Article
Sport Sciences
Marek Lyp, Marcin Rosinski, Jaroslaw P. Chmielewski, Malgorzata A. Czarny-Dzialak, Magdalena Osuch, Daria Urbanska, Tomasz Wojcik, Magdalena Florek-Luszczki, Iwona A. Stanislawska
Summary: The aim of this study was to determine whether the Functional Movement Screen (FMS) test can identify previous injuries among young boys practising football training. The results showed significant differences in the total scores of the FMS tests between the injured group and the non-injured group, indicating that the FMS test is an effective tool for identifying previous injuries among young football players.
Article
Rehabilitation
Sinikka Tarvonen-Schroder, Mari Koivisto
Summary: This study compares the functioning of patients with traumatic brain injury measured using the World Health Organization Disability Assessment Schedule (WHODAS-12) completed by patients and proxies with assessments made by professionals. The study found that disability increased with the severity of traumatic brain injury, as measured by different assessment tools. Proxies rated functioning as more impaired than patients, but there was still a strong correlation between patient and proxy assessments.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Ergonomics
Fritjof Gidion, Jolyon Carroll, Nils Lubbe
Summary: With over 350,000 PTW fatalities globally each year, safety concepts for PTW riders need appropriate procedures and test tools. Studies show that rib, femur, and tibia injuries are most frequent, with current ATDs requiring further validation.
ACCIDENT ANALYSIS AND PREVENTION
(2021)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Food Science & Technology
Julen Sanz-Serrano, Ariane Vettorazzi, Damian Muruzabal, Amaya Azqueta, Adela Lopez de Cerain
Summary: This article provides a complete in vitro genotoxicity assessment of three nutrients widely used in the European market, demonstrating that they did not show genotoxicity in any of the conditions tested. This study contributes to the limited evidence available and complements EFSA recommendations for in vitro genotoxicity testing of nutrients.
Review
Neurosciences
Qasim M. Alhadidi, Ghaith A. Bahader, Oiva Arvola, Philip Kitchen, Zahoor A. Shah, Mootaz M. Salman
Summary: Astrocytes play a crucial role in regulating neuronal plasticity after central nervous system (CNS) injuries, with both pathogenic and protective effects. While there is extensive research on the negative consequences of astrocyte proliferation following brain injuries, there is a growing interest in exploring the potential protective functions of astrocytes and their contribution to chronic functional recovery. This review discusses the protective functions of astrocytes in aspects such as edema, inflammation, and blood-brain barrier dysfunction, as well as their role in tissue regeneration.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Critical Care Medicine
Thomas Gargadennec, Gioconda Ferraro, Rudy Chapusette, Xavier Chapalain, Elisa Bogossian, Morgane Van Wettere, Lorenzo Peluso, Jacques Creteur, Olivier Huet, Niloufar Sadeghi, Fabio Silvio Taccone
Summary: This study aimed to examine the accuracy of different monitoring tools in detecting cerebral hypoperfusion in patients with acute brain injury. The results showed that the combination of intracranial pressure (ICP) and brain tissue oxygen pressure (PbtO(2)) monitoring was more accurate than ICP alone. The use of a dynamic hyperoxia test did not significantly increase the diagnostic accuracy.
Article
Nanoscience & Nanotechnology
Xuyang Huang, Yongqing Ye, Jianyong Zhang, Xuefeng Zhang, Hongwei Ma, Yongkang Zhang, Xianhua Fu, JiaJia Tang, Ning Jiang, Yuhan Han, Hongmei Liu, Honglin Chen
Summary: This study presents a ROS-scavenging functional hydrogel that can deliver drugs by responding to the traumatic microenvironment. By avoiding the blood-brain barrier and directly targeting the traumatic area on the brain tissue surface, the hydrogel can release encapsulated drugs to regulate the cellular oxidative stress response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biology
Hui-Min Shan, Michael A. Maurer, Martin E. Schwab
Summary: This study improved the Rotarod test by adjusting the protocol and adding additional parameters, and successfully assessed motor deficits in a model of mild to moderate traumatic brain injury.
