Article
Engineering, Chemical
Akira Miwano, Takehiro Yonezawa, Noriko Yamauchi, Kouichi Nakashima, Yoshio Kobayashi
Summary: The study suggests a new coating technique for thermistors using zirconia, which shows excellent chemical resistance and electrical insulation properties. Pre-silica coating on the substrate can improve the adhesion of ZrO2 films.
Article
Engineering, Chemical
Airi Tago, Noriko Yamauchi, Kouichi Nakashima, Daisuke Nagao, Yoshio Kobayashi
Summary: A simple method has been developed to control the oxidation and aggregation of metallic particles, specifically metallic nickel particles in this study, through silica-coating. The oxidation of metallic particles was successfully controlled by the silica coating, and the Ni/SiO2 particles exhibited soft magnetic behavior at different annealing temperatures.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Chemistry, Physical
Eugenio Gibertini, Federico Carosio, Kubra Aykanat, Alessandra Accogli, Gabriele Panzeri, Luca Magagnin
Summary: The study proposes a new method of encapsulating red phosphorus particles with a silica shell for flame retardancy in textiles. Through sol-gel process, a uniform silica shell was successfully achieved, improving the thermal stability of red phosphorus.
SURFACES AND INTERFACES
(2021)
Article
Engineering, Chemical
Shoya Kobayashi, Noriko Yamauchi, Shohei Tada, Yoshio Kobayashi
Summary: Silica-coated titanium nitride (TiN/SiO2) particles were synthesized using a sol-gel method and the hardness of the sintered bodies fabricated with these particles was evaluated. The presence of few micropores in the TiN/SiO2 structure resulted in particles with small specific surface areas. The Vickers hardness increased in the order: TiN < TiN-SiO2 < TiN/SiO2A < TiN/SiO2S. The SiO2 shell acted as a sintering aid and the NaOH catalyst improved the density and hardness of the sintered body.
ADVANCED POWDER TECHNOLOGY
(2023)
Article
Chemistry, Applied
Alvaro G. Braz, Sandra H. Pulcinelli, Celso Santilli
Summary: This study investigates the use of glycerol as a crosslinker for polyurethane, which is hybridized with a silica network. The results show that this organic-inorganic hybrid coating can effectively enhance the corrosion resistance of metal alloys.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Chemistry, Applied
Alvaro G. Braz, Sandra H. Pulcinelli, Celso V. Santilli
Summary: This study investigates glycerol as a crosslinker for polyurethane segments hybridized with a silica network for protective coatings. Evaluations were made on the structure, thermal stability, and corrosion protection of the coatings at different APTES/4,4'-MDI molar ratios, confirming the suitability of the PU-silica hybrid for anticorrosive thin coatings to protect metal alloys against corrosion.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Materials Science, Ceramics
Sherif Elbasuney, Ibrahim Naeem, Mohamed Mokhtar, Mohamed Sheashea, Mahmoud Zorainy, Gharieb S. El-Sayyad, Mohamed Gobara
Summary: A novel Cr-substituted hydroxyapatite (Cr-HA) nanoparticles were synthesized using continuous hydrothermal technique. The synthesized material was embedded into a silica sol-gel matrix and applied on an AA2024 substrate to evaluate its corrosion inhibition efficiency. The results showed the formation of Cr-HA nanorods with a uniform distribution of Ca and Cr ions within the crystal structure. The Cr-HA sol-gel coating exhibited prolonged pitting resistance and self-healing properties in a corrosive media.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Sergei Galyshev, Evgeniya Postnova, Olga Shakhlevich, Dmitrii Agarkov, Ekaterina Agarkova, Alexey Nekrasov, Rais Mozhchil
Summary: This study focuses on the chemical and phase composition of a carbon fiber coating obtained by the electrochemical sol-gel method. The experimental data from various methods show the coating consists of amorphous silicon oxide and crystalline potassium carbonate, with optimal heat treatment temperature at around 870 degrees C. The study also estimates the loss of fiber strength during the coating process.
