Article
Neurosciences
Bradley Jay Edelman, Giovanna D. Ielacqua, Russell W. Chan, Mazen Asaad, Mankin Choy, Jin Hyung Lee
Summary: In comparison to fMRI, fUSI is more sensitive in detecting optogenetically-induced neuronal activation, with a more accurate signal interpretation and the ability to provide vascular readouts of neuronal activity and activation patterns. The study suggests that fUSI could be a valuable tool for studying brain-wide neural circuits in diverse behavioral states and tasks.
Review
Ophthalmology
Guiqu Wang, Longqian Liu
Summary: This article systematically searched the PubMed database to highlight the current progress and promises of functional magnetic resonance imaging (fMRI) technology in amblyopia research. The neural mechanism of amblyopia, comparison of different types of amblyopia, and evaluation of therapeutic effect were explored.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Han Lv, Qian Chen, Xuan Wei, Chunli Liu, Pengfei Zhao, Zhaodi Wang, Zhenghan Yang, Shusheng Gong, Hong You, Zhenchang Wang
Summary: The study demonstrates that sound therapy can modulate the functional connectivity of the auditory network in tinnitus patients, with increased connectivity in the left primary auditory cortex and decreased values in the secondary auditory cortex. Additionally, increased connections between the auditory network and limbic network, as well as decreased values with the bilateral thalami, were observed. These changes were mainly driven by alterations in the functional connectivity of the secondary auditory cortex.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Zi-Jian Cheng, Lingxiao Yang, Wen-Hao Zhang, Ru-Yuan Zhang
Summary: The effects of response correlations among neurons and voxel populations have been a subject of debate in computational neuroscience. In this study, we used functional magnetic resonance imaging (fMRI) to investigate the effects of response correlations in the human visual cortex. We found that voxelwise response correlations generally enhance stimulus information, contrary to previous empirical neurophysiological studies. Our results suggest that multivariate fMRI data contain rich statistical structures that are directly related to sensory information representation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Katherine Conway Wilson, Myriam Kornisch, Toshikazu Ikuta
Summary: This study investigated the functional connectivity of the primary auditory cortex in individuals with Autism Spectrum Disorder (ASD). The results showed reduced connectivity between the auditory cortex and specific regions, such as the medial occipital cortex and primary motor cortex, in individuals with ASD compared to those without ASD. This reduced connectivity may contribute to deficient sensory integration associated with ASD.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2022)
Article
Multidisciplinary Sciences
Georgia Calhoun, Chih-Ting Chen, Patrick O. Kanold
Summary: Coordinated functioning of the two cortical hemispheres is crucial for perception. The left hemisphere of the human auditory cortex is specialized for processing speech, while the right hemisphere analyzes spectral content. In mice, virgin female mice show a left-hemisphere bias in response to pup vocalizations, which strengthens with motherhood. However, the establishment of this lateralized function is still unclear. This study developed a widefield imaging microscope to monitor functional responses in both hemispheres of mice simultaneously. The results showed that the secondary auditory cortex in the left hemisphere of both male and virgin female mice exhibited larger responses than the right hemisphere to high-frequency tones and adult vocalizations. Only virgin female mice showed a left-hemisphere bias in response to adult pain calls. The study also found that the development of functional cross-hemispheric connections depends on sensory experience.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Ke Song, Yong Wang, Mei-Xia Ren, Jiao Li, Ting Su, Si-Yi Chen, Yi Shao, Ya-Li Lv
