Article
Clinical Neurology
Kang Qian, Jiajing Wang, Jing Rao, Peng Zhang, Yaqiang Sun, Wenqing Hu, Jie Hao, Xiaobing Jiang, Peng Fu
Summary: This study analyzed the influence of general anesthesia (GA) on intraoperative microelectrode recording (MER) guided subthalamic nucleus deep brain stimulation (STN-DBS), and evaluated the feasibility and effectiveness of GA in MER guided STN-DBS. The results showed that both GA and local anesthesia (LA) achieved similar electrode implantation accuracy, clinical outcome, and postoperative adverse events.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
R. Saman Vinke, Martin Geerlings, Ashok K. Selvaraj, Dejan Georgiev, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels
Summary: This study systematically reviewed the differences in clinical outcomes between STN-DBS surgery with and without microelectrode recording (MER). The results showed that there was no difference in the change of motor symptoms between the two groups, but the reduction in levodopa equivalent daily dose (LEDD) was greater in the MER group. Due to the lack of high-quality comparative studies, further well-designed trials are needed.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
R. Saman Vinke, Ashok K. Selvaraj, Martin Geerlings, Dejan Georgiev, Aleksander Sadikov, Pieter L. Kubben, Jonne Doorduin, Peter Praamstra, Bastiaan R. Bloem, Ronald H. M. A. Bartels, Rianne A. J. Esselink
Summary: This study evaluated the added value of MER and intraoperative clinical testing in PD-STN-DBS surgery, and found that these steps did not provide additional value in determining final lead position, leading to a change in clinical practice towards an asleep MRI-guided and stereotactic CT-verified approach.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Oncology
Wen Liu, Xiumin Zhang, Pan Nie, Lidao Chen, Kai Fu, Jibo Zhang, Jincao Chen, Jie Zhang
Summary: This study suggests that continuing L-dopa therapy before subthalamic nucleus-deep brain stimulation (STN-DBS) procedures can improve intraoperative cooperation, reduce operation duration, and enhance clinical outcomes.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Anesthesiology
Yu-Chen Chen, Shin-Yuan Chen, Tsung-Ying Chen, Jiann-I Pan, Sheng-Tzung Tsai
Summary: Desflurane and sevoflurane produced different neurophysiological profiles in STN during deep brain stimulation (DBS) surgery in patients with Parkinson's disease. Desflurane resulted in lower neuronal firing rate while sevoflurane entrained greater gamma oscillation power. The choice of anesthetic did not affect STN mapping accuracy or the clinical outcome of DBS electrode implantation.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Medicine, General & Internal
Michael J. Bos, Dianne de Korte-de Boer, Ana Maria Alzate Sanchez, Annelien Duits, Linda Ackermans, Yasin Temel, Anthony R. Absalom, Wolfgang F. Buhre, Mark J. Roberts, Marcus L. F. Janssen
Summary: During STN DBS surgery, the addition of PSA did not show significant differences in motor and non-motor outcomes in PD patients compared to LA alone after twelve months. Both groups had similar changes in motor function, medication dosages, and cognitive function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Yuting Ling, Lige Liu, Simin Wang, Qianqian Guo, Qingyuan Xiao, Yi Liu, Bo Qu, Zhishuang Wen, Yongfu Li, Changming Zhang, Bin Wu, Zihuan Huang, Jianping Chu, Ling Chen, Jinlong Liu, Nan Jiang
Summary: This study aimed to analyze the characteristics of prefrontal cortex EEG during propofol general anesthesia in patients with Parkinson's disease, and determine the reference range of parameters derived from the depth of anesthesia monitoring. Additionally, the study explored whether the use of benzodiazepines in the 3 days before surgery impacted the interpretation of the EEG parameters.
