Article
Critical Care Medicine
Benjamin E. E. Zusman, Yijen Wu, Patrick M. M. Kochanek, Vincent E. E. Vagni, Keri Janesko-Feldman, Volodymyr Gerzanich, J. Marc Simard, Katherine Karahalios, Sandra Mihaljevic, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shashvat M. M. Desai, Joshua Catapano, Ruchira M. M. Jha
Summary: This study evaluated the differential effects of glibenclamide on dose, TBI type, and imaging endophenotype. High-dose glibenclamide showed benefits in reducing hematoma volume, vasogenic edema, cytotoxic edema, and maintaining blood-brain barrier integrity after isolated brain contusion. However, its anti-edema effects were not robust in the presence of concomitant hemorrhagic shock.
CRITICAL CARE MEDICINE
(2023)
Article
Biology
Fritz I. Schneider, Sandro M. Krieg, Ute Lindauer, Michael Stoffel, Yu-Mi Ryang
Summary: This study aims to investigate the effects of argon gas on traumatic brain injury. The results showed that argon treatment at different concentrations did not significantly reduce the primary outcome parameter, brain contusion volume, and the secondary outcome parameter, brain edema. However, there was a significant decrease in intracranial pressure at 50% argon concentration and significant neurological improvement at 25% and 50% argon concentrations.
Article
Multidisciplinary Sciences
Ao Xiong, Junxia Li, Renping Xiong, Yiming Xia, Xu Jiang, Fuyang Cao, Hong Lu, Jianzhong Xu, Fabo Shan
Summary: This study investigated the roles of AQP4 and HIF-1 alpha in traumatic brain injury (TBI) and found that blocking AQP4 and inhibiting HIF-1 alpha can significantly improve brain edema, reduce neuronal loss, and alleviate neurological deficits after TBI, suggesting potential therapeutic targets for TBI in clinical practice.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Nicole A. Terpollili, Reinhard Dolp, Kai Waehner, Susanne M. Schwarzmaier, Elisabeth Rumbler, Boyan Todorov, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Nikolaus Plesnila
Summary: Patients with familial hemiplegic migraine type 1 (FHM1) may have severe outcomes after head trauma, and this study found that mice carrying FHM1 mutations had worse histopathological and functional outcomes after traumatic brain injury (TBI), possibly due to increased cortical spreading depolarizations (CSDs) and seizure activity.
Article
Clinical Neurology
Dong-Seok Gwak, Inyoung Chung, Baik-Kyun Kim, Sukyoon Lee, Han-Gil Jeong, Yong Soo Kim, Heeyun Chae, Chan-Young Park, Moon-Ku Han
Summary: High maximum serum chloride concentrations are associated with poor clinical outcomes in critically ill patients with large hemispheric infarction. Each 5-mmol/L increase in maximum serum chloride concentration independently increases the risk of in-hospital mortality, 3-month mortality, and acute kidney injury.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Elliot J. Glotfelty, Shih-Chang Hsueh, Quia Clayborne, Alicia Bedolla, Katherine O. Kopp, Tonya Wallace, Binhai Zheng, Yu Luo, Tobias E. Karlsson, Ross A. McDevitt, Lars Olson, Nigel H. Greig
Summary: Nogo proteins are negative regulators of CNS neurite outgrowth and repair. Recent research suggests a relationship between Nogo proteins and inflammation. In this study, microglial-specific Nogo knockout mice showed decreased tissue inflammation and altered behavior following traumatic brain injury.
Article
Health Care Sciences & Services
Wilmer Danilo Esparza, Arian Ramon Aladro-Gonzalvo, Antonio Ruiz-Hontangas, Daniela Celi, Maria Belen Aguirre
Summary: This study aimed to explore the effect of craniofacial MLD in combination with pharmacological treatment for improving cranial pain intensity, vital signs, and cerebral edema in moderate traumatic brain injury (mTBI) patients. The results showed that patients who received both pharmacological and MLD treatment experienced decreased cranial pain intensity, reduced systolic blood pressure, and decreased cerebral edema.
Article
Critical Care Medicine
Johannes Walter, Olga Kovalenko, Alexander Younsi, Martin Grutza, Andreas Unterberg, Klaus Zweckberger
Summary: This study evaluated the impact of IL-4 deficiency on brain damage and functional impairment in mice with traumatic brain injury. The results showed that IL-4 reduced structural damage and improved functional outcome in the acute phase after controlled cortical impact. Assessment of motor function in the first 3 days after trauma induction is important in IL-4-related studies.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Pharmacology & Pharmacy
Ping Ma, Ning Huang, Jun Tang, Zunjie Zhou, Jing Xu, Yi Chen, Maoxin Zhang, Qin Huang, Yuan Cheng
Summary: The study shows that 9-PH effectively reduces cerebral edema by inhibiting the TRPM4 channel, reducing cytotoxic edema and preventing vasogenic edema. It also alleviates secondary brain injury by reducing inflammation and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neuroimaging
Immanuel Babu Henry Samuel, Kamila U. Pollin, Charity B. Breneman
Summary: This report investigated the association between sleep quality and cortical volume in TBI patients. The findings revealed a significant correlation between poor sleep quality and smaller gray matter volume in the cerebellum, with no association found in white matter volume. Additionally, regions involved in inhibitory brain function showed a trend towards association with sleep quality.
