Review
Clinical Neurology
Bethany L. Sussman, Sarah N. Wyckoff, Jennifer Heim, Angus A. Wilfong, P. David Adelson, Michael C. Kruer, Maria Jose Gonzalez, Varina L. Boerwinkle
Summary: This article provides a focused review of the resting state fMRI functional and effective connectivity of the human motor network across the lifespan, highlighting its potential implications for network-targeted movement disorder therapies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xin Hao, Taicheng Huang, Yiying Song, Xiangzhen Kong, Jia Liu
Summary: The study reveals age-related changes in the navigation network organization, with increasing modularity under resting-state and increasing flexibility under task-state. Task-modulated FC changes were found to be greater in adults than in children, suggesting differences in network organization between age groups during tasks.
Article
Multidisciplinary Sciences
Su Hyoun Park, Anne K. Baker, Vinit Krishna, Sean C. Mackey, Katherine T. Martucci
Summary: The brain corticostriatal circuits play a crucial role in understanding chronic pain. In this study, the authors investigated the connectivity of the nucleus accumbens (NAcc) - medial prefrontal cortex (MPFC) circuit in patients with fibromyalgia. They found that the connectivity of this circuit was significantly reduced in fibromyalgia patients compared to healthy controls. The connectivity between the NAcc and subcortical brain regions was also reduced in fibromyalgia. These findings provide novel evidence of altered corticostriatal and mesolimbic circuits in chronic pain.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Zongxin Tan, Guanya Li, Wenchao Zhang, Jia Wang, Yang Hu, Hao Li, Lei Zhang, Shuai Lv, Zhenzhen Jia, Xiaohua Li, Yu Han, Guangbin Cui, Peter Manza, Nora D. Volkow, Yongzhan Nie, Gang Ji, Gene-Jack Wang, Yi Zhang
Summary: This study found an association between obesity and alterations in intrinsic functional connectivity, with dynamic functional connectivity analysis revealing more detailed node information, uncovering some associations that traditional connectivity analysis cannot see.
Article
Clinical Neurology
Audrey Riou, Jean-Francois Houvenaghel, Thibaut Dondaine, Sophie Drapier, Paul Sauleau, Dominique Drapier, Joan Duprez, Murielle Guillery, Florence Le Jeune, Marc Verin, Gabriel Robert
Summary: The study revealed the involvement of the cerebellum in nonmotor domains of PD, with differential but overlapping patterns of metabolic correlations, suggesting the involvement of cerebello-thalamo-striatal-cortical loops.
Article
Behavioral Sciences
Angela W. Huang, Anita D. Barber
Summary: The study investigated the role of the lateral pulvinar nucleus (LPN) in visual attention and its development throughout late childhood to early adulthood. The findings revealed changes in LPN functional connectivity with visual processing regions, as well as the association between LPN connectivity patterns and attention deficits, particularly in Attention Deficit Hyperactivity Disorder (ADHD). The results suggest that LPN connectivity with higher order attention networks plays a crucial role in attention abilities.
Article
Neurosciences
Christelle Langley, Naoki Masuda, Simon Godwin, Giovanni De Marco, Angela Davies Smith, Rosemary Jones, Jared Bruce, Ngoc Jade Thai
Summary: This study aimed to establish the role of the basal ganglia in fatigue in multiple sclerosis (MS) using functional connectivity measures. The results suggest that decreased local functional connectivity within the basal ganglia plays a key role in cognitive fatigue in MS. Increased global functional connectivity between the basal ganglia and the cortex may serve as a compensatory mechanism to reduce the impact of fatigue in MS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Qianqian Li, Su Hu, Yingmin Mo, Hao Chen, Chaoguo Meng, Linlin Zhan, Mengting Li, Xuemei Quan, Yanyan Gao, Lulu Cheng, Zeqi Hao, Xize Jia, Zhijian Liang
Summary: This study investigated the spontaneous regional neural activity abnormalities in patients with acute basal ganglia ischemic stroke (BGIS) using a multifrequency bands regional homogeneity (ReHo) method. The study found that ReHo values were altered in specific frequency bands and were associated with clinical characteristics.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
John R. Younce, Meghan C. Campbell, Tamara Hershey, Aaron B. Tanenbaum, Mikhail Milchenko, Mwiza Ushe, Morvarid Karimi, Samer D. Tabbal, Albert E. Kim, Abraham Z. Snyder, Joel S. Perlmutter, Scott A. Norris
Summary: Resting-state functional connectivity MRI may predict motor response to subthalamic nucleus deep brain stimulation, with stronger connectivity between the left subthalamic nucleus and ipsilateral internal globus pallidus correlating with greater improvement in postsurgical motor outcomes. The integrity of pallidal-subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation.