Article
Multidisciplinary Sciences
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Summary: Stimulation of the zona incerta can reduce heat pain perception, but does not affect warmth perception or pressure pain. These findings provide a mechanistic explanation for sensory changes observed in Parkinsonian patients undergoing subthalamic deep brain stimulation and identify the zona incerta as a potential target for neuromodulation of pain.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Lin Shi, Shiying Fan, Tianshuo Yuan, Huaying Fang, Jie Zheng, Zunyu Xiao, Yu Diao, Guanyu Zhu, Quan Zhang, Huanguang Liu, Hua Zhang, Fangang Meng, Jianguo Zhang, Anchao Yang
Summary: Microstimulation near the bottom of STN is an effective method to identify the boundary between STN and SNr, leading to better lead placement and therapeutic outcomes in STN-DBS surgery. This study provides clinical evidence supporting the routine use of microstimulation for optimal lead placement.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Zhe Zheng, Zhoule Zhu, Yuqi Ying, Hongjie Jiang, Hemmings Wu, Jun Tian, Wei Luo, Junming Zhu
Summary: Image-guided awake DBS with MER in subthalamic nucleus can accurately target Parkinson's disease. The majority of electrodes guided by preoperative MRI did not require adjustment, but a certain proportion needed repositioning. MER signals with a length <4mm may result in target deviation, thus requiring adjustment through MER and intraoperative testing.
JOURNAL OF PARKINSONS DISEASE
(2022)
Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ying-Fa Chen, Yang-Pei Chang, Wu-Fu Chen, Wei-Che Lin, Yung-Yee Chang, Hui-Chen Lin, Fu-Yuan Shih
Summary: The study retrospectively collected data from 28 PD patients, showing that patients who received iCT had fewer MER tracks and higher surgical accuracy. Further studies are needed to investigate whether iCT can reduce surgical complications and improve surgical outcomes.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Yue Lu, Lei Chang, Jinwen Li, Bei Luo, Wenwen Dong, Chang Qiu, Wenbin Zhang, Yifeng Ruan
Summary: This study compared the effects of local anesthesia (LA) and general anesthesia (GA) on clinical improvement in patients with Parkinson's disease (PD) after subthalamic nucleus deep brain stimulation (STN-DBS) surgery. The study found that, although both groups of patients showed overall improvement in motor function, patients in the GA group had significantly lower UPDRS-III scores in the medicated state compared to those in the LA group. Additionally, the GA group had a shorter surgical duration, lower intracranial volume, and longer iMER signal length.
FRONTIERS IN NEUROSCIENCE
(2022)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Biochemical Research Methods
Mohamed Hosny, Minwei Zhu, Wenpeng Gao, Yili Fu
Summary: This study has developed a new deep learning model based on convolutional neural system for automatically delineating the neurophysiological borders of the STN along the electrode trajectory. The proposed model does not involve any traditional standardization, feature extraction or selection steps. With the proposed convolutional neural network (CNN) model, promising results of 98.67% accuracy, 99.03% sensitivity, 98.11% specificity, 98.79% precision and 98.91% F1-score for subject based testing were achieved.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Chemistry, Physical
Qiankai Ba, Junu Kim, Hyunsik Im, Shenghuang Lin, Atanu Jana
Summary: In this study, water-stable, lead-free organic-inorganic hybrid colloidal tin perovskite nanocrystals with high photoluminescence quantum yield were reported. These nanocrystals exhibit bright emission, are well-dispersed in nonpolar solvents, and can be used to fabricate homogeneous thin films. The in-situ generation of a hydrophobic and oxygen-resistant passivating layer provides excellent stability in water.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Wenzhi Yu, Kaiwen Gong, Yanyong Li, Binbin Ding, Lei Li, Yongkang Xu, Rong Wang, Lianbi Li, Guangyu Zhang, Shenghuang Lin
Summary: 2D materials have gained significant attention in the field of nanotechnology due to their unique structures and properties. They play an important role in the development of flexible devices. This review discusses recent progress in improving the state of the art for 2D materials beyond graphene, including their properties, synthesis techniques, advantages, challenges, and future directions towards efficient and low-cost flexible devices.
Article
Biochemistry & Molecular Biology
Yu-Chen Chen, Chang-Chih Kuo, Shin-Yuan Chen, Tsung-Ying Chen, Yan-Hong Pan, Po-Kai Wang, Sheng-Tzung Tsai
Summary: Deep brain stimulation (DBS) improves Parkinson's disease (PD) symptoms by suppressing neuropathological oscillations. Inhalational anesthetics used during DBS surgery can modulate these oscillations and affect electrode placement accuracy. Research found that neuronal oscillations in the subthalamic nucleus (STN) were associated with motor disabilities in PD patients, and median nerve stimulation (MNS) aided in localizing the sensorimotor STN.
