Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 87, Issue 1, Pages 260-268Publisher
WILEY
DOI: 10.1002/jnr.21834
Keywords
BT-11; memory; Polygala tenuifolia; stress; 3,4,5-trimethoxycinnamic acid
Categories
Funding
- Ministry of Science and Technology, Korea
- BK21 Human Life Sciences, Korea
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In Oriental medicine, roots of Polygala tenuifolia Willde-now have been known to be an important herb that exhibits sedative effects in insomnia, palpitation with anxiety, restlessness, and disorientation in humans. We previously reported that BT-11, extracted from those roots, improved scopolamine-induced amnesia in rats and inhibited acetylcholinesterase activities in vitro. Therefore, we proposed that BT-11 could remedy stress-induced memory deficits in rats. In this study, the stress-induced memory impairments in rats were significantly reversed almost to the control level by BT-11 treatment. To seek an active component of BT-11 that plays an important role in antipsychotic effects, we compared BT-11 with 3,4,5-trimethoxycinnamic acid (TMCA), which is a constituent of those root extracts. However, the effects of TMCA were less or were not consistent with those of BT-11 in some of tests. In perticular, BT-11 reversed the stress-induced reduction of glucose utilization by [(18)fluorodeoxyglucose] FDG-PET and the levels of neural cell adhesion molecule (NCAM) in rat brains to the control levels, whereas TMCA did not. Therefore, BT-11 improved stress-induced memory impairments through increment of glucose utilization and total NCAM levels in rat brains. In conclusion, BT-11 may be strongly effective against stress-induced amnesia in rats, through the combined effects of TMCA and other active components of BT-11. (C) 2008 Wiley-Liss, Inc.
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