Article
Surgery
Randall S. Burd, Aaron R. Jensen, John M. VanBuren, Jessica S. Alvey, Rachel Richards, Richard Holubkov, Murray M. Pollack
Summary: This study focused on determining the long-term functional status and health-related quality of life after serious pediatric injury, finding associations between impaired discharge functional status and decreased 6-month functional status and health-related quality of life.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Cell Biology
Ruslan Prus, Olena Appelhans, Maksim Logash, Petro Pokotylo, Grzegorz Jozef Nowicki, Barbara Slusarska
Summary: Traumatic brain injury is a serious issue in modern medicine, with our study showing that mild TBI causes different histological changes in the livers of adult and juvenile rats. The most significant changes were observed on days 5-7, with compensatory phenomena prevailing on days 14-21 in both groups.
Article
Neurosciences
Alja Kavcic, Jure Demsar, Dejan Georgiev, Nuska Pecaric Meglic, Aneta Soltirovska Salamon
Summary: Impaired cognitive functioning after perinatal stroke is linked to long-term changes in functional brain networks. We used a 64-channel electroencephalogram to study brain functional connectivity in 12 participants with a history of unilateral perinatal stroke. Results showed evidence of disrupted brain networks in these children, years after the stroke, with the extent of changes influenced by the lesion size. The networks remained more segregated and exhibited higher synchronization at both whole-brain and intrahemispheric levels, with greater interhemispheric connectivity compared to healthy controls.
Review
Clinical Neurology
Shane Musick, Anthony Alberico
Summary: Sedation is a common practice in ICUs and NCCUs, reducing cerebral energy demands but hindering accurate neurological assessment. Neurologic wake-up tests (NWTs) are considered the gold-standard for assessing brain-injured patients under sedation, but can also induce acute stress responses. There are strict contraindications for NWTs, and concerns regarding safety in certain situations such as hemodynamic instability and sedative use for ICP control or respiratory distress.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Diego Candia-Rivera, Vincenzo Catrambone, Riccardo Barbieri, Gaetano Valenza
Summary: The study of functional Brain-Heart Interplay (BHI) from non-invasive recordings has made significant progress, providing a new computational framework for the assessment of the interplay between cortical and cardiac neural control.
Article
Immunology
Timothy B. Meier, Lezlie Espana, Morgan E. Nitta, T. Kent Teague, Benjamin L. Brett, Lindsay D. Nelson, Michael A. McCrea, Jonathan Savitz
Summary: This study found a positive association between elevated QuinA levels and functional connectivity strength in concussed athletes with prior concussion. Additionally, concussed athletes who reported depressive symptoms on the first day post-injury had significantly higher global connectivity strength.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Isabel Lestro Henriques, Mara Gutierrez-Fernandez, Berta Rodriguez-Frutos, Jaime Ramos-Cejudo, Laura Otero-Ortega, Teresa Navarro Hernanz, Sebastian Cerdan, Jose M. Ferro, Exuperio Diez-Tejedor
CEREBROVASCULAR DISEASES
(2015)
Article
Engineering, Biomedical
Berta Rodriguez-Frutos, Laura Otero-Ortega, Jaime Ramos-Cejudo, Patricia Martinez-Sanchez, Ines Barahona-Sanz, Teresa Navarro-Hernanz, Maria del Carmen Gomez-de Frutos, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Article
Clinical Neurology
Berta Rodriguez-Frutos, Laura Otero-Ortega, Maria Gutierrez-Fernandez, Blanca Fuentes, Jaime Ramos-Cejudo, Exuperio Diez-Tejedor
TRANSLATIONAL STROKE RESEARCH
(2016)
Article
Clinical Neurology
B. Fuentes, B. E. Sanz-Cuesta, M. Gutierrez-Fernandez, P. Martinez-Sanchez, A. Lisbona, R. Madero-Jarabo, R. Delgado-Mederos, J. Gallego-Cullere, M. Rodriguez-Yanez, M. Martinez-Zabaleta, M. Freijo, M. Alonso de Lecinana, J. C. Portilla, A. Gil-Nunez, E. Diez-Tejedor