Review
Neurosciences
Yi-Jen Ho, Wen-Chun Chiang, Hsin-Yi Huang, Shinn-Zong Lin, Sheng-Tzung Tsai
Summary: This meta-analysis evaluates the safety and effectiveness of lumboperitoneal shunt (LPS) compared to ventriculoperitoneal shunt (VPS) for treating communicating hydrocephalus. The results show that LPS has lower complication and obstruction rates, and improves radiological outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Mingyue Han, Yingrui Xiao, Chao Zhou, Zijie Xiao, Wenyan Tan, Guowei Yao, Xiaoxue Wu, Renzhong Zhuang, Shiming Deng, Qi Hu, Yuxuan Yang, Zhaoheng Tang, Xunsheng Zhou, Haobo Lin, Huili Liang, Shenghuang Lin, Zengxia Mei, Cailin Wang, Qi Chen, Wei Zhang, Yan Jiang
Summary: Organic-inorganic hybrid perovskites show promise for direct X-ray detection and imaging. The study reveals that the high dark current in MAPbBr(3) single crystals is dominated by ionic conductivity. By applying a multilayer heterojunctions passivation strategy, the ionic and electronic conductivity are suppressed, resulting in high sensitivity and low detection limit.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Kaiwen Gong, Lianbi Li, Wenzhi Yu, Haoran Mu, Jian Yuan, Ran Hao, Baiquan Liu, Zengxia Mei, Luyao Mei, Haozhe Li, Shenghuang Lin
Summary: This paper reports a synthesis method using exfoliation and CVD to fabricate GaSe/PtSe2 heterojunction photodetectors. The devices exhibit the highest responsivity of about 1.7 A/W and detectivity of 3.51 x 1012 Jones at a -10 V bias under the avalanche mode. Additionally, the photodetector shows a clear photovoltaic effect and can operate in a self-powered mode.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Haozhe Li, Kai Zhang, Xiu Li, Baiquan Liu, Lianbi Li, Zengxia Mei, Tongsheng Chen, Qinzhuang Liu, Wenzhi Yu, Jian Yuan, Haoran Mu, Shenghuang Lin
Summary: This paper introduces a narrow bandgap, direct bandgap 2D semiconductor Ta2NiSe5 and makes an a-In2Se3/Ta2NiSe5 heterojunction photodetector, achieving a wide response wavelength range of 405-1550 nm and high performance. The potential barriers of holes at the a-In2Se3/Ta2NiSe5 interface are much higher than that of electrons, resulting in ultra-high responsivity. The photodetector shows a photoresponsivity of 12 A/W under a self-driven state and 533 A/W under a slight bias voltage of 0.1 V at 520 nm illumination. The highest detectivity is over 8.2 x 1013 Jones. The rise and fall time is shortly at 25 and 423 μs, respectively. The high-sensitive, broadband, and fast photodetector has great potential in the emerging field of 2D optoelectronics.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Luyao Mei, Kai Zhang, Nan Cui, Wenzhi Yu, Yang Li, Kaiwen Gong, Haozhe Li, Nianqing Fu, Jian Yuan, Haoran Mu, Zhanfeng Huang, Zhengji Xu, Shenghuang Lin, Lu Zhu
Summary: This study demonstrates an individual monocrystalline MAPbBr(3) nanoplate-based photodetector that achieves efficient UV-Vis-SWIR detection and fast-response. The detector exhibits high external quantum efficiency and detectivity, as well as a fast response with a rise time of 80 μs. The high performance is attributed to the high specific surface area of the nanoplate and surface-trap-assisted absorption.
Article
Multidisciplinary Sciences
Renzhong Zhuang, Songhua Cai, Zengxia Mei, Huili Liang, Ningjiu Zhao, Haoran Mu, Wenzhi Yu, Yan Jiang, Jian Yuan, Shuping Lau, Shiming Deng, Mingyue Han, Peng Jin, Cailin Wang, Guangyu Zhang, Shenghuang Lin
Summary: In order to reduce radiation health risks, X-ray detectors need to be operated at minimal doses during X-ray security examination or medical inspection, which requires high sensitivity and low detection limits. This study presents the realization of highly sensitive X-ray detectors based on an environmentally friendly solution-grown thick BiI/BiI3/BiI van der Waals heterostructure. These detectors show anisotropic X-ray detection response, with a sensitivity of up to 4.3 x 10(4) μC Gy(-1) cm(-2) and a detection limit as low as 34 nGy s(-1). Additionally, the BixIy detectors demonstrate high environmental and hard radiation stabilities.