Article
Chemistry, Physical
Airi Tago, Masato Yanase, Noriko Yamauchi, Kouichi Nakashima, Daisuke Nagao, Yoshio Kobayashi
Summary: A simple method was developed to suppress the oxidation and aggregation of metallic particles by coating metallic nickel particles with silica shells. The coated particles exhibited controlled oxidation and aggregation behavior, as well as paramagnetic properties after annealing in air.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Materials Science, Ceramics
Matjaz Kristl, Irena Ban, Saso Gyergyek, Uros Maver, Janja Stergar
Summary: The use of magnetic nanoparticles in biomedical applications, such as magnetic resonance imaging, drug delivery, and magnetic hyperthermia, is a topic of great interest. Nickel-copper nanoparticles with the formula Ni(x)Cu(1-x) are particularly attractive due to their simple synthesis, high magnetization, biocompatibility, and therapeutic Curie temperature (T-C). Coating the nanoparticles with silica improves their stability, biocompatibility, and allows for further functionalization or drug incorporation. In this study, Ni(67.5)Cu(32.5) nanoparticles were prepared using the sol-gel method and characterized for their potential in magnetic hyperthermia.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Metallurgy & Metallurgical Engineering
K. S. Duran, N. Hernandez, L. M. Rueda, C. A. Hernandez-Barrios, A. E. Coy, F. Viejo
Summary: This study developed multilayer barrier-bioactive coatings to enhance the corrosion resistance of magnesium alloy and promote the growth of apatite-like phases. However, an increase in salt content led to the formation of porous coatings, affecting the corrosion resistance of magnesium alloy.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Article
Materials Science, Ceramics
Raquel Rodriguez-Gonzalez, Elia Bosch-Rue, Leire Diez-Tercero, Luis M. Delgado, Roman A. Perez
Summary: Sol-gel silica-based hybrids can be tailored for tissue regeneration by adjusting their properties. Factors such as water content, TEOS:GPTMS volume ratio, and gelatin:sol volume ratio during the sol-gel preparation process influence the material's performance. Higher water content reduces degradation rate and mechanical properties, while decreasing water uptake. Increasing the amount of cross-linker in the TEOS:GPTMS volume ratio slightly decreases water uptake and degradation rate, and improves mechanical properties. Lastly, the gelatin:sol volume ratio affects water uptake, degradation rate, and mechanical properties.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
J. Molina, A. Valero-Gomez, S. Pocovi-Martinez, M. S. Ibiza-Palacios, F. Bosch
Summary: A silica-based sol-gel antibacterial coating with silver nanoparticles has been prepared and compared with a hydroxyapatite-based coating. The silica-based coating showed better and more homogeneous distribution of Ag NPs and sustained release of Ag+ over 40 days, with excellent antibacterial activity.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shroq AlZadjali, Zineb Matouk, Abdulla AlShehhi, Nitul Rajput, Meriam Mohammedture, Monserrat Guttierrez
Summary: Superhydrophobic coatings are becoming increasingly popular due to their low maintenance requirements, high durability, and wide range of potential applications. These coatings can provide resistance to fouling, icing, smear, and corrosion, as well as the ability to separate oil from water. Consequently, the development of superhydrophobic materials is a topic of significant interest among academics worldwide. In this paper, a spray-coating deposition technique is utilized to deposit silica nanoparticles on glass using a sol-gel as a base. The resulting coating significantly increased transmittance to 99% at 600 nm. Water contact angle (WCA) and scanning electron microscopy (SEM) analysis of the coated layer's grade index and induced porousness demonstrated superhydrophobic behavior with a water contact angle exceeding 158 degrees.
