Article
Neurosciences
Mieke Verfaellie, Renee Hunsberger, Margaret M. Keane
Summary: Studies on amnesic patients with medial temporal lobe (MTL) lesions have shown inconsistent results in moral decision-making, with personal framing not affecting the participants' moral judgments. Patients with MTL damage were less willing to endorse utilitarian options and rated actions as more emotionally intense compared to controls, suggesting the necessity of episodic processes in evaluating action-outcome contingencies.
Article
Behavioral Sciences
Aubrey A. Wank, Anna Robertson, Sean C. Thayer, Mieke Verfaellie, Steven Z. Rapcsak, Matthew D. Grilli
Summary: Autobiographical memory consists of different types of memory, ranging from abstract to episodic. Self trait knowledge relies on specific regions of the autobiographical memory network, not the medial temporal lobes. This case study reveals a rare amnesia case with impaired self trait knowledge but preserved conceptual knowledge for personality traits and the ability to accurately evaluate others' traits.
Article
Neurosciences
Daniela J. Palombo, Virginie M. Patt, Renee Hunsberger, Mieke Verfaellie
Summary: A prevailing view in cognitive neuroscience suggests that different forms of learning are mediated by dissociable memory systems; however, growing evidence suggests that the hippocampus may also be important for trial-and-error learning, particularly value or reward-based learning. The study found that patients with hippocampal damage were significantly impaired in a learning task, indicating a role of the hippocampus beyond episodic memory tasks.
Article
Clinical Neurology
Yuanzhi Xu, Ahmed Mohyeldin, Maximiliano Alberto Nunez, Ayoze Doniz-Gonzalez, Vera Vigo, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: The authors investigated the microvascular anatomy of the hippocampus and its implications for medial temporal tumor surgery, revealing the anatomical variability of the arterial supply and venous drainage of the hippocampus. The study found rich anastomoses between hippocampal arteries and highlighted the importance of understanding the vascular variability and network of the hippocampus for surgery in this region, including anterior temporal lobectomy with amygdalohippocampectomy and transsylvian selective amygdalohippocampectomy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Robin de Flores, Sandhitsu R. Das, Long Xie, Laura E. M. Wisse, Xueying Lyu, Preya Shah, Paul A. Yushkevich, David A. Wolk
Summary: This study reveals the relationship between the medial temporal lobe and the anterior-temporal and posterior-medial networks, and explores the vulnerability of these networks to proteinopathies in Alzheimer's disease. The results show that the atrophy of distinct subregions in the medial temporal lobe propagates differently within the anterior-temporal and posterior-medial networks. Additionally, these networks are differentially associated with relative tau and amyloid burden.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Eric R. Cole, Dayton P. Grogan, Nealen G. Laxpati, Alejandra M. Fernandez, Henry M. Skelton, Faical Isbaine, Claire-Anne Gutekunst, Robert E. Gross
Summary: Electrical brain stimulation is an effective treatment option for epilepsy patients who do not respond to medication. Stimulation of the medial septum can reduce seizure frequency and restore cognitive comorbidities associated with epilepsy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yen-Cheng Shih, Tse-Hao Lee, Hsiang-Yu Yu, Chien-Chen Chou, Cheng-Chia Lee, Po-Tso Lin, Syu-Jyun Peng
Summary: A robust quantitative algorithm for the lateralization of epileptogenic foci using F-18-FDG PET data in medial temporal lobe epilepsy (MTLE) patients was established, and it was found that machine learning had a higher accuracy in lateralizing the epileptogenesis compared to visual analysis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Behavioral Sciences
Bohee Lee, June Sic Kim, Chun Kee Chung
Summary: Working memory is crucial for goal-directed behavior, and the frontoparietal network and medial temporal lobe play important roles in working memory. Through intracranial electroencephalography recording, it was found that low-frequency power in the frontal lobe and medial temporal lobe increased and sustained throughout the working memory task, while parietal alpha power peaked during memory operation. Furthermore, there was a positive correlation in the alpha band between the medial temporal lobe and the parietal lobe during memory operation.
