Article
Clinical Neurology
Lior Ungar, Ortal Nachum, Zion Zibly, Anton Wohl, Ran Harel, Moshe Attia, Roberto Spiegelmann, Jacob Zaubermann, Zeev Feldman, Nachshon Knoller, Zvi R. Cohen
Summary: This study evaluated the safety and accuracy of frameless and frame-based image-guided stereotactic brain biopsy techniques. The results showed that there was no significant difference in diagnostic yield and complication rates between the two techniques. Lesion volume was found to be the only predictive factor of diagnostic yield. The minimally invasive twist drill technique was proven to be safe and efficient.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Giorgio Maria Callovini, Shahram Sherkat, Isabella Sperduti, Francesco Crispo, Laura Raus, Roberto Gazzeri, Stefano Telera
Summary: Stereotactic brain biopsy is necessary for histopathologic diagnosis of deep-seated PCNSLs, which present a higher risk of biopsy-related morbidity and mortality. Intraoperative frozen section can improve the diagnostic yield and reduce the need for additional sampling procedures, while postoperative computed tomography is recommended for suspected PCNSL cases.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Oliver Bichsel, Markus F. Oertel, Lennart H. Stieglitz
Summary: The combination of neuronavigation-based frameless stereotaxy, MRI-guided trajectory planning, and intraoperative CT examination using a mobile unit can achieve seamlessly integrated approach yielding optimal target accuracy for brain biopsies. This method is safe, highly accurate, and enables single-millimeter accuracy for deep-seated brain lesions without the need for repositioning due to inaccurate targeting.
Article
Oncology
Iulia Peciu-Florianu, Victor Legrand, Apolline Monfilliette-Djelad, Claude-Alain Maurage, Quentin Vannod-Michel, Serge Blond, Gustavo Touzet, Nicolas Reyns
Summary: Frameless robot-assisted stereotactic biopsies are accurate and safe for tissue diagnosis, providing an initial platform for the safe and accurate management of brainstem lesions with a high diagnostic yield and low permanent morbidity.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Neurosciences
Martin Vychopen, Johannes Wach, Valeri Borger, Matthias Schneider, Lars Eichhorn, Jaroslaw Maciaczyk, Gregor Bara, Hartmut Vatter, Mohammed Banat, Motaz Hamed
Summary: This study compared the efficacy of frameless biopsy using VarioGuide and frame-based biopsy using the Leksell stereotactic system (LSS) in brain biopsy surgeries. The results showed that VarioGuide biopsies took less time than LSS biopsies, with no significant differences in complication rates and lesion sizes between the two groups. Therefore, both systems provided a high degree of patient safety.
Article
Oncology
Mohamed H. Khattab, Alexander D. Sherry, Sean P. Devan, Guozhen Luo, Basil H. Chaballout, Samuel Jean-Baptiste, Junzhong Xu, Sarah Bick, William M. Petrie, Anthony J. Cmelak
Summary: The study combined precise ablative radiation and functional neurologic connectome analysis to treat refractory major depressive disorder. The results showed that radiosurgical capsulotomy significantly reduced the burden of depression in three patients. Connectome reorganization may play a role in the clinical response.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Clinical Neurology
Stephen G. Bowden, Christian Lopez G. Ramos, Barry Cheaney II, Emma Richie, Nasser K. Yaghi, Daniel N. Munger, David J. Mazur-Hart, Hao Tan, Matthew D. Wood, Justin S. Cetas, Aclan Dogan, Ahmed M. Raslan, Seunggu J. Han
Summary: It is not known how steroids affect the improvement of focal neurological deficits in patients with brain metastases before surgery, and whether such improvement can predict long-term recovery of neurological function. This study aimed to determine the rate of improvement in focal deficits with preoperative corticosteroids and its predictive value for postoperative recovery in brain metastasis patients.
Article
Veterinary Sciences
Felix Meneses, Arianna Maiolini, Franck Forterre, Anna Oevermann, Daniela Schweizer-Gorgas
Summary: The aim of this study was to evaluate the use of a novel intraoperative cone-beam computed tomography (CBCT)-based automated registration system for frameless stereotactic brain biopsy in companion animals. The results showed that this system is capable of providing diagnostic brain biopsy specimens independent of skull size and morphology, with diagnostic yield and accuracy comparable to other systems, and the duration of the procedure is within a reasonable range.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Surgery
Domagoj Dlaka, Marko Svaco, Darko Chudy, Bojan Jerbic, Bojan Sekoranja, Filip Suligoj, Josip Vidakovic, Dominik Romic, Marina Raguz
Summary: The study presents the RONNA G4 robotic neuronavigation system as a precise and highly accurate assistant for frameless brain biopsies, with a total diagnostic yield of 96.87%. Linear regression showed statistical significance between target point error (TPE) and entry point error (EPE).
