Review
Radiology, Nuclear Medicine & Medical Imaging
Teng Zhang, Shuang Wu, Xiaohui Zhang, Yiwu Dai, Anxin Wang, Hong Zhang, Mei Tian
Summary: Quantification approaches of PET imaging in living brains have been recommended for clinical diagnosis of neurological disorders. This review compared PET template-based and MRI-aided spatial normalization approaches. The study also discussed ROI-based and voxel-wise quantitative methods, as well as the concerns and clinical applications of these approaches. A recipe for PET spatial normalization and quantification was concluded to improve diagnosis accuracy in clinical practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, Research & Experimental
Aisling M. Chaney, Francisco R. Lopez-Picon, Sophie Serriere, Rui Wang, Daniela Bochicchio, Samuel D. Webb, Matthias Vandesquille, Michael K. Harte, Christina Georgiadou, Catherine Lawrence, Julie Busson, Johnny Vercouillie, Clovis Tauber, Frederic Buron, Sylvain Routier, Tristan Reekie, Anniina Snellman, Michael Kassiou, Johanna Rokka, Karen E. Davies, Juha O. Rinne, Dervis A. Salih, Frances A. Edwards, Llwyd D. Orton, Stephen R. Williams, Sylvie Chalon, Herve Boutin
Summary: The TgF344-AD rat model shows improved AD pathology modeling, including neuronal loss and Tau accumulation, with alterations in neuroinflammation and cholinergic receptors observed in vivo. This model can be useful for assessing early neurotransmission dysfunction and neuroinflammation in AD longitudinally, showing a potential for PET detection of Tau pathology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Jannusch, Maike E. Lindemann, Nils Martin Bruckmann, Janna Morawitz, Frederic Dietzel, Kelsey L. Pomykala, Ken Herrmann, Ann-Kathrin Bittner, Oliver Hoffmann, Svjetlana Mohrmann, Lale Umutlu, Gerald Antoch, Harald H. Quick, Julian Kirchner
Summary: Breast PET/MRI protocols can be shortened from 20 to below 10 minutes without losing essential diagnostic information.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Jannusch, Nils Martin Bruckmann, Janna Morawitz, Matthias Boschheidgen, Harald H. Quick, Ken Herrmann, Wolfgang P. Fendler, Lale Umutlu, Martin Stuschke, Boris Hadaschik, Gerald Antoch, Lars Schimmoeller, Julian Kirchner
Summary: Combined assessment of Ga-68-PSMA-11 PET/MRI improves tumor localization in men with biochemical recurrence. The MRI detected local recurrence of PCa more often whereas (68) Ga-PSMA-11 PET detected lymph node metastases more often, especially for PSA < 1.69 ng/mL.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hiroki Kato, Tatsusada Okuno, Kayako Isohashi, Toru Koda, Mikito Shimizu, Hideki Mochizuki, Yuji Nakatsuji, Jun Hatazawa
Summary: This study used quantitative PET scans to observe increased metabolism of reactive astrocytes and compromised integrity of neuronal tracts in the brains of patients with multiple sclerosis. The activation of astrocytes and the associated pathology in multiple sclerosis were visualized through quantitative 1-C-11 acetate PET imaging.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lipei Zhang, Zizheng Xiao, Chao Zhou, Jianmin Yuan, Qiang He, Yongfeng Yang, Xin Liu, Dong Liang, Hairong Zheng, Wei Fan, Xu Zhang, Zhanli Hu
Summary: PET is widely used in clinical applications, and joint PET/MRI reduces radiation exposure risk for patients. This study introduces a novel deep learning method, STFNet, for denoising low-count PET with MRI input.