Article
Neurosciences
Georgios P. D. Argyropoulos, Carola Dell'Acqua, Emily Butler, Clare Loane, Adriana Roca-Fernandez, Azhaar Almozel, Nikolas Drummond, Carmen Lage-Martinez, Elisa Cooper, Richard N. Henson, Christopher R. Butler
Summary: This study investigates the role of different medial temporal lobe structures in recognition memory, finding that recollection and familiarity depend on different structures. The results also highlight the unique roles of the hippocampus and parahippocampal structures in recognition memory.
Article
Medicine, General & Internal
Xiao-Ming Yan, Cui-Ping Xu, Yu-Ping Wang, Kai Ma, Tao Yu, Xiao-Hua Zhang, Xi Zhang, Run-Shi Gao, Guo-Jun Zhang, Yong-Jie Li
Summary: Patients with medial temporal lobe seizures had more favorable surgical outcomes and distinct SEEG features compared to patients with lateral temporal lobe seizures.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Cedric Dusanter, Marion Houot, Marie Mere, Marisa Denos, Severine Samson, Bastien Herlin, Vincent Navarro, Sophie Dupont
Summary: The aim of this study was to evaluate the specific effects of antiseizure medications (ASMs) on cognition in a group of refractory patients with epilepsy. The results showed that the type and number of ASMs had a significant impact on cognition, especially topiramate (TPM) and sodium valproate (VPA). Based on the findings, it is recommended to reduce the total number of drugs received and avoid medications with unfavorable cognitive profiles.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Article
Neurosciences
Samuel D. McDougle, Sarah A. Wilterson, Nicholas B. Turk-Browne, Jordan A. Taylor
Summary: Classic taxonomies of memory distinguish between explicit and implicit memory systems, but this study suggests that the declarative memory processes in the medial temporal lobe play a significant role in motor learning, which requires a revision of the classic model.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Sara Seoane, Cristian Modrono, Jose Luis Gonzalez-Mora, Niels Janssen
Summary: By analyzing a high spatial resolution 7T rsfMRI dataset, we found the associations between the medial temporal lobe (MTL) and different resting-state networks. Specifically, different sub-regions of the MTL were associated with different resting-state networks such as the default mode, visual, and dorsal attention networks. These findings provide new insights into the role of the MTL in resting-state networks.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Psychology, Clinical
Bethan Dalton, Karin Foerde, Savani Bartholdy, Jessica McClelland, Maria Kekic, Luiza Grycuk, Iain C. Campbell, Ulrike Schmidt, Joanna E. Steinglass
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2020)
Article
Psychology, Clinical
Blair Uniacke, Reile Slattery, B. Timothy Walsh, Daphna Shohamy, Karin Foerde, Joanna Steinglass
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2020)
Article
Psychology, Clinical
Karin Foerde, Janet E. Schebendach, Lauren Davis, Nathaniel Daw, B. Timothy Walsh, Daphna Shohamy, Joanna E. Steinglass
Summary: Restrictive eating is a central feature of anorexia nervosa (AN) and other eating disorders. This study examined the behavioral and neural mechanisms of restrictive eating among individuals with and without eating disorders. The findings showed that healthy individuals tended to choose high-fat foods, while patients with AN focused more on the healthiness of the food. Dorsal striatal activation associated with food choice was most pronounced among individuals with AN, and it was significantly associated with selecting fewer high-fat choices and lower caloric intake.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Karin Foerde, Nathaniel D. Daw, Teresa Rufin, B. Timothy Walsh, Daphna Shohamy, Joanna E. Steinglass
Summary: Research in computational psychiatry has found that individuals with anorexia nervosa show impairments in model-based learning, indicating a persistent contribution of habitual over goal-directed control. This pattern remains consistent across different contexts and time points, suggesting that achieving weight restoration may not remediate the preference for habitual behavior over goal-directed behavior in individuals with AN.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Mieke Verfaellie, Renee Hunsberger, Margaret M. Keane
Summary: Studies on amnesic patients with medial temporal lobe (MTL) lesions have shown inconsistent results in moral decision-making, with personal framing not affecting the participants' moral judgments. Patients with MTL damage were less willing to endorse utilitarian options and rated actions as more emotionally intense compared to controls, suggesting the necessity of episodic processes in evaluating action-outcome contingencies.