BRAIN IMAGING AND BEHAVIOR
(2022)
Review
Neurosciences
Olivia J. Kalimon, Patrick G. Sullivan
Summary: TBI is a complex disease with multifactorial injury cascades. Mitochondria play important roles in cellular energy generation, cell death regulation, and intracellular calcium modulation, making them susceptible to TBI.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Terry Dean, Javid Ghaemmaghami, John Corso, Vittorio Gallo
Summary: Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide, with no targeted therapies available. The functions and mechanisms of NG2-glia, the largest population of regenerative cells in the mature cortex, are not well understood in the context of TBI. This study synthesizes results from multiple rodent models and proposes future avenues for exploring the role of NG2-glia in TBI, suggesting that targeting these cells may enhance local cellular recovery.
Article
Critical Care Medicine
Jeanette Tas, Erta Beqiri, Ruud C. van Kaam, Marek Czosnyka, Joseph Donnelly, Roel H. Haeren, Iwan C. C. van der Horst, Peter J. Hutchinson, Sander M. J. van Kuijk, Analisa L. Liberti, David K. Menon, Cornelia W. E. Hoedemaekers, Bart Depreitere, Peter Smielewski, Geert Meyfroidt, Ari Ercole, Marcel J. H. Aries
Summary: This study evaluated the feasibility and safety of CA-guided CPP management in TBI patients requiring intracranial pressure monitoring and therapy. The results demonstrate that targeting an individual and dynamic CA-guided CPP is feasible and safe in TBI patients, encouraging further prospective trials powered for clinical outcomes.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Yuheng Liu, Xuanhui Liu, Zhijuan Chen, Yuanzhi Wang, Jing Li, Junjie Gong, Anqi He, Mingyu Zhao, Chen Yang, Weidong Yang, Zengguang Wang
Summary: Decompressive craniectomy (DC) is crucial for decreasing intracranial pressure and improving neurological function after traumatic brain injury (TBI). This study investigated the effects of DC on a severe TBI mouse model and found that DC can reduce intracranial pressure, improve neurological and motor function, and attenuate blood-brain barrier damage, inflammatory response, and neuronal apoptosis. However, DC may also lead to brain edema and long-term impairment of neurological function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Wei Wang, Qiu-Yuan Gong, Lin Cai, Yao Jing, Dian-Xu Yang, Fang Yuan, Hao Chen, Heng-Li Tian
Summary: Knockout of SIRT2 gene provides neuroprotection against traumatic brain injury (TBI) by reducing brain edema, inflammation, and improving neurological function. SIRT2 could be a potential novel target for the treatment of TBI.
NEURAL REGENERATION RESEARCH
(2023)
Article
Critical Care Medicine
Anand Veeravagu, Byung C. Yoon, Bowen Jiang, Carla M. Carvalho, Fred Rincon, Mitchell Maltenfort, Jack Jallo, John K. Ratliff
JOURNAL OF BURN CARE & RESEARCH
(2015)
Article
Clinical Neurology
George M. Ghobrial, Sara Beygi, Matthew J. Viereck, Joshua E. Heller, Ashwini Sharan, Jack Jallo, James S. Harrop, Srinivas Prasad
JOURNAL OF NEUROSURGERY-SPINE
(2015)
Article
Critical Care Medicine
Peter A. Abdelmalik, David W. Boorman, Joseph Tracy, Jack Jallo, Fred Rincon
NEUROCRITICAL CARE
(2016)
Article
Clinical Neurology
Tessa Hart, Thomas A. Novack, Nancy Temkin, Jason Barber, Sureyya S. Dikmen, Ramon Diaz-Arrastia, Joseph Ricker, Dale C. Hesdorffer, Jack Jallo, Nancy H. Hsu, Ross Zafonte
JOURNAL OF HEAD TRAUMA REHABILITATION
(2016)
Article
Clinical Neurology
Anthony N. Grieff, George M. Ghobrial, Jack Jallo
JOURNAL OF NEUROSURGERY-SPINE
(2016)
Review
Clinical Neurology