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2021)
Article
Clinical Neurology
Felipe Branco de Paiva, Brett A. Campbell, Leonardo A. Frizon, Adriana Martin, Andres Maldonado-Naranjo, Andre G. Machado, Kenneth B. Baker
Summary: DBS is an effective therapy for neurological diseases, and using NHPs can help uncover its therapeutic mechanisms. The use of microTargeting platform for targeting deep brain regions in NHPs shows good feasibility and accuracy, enhancing the surgical insertion of DBS leads.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Benjamin Sass, Mirza Pojskic, Miriam Bopp, Christopher Nimsky, Barbara Carl
Summary: Comparing fiducial-based and intraoperative computed tomography (iCT)-based registration for frameless stereotactic brain biopsy, the study found that iCT-based registration significantly reduces target registration error and radiation exposure, with shorter surgical time. iCT is more favorable for biopsies of small tumors or lesions near eloquent brain areas.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
Review
Oncology
Thien Nguyen, Sabine Mueller, Fatema Malbari
Summary: Surgery, chemotherapy and radiation have been the main treatments for pediatric brain tumors, but recently new modalities have emerged. These new therapies aim to improve survival and reduce complications, but their side effects are not well understood yet. Treatment complications can be caused by drug toxicity or vascular, infectious, or autoimmune mechanisms. More research is needed to improve neurocognitive outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Fabien Almairac, Aurelie Leplus, Lydiane Mondot, Denys Fontaine
Summary: This study introduces a new noninvasive registration tool called Neurolocate, which, when combined with an intraoperative cone-beam computed tomography imaging system like O-ARM (Medtronic), may improve the workflow and efficiency of robot-assisted intracranial biopsies.
OPERATIVE NEUROSURGERY
(2023)
Article
Oncology
Min Wang, Yi Zhang, Wei Shi, Renqing Zhu, Hao Li, Rui Zhao
Summary: This study compared the value of microsurgical biopsies and frameless robot-assisted stereotactic biopsies in the treatment of pediatric DIPGs. The results showed that frameless robot-assisted stereotactic biopsy is an effective and minimally invasive technique, which can reduce operation time, postoperative hospitalization time, and bleeding volume compared to microsurgical biopsies. It also decreases the need for perioperative blood transfusion and the occurrence of new neurological impairments.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Stephen T. Magill, Minh P. Nguyen, Manish K. Aghi, Philip Theodosopoulos, Javier E. Villanueva-Meyer, Michael W. McDermott
Summary: A DWI signal > 1 cm is significantly associated with postoperative neurological deficits, both immediate and long-lasting. Greater estimated blood loss, older age, tumor location over the motor strip, and preoperative peri-tumoral edema increase the risk of having a postoperative DWI signal > 1 cm, reflective of perilesional ischemia. Most immediate postoperative deficits will improve over time.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Thomas M. Zervos, Karam Asmaro, Ellen L. Air
Summary: MCID varies depending on population characteristics and calculation methods. In the context of pain, MCID is influenced by pain quality, chronicity, and treatment options. Using MCID in outcome evaluation helps avoid misinterpreting statistically significant but clinically insignificant results.
Letter
Clinical Neurology
Thomas M. Zervos, Karam Asmaro, Ellen L. Air
Article
Clinical Neurology
Ellen L. Air, Katie O. Orrico, Deborah L. Benzil, Alan M. Scarrow, James R. Bean, Catherine A. Mazzola, Linda M. Liau, James T. Rutka, Karin M. Muraszko
Summary: Leading neurosurgical professional organizations have come together to establish a foundational policy setting behavior expectations and providing a unified roadmap for prompt response to untoward events during sponsored activities. This initiative aims to inspire other medical organizations to develop their own meeting and conference policies, while emphasizing everyone's responsibility for creating a safe and respectful environment during organized events for education, scientific debate, and networking.
Article
Clinical Neurology
Karam Asmaro, Hassan A. Fadel, Sameah A. Haider, Jacob Pawloski, Edvin Telemi, Tarek R. Mansour, Ankush Chandra, Michael Bazydlo, Adam M. Robin, Ian Y. Lee, Ellen L. Air, Jack P. Rock, Steven N. Kalkanis, Jason M. Schwalb
Summary: A targeted educational intervention successfully reduced excessive opioid prescribing after intracranial surgery without affecting patient satisfaction or analgesic effect. This simple, evidence-based intervention highlights the ability to impact clinical decision-making, reduce potential patient harm, and address national public health concerns.
