Article
Neurosciences
Marianne van der Vaart, Caroline Hartley, Luke Baxter, Gabriela Schmidt Mellado, Foteini Andritsou, Maria M. Cobo, Ria Evans Fry, Eleri Adams, Sean Fitzgibbon, Rebeccah Slater
Summary: The study found that heart rate responses increase with age, and noxious-evoked brain activity undergoes three developmental stages, including a previously unreported transitory stage. Additionally, infant responses to noxious and nonnoxious stimuli are discriminable in prematurity.
Article
Neurosciences
L. E. D. Lykholt, C. D. Morch, W. Jensen
Summary: This study aimed to investigate the possibility of distinguishing between non-noxious and noxious cortical responses with two different types of anesthesia. The results showed that it was possible to differentiate between different levels of stimulation intensities based on specific features in one type of anesthesia.
Article
Biotechnology & Applied Microbiology
Kui Zhang, Yaoyao Liu, Yilin Song, Shihong Xu, Yan Yang, Longhui Jiang, Shutong Sun, Jinping Luo, Yirong Wu, Xinxia Cai
Summary: To overcome the limitations of traditional MEAs in studying retinal ganglion cells (RGCs), researchers have developed a 3D MEA based on the planar MEA platform. The 3D MEA showed improvements in impedance, phase delay, charge storage capacity, and signal-to-noise ratio compared to planar MEA. Using the advanced 3D MEA, researchers investigated the encoding characteristics of RGCs under multi-modal stimulation, revealing different response patterns, response times, and encoding properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Jiaojiao Zhang, Lee Embray, Yevgenij Yanovsky, Jurij Brankack, Andreas Draguhn
Summary: Studying pain processing in animals faces challenges in applying reproducible stimuli and assessing behavioral and physiological correlates of pain. Laser-evoked heat stimuli are ideal for precisely studying pain-related brain activity in freely behaving mice, although their use in awake unrestrained rodents is limited due to technical difficulties. The development of a versatile stimulation and recording system allows for simultaneous acquisition of electrophysiological and behavioral responses in freely moving mice, which can benefit pain research and sensory physiology in other fields.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Kazuhiro Shimo, Sho Ogawa, Yuto Niwa, Yuji Tokiwa, Ayaka Dokita, Sho Kato, Takafumi Hattori, Takako Matsubara
Summary: The study investigates the threshold changes of different nerve fibers (A beta, A delta, and C) due to somatosensory stimulation. Non-noxious stimulation showed a significant increase only in A beta fibers, while noxious stimulation increased pain thresholds in both A delta and C fibers and sensory thresholds in A beta fibers. These findings suggest that nociceptive inputs selectively suppress nociceptive stimuli.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Connor M. Peck, David A. Bereiter, Lynn E. Eberly, Christophe Lenglet, Estephan J. Moana-Filho
Summary: High-impact temporomandibular disorder (TMD) pain participants showed abnormal brain responses to sensory processing of noxious stimuli, indicating the presence of maladaptive brain plasticity in chronic TMD pain.
Article
Anesthesiology
Jesus Pujol, Gerard Martinez-Vilavella, Lluis Gallart, Laura Blanco-Hinojo, Susana Pacreu, Vincent Bonhomme, Joan Deus, Victor Perez-Sola, Pedro L. Gambus, Juan Fernandez-Candil
Summary: The study evaluates the effect of the analgesic remifentanil on brain response to painful stimuli during deep sedation. The results show that at low doses, there is still partial activation in pain-related brain areas. At medium doses, a wider range of brain activation is observed, including the brainstem, cerebellum, thalamus, auditory and visual cortices, and the frontal lobe. No significant activation is observed at high doses.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Viktor Bublitz, Carlo Jurth, Matthias Kreuzer, Gregor Lichtner, Falk von Dincklage
Summary: This study investigated the potential correlations between electroencephalogram (EEG) band power and behavioral responses to noxious stimulation in critical care patients. The results indicated that specific EEG power bands were associated with behavioral responses preceding and following the stimulation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Computer Science, Theory & Methods
Anubhav Jangra, Sourajit Mukherjee, Adam Jatowt, Sriparna Saha, Mohammad Hasanuzzaman
Summary: This article presents a comprehensive survey of existing research on automatic multi-modal summarization (MMS), covering various modalities such as text, image, audio, and video. It discusses the importance of MMS, highlights different evaluation metrics and datasets used for this task, and identifies current challenges and future directions in the field.
ACM COMPUTING SURVEYS
(2023)
Article
Multidisciplinary Sciences
Nataliya Kraynyukova, Simon Renner, Gregory Born, Yannik Bauer, Martin A. Spacek, Georgi Tushev, Laura Busse, Tatjana Tchumatchenko
Summary: In this study, a theory-driven approach was used to deduce V1 network connectivity from visual responses in mouse V1 and visual thalamus (dLGN). The researchers found that connectivity weights followed a specific order across different connectivity configurations, which may be related to the shape of contrast response functions and contrast invariance of orientation tuning. Furthermore, the study also revealed that despite variability across connectivity studies, connectivity weights computed from individual published connectivity reports still followed the same order.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Computer Science, Artificial Intelligence
Yongjing Yin, Jiali Zeng, Jinsong Su, Chulun Zhou, Fandong Meng, Jie Zhou, Degen Huang, Jiebo Luo
Summary: This paper proposes a graph-based multi-modal fusion encoder for neural machine translation. It represents the input sentence and image using a unified multi-modal graph, and learns node representations through graph-based fusion layers. Experimental results show that the proposed model achieves significant improvements over baselines and achieves state-of-the-art performance on the Multi30K dataset.