MOVEMENT DISORDERS
(2021)
Article
Computer Science, Artificial Intelligence
Mingliang Wang, Jiashuang Huang, Mingxia Liu, Daoqiang Zhang
Summary: This study proposes a temporal dynamics learning (TDL) method for network-based brain disease identification using rs-fMRI time-series data. By integrating network feature extraction and classifier training into a unified framework, it addresses the issues of previous studies paying less attention to the evolution of global network structures over time and treating feature extraction and training as separate tasks.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Fabian Hirsch, Afra Wohlschlaeger
Summary: This study investigates the impact of subcortical structures on the topological features of cortical networks using a multivariable approach and graph-theoretic tools. The results show that the overall architecture of cortical networks becomes more integrated after accounting for subcortical influences. Specifically, "transmodal" systems become more connected with the rest of the network while "unimodal" networks show the opposite effect. These findings provide new insights into the interplay between subcortex and cortical networks.
Article
Neurosciences
Limin Peng, Zhiguo Luo, Ling-Li Zeng, Chenping Hou, Hui Shen, Zongtan Zhou, Dewen Hu
Summary: This study developed a brain parcellation method based on dynamic functional connectivity and created a new functional brain atlas. The atlas can reveal finer functional boundaries that static methods may overlook, and shows good agreement with cytoarchitectonic areas and task activation maps.
Article
Neurosciences
Luoyao Pang, Huidi Li, Quanying Liu, Yue-Jia Luo, Dean Mobbs, Haiyan Wu
Summary: Motivated dishonesty is a common social behavior that varies among individuals. This study explores the relationship between brain networks and dishonesty using resting-state functional magnetic resonance imaging (rsfMRI), and demonstrates the ability to predict dishonest behavior through a model based on functional connectivity.
Article
Geriatrics & Gerontology
Clara Rodriguez-Sabate, Ingrid Morales, Manuel Rodriguez
Summary: This study investigates the impact of aging on the functional connectivity of the basal ganglia motor circuit. The results show significant changes in connectivity induced by aging, which may contribute to motor handicaps in older individuals during motor task execution and at rest.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Nicole A. Seider, Babatunde Adeyemo, Ryland Miller, Dillan J. Newbold, Jacqueline M. Hampton, Kristen M. Scheidter, Jerrel Rutlin, Timothy O. Laumann, Jarod L. Roland, David F. Montez, Andrew N. Van, Annie Zheng, Scott Marek, Benjamin P. Kay, G. Larry Bretthorst, Bradley L. Schlaggar, Deanna J. Greene, Yong Wang, Steven E. Petersen, Deanna M. Barch, Evan M. Gordon, Abraham Z. Snyder, Joshua S. Shimony, Nico U. F. Dosenbach
Summary: This study evaluated the accuracy and reliability of diffusion imaging methods in relation to data quantity and analysis method. A novel Bayesian Multi-tensor Model-selection (BaMM) method was developed to address overfitting and showed high reliability and improved accuracy with increasing amounts of diffusion data.
Meeting Abstract
Psychology, Developmental
Kevin J. Black
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Meeting Abstract
Psychology, Developmental
Ann Iverson, Emily C. Bihun, Amanda L. Arbuckle, David Song, Kevin J. Black
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Peristera Paschou, Yin Jin, Kirsten Mueller-Vahl, Harald E. Moeller, Renata Rizzo, Pieter J. Hoekstra, Veit Roessner, Nanette Mol Debes, Yulia Worbe, Andreas Hartmann, Pablo Mir, Danielle Cath, Irene Neuner, Heike Eichele, Chencheng Zhang, Katarzyna Lewandowska, Alexander Munchau, Julius Verrel, Richard Musil, Tim J. Silk, Colleen A. Hanlon, Emily D. Bihun, Valerie Brandt, Andrea Dietrich, Natalie Forde, Christos Ganos, Deanna J. Greene, Chunguang Chu, Michel J. Grothe, Tamara Hershey, Piotr Janik, Jonathan M. Koller, Juan Francisco Martin-Rodriguez, Karsten Mueller, Stefano Palmucci, Adriana Prato, Shukti Ramkiran, Federica Saia, Natalia Szejko, Renzo Torrecuso, Zeynep Tumer, Anne Uhlmann, Tanja Veselinovic, Tomasz Wolanczyk, Jade-Jocelyne Zouki, Pritesh Jain, Apostolia Topaloudi, Mary Kaka, Zhiyu Yang, Petros Drineas, Sophia Thomopoulos, Tonya White, Dick J. Veltman, Lianne Schmaal, Dan J. Stein, Jan Buitelaar, Barbara Franke, Odile van den Heuvel, Neda Jahanshad, Paul M. Thompson, Kevin J. Black
Summary: TS is characterized by multiple motor and vocal tics and high comorbidity rates with other neuropsychiatric disorders. The ENIGMA-TS working group aims to understand brain structure and function in TS and related disorders through collaborative efforts and transdiagnostic approaches.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Irene A. Malaty, Seonaid Anderson, Shannon M. Bennett, Cathy L. Budman, Barbara J. Coffey, Keith A. Coffman, Erica Greenberg, Joseph F. McGuire, Kirsten R. Mueller-Vahl, Michael S. Okun, Julio Quezada, Amy Robichaux-Viehoever, Kevin J. Black
Summary: A global phenomenon characterized by sudden onset and rapid escalation of tics and tic-like movements and phonations has emerged in the past 3 years. It has been observed not only in youth known to have tics or Tourette syndrome, but also in those with no prior history of tics.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Ann M. Iverson, Kevin J. Black
Summary: Research on Tourette's syndrome focuses on why some individuals develop tics and how momentary influences can cause tics to increase or decrease. Factors such as stress, distraction, and being observed have varying effects on tics, while other influences like social media exposure and dietary habits require further study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Behavioral Sciences
Jordan E. Pierce, Elizabeth Clancy, Nathan M. Petro, Michael D. Dodd, Maital Neta
Summary: Cognitive control plays a crucial role in task performance by selectively attending to relevant stimuli and inhibiting distraction. This study examined how contextual factors such as trial timing and emotional content interact with cognitive control using an antisaccade task. The results showed that greater BOLD activation in frontal and parietal brain regions was associated with inhibiting prepotent glance towards a peripheral stimulus. Additionally, neutral faces elicited increased attention, particularly in prosaccade and overlap trials.