Summary: Using resting-state functional connectivity, this study found abnormal neural activities in specific brain regions of patients with optic neuritis, with significant changes in rsFC, longFCD, and IFCD values, which may help identify the specific mechanism of change in brain function in ON.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Zhijun Zhang, Hongxing Zhang, Chun-Ming Xie, Meng Zhang, Yachen Shi, Ruize Song, Xiang Lu, Haisan Zhang, Kun Li, Bi Wang, Yongfeng Yang, Xianrui Li, Jianli Zhu, Yang Zhao, Ti-Fei Yuan, Georg Northoff
Summary: The study demonstrated the therapeutic potential and good tolerance of VC rTMS in MDD patients, as indicated by biomarkers of fMRI measurement.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Neurosciences
Dong-Jin Li, Bing-Lin Huang, Yuan Peng, Ling-Yan Liang, Hui Liu
Summary: Patients with primary angle-closure glaucoma (PACG) exhibit dynamic functional connectivity changes in the primary visual cortex (V1), indicating increased variability in the visual network.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Yang Liu, Hui-Qun Fu, Yan Wu, Zun-Shu Du, Bo-Ran Li, Xin Gao, Guan-Wen Lin, Shu-Yi Yang, Tian-Long Wang
Summary: Resting-state functional magnetic resonance imaging (rs-fMRI) is a promising method for studying brain function, typically performed on anesthetized animals. This study found that different anesthesia methods in aged rats can lead to variations in functional connectivity in different brain regions. Isoflurane anesthesia may be a suitable substitute for Isoflurane + Dexmedetomidine anesthesia in default mode network studies, depending on the regions of interest.
CHINESE MEDICAL JOURNAL
(2021)
Article
Neurosciences
Jianxun Ren, Ting Xu, Danhong Wang, Meiling Li, Yuanxiang Lin, Franziska Schoeppe, Julian S. B. Ramirez, Ying Han, Guoming Luan, Luming Li, Hesheng Liu, Jyrki Ahveninen
Summary: Research indicates that there is significant individual variability in the auditory cortex of humans and macaques, with greater variability near the non-primary auditory cortex. The left hemisphere of the auditory cortex shows higher variability compared to the right hemisphere, potentially linked to language-related functions. Similar modality differences and lateralization of variability were also observed in macaques, suggesting evolutionary implications for advanced auditory functions in humans.
Article
Neurosciences
Jianxun Ren, Catherine S. Hubbard, Jyrki Ahveninen, Weigang Cui, Meiling Li, Xiaolong Peng, Guoming Luan, Ying Han, Yang Li, Ann K. Shinn, Danhong Wang, Luming Li, Hesheng Liu
Summary: This study identified multiple auditory cortico-cerebellar pathways, revealing different levels of functional connectivity between auditory subareas and cerebellar regions. It also showed divergent connectivity patterns between auditory and sensorimotor areas, as well as the potential for functional segmentation of the AC based on different connectivity methods.
Article
Neurosciences
Jianing Hao, Xintao Hu, Liting Wang, Lei Guo, Junwei Han
Summary: The study suggests that the human cerebellum is involved in a wide range of cognitive tasks beyond traditional motor control and can be divided into distinct functional subregions. By utilizing a naturalistic paradigm of fMRI, the research successfully identified different subregions of the cerebellum, providing an alternative template for exploring neural activities in naturalistic environments.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Binyin Li, Miao Zhang, Ikbeom Jang, Guanyu Ye, Liche Zhou, Guiying He, Xiaozhu Lin, Hongping Meng, Xinyun Huang, Wangxi Hai, Shengdi Chen, Biao Li, Jun Liu
Summary: In early stages of Alzheimer's disease (AD), patients exhibit decreased connectivity in specific networks during the memory retrieval phase, with impaired functional connectivity mediating the adverse effect of beta-amyloid on memory performance. These findings help elucidate the role of cortical beta-amyloid (A beta) in memory performance in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Nathan T. Cohen, Hua Xie, Taha Gholipour, William D. Gaillard
Summary: This article summarizes the evidence to date on the network basis of FCD-related epilepsy, and highlights the potential applications of rsfMRI in the diagnosis and treatment of FCD-related epilepsy. Numerous studies have shown a global disruption of cortical functional networks in FCD-related epilepsy, and the underlying pathological subtypes of FCD influence overall functional network patterns.
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)