Detoxification of oxidative stress in glioma stem cells: Mechanism, clinical relevance, and therapeutic development

Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

(2014) Tae Hyong Kim et al.   NEURO-ONCOLOGY

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

(2013) Ju Mei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tissue distribution profiles of three antiparkinsonian alkaloids from Piper longum L. in rats determined by liquid chromatography–tandem mass spectrometry

(2013) Haolong Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Targeting Cancer Cells With the Natural Compound Obtusaquinone

(2013) Christian E. Badr et al.   JNCI-Journal of the National Cancer Institute

Reactive Oxygen Species in Cancer Stem Cells

(2012) Xiaoke Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene,c-Myb

(2012) Takeshi Miyazaki et al.   CLINICAL CANCER RESEARCH

Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway

(2012) Yuan Yuan et al.   CNS Neuroscience & Therapeutics

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

(2012) Seong-Su Han et al.   LEUKEMIA RESEARCH

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells

(2012) Chien-Ju Lin et al.   PLoS One

Suppression of Peroxiredoxin 4 in Glioblastoma Cells Increases Apoptosis and Reduces Tumor Growth

(2012) Tae Hyong Kim et al.   PLoS One

Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells

(2012) Konstantin V. Golovine et al.   PROSTATE

Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas

(2011) Peeter Karihtala et al.   BMC CANCER

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models

(2011) Thomas C. Chen et al.   CANCER LETTERS

Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

(2011) Justin D. Lathia et al.   Cell Stem Cell

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

(2011) Monica Venere et al.   GLIA

The cancer stem cell niche-there goes the neighborhood?

(2011) Stephanie M. Cabarcas et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of PRDX4 and P4HA2 as Metastasis-Associated Proteins in Oral Cavity Squamous Cell Carcinoma by Comparative Tissue Proteomics of Microdissected Specimens Using iTRAQ Technology

(2011) Kai-Ping Chang et al.   JOURNAL OF PROTEOME RESEARCH

A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells

(2011) K. Visnyei et al.   MOLECULAR CANCER THERAPEUTICS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway

(2011) I. Nakano et al.   NEURO-ONCOLOGY

CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway

(2011) Mayumi Jijiwa et al.   PLoS One

Acquisition of Chemoresistance in Gliomas Is Associated with Increased Mitochondrial Coupling and Decreased ROS Production

(2011) Claudia R. Oliva et al.   PLoS One

Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling

(2011) Q. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation

(2010) T. J. Tavender et al.   JOURNAL OF CELL SCIENCE

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

(2010) Kathryn E. Wellen et al.   MOLECULAR CELL

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Comparative Proteomic Analysis of Osteosarcoma Cell and Human Primary Cultured Osteoblastic Cell

(2009) Xudong Liu et al.   CANCER INVESTIGATION

Conserved Gene Expression Programs Integrate Mammalian Prostate Development and Tumorigenesis

(2009) C. Pritchard et al.   CANCER RESEARCH

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

Peroxiredoxin 4knockout results in elevated spermatogenic cell death via oxidative stress

(2008) Yoshihito Iuchi et al.   BIOCHEMICAL JOURNAL

Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

(2008) C.-H. Kwon et al.   CANCER RESEARCH

Proteomic Profiling of Endothelial Cells in Human Lung Cancer

(2008) Hye-Jeong Park et al.   JOURNAL OF PROTEOME RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

In vivogrowth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from thePiperspecies

(2007) Daniel P. Bezerra et al.   JOURNAL OF APPLIED TOXICOLOGY

Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

(2007) Ichiro Nakano et al.   JOURNAL OF NEUROSCIENCE RESEARCH