Teodor Svedung Wettervik, Henrik Engquist, Timothy Howells, Samuel Lenell, Elham Rostami, Lars Hillered, Per Enblad, Anders Lewen
Summary: This study investigated the relationship between arterial oxygen levels and cerebral energy metabolism, pressure autoregulation, and clinical outcomes in severe traumatic brain injury patients. Results showed that maintaining higher arterial oxygen levels in the early phase may improve oxidative cerebral energy metabolism and pressure autoregulation, especially in cases with limited energy substrate supply. Evaluating cerebral energy metabolic profiles could help in selecting patients for hyperoxic treatment in future trials.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wei Sun, Ling Wang, Shiqi Yuan, Rongrong Liu, Pingping Song, Wenqiang Che, Jiamin Xu, Jun Lyu, Yusheng Zhang
Summary: This study investigated the correlation between percutaneous oxygen saturation (SpO2) level and 30- and 90-day mortality among patients with mild traumatic brain injury. The results revealed a U-shaped curve relationship, with both low and high SpO2 levels associated with increased mortality risk. The optimal SpO2 level for mild TBI patients was found to be 95-98%.
ADVANCES IN THERAPY
(2023)
Article
Medicine, General & Internal
Zhiguo Liu, Xirui Wang, Zhiyou Wu, Gangfeng Yin, Haibin Chu, Pengyue Zhao
Summary: This study compares the cognitive outcomes of normobaric hyperoxia (NBH) and hyperbaric oxygen therapy (HBOT) in mild traumatic brain injury (TBI) patients. It found that both NBH and HBOT can improve cognitive outcome and reduce brain injury, with HBOT showing better results.
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Chiara Mele, Valeria Pingue, Marina Caputo, Marco Zavattaro, Loredana Pagano, Flavia Prodam, Antonio Nardone, Gianluca Aimaretti, Paolo Marzullo
Summary: The incidence of traumatic brain injury (TBI) has been increasing, impacting public health. Research indicates that post-TBI neuroinflammation may lead to long-term clinical consequences, such as hypopituitarism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
William P. Flavin, Helia Hosseini, Jeffrey W. Ruberti, H. Pirouz Kavehpour, Christopher C. Giza, Mayumi L. Prins
Summary: This review summarizes the structure and functions of Tau protein, highlighting its associations with various diseases and conditions including diabetes, stroke, Alzheimer's disease, brain injury, aging, and drug use. It explores the role of Tau phosphorylation in disease progression and discusses the potential for therapeutic interventions to prevent or reverse tau-mediated neurodegeneration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jared A. Rifkin, Taotao Wu, Adam C. Rayfield, Erin D. Anderson, Matthew B. Panzer, David F. Meaney
Summary: Research on data from the Human Connectome Project (HCP) reveals similar brain architecture groups in both men and women, with some architectures being more vulnerable to traumatic brain injuries (TBI).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Neurosciences
Zhiwen Geng, Zhiliang Guo, Ruibing Guo, Ruidong Ye, Wusheng Zhu, Bernard Yan
Summary: Traumatic brain injury (TBI) is a global health issue with significant economic burden, where ferroptosis may play a crucial role in its pathophysiology. Inhibition of ferroptosis could potentially improve long-term outcomes of TBI, emphasizing the importance of understanding the association between ferroptosis and TBI for new treatment targets.
BRAIN RESEARCH BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Shotaro Michinaga, Yutaka Koyama
Summary: Traumatic brain injury (TBI) is immediate damage to the brain caused by a blow to the head, resulting in death or serious disabilities. Astrocytes play a key role in the pathogenesis of TBI, with both beneficial and detrimental effects. They are attractive targets for novel therapeutic drugs for TBI, although such drugs have not yet been developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong, Yanqin Gao
Summary: The study demonstrates that cordycepin can protect neurological function by suppressing neutrophil infiltration, preserving blood-brain barrier integrity, and altering microglia/macrophage polarization after traumatic brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Engineering, Biomedical
Xiaowei Shao, Zhongqian Liu, Shijie Mao, Lin Han
Summary: This article explores traumatic brain injury (TBI) and subsequent brain dysfunction from the perspective of neuromechanobiology. It discusses the mechanobiological insights into the molecular pathology of TBI and provides an overview of the latest research technologies, such as microfluidics and biomaterials. The article emphasizes the importance of extensive technical innovation in biomedical devices and materials to advance the field of neuromechanobiology.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
