Article
Ophthalmology
John R. Economides, Daniel L. Adams, Jonathan C. Horton
Summary: In patients with intermittent exotropia, occlusion of both eyes reveals a state of alignment different from orthotropia, demonstrating that the deviation angle is actively mediated by visual feedback, which the fixating eye is capable of providing alone.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Ophthalmology
T. Rowan Candy, Lawrence K. Cormack
Summary: This review discusses how recent technological advances have allowed us to measure the information available to the visual system and the behaviors supported by it. It specifically focuses on the tasks performed by the binocular visual system and highlights the differences from the tasks considered during fixation on a static target. The article also discusses the challenges involved in generating a stable and useful binocular percept of the environment and highlights the limited addressing of these challenges in current clinical interpretation. The implications of new technology, such as virtual reality, in clinical and basic research applications are also emphasized.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Wen Zhao, Jiajia Yang, Zhonghua Hu
Summary: This study investigated whether a prior interaction with a cueing face that induced guilt could modulate the gaze-cueing effect. The results showed that guilt-directed faces and control faces induced equal magnitudes of gaze-cueing effect at 200ms SOA, while guilt-directed faces induced a smaller gaze-cueing effect than control faces at 700ms SOA. These findings provide preliminary evidence that guilt may modulate social attention triggered by eye gaze at a later stage of processing.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Krista R. Kelly, Dorsa Mir Norouzi, Mina Nouredanesh, Reed M. Jost, Christina S. Cheng-Patel, Cynthia L. Beauchamp, Lori M. Dao, Becky A. Luu, David R. Stager Jr, James Y. Tung, Ewa Niechwiej-Szwedo
Summary: Strabismic children showed longer saccade latency, decreased saccade precision, and more reach-related saccades during visually guided reaching compared to control children. Poor binocularity was associated with impaired saccade kinematics, indicating a lack of adaptation or efficient compensatory strategy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gil Guilherme Gasparello, Sergio Luiz Mota Junior, Giovani Ceron Hartmann, Thiago Martins Meira, Elisa Souza Camargo, Matheus Melo Pithon, Orlando Tanaka
Summary: Malocclusion may affect the appearance of an individual's smile. The perception of age, employability, honesty, and intelligence may be influenced by the individual's malocclusion. A well-balanced and attractive smile is perceived as more youthful and attractive and may increase the chances of job selection and employment.
PROGRESS IN ORTHODONTICS
(2022)
Article
Neurosciences
Juliana Tessari Dias Rohr, Cassiano Rodrigues Isaac, Adriano de Almeida de Lima, Ana Garcia, Procopio Miguel dos Santos, Maria Clotilde Henriques Tavares
Summary: This study aimed to investigate the perception of visual illusions in children/adolescents with strabismus. The results showed that children with strabismus had a higher susceptibility and longer response time to the Ponzo illusion, as well as impaired perception of other geometric illusions and neutral images. The findings suggest that studying visual illusory perception can provide new insights into the visual function of strabismus patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Surgery
Deepa Bhat, Tejas Kollu, Joseph A. Ricci, Ashit Patel
Summary: The number of followers or likes on social media does not have a direct impact on surgeon competence or likelihood of recruiting new patients. The aesthetic results of the surgery seem to be the most important factor in determining surgeon competence and attracting new patients.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Multidisciplinary Sciences
Sadik Taju Sherief, Samson Tesfaye, Zelalem Eshetu, Asim Ali, Helen Dimaras
Summary: The study revealed a lack of awareness and understanding among parents regarding childhood eye health, which may impact their behavior in seeking eye care for their children. Health promotion efforts and professional training could be effective in raising awareness and promoting positive health behaviors among parents.
Article
Neurosciences
Xiaoxiao Cai, Zidong Chen, Yanping Liu, Daming Deng, Minbin Yu
Summary: The study demonstrated that the dichoptic optokinetic nystagmus test can effectively and objectively quantify interocular suppression in IXT patients, revealing how it fluctuates under different eye positions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Ophthalmology
Gil Binenbaum, Melinda Y. Chang, Gena Heidary, David G. Morrison, Rupal H. Trivedi, Jennifer A. Galvin, Stacy L. Pineles
Summary: This study reviewed the effectiveness of extraocular muscle BTXA injection compared to eye muscle surgery for nonparalytic, nonrestrictive horizontal strabismus. Results showed that BTXA injection can achieve a high rate of successful motor alignment similar to eye muscle surgery, though multiple injections may be necessary for good alignment.