ARTIFICIAL INTELLIGENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Larissa Weiss, Anna M. Saller, Julia Werner, Stephanie C. Suess, Judith Reiser, Sandra Kollmansperger, Malte Anders, Heidrun Potschka, Thomas Fenzl, Benjamin Schusser, Christine Baumgartner
Summary: This research aimed to determine when chickens acquire the ability to sense pain during embryonic development. By applying mechanical stimuli to chicken embryos and measuring changes in blood pressure and heart rate, it was found that embryos at around two days before hatching showed significant responses to noxious stimuli, indicating the emergence of nociception.
Article
Computer Science, Interdisciplinary Applications
Yiran Wei, Xi Chen, Lei Zhu, Lipei Zhang, Carola-Bibiane Schonlieb, Stephen Price, Chao Li
Summary: The proposed study presents a multi-modal learning framework for predicting the genotype of glioma by integrating focal tumor image, tumor geometrics, and global brain network features. Experimental results demonstrate that the model outperforms baseline deep learning models, and the visualized interpretation aligns with clinical knowledge.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Information Systems
Yang Wang
Summary: With the advancement of web technology, the analysis of multi-modal data has become a focus, with the fusion of multi-modal feature spaces being a key factor in enhancing performance. Deep neural networks have shown excellent performance in handling multi-modal data, and research from shallow to deep spaces is gradually expanding, with collaboration, adversarial competition, and fusion playing important roles in this field.
ACM TRANSACTIONS ON MULTIMEDIA COMPUTING COMMUNICATIONS AND APPLICATIONS
(2021)
Review
Medicine, General & Internal
Anna Xu, Bart Larsen, Alina Henn, Erica B. Baller, J. Cobb Scott, Vaishnavi Sharma, Azeez Adebimpe, Allan I. Basbaum, Gregory Corder, Robert H. Dworkin, Robert R. Edwards, Clifford J. Woolf, Simon B. Eickhoff, Claudia R. Eickhoff, Theodore D. Satterthwaite
Summary: Functional neuroimaging is a valuable tool for understanding how patients with chronic pain respond to painful stimuli. Previous studies have shown inconsistent results, prompting a quantitative meta-analysis to integrate data and identify consistent associations. This systematic review and meta-analysis found that chronic pain patients do not exhibit significant differential brain responses to noxious stimuli compared to healthy controls.
Article
Clinical Neurology
Anastasis Georgoulas, Laura Jones, Maria Pureza Laudiano-Dray, Judith Meek, Lorenzo Fabrizi, Kimberley Whitehead
Summary: In this study of 175 infants, unique regulation of sleep-wake states was observed, with particularly long durations of active sleep. Stress and nociception were found to impact sleep durations, especially in preterm infants, highlighting the importance of environmental interventions in promoting healthy sleep patterns.
Review
Pediatrics
Christopher Eccleston, Emma Fisher, Richard F. Howard, Rebeccah Slater, Paula Forgeron, Tonya M. Palermo, Kathryn A. Birnie, Brian J. Anderson, Christine T. Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B. Sieberg, Dick Tibboel, Suellen M. Walker, Dominic Wilkinson, Chantal Wood
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Letter
Anesthesiology
Caroline Hartley, Luke Baxter, Fiona Moultrie, Ryan Purdy, Aomesh Bhatt, Richard Rogers, Chetan Patel, Eleri Adams, Rebeccah Slater
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Multidisciplinary Sciences
Luke Baxter, Fiona Moultrie, Sean Fitzgibbon, Marianne Aspbury, Roshni Mansfield, Matteo Bastiani, Richard Rogers, Saad Jbabdi, Eugene Duff, Rebeccah Slater
Summary: Studying the neurophysiology of neonatal responses to noxious stimulation can predict brain responses and their associations with white matter structure. The research shows that brain activity evoked by noxious stimulation in healthy neonates is linked to resting-state activity and white matter microstructure, providing valuable insights for early life pain management.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Maria M. Cobo, Caroline Hartley, Deniz Gursul, Foteini Andritsou, Marianne van der Vaart, Gabriela Schmidt Mellado, Luke Baxter, Eugene P. Duff, Miranda Buckle, Ria Evans Fry, Gabrielle Green, Amy Hoskin, Richard Rogers, Eleri Adams, Fiona Moultrie, Rebeccah Slater
Summary: Despite the high burden of pain in hospitalised neonates, few analgesics have proven efficacy. Testing analgesics in neonates comes with challenges, both experimentally and ethically; however, EEG-derived measures of noxious-evoked brain activity can help assess efficacy. A new experimental paradigm accounting for individual differences in noxious-evoked baseline sensitivity was developed and tested across four studies, providing evidence of the efficacy of gentle brushing and paracetamol in neonates. This work represents an important step towards safe and cost-effective clinical trials of analgesics in neonates.
