Article
Neurosciences
Guangkuo Dong, Schuyler Kogan, Natasha Venugopal, Eddy Chang, Lianying He, Fama Faal, Yang Shi, Lynnette Phillips McCluskey
Summary: Experimental or traumatic nerve injury leads to degeneration of taste buds, but the regeneration and recovery of taste function can occur through the action of proinflammatory cytokines IL-1a and IL-1b and their receptors. However, mice lacking the IL-1 receptor fail to regenerate taste buds and recover normal taste transmission after injury.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Archana Kumari, Charlotte M. Mistretta
Summary: Sensory receptors throughout the tongue are involved in eating. The tongue has distinct regions with taste and non-taste organs composed of specialized tissues, which require tailored molecular pathways for homeostasis and regeneration. However, generalizations are often made between mechanisms that regulate different taste papillae without highlighting the unique taste cell types and receptors in each papilla. Understanding the signaling differences in anterior and posterior taste and non-taste papillae, particularly the Hedgehog pathway, is crucial for developing effective treatments for taste dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Bryan E. Fowler, Jiahao Ye, Saima Humayun, Hojoon Lee, Lindsey J. Macpherson
Summary: This study compares the encoding of taste information in the geniculate and petrosal ganglia in mice, finding that there is a specialization of taste information coding from the anterior and posterior tongue. It is observed that petrosal neurons are more responsive to umami or bitter taste and less responsive to sweet or salty taste compared with geniculate neurons. The findings also suggest a functional taste map of the mammalian tongue, where the anterior and posterior taste pathways differentially respond to specific taste qualities and regulate downstream physiological functions such as saliva production.
Article
Anatomy & Morphology
Archana Kumari, Libo Li, Alexandre N. Ermilov, Nicole E. Franks, Andrzej A. Dlugosz, Benjamin L. Allen, Charlotte M. Mistretta
Summary: This study reveals that the HH pathway antagonist HHIP maintains the stability of non-gustatory filiform papillae through localized expression during taste organ homeostasis.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Andrew Padalhin, Celine Abueva, So Young Park, Hyun Seok Ryu, Hayoung Lee, Jae Il Kim, Phil-Sang Chung, Seung Hoon Woo
Summary: This study is the first attempt to correlate the disruption in taste preference caused by CT nerve transection with the altered expression of taste receptors and taste signaling proteins in the tongue.
Article
Biochemistry & Molecular Biology
Hayeon Sung, Iva Vesela, Hannah Driks, Carrie R. Ferrario, Charlotte M. Mistretta, Robert M. Bradley, Monica Dus
Summary: Consuming sucrose has selective and modality-specific effects on peripheral taste nerve responses and taste bud cells, but does not affect the number and size of taste buds. Replacing sucrose with water can fully restore these effects.
Article
Nutrition & Dietetics
Haruno Mizuta, Natsuko Kumamoto, Shinya Ugawa, Takashi Yamamoto
Summary: The study shows that ornithine enhances preferences for sweet, salty, umami, and fat taste solutions in mice, particularly increasing preference for monosodium glutamate (MSG). The newly identified kokumi receptor, GPRC6A, was found to be involved in the additive effects of ornithine on taste stimuli, suggesting a potential relationship between ornithine and taste modulation in the oral cavity.
Article
Behavioral Sciences
Takashi Yamamoto, Haruno Mizuta
Summary: In addition to the basic taste receptors, there is another type of taste receptor called the calcium-sensing receptor (CaSR) that is involved in enhancing flavor characteristics. gamma-Glu-Val-Gly (EVG) is the most potent agonist of CaSR and enhances preferences for umami, fat, and sweet taste solutions in rats.
Article
Clinical Neurology
Ruowei Tang, Zhengyu Zhang, Lei Zhao, Ning Xu, Qian Wu, Jing Xie, Pengfei Zhao, Hongxia Yin, Zhenghan Yang, Zhenchang Wang
Summary: This study visualized the course of the tympanic segment of chorda tympani nerve (CTN) using ultra-high-resolution computed tomography. Preoperative evaluation of CTN might help in avoiding iatrogenic injury during middle ear surgery.