APPLIED SCIENCES-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Zeinab Chehadi, Mohammed Bouabdellaoui, Mehrnaz Modaresialam, Thomas Bottein, Marco Salvalaglio, Monica Bollani, David Grosso, Marco Abbarchi
Summary: Fabrication and scaling of disordered hyperuniform materials are still facing challenges, but a hybrid top-down/bottom-up approach has been demonstrated for faithful reproduction of such materials. The antireflective character of titania structures on silicon shows potential applications, opening up possibilities for large-scale implementation of metal oxide-based nano- and microarchitectures in wet chemical assembly.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
L. Savannah Dewberry, Alexander B. Dru, Maxwell Gravenstine, Brian Nguyen, James Anderson, Sasha Vaziri, Daniel J. Hoh, Kyle D. Allen, Kevin J. Otto
Summary: The study showed that HF block can rapidly reduce tactile sensitivity in a limb with neuropathic injury. No significant increase in gait disability was observed during HF block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biology
Michael D. Sunshine, Antonino M. Cassara, Esra Neufeld, Nir Grossman, Thomas H. Mareci, Kevin J. Otto, Edward S. Boyden, David D. Fuller
Summary: The study demonstrates that temporal interference stimulation can restore breathing in rats after opioid overdose and spinal cord injury, potentially offering an alternative and minimally invasive treatment option.
COMMUNICATIONS BIOLOGY
(2021)
Article
Engineering, Biomedical
Morgan E. Urdaneta, Nicolas G. Kunigk, Francisco Delgado, Shelley Fried, Kevin J. Otto
Summary: The study found that sensitivity and responses to stimulation parameters in S1 vary with cortical depth, suggesting that cortical depth may play an important role in fine-tuning stimulation parameters and designing intracortical neuroprostheses for clinical applications.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Neurosciences
Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan, Tricia N. Cunningham, Sameer A. Sheth, Nader Pouratian, Katherine W. Scangos, Helen S. Mayberg, Andreas Horn, Kara A. Johnson, Christopher R. Butson, Ro'ee Gilron, Coralie de Hemptinne, Robert Wilt, Maria Yaroshinsky, Simon Little, Philip Starr, Greg Worrell, Prasad Shirvalkar, Edward Chang, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa, Andrea A. Kuhn, Luming Li, Matthew Johnson, Kevin J. Otto, Robert Raike, Steve Goetz, Chengyuan Wu, Peter Silburn, Binith Cheeran, Yagna J. Pathak, Mahsa Malekmohammadi, Aysegul Gunduz, Joshua K. Wong, Stephanie Cernera, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Wissam Deeb, Addie Patterson, Kelly D. Foote, Michael S. Okun
Summary: An estimated 208,000 deep brain stimulation (DBS) devices have been implanted worldwide to treat neurological and neuropsychiatric disorders. The DBS Think Tank provides a space for clinicians, engineers, and researchers to discuss current and emerging DBS technologies and ethical issues, with a focus on advancing the field through cutting-edge research and collaboration. The Eighth Annual DBS Think Tank, held virtually in 2020, showcased advancements in optogenetics, emerging DBS technologies, ethical issues, neuromodulatory approaches, novel hardware/software/imaging methodologies, adaptive neurostimulation, and advanced technologies for improved clinical outcomes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Neurosciences
Ian G. Malone, Rachel L. Nosacka, Marissa A. Nash, Kevin J. Otto, Erica A. Dale
Summary: This article details the development and success of electrical epidural stimulation (EES) in recovering locomotor function, as well as exploring its potential in other systems. While there has been some success in using EES for locomotor function recovery, its effectiveness in improving breathing function after cSCI remains limited.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Electrochemistry
Kaitlynn P. Olczak, Kevin J. Otto
Summary: During neural stimulation, it is important to consider the impact of electrical stimulation on biological molecules, especially those with low oxidation potentials like ascorbic acid (AA). Research findings indicate that significant AA oxidation occurs even at stimulation levels typically deemed safe.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Neurosciences
Ian G. Malone, Mia N. Kelly, Rachel L. Nosacka, Marissa A. Nash, Sijia Yue, Wei Xue, Kevin J. Otto, Erica A. Dale
Summary: More than half of spinal cord injuries are cervical, leading to paralysis and respiratory compromise. Existing treatments for restoring breathing after severe cervical injuries are lacking. Closed-loop stimulation triggered by healthy muscle activity has the potential to promote neuroplasticity in the respiratory pathways of the spinal cord.