Article
Neurosciences
Marianne van der Vaart, Caroline Hartley, Luke Baxter, Gabriela Schmidt Mellado, Foteini Andritsou, Maria M. Cobo, Ria Evans Fry, Eleri Adams, Sean Fitzgibbon, Rebeccah Slater
Summary: The study found that heart rate responses increase with age, and noxious-evoked brain activity undergoes three developmental stages, including a previously unreported transitory stage. Additionally, infant responses to noxious and nonnoxious stimuli are discriminable in prematurity.
Article
Neuroimaging
Gabriela Schmidt Mellado, Kirubin Pillay, Eleri Adams, Ana Alarcon, Foteini Andritsou, Maria M. Cobo, Ria Evans Fry, Sean Fitzgibbon, Fiona Moultrie, Luke Baxter, Rebeccah Slater
Summary: This study investigates the impact of prematurity on neurodevelopment in infants, finding that premature birth may accelerate maturation of the visual and tactile sensory systems. By analyzing evoked responses in infants using EEG and comparing different groups of infants, it was observed that visual and tactile response template magnitudes differ between premature and late preterm infants.
NEUROIMAGE-CLINICAL
(2022)
Article
Respiratory System
Tricia Adjei, Ryan Purdy, Joao Jorge, Eleri Adams, Miranda Buckle, Ria Evans Fry, Gabrielle Green, Chetan Patel, Richard Rogers, Rebeccah Slater, Lionel Tarassenko, Mauricio Villarroel, Caroline Hartley
Summary: A new algorithm was developed and validated to identify interbreath intervals and apnoeas in preterm infants, showing high accuracy in detection. The study also found that morphine caused a shift towards longer interbreath intervals, and there was a significant increase in the number of pauses in breathing lasting more than 10 seconds following ROP screening.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Article
Biology
Laura Jones, Madeleine Verriotis, Robert J. Cooper, Maria Pureza Laudiano-Dray, Mohammed Rupawala, Judith Meek, Lorenzo Fabrizi, Maria Fitzgerald
Summary: Topographic cortical maps are crucial for spatial localization of sensory stimulation and generation of appropriate motor responses. In adult somatosensory (S1) cortex, somatosensation and nociception are finely mapped and aligned. However, in infancy, when pain behavior is disorganized and poorly directed, nociceptive maps may be less refined.
Article
Multidisciplinary Sciences
Maria M. Cobo, Gabrielle Green, Foteini Andritsou, Luke Baxter, Ria Evans Fry, Annika Grabbe, Deniz Gursul, Amy Hoskin, Gabriela Schmidt Mellado, Marianne van der Vaart, Eleri Adams, Aomesh Bhatt, Franziska Denk, Caroline Hartley, Rebeccah Slater
Summary: The relationship between immune function, pain sensitivity, and early life inflammation is not well understood in humans. This study found that neonatal inflammation is associated with increased spinal cord excitability and evoked brain activity following tactile and noxious stimulation. These findings suggest that hyperalgesia may persist post-inflammation, supporting previous research on immune dysfunction and pain sensitivity in adults.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Pishan Chang, Lorenzo Fabrizi, Maria Fitzgerald
Summary: Early life pain experience alters adult pain behavior and hypersensitivity, affecting functional brain connectivity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shaun Warrington, Elinor Thompson, Matteo Bastiani, Jessica Dubois, Luke Baxter, Rebeccah Slater, Saad Jbabdi, Rogier B. Mars, Stamatios N. Sotiropoulos
Summary: This study proposes a novel framework that integrates structural connectivity maps from humans and nonhuman primates onto a common space, allowing the study of divergences and similarities in connectivity over evolutionary and developmental scales to reveal brain maturation trajectories.
Article
Biochemistry & Molecular Biology
Mohammed Rupawala, Oana Bucsea, Maria Pureza Laudiano-Dray, Kimberley Whitehead, Judith Meek, Maria Fitzgerald, Sofia Olhede, Laura Jones, Lorenzo Fabrizi
Summary: Habituation to recurrent non-threatening or unavoidable noxious stimuli is an important aspect of adaptation to pain. Neonates, especially if preterm, are exposed to repeated noxious procedures during their clinical care. This study investigated changes in cortical microstates following repeated heel lances in term and preterm infants, and found that term infants showed habituation while preterm infants did not. However, both groups engaged different longer-latency cortical microstates with repeated stimulation.
Article
Medical Informatics
Eugene P. Duff, Fiona Moultrie, Marianne van der Vaart, Sezgi Goksan, Alexandra Abos, Sean P. Fitzgibbon, Luke Baxter, Tor D. Wager, Rebeccah Slater
LANCET DIGITAL HEALTH
(2020)
Article
Neuroimaging
Kimberley Whitehead, Laura Jones, Maria Pureza Laudiano-Dray, Judith Meek, Lorenzo Fabrizi
NEUROIMAGE-CLINICAL
(2020)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
