Article
Multidisciplinary Sciences
Ping Dong, Yang Zhang, Arsen S. Hunanyan, Mohamad A. Mikati, Jianmin Cui, Huanghe Yang
Summary: An increasing number of gain-of-function BK channelopathies have been found to be associated with motor deficits and dyskinesia-like behaviors. Our study reveals the neuronal mechanism of BK gain-of-function in absence epilepsy and dyskinesia, and suggests that BK inhibition is a promising therapeutic strategy for BK gain-of-function-induced neurological disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu, Zhaoshi Bao, Shuhui Sun, Xiaoqian Liu, Shuai Ma, Zunpeng Liu, Kaowen Yan, Zeming Wu, Yanling Fan, Xiaoyan Sun, Yixin Zhang, Qianzhao Ji, Fang Cheng, Peng-Hu Wei, Xibo Ma, Shiqian Zhang, Zhengwei Xie, Yuyu Niu, Yan-Jiang Wang, Jing-Dong J. Han, Tao Jiang, Guoguang Zhao, Weizhi Ji, Juan Carlos Izpisua Belmonte, Si Wang, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Summary: By analyzing aged non-human primates, we uncovered the molecular and neuropathological changes in the primate frontal lobe associated with aging, including nuclear lamina and heterochromatin erosion, resurrection of endogenous retroviruses, activation of pro-inflammatory signaling, and cellular senescence. We also demonstrated that these aging-related changes can be alleviated by treatment with the nucleoside reverse transcriptase inhibitor abacavir, both in vitro and in vivo.
Article
Plant Sciences
Raphael Groux, Elia Stahl, Caroline Gouhier-Darimont, Envel Kerdaffrec, Pedro Jimenez-Sandoval, Julia Santiago, Philippe Reymond
Summary: Through a genome-wide association study, LecRK-I.1 was identified as an important protein controlling Arabidopsis response to eggs of the large white butterfly, with signatures of balancing selection suggesting ecological importance. Further research showed that LecRK-I.1 functions in the same signaling pathway as LecRK-I.8.
Article
Biochemistry & Molecular Biology
Caspar Liesenhoff, Simon Martin Paulus, Caroline Havertz, Arie Geerlof, Siegfried Priglinger, Claudia Sybille Priglinger, Andreas Ohlmann
Summary: Galectin-1 deficiency in retinal pigment epithelium (RPE) cells affects various cell biological processes, including cell survival, proliferation, migration, adhesion, and maintenance of the epithelial phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tao Zhang, Yongfang Xia, Li Hu, Dongmei Chen, Chen-Ling Gan, Long Wang, Yingxue Mei, Guihua Lan, Xindong Shui, Yuan Tian, Ruomeng Li, Mi Zhang, Tae Ho Lee
Summary: The aggregation of A13 peptides into oligomers and fibrils is a key feature of Alzheimer's disease. This study reveals that A13 oligomers can upregulate DAPK1 levels and cause neuronal apoptosis and tau phosphorylation. The inhibition of DAPK1 can protect neurons against A13-induced damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu, Shun-Hua Chen
Summary: The study revealed that deficiency of TM-LeD reduces mortality, tissue viral loads, and brain neuron apoptosis in HSV-1-infected mice, while enhancing the phagocytic activity of brain microglia. Additionally, TM-LeD deficiency was found to augment the capacity of microglia to reduce HSV-1 replication in neurons.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Food Science & Technology
Daniel Souza Bezerra, Gyllyandeson de Araujo Delmondes, Maria Janice Pereira Lopes, Isaac Moura Araujo, Giovana Mendes de Lacerda Leite, Maysa de Oliveira Barbosa, Roseli Barbosa, Adriano Francisco Alves, Cassio Rocha Medeiros, Sloana Giesta Lemos Florencio, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Cicero Francisco Bezerra Felipe, Marta Regina Kerntopf
Summary: This study evaluated the anticonvulsant and neuroprotective effects of eucalyptol on mice with pilocarpine-induced seizures. The results demonstrate the potential of eucalyptol to effectively control seizure onset through muscarinic cholinergic antagonism, oxidative stress mitigation, and monoaminergic system modulation.
Article
Biochemistry & Molecular Biology
Zak Vilen, Eugene Joeh, Meg Critcher, Christopher G. Parker, Mia L. Huang
Summary: Galectin-1 is a key protein in promoting myogenic differentiation, but the glycoprotein interactors of galectin-1 are not fully understood. A proximity tagging strategy has been used to capture and identify the glycan-mediated glycoprotein interactors of galectin-1 in myoblasts, providing valuable resources for studying the mechanisms through which galectin-1 promotes myogenic differentiation.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qinglian Dong, Yongxia Li, Juan Chen, Nan Wang
Summary: Azilsartan was found to suppress LPS-induced oxidative stress and inhibit the TLR/MyD88 signaling pathway, thereby inhibiting inflammation in U937 macrophages.
Article
Neurosciences
Hao Wu, Qiang Meng, Yu Zhang, Huanfa Li, Yong Liu, Shan Dong, Bei Liu, Hua Zhang
Summary: Nmnat2, originally thought to be a neuronal maintenance factor, has unexpected pro-epileptic effects in refractory temporal lobe epilepsy (TLE). Overexpression of Nmnat2 increases seizure susceptibility and neuronal loss, while mutation in its chaperone function leads to increased apoptosis. Additionally, Nmnat2 overexpression reduces SOD2 expression and increases FoxO3a expression in vivo.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Anna Hillenmayer, Christian M. Wertheimer, Arie Geerlof, Kirsten H. Eibl, Siegfried Priglinger, Claudia Priglinger, Andreas Ohlmann
Summary: This study found that hr-GAL1 and 3 can inhibit the proliferation, migration, and apoptosis of human retinal microvascular endothelial cells, and have inhibitory effects on angiogenesis. However, hr-GAL1 and 3 do not show toxic effects on HRMEC. In addition, hr-GAL1 and 3 treatment can activate the proangiogenic Wnt/β-catenin signaling pathway.