Paul G. Matz, R. J. Meagher, Tim Lamer, William L. Tontz, Thiru M. Annaswamy, R. Carter Cassidy, Charles H. Cho, Paul Dougherty, John E. Easa, Dennis E. Enix, Bryan A. Gunnoe, Jack Jallo, Terrence D. Julien, Matthew B. Maserati, Robert C. Nucci, John E. O'Toole, Karie Rosolowski, Jonathan N. Sembrano, Alan T. Villavicencio, Jens-Peter Witt
Article
Clinical Neurology
Paul Vespa, Daniel Hanley, Joshua Betz, Alan Hoffer, Johnathan Engh, Robert Carter, Peter Nakaji, Chris Ogilvy, Jack Jallo, Warren Selman, Amanda Bistran-Hall, Karen Lane, Nichol McBee, Jeffery Saver, Richard E. Thompson, Neil Martin
Article
Clinical Neurology
Daniele Marchioni, Dario Bertossi, Davide Soloperto, Luca Bianconi, Pasquale Procacci, Pier Francesco Nocini
OPERATIVE NEUROSURGERY
(2016)
Article
Medicine, General & Internal
Daniel F. Hanley, Karen Lane, Nichol McBee, Wendy Ziai, Stanley Tuhrim, Kennedy R. Lees, Jesse Dawson, Dheeraj Gandhi, Natalie Ullman, W. Andrew Mould, Steven W. Mayo, A. David Mendelow, Barbara Gregson, Kenneth Butcher, Paul Vespa, David W. Wright, Carlos S. Kase, J. Ricardo Carhuapoma, Penelope M. Keyl, Marie Diener-West, John Muschelli, Joshua F. Betz, Carol B. Thompson, Elizabeth A. Sugar, Gayane Yenokyan, Scott Janis, Sayona John, Sagi Harnof, George A. Lopez, E. Francois Aldrich, Mark R. Harrigan, Safdar Ansari, Jack Jallo, Jean-Louis Caron, David LeDoux, Opeolu Adeoye, Mario Zuccarello, Harold P. Adams, Michael Rosenblum, Richard E. Thompson, Issam A. Awad
Article
Clinical Neurology
Santosh B. Murthy, Issam Awad, Sagi Harnof, Francois Aldrich, Mark Harrigan, Jack Jallo, Jean-Louis Caron, Judy Huang, Paul Camarata, Lucia Rivera Lara, Rachel Dlugash, Nichol McBee, Vahid Eslami, Daniel F. Hanley, Wendy C. Ziai
Article
Clinical Neurology
George M. Ghobrial, Christopher M. Maulucci, Matthew J. Viereck, Sara Beygi, Ameet Chitale, Srinivas Prasad, Jack Jallo, Joshua Heller, Ashwini D. Sharan, James S. Harrop
CLINICAL SPINE SURGERY
(2017)
Article
Medicine, General & Internal
Daniel F. Hanley, Richard E. Thompson, Michael Rosenblum, Gayane Yenokyan, Karen Lane, Nichol McBee, Steven W. Mayo, Amanda J. Bistran-Hall, Dheeraj Gandhi, W. Andrew Mould, Natalie Ullman, Hasan Ali, J. Ricardo Carhuapoma, Carlos S. Kase, Kennedy R. Lees, Jesse Dawson, Alastair Wilson, Joshua F. Betz, Elizabeth A. Sugar, Yi Hao, Radhika Avadhani, Jean-Louis Caron, Mark R. Harrigan, Andrew P. Carlson, Diederik Bulters, David LeDoux, Judy Huang, Cully Cobb, Gaurav Gupta, Ryan Kitagawa, Michael R. Chicoine, Hiren Patel, Robert Dodd, Paul J. Camarata, Stacey Wolfe, Agnieszka Stadnik, P. Lynn Money, Patrick Mitchell, Rosario Sarabia, Sagi Harnof, Pal Barzo, Andreas Unterberg, Jeanne S. Teitelbaum, Weimin Wang, Craig S. Anderson, A. David Mendelow, Barbara Gregson, Scott Janis, Paul Vespa, Wendy Ziai, Mario Zuccarello, Issam A. Awad
Article
Clinical Neurology
Nikolaos Mouchtouris, Justin Turpin, Nohra Chalouhi, Fadi Al Saiegh, Thana Theofanis, Somnath Das, Syed Omar Shah, Jack Jallo
WORLD NEUROSURGERY
(2019)
Review
Clinical Neurology
Geoffrey Stricsek, Justin Iorio, Yusef Mosley, Srinivas Prasad, Joshua Heller, Jack Jallo, Soroush Shahrokh, James S. Harrop
GLOBAL SPINE JOURNAL
(2018)
Article
Critical Care Medicine
David O. Okonkwo, Lori A. Shutter, Carol Moore, Nancy R. Temkin, Ava M. Puccio, Christopher J. Madden, Norberto Andaluz, Randall M. Chesnut, M. Ross Bullock, Gerald A. Grant, John McGregor, Michael Weaver, Jack Jallo, Peter D. LeRoux, Dick Moberg, Jason Barber, Christos Lazaridis, Ramon R. Diaz-Arrastia
CRITICAL CARE MEDICINE
(2017)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)