Review
Oncology
Pierre Decazes, Pauline Hinault, Ovidiu Veresezan, Sebastien Thureau, Pierrick Gouel, Pierre Vera
Summary: Computed Tomography (CT) has greatly enhanced external radiotherapy by allowing visualization and segmentation of tumors and organs in three dimensions. However, limitations exist, particularly in tumor characterization and delineation. By combining CT with functional and anatomical images such as Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) in a trimodality PET/CT/MRI, these limitations can be overcome. This approach, which requires specialized equipment and precise alignment, can have significant clinical impact and good agreement among healthcare professionals.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Tomohiro Nakayama, Yoshiyuki Kitamura, Yoshitomo Kikuchi, Shingo Baba, Koji Sagiyama, Keisuke Ishimatsu, Ryotaro Kamei, Nobutaka Mukae, Koji Iihara, Satoshi O. Suzuki, Toru Iwaki, Akio Hiwatashi
Summary: The study demonstrated that FDG-PET/MRI had higher sensitivity and visual scores compared to FDG-PET/CT and standalone MRI in patients with epilepsy, leading to improved diagnostic accuracy in detecting the epileptogenic zone (EZ). EZs were histopathologically confirmed through surgical resection, with common pathologies including hippocampal sclerosis, gliosis, focal cortical dysplasia, and brain tumors. FDG-PET/MRI showed significant improvement over FDG-PET/CT and standalone MRI, increasing visual scores and enhancing detection of EZs.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Guo, Jingjuan Wang, Bixiao Cui, Yihe Wang, Yaqin Hou, Guoguang Zhao, Jie Lu
Summary: The combination of [F-18]FDG PET/MRI and MEG in localizing the EZ in TLE patients showed higher concordance with surgical resection compared to PET/MRI or MEG alone. Lobar localization was clearly defined in majority of patients by [F-18]FDG PET/MRI/MEG. The results of PET/MRI/MEG in concordance with surgical outcome were found to be superior to PET/MRI or MEG alone.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Cici Zhang, Zhishan Liang, Wei Liu, Xuwen Zeng, Yuzhen Mo
Summary: This study aimed to compare the diagnostic accuracy of 18F-FDG PET/CT and PET/MRI for the diagnosis of distant metastases in patients with malignant tumors. The study found that 18F-FDG PET/MRI had higher sensitivity and AUC value than PET/CT for detecting distant metastases overall, while in breast cancer patients and lung cancer patients, the accuracies of PET/MRI and PET/CT differed.
Review
Medicine, General & Internal
Elisabetta Tonet, Graziella Pompei, Evelina Faragasso, Alberto Cossu, Rita Pavasini, Giulia Passarini, Matteo Tebaldi, Gianluca Campo
Summary: Microvascular dysfunction is a common cause of chest pain in patients with various conditions. Advanced imaging techniques such as positron emission tomography are used for diagnosis, with cardiovascular magnetic resonance and cardiac computed tomography also emerging as modalities for assessment. Identification of microvascular disease is crucial for improving patient prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Lisbeth Marner, Michael Lundemann, Astrid Sehested, Karsten Nysom, Lise Borgwardt, Rene Mathiasen, Peder S. Wehner, Otto M. Henriksen, Carsten Thomsen, Jane Skjoth-Rasmussen, Helle Broholm, Olga Ostrup, Julie L. Forman, Liselotte Hojgaard, Ian Law
Summary: The study found that adding [F-18]FET PET to MRI in pediatric CNS tumor patients significantly improved diagnostic accuracy, especially in treated lesions. This combination imaging technique helps differentiate tumor from non-tumor lesions more effectively, with a substantial impact on clinical management and decision-making.