NATURE COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Jiin-Ling Jiang, Shin-Yuan Chen, Sheng-Tzung Tsai, Yu-Chin Ma, Jen-Hung Wang
Summary: This study compared motor symptoms and quality of life in Parkinson's disease patients before and at 1 and 5 years after subthalamic nucleus deep brain stimulation (STN-DBS) surgery. The results showed that STN-DBS surgery can significantly improve motor symptoms, but the long-term effects on quality of life are not lasting.
Article
Chemistry, Multidisciplinary
Yang Lu, Wenzhi Yu, Yan Zhang, Junrong Zhang, Cheng Chen, Yongping Dai, Xingang Hou, Zhuo Dong, Liu Yang, Long Fang, Luyi Huang, Shenghuang Lin, Junyong Wang, Jun Wang, Jie Li, Kai Zhang
Summary: This study reports the growth of 1D vdW ternary HfSnS3 high-quality single crystals via the chemical vapor transport technique. The Raman vibration modes and band structure of HfSnS3 are analyzed, and its strong in-plane anisotropy is verified by polarized Raman spectroscopy. Field-effect transistors based on HfSnS3 nanowires exhibit p-type semiconducting behavior and outstanding photoresponse in a broadband range.
Review
Computer Science, Information Systems
Yubu Zhou, Huayu Gao, Jing Wang, Fion Sze Yan Yeung, Shenghuang Lin, Xianbo Li, Shaolin Liao, Dongxiang Luo, Hoi Sing Kwok, Baiquan Liu
Summary: Organic light-emitting diodes (OLEDs) are a promising technology for displays and lighting due to their numerous advantages. Ultrathin emitting nanolayers (UENs) have been used to develop OLEDs without the doping technique, simplifying device structure and achieving comparable performance to doped devices. This review comprehensively summarizes recent progress in UEN-based OLEDs, including a comparison between doped and doping-free OLEDs, effective design approaches, and future development prospects.
Article
Chemistry, Multidisciplinary
Han Song, Haoran Mu, Jian Yuan, Baiquan Liu, Gongxun Bai, Shenghuang Lin
Summary: To improve the capacity of light-harvesting in quantum dot-sensitized solar cells, new light absorption materials are implanted into the cells for charge transfer stimulation. In this study, few-layer black phosphorus quantum dots (BPQDs) were synthesized and deposited onto a ZCISSe QD-sensitized TiO2 substrate. The results showed that BPQDs increased absorption intensity and reduced charge recombination processes, resulting in an increased power conversion efficiency of the QDSCs to 15.66%.
Article
Medicine, General & Internal
Ching-Yuan Hu, Ying-Zhen Huang, Sheng-Tzung Tsai, Po-Kai Wang
Summary: This study presents a rare case of head and neck pain occurring 2 years after VP shunt surgery, caused by irritation of the superficial cervical plexus. The patient experienced relief from symptoms after receiving appropriate treatment.
MEDICINA-LITHUANIA
(2023)
Review
Materials Science, Multidisciplinary
Chao Zhou, Mingyue Han, Yingrui Xiao, Wenyan Tan, Xi Jin, Xiaoxue Wu, Yuxuan Yang, Siyuan Zhu, Haobo Lin, Shenghuang Lin, Qi Chen, Qijie Liang, Jinsong Hu, Wei Zhang, Yan Jiang
Summary: This review summarizes recent progress in lead-free halide perovskites (LFHPs) and derivatives for X-ray detectors and imaging. The working principle and key figure of merit of X-ray detectors are introduced, and state-of-the-art preparation methods for lead-free halide perovskites are summarized. The structural dimensions, optoelectronic properties, and recent advances in X-ray detection and imaging are comprehensively discussed. The stabilities of LFHPs-based X-ray detectors are also addressed, and prospects for overcoming current limitations are outlined.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
