Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Shaoqi Duan, Takashi Kondo, Hiroto Miwa, Yanjing Yang, Shenglan Wang, Hirosato Kanda, Yoko Kogure, Nobuko Imamura, Tadahiro Fujimura, Tomoaki Kono, Masashi Fukushima, Katsuyuki Tozawa, Toshihiko Tomita, Hirokazu Fukui, Satoshi Yamamoto, Koichi Noguchi, Yi Dai
Summary: Gastric hypersensitivity is a major feature of functional dyspepsia (FD) and many patients with FD exhibit gastroduodenal microinflammation. This study used a maternal separation-induced FD model to demonstrate the functional link between gastroduodenal microinflammation and gastric hypersensitivity. The findings suggest that anti-inflammatory therapy may be effective in treating FD patients with gastroduodenal microinflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Neurosciences
Qian Sun, Shiyu Zhang, Bing-Yu Zhang, Yilian Zhang, Lijun Yao, Ji Hu, Hong-Hong Zhang
Summary: The aim of this study was to investigate the mechanism and interaction of miR-181a, TLR4, and NF-kappa B in gastric hypersensitivity in diabetic rats. The expression of TLR4 was up-regulated in the DRGs of diabetic rats, while miR-181a and miR-7a were down-regulated. MiR-181a directly regulated TLR4 expression and reduced the hyper-excitability of gastric-specific neurons, thus alleviating gastric hypersensitivity.
Article
Biochemistry & Molecular Biology
Yanhong Ma, Fanghao Cai, Xiaohan Huang, Huijing Wang, Binfeng Yu, Junni Wang, Wanyun Nie, Kedan Cai, Yi Yang, Jianghua Chen, Liang Xiao, Fei Han
Summary: Increased serum mannose-binding lectin (MBL) level has been proven to correlate with the development of diabetic nephropathy (DN). This study found that MBL promotes the progression of DN by activating the nuclear factor-kappa B pathway in macrophages. This finding provides a new direction for the treatment of DN patients.
Article
Cell Biology
Yan Zhang, Jielu Hao, Zijun Du, Peiyao Li, Jinghua Hu, Mengna Ruan, Shulian Li, Yuanfang Ma, Qiang Lou
Summary: Cisplatin nephrotoxicity, a serious side effect of cisplatin-based chemotherapy, can be exacerbated by HNF1 beta deficiency, leading to increased renal tubular cell apoptosis. HNF1 beta may ameliorate cisplatin nephrotoxicity by regulating the NF-kappa B signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Xiaowen Zhu, Yumin Zou, Tong Wu, Jian Ni, Qingyun Tan, Qingdong Wang, Meijia Zhang
Summary: This study investigates the potential role of ANP32E in the development of gastric cancer. The results demonstrate that ANP32E is overexpressed in gastric cancer tissues and its overexpression promotes malignancy while its knockdown inhibits proliferation and induces apoptosis of gastric cancer cells. ANP32E is also found to be positively associated with NUF2 expression and shown to induce NUF2 expression, promoting tumor cell proliferation and inhibiting apoptosis in gastric cancer cell lines.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Multidisciplinary Sciences
Dezhen Yang, Yang Hui, Shaokai Bai, Weijian Liang, Junming Hou, Jing Jiang
Summary: DUB3 contributes to CRC metastasis and angiogenesis by regulating NF-KB/HIF-1 alpha pathway via EZH2, providing a novel insight for the pathogenesis of CRC.
Article
Oncology
Yan Yan, Heya Qian, Ying Cao, Tao Zhu
Summary: The study showed that Bay11-7082 inhibited the proliferation, migration, and invasion abilities of gastric cancer cells by suppressing the expression of Gli1.
Article
Cell & Tissue Engineering
Jing Niu, Fan Feng, Songbai Zhang, Yue Zhu, Runfang Song, Junrong Li, Liang Zhao, Hui Wang, Ying Zhao, Min Zhang
Summary: This study investigates the effect of thrombospondin-2 (TSP-2) on the mechanical pressure-stimulated chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). It also explores the role of NF-?B signaling in the mechano-chemical coupling regulation of chondrogenesis. The results demonstrate that TSP-2 plays a crucial role in the chondrogenic differentiation of BMSCs under mechanical pressure, and the NF-?B signaling pathway is involved in this process.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Oncology
Xiaohong Xu, Liexiang Zhang, Fei Hua, Ce Zhang, Chi Zhang, Xia Mi, Nan Qin, Junsheng Wang, Aimin Zhu, Zihan Qin, Feihong Zhou
Summary: FOXM1 plays a protective role in diabetic nephropathy by transcriptionally activating SIRT4 and inhibiting NF-kappa B signaling and the NLRP3 inflammasome, alleviating kidney injury and podocyte pyroptosis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xiaojun Zhao, Xiaolan You, Chuanjiang Huang, Guiyuan Liu, Zhiyi Cheng, Haitao Zhang
Summary: The study revealed that SRC-1 promotes metastasis of gastric cancer through activation of VEGFC via NF-kappa B. These findings have important implications for understanding the pathogenesis of gastric cancer and potential precursor markers.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2022)
Article
Oncology
Qinyang Jin, Qin Zhu, Kai Wang, Mengli Chen, Xinli Li
Summary: The research demonstrated that allisartan isoproxil alleviated diabetic cardiomyopathy by attenuating diabetes-induced oxidative stress and inflammation through the SIRT1/Nrf2/NF-kappa B signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Kangyi Zhang, Xiaochun Teng
Summary: This study aimed to investigate the protective role of mimetic peptide Ac2-26 of annexin A1 in regulating p38MAPK/NF-Kappa B in a diabetic mouse model. The results showed that treatment with Ac2-26 significantly improved fasting blood glucose, blood lipid levels, and renal function, while reducing body weight in the Ac2-26 group compared to the model group. The levels of inflammatory factors in renal tissue were also significantly decreased in the Ac2-26 group. Moreover, the mRNA and protein expressions of p38MAPK, NF-Kappa BP6, and ANXA1 were significantly reduced in the Ac2-26 group.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Allam, Reham M. Ibrahim, Walaa Bayoumie El Gazzar, Mona A. Said
Summary: Inflammatory and immune pathways are crucial in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), and Sitagliptin's role in altering these pathways to improve NAFLD was investigated in this study. The results demonstrated that Sitagliptin can ameliorate NAFLD by decreasing HMGB1-mediated TLR4/NF-kappa B signaling to suppress inflammation and reduce insulin resistance, suggesting its potential as a therapeutic intervention for NAFLD.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