Article
Endocrinology & Metabolism
V. Salem, C. Izzi-Engbeaya, C. Coello, D. B. Thomas, E. S. Chambers, A. N. Comninos, A. Buckley, Z. Win, A. Al-Nahhas, E. A. Rabiner, R. N. Gunn, H. Budge, M. E. Symonds, S. R. Bloom, T. M. Tan, W. S. Dhillo
DIABETES OBESITY & METABOLISM
(2016)
Article
Neurosciences
Nazanin Mirzaei, Sac Pham Tang, Sharon Ashworth, Christopher Coello, Christophe Plisson, Jan Passchier, Vimal Selvaraj, Robin J. Tyacke, David J. Nutt, Magdalena Sastre
Article
Clinical Neurology
Heather Wilson, Flavia Niccolini, Salman Haider, Tiago Reis Marques, Gennaro Pagano, Christopher Coello, Sridhar Natesan, Shitij Kapur, Eugenii A. Rabiner, Roger N. Gunn, Sarah J. Tabrizi, Marios Politis
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mickael Huiban, Christopher Coello, Kai Wu, Yanmei Xu, Yvonne Lewis, Andrew P. Brown, Mauro Buraglio, Chenbing Guan, Shaila Shabbir, Regan Fong, Jan Passchier, Eugenii A. Rabiner, Andrew Lockhart
MOLECULAR IMAGING AND BIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dag E. Olberg, Nadine Bauer, Kjetil W. Andressen, Trine Hjornevik, Paul Cumming, Finn O. Levy, Jo Klaveness, Ira Haraldsen, Julie L. Sutcliffe
NUCLEAR MEDICINE AND BIOLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mikael Palner, Corinne Beinat, Sam Banister, Francesca Zanderigo, Jun Hyung Park, Bin Shen, Trine Hjoernevik, Jae Ho Jung, Byung Chul Lee, Sang Eun Kim, Lawrence Fung, Frederick T. Chin
Article
Endocrinology & Metabolism
Ingrid Digernes, Atle Bjornerud, Svein Are S. Vatnehol, Grete Lovland, Frederic Courivaud, Einar Vik-Mo, Torstein R. Meling, Kyrre E. Emblem
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Trine Hjornevik, Peter W. Cipriano, Bin Shen, Jun Hyung Park, Praveen Gulaka, Dawn Holley, Harsh Gandhi, Daehyun Yoon, Erik S. Mittra, Greg Zaharchuk, Sanjiv S. Gambhir, Christopher R. McCurdy, Frederick T. Chin, Sandip Biswal
JOURNAL OF NUCLEAR MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bin Shen, Jun Hyung Park, Trine Hjornevik, Peter W. Cipriano, Daehyun Yoon, Praveen K. Gulaka, Dawn Holly, Deepak Behera, Bonnie A. Avery, Sanjiv S. Gambhir, Christopher R. McCurdy, Sandip Biswal, Frederick T. Chin
MOLECULAR IMAGING AND BIOLOGY
(2017)
Article
Endocrinology & Metabolism
Guro E. Loseth, Marie Eikemo, Peder Isager, Jostein Holmgren, Bruno Laeng, Vigdis Vindenes, Trine Hjornevik, Siri Leknes
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Psychiatry
E. Boen, T. Hjornevik, B. Hummelen, T. Elvsashagen, T. Moberget, J. E. Holtedahl, A. Babovic, P. K. Hol, S. Karterud, U. F. Malt
ACTA PSYCHIATRICA SCANDINAVICA
(2019)
Article
Psychiatry
J. Paul Hamilton, Matthew D. Sacchet, Trine Hjornevik, Frederick T. Chin, Bin Shen, Robin Kampe, Jun Hyung Park, Brian D. Knutson, Leanne M. Williams, Nicholas Borg, Greg Zaharchuk, M. Catalina Camacho, Sean Mackey, Markus Heilig, Wayne C. Drevets, Gary H. Glover, Sanjiv S. Gambhir, Ian H. Gotlib
TRANSLATIONAL PSYCHIATRY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ulrik Carling, Leonid Barkhatov, Henrik M. Reims, Tryggve Storas, Frederic Courivaud, Airazat M. Kazaryan, Per Steinar Halvorsen, Eric Dorenberg, Bjorn Edwin, Per Kristian Hol
EUROPEAN RADIOLOGY
(2019)
Article
Oncology
Siri Flogstad Svensson, Skarpheoinn Halldorsson, Anna Latysheva, Elies Fuster-Garcia, Trine Hjornevik, Jorunn Fraser-Green, Robin Anthony Birkeland Bugge, Jack Grinband, Sverre Holm, Ralph Sinkus, Einar Osland Vik-Mo, Kyrre Eeg Emblem
Summary: The combination of magnetic resonance elastography (MRE) and RNA sequencing revealed the molecular characteristics of glioblastoma tumor stiffness and its correlation with patient survival.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Cardiac & Cardiovascular Systems
Soeren E. Pischke, A. Gustavsen, H. L. Orrem, K. H. Egge, F. Courivaud, H. Fontenelle, A. Despont, A. K. Bongoni, R. Rieben, T. I. Tonnessen, M. A. Nunn, H. Scott, H. Skulstad, A. Barratt-Due, T. E. Mollnes
BASIC RESEARCH IN CARDIOLOGY
(2017)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