Article
Biology
Lukas Klimmasch, Johann Schneider, Alexander Lelais, Maria Fronius, Bertram Emil Shi, Jochen Triesch
Summary: The computational model presented is based on the Active Efficient Coding framework and is capable of developing disparity tuned neurons and precise eye control under normal rearing conditions, as well as reproducing experimental results under altered conditions. The model predicts how altered rearing conditions affect the learning of precise eye control, and also reveals a surprising effect on the statistics of orientation tuning in visual cortical neurons when vergence control is impaired.
Article
Multidisciplinary Sciences
Yael Zilbershtain-Kra, Shmuel Graffi, Ehud Ahissar, Amos Arieli
Summary: By training adults to perceive remote objects through their fingers using a sensory substitution device, participants quickly learned and maintained a high level of performance for over 20 months. Both sighted and blind participants showed almost complete transfer of performance from 2D images to 3D objects, with perceptual accuracy and speed using the device improving significantly.
Article
Ophthalmology
Frea Sloot, Marieke Alberdina Johanna Telleman, Janine Benjamins, Aya Sami, Jacob Pieter Hoogendam, Huibert Jan Simonsz
Summary: The study evaluated the effectiveness of preverbal orthoptic tests in population-wide screening at 6-24 months of age, showing that omission of these tests did not affect the efficacy of vision screening. Refractive and bilateral amblyopia were predominantly detected through visual acuity measurements.
ACTA OPHTHALMOLOGICA
(2022)
Article
Psychology, Multidisciplinary
Althea Frisanco, Marco Biella, Marco Brambilla, Mariska E. Kret
Summary: This study investigates the pupillary reactions induced by exposure to faces with different levels of trustworthiness and suggests that pupil mimicry may be a stronger predictor than reward processing of participants' pupillary dilation.
CURRENT PSYCHOLOGY
(2023)
Article
Nutrition & Dietetics
Saar Bossuyt, Kathleen Custers, Jose Tummers, Laura Verbeyst, Bert Oben
Summary: Research shows that Nutri-Score has a positive impact on healthfulness estimation accuracy, while NFP may not have the same effect as Nutri-Score. Eye-tracking data suggests that cognitive overload issues could explain the difference in effectiveness between the two labels.
Article
Neurosciences
John R. Economides, Daniel L. Adams, Jonathan C. Horton
Summary: Electrophysiological recordings in awake monkeys raised with strabismus show that individuals with acquired childhood strabismus can prevent diplopia, but visual neurons in the primary visual cortex do not appear to reflect suppression, suggesting that the elimination of double vision may occur at a higher cortical level.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Jonathan C. Horton, John R. Economides, Daniel L. Adams
Summary: Patients with homonymous hemianopia may have preservation of the central visual fields, known as macular sparing, up to 10 degrees. Two main theories have been proposed to explain this phenomenon, with studies suggesting that misprojection of retinal ganglion cells may play a role in macular sparing.
ANNUAL REVIEW OF VISION SCIENCE, VOL 7, 2021
(2021)
Article
Multidisciplinary Sciences
Kirby P. Gardner, Susan Tsai, Mohammed Aldakkak, Stephen Gironda, Daniel L. Adams
Summary: This study aimed to investigate the expression of CXCR4 in tumor-associated cells in the blood of pancreatic cancer patients and explore its relationship with cell migration and patient clinical outcomes. The results showed that high expression of CXCR4 in circulating tumor cells, cancer-associated macrophage-like cells, and epithelial-to-mesenchymal transition cells was significantly associated with increased numbers in circulation, and higher expression of CXCR4 in cancer-associated macrophage-like cells and epithelial-to-mesenchymal transition cells was significantly related to faster progression and worse survival.
Article
Biochemistry & Molecular Biology
Cha-Mei Tang, Daniel L. Adams
Summary: The ability to obtain tumor material from blood of cancer patients has significant advantages over the use of tumor tissue, with cancer-associated macrophage-like cells (CAMLs) being more useful than traditionally defined circulating tumor cells (CTCs) in some cases.