EUROPEAN JOURNAL OF NEUROLOGY
(2017)
Article
Endocrinology & Metabolism
Laura Otero-Ortega, Mari Carmen Gomez de Frutos, Fernando Laso-Garcia, Berta Rodriguez-Frutos, Esperanza Medina-Gutierrez, Juan Antonio Lopez, Jesus Vazquez, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2018)
Article
Immunology
Enrique Hernandez-Jimenez, Maria Gutierrez-Fernandez, Carolina Cubillos-Zapata, Laura Otero-Ortega, Berta Rodriguez-Frutos, Victor Toledano, Patricia Martinez-Sanchez, Blanca Fuentes, Anibal Varela-Serrano, Jose Avendano-Ortiz, Alberto Blazquez, Maria Angeles Mangas-Guijarro, Exuperio Diez-Tejedor, Eduardo Lopez-Collazo
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Laura Otero-Ortega, Fernando Laso-Garcia, Maria del Carmen Gomez-de Frutos, Berta Rodriguez-Frutos, Jorge Pascual-Guerra, Blanca Fuentes, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Fernando Laso-Garcia, Jaime Ramos-Cejudo, Francisco Javier Carrillo-Salinas, Laura Otero-Ortega, Ana Feliu, MariCarmen Gomez-de Frutos, Miriam Mecha, Exuperio Diez-Tejedor, Carmen Guaza, Maria Gutierrez-Fernandez
Article
Multidisciplinary Sciences
Laura Otero-Ortega, Mari Carmen Gomez-de Frutos, Fernando Laso-Garcia, Alba Sanchez-Gonzalo, Arturo Martinez-Arroyo, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
SCIENTIFIC REPORTS
(2017)
Review
Clinical Neurology
Laura Otero-Ortega, Fernando Laso-Garcia, MariCarmen Gomez-de Frutos, Blanca Fuentes, Luke Diekhorst, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
TRANSLATIONAL STROKE RESEARCH
(2019)
Review
Clinical Neurology
Fernando Laso-Garcia, Luke Diekhorst, Mari Carmen Gomez-de Frutos, Laura Otero-Ortega, Blanca Fuentes, Gerardo Ruiz-Ares, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
FRONTIERS IN NEUROLOGY
(2019)
Article
Cell & Tissue Engineering
Mari Carmen Gomez-de Frutos, Fernando Laso-Garcia, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martinez-Arroyo, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
STEM CELL RESEARCH & THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Laura Otero-Ortega, Elisa Alonso-Lopez, Maria Perez-Mato, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Luke Diekhorst, Maria Laura Garcia-Bermejo, Elisa Conde-Moreno, Blanca Fuentes, Maria Alonso de Lecinana, Eduardo Armada, Lorena Buiza-Palomino, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Summary: The study analyzed the content of circulating EVs in patients with IS and MI, finding common proteins and miRNAs as well as differences between the two groups. The research suggests a relationship between circulating EV content and the patient's disease state, with certain proteins and miRNAs participating in both diseases while others are specific to IS patients.
Review
Biochemistry & Molecular Biology
Maria Gutierrez-Fernandez, Fernando de la Cuesta, Antonio Tallon, Inmaculada Cuesta, Mireya Fernandez-Fournier, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Exuperio Diez-Tejedor, Laura Otero-Ortega
Summary: Extracellular vesicles (EVs) play a key role as potential biomarkers in multiple sclerosis (MS), aiding in monitoring disease activity and progression and discovering new pathways for therapeutic targets. EVs also have the potential to serve as treatment and vaccine delivery vehicles for immune tolerance restoration in MS autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mari Carmen Gomez-de Frutos, Fernando Laso-Garcia, Ivan Garcia-Suarez, Luke Diekhorst, Laura Otero-Ortega, Maria Alonso de Lecinana, Blanca Fuentes, Dolores Piniella, Gerardo Ruiz-Ares, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Summary: Ultrasound has shown potential in monitoring and treating acute ischemic stroke in experimental animal models, with studies demonstrating its safety and effectiveness in therapeutic applications. Further exploration is needed to determine the limitations and ensure accuracy in translational research.
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