Letter
Clinical Neurology
Thomas M. Zervos, Karam Asmaro, Ellen L. Air
Meeting Abstract
Clinical Neurology
Karam Asmaro, Hassan A. Fadel, Sameah A. Haider, Jacob Pawloski, Edvin Telemi, Tarek R. Mansour, Ankush Chandra, Michael Bazydlo, Adam M. Robin, Ian Y. Lee, Ellen L. Air, Jack P. Rock, Steven N. Kalkanis, Jason M. Schwalb
Article
Clinical Neurology
Jillian H. Plonsker, Deborah Benzil, Ellen L. Air, Sarah Woodrow, Martina Stippler, Sharona Ben-Haim
Summary: This article reviews the achievements made in the field of neurosurgery over the past decade and proposes updated recommendations and goals to recruit and retain diverse talent, aiming to achieve gender balance in the neurosurgical workforce.
Article
Clinical Neurology
Raj Singh, Greg Bowden, David Mathieu, Haley K. Perlow, Joshua D. Palmer, Shahed Elhamdani, Matthew Shepard, Yun Liang, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Ahmed Hesham Elazzazi, Ronald E. Warnick, Yair M. Gozal, Megan Daly, Brendan McShane, Marcel Addis-Jackson, Gokul Karthikeyan, Sian Smith, Piero Picozzi, Andrea Franzini, Tehila Kaisman-Elbaz, Huai-che Yang, Zhishuo Wei, Andrew Legarreta, Judith Hess, Kelsey Templeton, Stylianos Pikis, Georgios Mantziaris, Gabriela Simonova, Roman Liscak, Selcuk Peker, Yavuz Samanci, Veronica Chiang, Ajay Niranjan, Charles R. Kersh, Cheng-Chia Lee, Daniel M. Trifiletti, L. Dade Lunsford, Jason P. Sheehan
Summary: Limited data is available regarding outcomes for GI primaries patients with brain metastases treated with SRS. This study aimed to examine the clinical outcomes of SRS for patients with brain metastases from GI primaries and evaluate potential prognostic factors. SRS resulted in comparable LC with common primaries. Age and KPS were associated with both LC and OS, and planning target volume and extracranial metastases were correlated with LC and OS, respectively. These factors should be considered in selecting GI cancer patients for SRS.
Meeting Abstract
Clinical Neurology
Thomas Zervos, Kenneth Kutschman, Tarek R. Mansour, Tiberio Frisoli, Ellen L. Air, Jason M. Schwalb
Meeting Abstract
Clinical Neurology
Stacy Hatcher, David Jacobs, Ellen L. Air
Meeting Abstract
Clinical Neurology
Jillian Hannah Plonsker, Deborah L. Benzil, Ellen L. Air, Sarah Woodrow, Martina Stippler, Sharona Ben-Haim
Article
Clinical Neurology
Deborah L. Benzil, Karin M. Muraszko, Pranay Soni, Ellen L. Air, Katie O. Orrico, James T. Rutka
Summary: This study reveals significant sexual harassment issues in the field of neurosurgery, affecting individuals of all ages and practice settings. Both men and women are impacted by sexual harassment, with over half personally experiencing it and two-thirds witnessing it. Factors such as male dominance, hierarchical environment, and permissive culture remain prevalent in the neurosurgical community, requiring a cultural shift with a zero tolerance policy, new awareness of unconscious bias, and commitment to diversity to combat such behavior in the workplace effectively.
JOURNAL OF NEUROSURGERY
(2021)
Letter
Clinical Neurology
Deborah L. Benzil, Karin M. Muraszko, Pranay Soni, Ellen L. Air, Katie O. Orrico, James T. Rutka
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Katelyn Donaldson, Katherine E. Callahan, Aaron Gelinne, Wyll Everett, S. Elizabeth Ames, Ellen L. Air, Susan R. Durham
Summary: This study analyzed gender distribution of faculty and residents in ACGME-accredited neurosurgery training programs for the 2017-2018 academic year. The results showed that female residents accounted for 18.2% and female faculty accounted for 8.7%. While programs with both female faculty and residents constituted 53.2%, some programs still lacked female representation in either faculty or residents.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Ellen L. Air, Katie O. Orrico, Deborah L. Benzil, Alan M. Scarrow, James R. Bean, Catherine A. Mazzola, Linda M. Liau, James T. Rutka, Karin M. Muraszko
Summary: The leading neurosurgical professional organizations collaborated to establish guidelines for participant behavior and prompt response to untoward events at sponsored events in order to promote open exchange of ideas and professional growth. By publishing this policy, they hope to inspire other medical organizations to set their own meeting policies and emphasize everyone's responsibility in creating a safe and respectful environment for education and networking during organized events.
JOURNAL OF NEUROSURGERY
(2021)