Article
Biochemistry & Molecular Biology
Kirby P. Gardner, Massimo Cristofanilli, Saranya Chumsri, Rena Lapidus, Cha-Mei Tang, Ashvathi Raghavakaimal, Daniel L. Adams
Summary: The usage of beta blockers in breast cancer patients is associated with a reduction in distant metastases, cancer recurrence, and cancer mortality. Studies indicate that the adrenergic pathway plays a role in the promotion of tumor growth and cancer cell dissemination. Cancer-associated macrophage-like cells (CAMLs) originating from tumors may facilitate the spread of circulating tumor cells (CTCs). The expression of the Beta-2 adrenergic receptor (B2AR) in CAMLs is closely linked to their presence in the circulation, size, as well as the progression-free survival and overall survival of breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
John R. Economides, Mikayla D. Dilbeck, Thomas N. Gentry, Jonathan C. Horton
Summary: This study explores the usefulness of eye tracking glasses in measuring the occurrence of exotropia in patients with intermittent exotropia. The study used eye tracking glasses to monitor the vergence angle in 44 patients, and found that 31 patients had intermittent exotropia with an average exotropia angle of 19.3 degrees and an average occurrence rate of 40%.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dimpal M. Kasabwala, Raymond C. Bergan, Kirby P. Gardner, Rena Lapidus, Susan Tsai, Mohammed Aldakkak, Daniel L. Adams
Summary: Micronuclei (MN), fragments of damaged nucleic acids, are a repair mechanism for chromosomal instabilities in cells. Presence of MN in circulating white blood cells indicates increased cancer risk, while their presence in tumor cells indicates aggressive subtypes. MN form independently over time and therapy induction, and are correlated with poor clinical outcomes in colorectal cancer.
Article
Oncology
Jillian A. Moran, Daniel L. Adams, Martin J. Edelman, Pablo Lopez, Jianzhong He, Yawei Qiao, Ting Xu, Zhongxing Liao, Kirby P. Gardner, Cha-Mei Tang, Steven H. Lin
Summary: This study found that blood-based monitoring of dynamic changes in PD-L1 in TACs can identify patients with rmNSCLC who may benefit from ICI therapy.
JCO PRECISION ONCOLOGY
(2022)
Meeting Abstract
Oncology
Jillian Moran, Daniel L. Adams, Pablo Lopez Bravo, Jianzhong He, Yawei Qiao, Ting Xu, Zhongxing X. Liao, Kirby P. Gardner, Cha-Mei Tang, Steven H. Lin
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Kirby P. Gardner, Daniel L. Adams, Pablo Lopez Bravo, Jianzhong He, Yawei Qiao, Ting Xu, Zhongxing X. Liao, Cha-Mei Tang, Steven H. Lin
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Daniel L. Adams, R. Katherine Alpaugh, Rena G. Lapidus, Saranya Chumsri, Carolina Reduzzi, Cha-Mei Tang, William Williams, Massimo Cristofanilli
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Daniel L. Adams, Ashvathi Raghavakaimal, Cha-Mei Tang, Kirby P. Gardner, Scott Kelly, Nader Pourhassan, Nitya Ray
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Ashvathi Raghavakaimal, Massimo Cristofanilli, Cha-Mei Tang, R. K. Alpaugh, Kirby P. Gardner, Saranya Chumsri, Daniel L. Adams
Summary: Through studying the activation and endocytosis process of CCR5, it has been found that CCR5 forms clusters of less than 1 micron in breast cancer cells, which are endocytosed in the presence of RANTES. When analyzing TACs from patients, it was also observed that CCR5 clusters appeared on the cell surface and translocated to the nuclear area, and the number of CCR5 clusters had a positive correlation with the increase of TACs. Furthermore, patients with a very high number of CCR5 clusters (>10 clusters) in circulating stromal cells were associated with worse progression-free survival (hazard ratio = 4.5, p = 0.002) and worse overall survival (hazard ratio = 3.7, p = 0.014).
BREAST CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Toshiaki Iwase, Aaroh Parikh, Onur Sahin, Akshara S. Raghavendra, Maryanne E. Sapon, Anjali James, Tushaar V. Shrimanker, Sudpreeda Chainitikun, Kumiko Kida, Daniel L. Adams, Cha-Mei Tang, Andrea Y. D. Medrano, Ann H. Klopp, Naoto T. Ueno
Article
Ophthalmology
John R. Economides, Daniel L. Adams, Jonathan C. Horton
Summary: In patients with intermittent exotropia, occlusion of both eyes reveals a state of alignment different from orthotropia, demonstrating that the deviation angle is actively mediated by visual feedback, which the fixating eye is capable of providing alone.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)