Meeting Abstract
Biochemistry & Molecular Biology
Elliott W. Dirr, Christopher J. Martyniuk, Kevin J. Otto, Jasenka Zubcevic
Article
Neurosciences
Morgan E. Urdaneta, Nicolas G. Kunigk, Seth Currlin, Francisco Delgado, Shelley I. Fried, Kevin J. Otto
Summary: Intracortical microstimulation (ICMS) can restore sensory function in paralyzed patients. This study investigates the stability of ICMS and the impact of cortical layers on its performance. The results demonstrate that ICMS sensitivity and long-term performance are layer dependent, with different cortical layers exhibiting varying levels of foreign body response (FBR) and astrocytic glial scar.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Nicolas G. Kunigk, Morgan E. Urdaneta, Ian G. Malone, Francisco Delgado, Kevin J. Otto
Summary: This study investigates the effectiveness of simultaneous multi-channel ICMS in electrode arrays with stimulation sites spanning cortical depth. The results show that using two adjacent electrode sites for stimulation reduces the charge required to reach detection thresholds by half. The reduction in threshold charge is more significant with more stimulation channels and decreases with greater distance between channels. These improvements are due to charge summation rather than a summation of neural responses to stimulation. Additionally, the improved stimulation efficiency per electrode site is seen regardless of the cortical depth of each channel. This has implications for future advanced neuroprosthetic devices.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Eric W. Atkinson, Cary A. Kuliasha, Mary Kasper, Abbas Furniturewalla, Alexander S. Lim, Ladan Jiracek-Sapieha, Alexis Brake, Anne Gormaley, Victor Rivera-Llabres, Ishita Singh, Benjamin Spearman, Carlos M. Rinaldi-Ramos, Christine E. Schmidt, Jack W. Judy, Kevin J. Otto
Summary: This study investigated the in vivo functionality of the MARTEENI device as a potential approach to improving current issues in peripheral nerve interfaces. The results showed that the MARTEENI device exhibited channel-isolated activity in acute, chronic, and terminal experiments, with regenerating axons surrounding the device threads. These findings suggest that the MARTEENI device is a promising approach for interfacing with peripheral nerves.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Rheumatology
Carlos J. Cruz, L. Savannah Dewberry, Kevin J. Otto, Kyle D. Allen
Summary: This review discusses the potential of targeting the autonomic nervous system (ANS) for osteoarthritis (OA) treatment and suggests bioelectronic medicine as a novel strategy. Recent studies have shown that OA pathogenesis involves more than joint wear and tear, with the involvement of neuroplastic changes and autonomic dysfunction. Modulating the ANS may modify OA pathogenesis and reduce the impact of OA comorbidities.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Proceedings Paper
Engineering, Biomedical
Lars A. Gjesteby, Tzofi Klinghoffer, Meagan Ash, Matthew A. Melton, Kevin J. Otto, Damon G. Lamb, Sara N. Burke, Laura J. Brattain
Summary: The study examines the use of three-dimensional U-Nets for neuronal nuclei segmentation, demonstrating that weakly supervised and semi-supervised methods can reduce the burden of human annotation. By leveraging automated blob detection with classical algorithms to generate noisy labels, the experiments show that weak supervision can outperform fully supervised learning in resource-limited settings. These methods are also extended to analyze the coincidence of multiple fluorescent stains in cleared brain tissue, representing a step towards automated whole-brain analysis of plasticity-related gene expression.
2021 IEEE 18TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI)
(2021)
Article
Engineering, Biomedical
Nicholas J. Abuid, Morgan E. Urdaneta, Kerim M. Gattas-Asfura, Caterina Zientek, Cristina Isusi Silgo, Jose A. Torres, Kevin J. Otto, Cherie L. Stabler
Summary: Imbalance of oxidants leads to failure of implanted devices and tissues. Antioxidant materials, such as cerium oxide nanoparticles, can inhibit this cycle and enhance implant efficacy. The deposition of CONP coatings, based on certain parameters, can customize antioxidant properties and provide protection to encapsulated cells.
ADVANCED NANOBIOMED RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Ian Malone, Mia Kelly, Rachel Nosacka, Marissa Nash, Gordon Mitchell, Kevin Otto, Erica Dale
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)