Article
Psychology, Clinical
Karin Foerde, B. Timothy Walsh, Maya Dalack, Nathaniel Daw, Daphna Shohamy, Joanna E. Steinglass
Summary: The study found that there was a stronger association between caudate activity and food choices among individuals with anorexia nervosa compared to healthy controls before treatment, and decreases in caudate engagement among individuals with anorexia nervosa undergoing treatment were associated with increases in high-fat food choices.
JOURNAL OF EATING DISORDERS
(2021)
Article
Psychology, Clinical
Alexandra F. Muratore, Mariya Bershad, Joanna E. Steinglass, Karin E. Foerde, Loren Gianini, Allegra Broft, Evelyn Attia
Summary: The study found that HF-rTMS to the right DLPFC was associated with a reduction of fat avoidance among inpatients with anorexia nervosa in a food choice task. This suggests that this region and related neural circuits may be involved in restrictive food choice.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Behavioral Sciences
Aubrey A. Wank, Anna Robertson, Sean C. Thayer, Mieke Verfaellie, Steven Z. Rapcsak, Matthew D. Grilli
Summary: Autobiographical memory consists of different types of memory, ranging from abstract to episodic. Self trait knowledge relies on specific regions of the autobiographical memory network, not the medial temporal lobes. This case study reveals a rare amnesia case with impaired self trait knowledge but preserved conceptual knowledge for personality traits and the ability to accurately evaluate others' traits.
Article
Neurosciences
Alice M. Xue, Karin Foerde, B. Timothy Walsh, Joanna E. Steinglass, Daphna Shohamy, Akram Bakkour
Summary: Decisions about what to eat involve the OFC and the evaluation of taste and health attributes. By using fMRI and behavioral tasks, this study found that activity patterns in the OFC can decode subjective ratings of tastiness and healthiness. However, the OFC activity related to health attributes is more related to choice preferences in patients with AN compared to healthy individuals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
E. Caitlin Lloyd, Karin E. Foerde, Alexandra F. Muratore, Natalie Aw, David Semanek, Joanna E. Steinglass, Jonathan Posner
Summary: Diffusion-weighted magnetic resonance imaging and tractography were used to investigate the structural connectivity in patients with anorexia nervosa. Reduced subcortical connectivity and increased frontal cortical connectivity were found in individuals with AN compared to healthy controls. These findings suggest alterations in feeding, emotion, and executive control circuits in AN.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychology, Developmental
Sathesan Thavabalasingam, Supreet Aashat, Daniela J. Palombo, Mieke Verfaellie, Andy C. H. Lee
Summary: Temporal information is crucial for event sequence memory, and aging has a negative impact on memory for temporal order and duration. Older adults perform worse than younger adults in making temporal order match-mismatch judgments and duration match-mismatch judgments.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Behavioral Sciences
Mieke Verfaellie, Virginie Patt, Ginette Lafleche, Renee Hunsberger, Jennifer J. Vasterling
Summary: This study aimed to characterize emotional future thinking in PTSD and identify clinical and neurocognitive profiles associated with alterations in the level of detail in narratives of imagined future events. The results showed that individuals with current and past PTSD generated fewer internal details in their narratives compared to those without PTSD. Severity of PTSD symptoms was inversely associated with production of internal details, with a relatively weaker association for intrusion symptoms. Only relational verbal memory was associated with production of internal details.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Joanna E. Steinglass, Wenbo Fei, Karin Foerde, Caroline Touzeau, Julia Ruggiero, Caitlin Lloyd, Evelyn Attia, Yuanjia Wang, B. Timothy Walsh
Summary: This study examined the relationship between changes in food choices during inpatient treatment and longer-term clinical course in individuals with anorexia nervosa (AN). Short-term treatment led to improvements in body mass index (BMI), but did not result in significant changes in the food choices made in a task known to predict actual eating. However, the extent to which patients increased high-fat food choices and decreased the use of self-control in food choices during treatment were associated with less weight loss over the following three years.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Rotem Botvinik-Nezer, Akram Bakkour, Tom Salomon, Daphna Shohamy, Tom Schonberg
Summary: This study explores the role of memory in preference change, finding that enhanced memory for trained items influences individual choices, suggesting that memory plays a significant role in value-based decision-making.