Article
Psychology, Multidisciplinary
Maital Neta, M. Justin Kim
Summary: This paper responds to Andrew Ortony's argument about surprise as a basic emotion and presents viewpoints and evidence in support of surprise. The authors argue that surprise is a valenced emotion and meets the criteria for a basic emotion. Additionally, the paper raises concerns about the divergent definitions of basic emotions and calls for further research and definition.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2023)
Review
Psychology, Clinical
Jessica Frey, Kevin J. Black, Irene A. Malaty
Summary: Perceptions of Tourette syndrome and tic disorders are heavily influenced by social media, especially among adolescents. During the COVID-19 pandemic, increased social media consumption has been linked to a rise in tic severity and functional tic-like behavior (FTLB). Concerns have been raised that misleading tic videos on social media are driving the increase in FTLBs. Studies have found shared characteristics among newly presenting cases of FTLB, including a higher proportion of affected females, lower rates of childhood or family tics, and acute symptom onset during the teenage years. The tics associated with FTLB resemble those seen on popular social media channels, with higher rates of coprophenomena, tic attacks, and involvement of the trunk and extremities. Factors such as increased anxiety, social isolation, and general social media use during the pandemic are likely contributing to the surge in FTLBs. In the era of increased social media consumption, it is crucial for clinicians to educate patients about the spread of medical information to ensure accurate diagnosis, treatment, and outcomes.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Clinical Neurology
David Mataix-Cols, Kayoko Isomura, Gustaf Brander, Isabell Brikell, Paul Lichtenstein, Zheng Chang, Henrik Larsson, Ralf Kuja-Halkola, Kevin J. Black, Anna Sidorchuk, Lorena Fernandez de la Cruz
Summary: A Swedish study found that 20% of children with tic disorders continued to have chronic tic disorders into adulthood, with childhood psychiatric comorbidities and family history of psychiatric disorders being the strongest risk factors for tic disorder persistence.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Ann M. Iverson, Amanda L. Arbuckle, David Y. Song, Emily C. Bihun, Kevin J. Black
Summary: Median nerve stimulation (MNS) at 10-12 Hz was found to improve tic frequency and intensity in individuals with Tourette syndrome and other chronic tic disorders, with minimal side effects. Participants used a transcutaneous electrical nerve stimulation (TENS) unit to administer MNS and reported improvements in tic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ann M. Iverson, Amanda L. Arbuckle, Keisuke Ueda, David Y. Y. Song, Emily C. Bihun, Jonathan M. Koller, Michael Wallendorf, Kevin J. Black
Summary: A prior study found that rhythmic 12 Hz stimulation of the median nerve improved tics in Tourette syndrome (TS), but the cortical entrainment hypothesis could not explain this benefit. A replication study with 32 TS patients showed that both rhythmic and arrhythmic 12 Hz median nerve stimulation improved tic symptoms, but the two treatments did not differ significantly. The study suggests that another electrophysiological mechanism, or a placebo effect, may explain the improvement.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jaclyn M. Martindale, Harini Sarva, Davide Martino, Donald L. Gilbert, Christos Ganos, Tamara Pringsheim, Kevin Black, Irene A. Malaty
Summary: Based on expert opinion and literature review, this study discusses the barriers to the implementation of practice guidelines in the clinical care of patients with persistent tic disorders. The objectives are to identify divergences from existing guidelines and to identify categories of barriers leading to these gaps in clinical care.
Meeting Abstract
Clinical Neurology
Kevin J. Black, Amanda Arbuckle, Emily C. Bihun, David Song, Jonathan M. Koller, Amy Robichaux Viehoever, Keisuke Ueda
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Multidisciplinary Sciences
Payton Beeler, Nicholas O. Jensen, Soyoung Kim, Amy Robichaux-Viehoever, Bradley L. Schlaggar, Deanna J. Greene, Kevin J. Black, Rajan K. Chakrabarty
Summary: The study confirms the fractal nature of tics, indicating correlation between neighboring time scales. The fractal dimension is correlated with tic severity and serves as a sensitive parameter for examining the effects of tic suppression conditions. This finding opens up new possibilities for utilizing the fractal nature of tics as a tool for assessing and treating tic disorders.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