WORLD NEUROSURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Saad Elzayat, Haitham H. Elfarargy, Rasha Lotfy, Islam Soltan, Hisham N. Lasheen, Valerio Margani, Edoardo Covelli, Maurizio Barbara, Mahmoud Mandour
Summary: This study aimed to find an appropriate radiological method to evaluate the chorda-facial angle (CFA) and investigate its effect on round window accessibility during cochlear implantation. A retrospective study of 237 pediatric cochlear implant surgeries was conducted, and the results showed a significant correlation between CFA and round window accessibility. Decreased angle was associated with increased surgical difficulty.
EUROPEAN RADIOLOGY
(2023)
Article
Behavioral Sciences
Joseph M. Breza, Steven J. St. John
Summary: In behavioral experiments, rats perceive sodium carbonate (Na2CO3) as super salty. The chorda tympani nerve (CT) responds to salts through at least two receptor mechanisms and is a model system for understanding how salt taste is transmitted to the brain. Recording nerve activity of the CT nerve, the study investigated the reasons behind rats perceiving Na2CO3 as extremely salty.
Article
Clinical Neurology
Daniel H. Coelho, Seong Lee, Edward Yang, Matthew Carli
Summary: This study reviewed the literature on the impact of stapes surgery on the chorda tympani nerve and the incidence and prognosis of taste disturbances in patients after surgery. The results showed that 46.2% of patients experienced taste disturbances in the early postoperative period, and 15.0% had long-term problems. The authors recommend that surgeons continue to inform potential patients about the risks of both short- and long-term taste disturbances.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Clinical Neurology
Zachary A. Kons, Lawrance Lee, Daniel H. Coelho
Summary: This study conducted a systematic review and meta-analysis to investigate the occurrence of taste change after cochlear implantation surgery. The results showed that taste change from chorda tympani nerve injury is a common complication of this procedure and surgeons should inform patients about this potential risk and the possibility of long-term taste changes.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Biology
Philip K. Shiu, Gabriella R. Sterne, Stefanie Engert, Barry J. Dickson, Kristin Scott
Summary: This study combines synaptic resolution circuit reconstruction with genetic access to specific neurons to elucidate a gustatory sensorimotor circuit in adult Drosophila melanogaster. The circuit integrates external taste detection and internal hunger signals to flexibly execute feeding decisions.
Article
Otorhinolaryngology
Lukas Skoloudik, Jana Krtickova, Jiri Haviger, Jan Mejzlik, Viktor Chrobok
Summary: Taste perception is often affected after stapes surgery, with sweet and bitter tastes being most affected, while sour taste appears to be relatively resistant to damage. Men have more pronounced alterations in salty taste, and younger patients have better recovery in bitter taste.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Neurosciences
Devaki Kumarhia, Lianying He, Lynnette Phillips McCluskey
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Cell Biology
Lianying He, Lynnette Phillips McCluskey
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2018)
Article
Physiology
Nick A. Guagliardo, Katie Nicole West, Lynnette P. McCluskey, David L. Hill
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2009)
Article
Neurosciences
P. W. Steen, L. Shi, L. He, L. P. McCluskey
Article
Neurosciences
L. He, A. Yadgarov, S. Sharif, L. P. McCluskey
Article
Neurosciences
X. Zhu, L. He, L. P. McCluskey
Article
Behavioral Sciences
Lynnette Phillips McCluskey, Lianying He, Guankuo Dong, Ruth Harris
Article
Multidisciplinary Sciences
David W. Pittman, Guangkuo Dong, Alexandra M. Brantly, Lianying He, Tyler S. Nelson, Schuyler Kogan, Julia Powell, Lynnette Phillips McCluskey
SCIENTIFIC REPORTS
(2020)
Article
Behavioral Sciences
Pamela Lea Wall, Lynnette Phillips McCluskey
Article
Neurosciences
Melissa Ann Cavallin, Lynnette Phillips McCluskey
NEUROSCIENCE LETTERS
(2007)
Article
Neurosciences
Melissa Ann Cavallin, Lynnette Phillips McCluskey
JOURNAL OF NEUROSCIENCE RESEARCH
(2007)
Article
Pharmacology & Pharmacy
AE Linder, LP McCluskey, KR Cole, KM Lanning, RC Webb
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2005)
Article
Neurosciences
MA Cavallin, LP McCluskey
JOURNAL OF NEUROSCIENCE RESEARCH
(2005)
Article
Biochemistry & Molecular Biology
LM Jin, CE Foss, XY Zhao, TM Mills, MH Wang, LP McCluskey, GSS Yaddanapud, JR Falck, JD Imig, RC Webb