Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 90, Issue 10, Pages 1892-1902Publisher
WILEY
DOI: 10.1002/jnr.23076
Keywords
neuron-glia interaction; mouse embryonic stem cell; development; neurogenesis
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Funding
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro
- Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico
- Ministerio da Saude/DECIT
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Sphingosine 1-phosphate (S1P) is a bioactive signaling lysophospholipid. Effects of S1P on proliferation, survival, migration, and differentiation have already been described; however, its role as a mediator of interactions between neurons and glial cells has been poorly explored. Here we describe effects of S1P, via the activation of its receptors in astrocytes, on the differentiation of neural progenitor cells (NPC) derived from either embryonic stem cells or the developing cerebral cortex. S1P added directly to NPC induced their differentiation, but S1P-primed astrocytes were able to promote even more pronounced changes in maturation, neurite outgrowth, and arborization in NPC. An increase in laminin by astrocytes was observed after S1P treatment. The effects of S1P-primed astrocytes on neural precursor cells were abrogated by antibodies against laminin. Together, our data indicate that S1P-treated astrocytes are able to induce neuronal differentiation of NPC by increasing the levels of laminin. These results implicate S1P signaling pathways as new targets for understanding neuroglial interactions within the central nervous system. (c) 2012 Wiley Periodicals, Inc.
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