Article
Cell Biology
Phillip Wibisono, Shawndra Wibisono, Jan Watteyne, Chia-Hui Chen, Durai Sellegounder, Isabel Beets, Yiyong Liu, Jingru Sun
Summary: This study demonstrates that NMUR-1 regulates the expression of immune genes in C. elegans by modulating the activity of transcription factors involved in binding to RNA polymerase II regulatory regions. This finding provides a molecular basis for the specificity of C. elegans innate immunity and could potentially shed light on the specificity of innate immunity in other animals, including mammals.
Article
Biochemistry & Molecular Biology
Yasuhiro Nonaka, Takashi Ogawa, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura
Summary: Modification of galectins' domain architecture, such as the tandem-repeat mutant with a short linker peptide, retained the native structure, showed higher T-cell growth-inhibition activity, and prevented oxidation of internal cysteine residue.
Article
Neurosciences
Jie Yu, Yao Cheng, Yaru Cui, Yujie Zhai, Wenshen Zhang, Mengdi Zhang, Wenyu Xin, Jia Liang, Xiaohong Pan, Qiaoyun Wang, Hongliu Sun
Summary: Exogenous irisin can attenuate neuronal injury, learning and memory defects, and seizures induced by kainic acid. It increases the levels of BDNF and UCP2, which are initially reduced after kainic acid administration. The protective effects of irisin may be mediated through the BDNF-mediated UCP2 level.
NEUROSCIENCE BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Xiaoyuan Mao, Xuan Wang, Mingzhu Jin, Qin Li, Jining Jia, Menghuan Li, Honghao Zhou, Zhaoqian Liu, Weilin Jin, Yanli Zhao, Zhong Luo
Summary: Recent insights suggest the important roles of lysyl oxidase (LysOX) in various neurological diseases, but the molecular mechanisms are still unclear. This study reveals the regulatory role of LysOX in seizure-induced ferroptotic cell death of neurons and uncovers its association with the ERK-Alox5 pathway.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Neurosciences
Swetlana Sirko, Martin Irmler, Sergio Gascon, Sarah Bek, Sarah Schneider, Leda Dimou, Jara Obermann, Daisylea De Souza Paiva, Francoise Poirier, Johannes Beckers, Stefanie M. Hauck, Yves-Alain Barde, Magdalena Goetz
Article
Neurosciences
Kate E. Binley, Wai S. Ng, Yves-Alain Barde, Bing Song, James E. Morgan
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Pedro Chacon-Fernandez, Katharina Saeuberli, Maria Colzani, Thomas Moreau, Cedric Ghevaert, Yves-Alain Barde
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Neurosciences
Emilia Favuzzi, Andre Marques-Smith, Ruben Deogracias, Christian M. Winterflood, Alberto Sanchez-Aguilera, Laura Mantoan, Patricia Maeso, Cathy Fernandes, Helge Ewers, Beatriz Rico
Editorial Material
Multidisciplinary Sciences
Laura Cassels, Yves-Alain Barde
Article
Multidisciplinary Sciences
Spyros Merkouris, Yves-Alain Barde, Kate E. Binley, Nicholas D. Allen, Alexey V. Stepanov, Nicholas C. Wu, Geramie Grande, Chih-Wei Lin, Meng Li, Xinsheng Nan, Pedro Chacon-Fernandez, Peter S. DiStefano, Ronald M. Lindsay, Richard A. Lerner, Jia Xie
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Cell Biology
Martijn P. J. Dekkers, Vassiliki Nikoletopoulou, Yves-Alain Barde
JOURNAL OF CELL BIOLOGY
(2013)
Article
Cell Biology
Antonio Jesus Hinojosa, Ruben Deogracias, Beatriz Rico
Article
Multidisciplinary Sciences
Emilia Favuzzi, Ruben Deogracias, Andr Marques-Smith, Patricia Maeso, Julie Jezequel, David Exposito-Alonso, Maddalena Balia, Tim Kroon, Antonio J. Hinojosa, Elisa F. Maraver, Beatriz Rico
Article
Cell Biology
Carlos Martin-Rodriguez, Minseok Song, Begona Anta, Francisco J. Gonzalez-Calvo, Ruben Deogracias, Deqiang Jing, Francis S. Lee, Juan Carlos Arevalo
JOURNAL OF CELL SCIENCE
(2020)
Article
Psychiatry
Hayley Dingsdale, Xinsheng Nan, Samantha M. Garay, Annett Mueller, Lorna A. Sumption, Pedro Chacon-Fernandez, Isabel Martinez-Garay, Cedric Ghevaert, Yves-Alain Barde, Rosalind M. John
Summary: Maternal depression during pregnancy did not show an association with serum BDNF levels, while maternal anxiety was correlated with increased BDNF in mothers of male infants. Male infants had lower serum BDNF levels compared to female infants, but this was not related to maternal anxiety. The study did not find evidence of BDNF transfer across the placenta, indicating the placenta's protective role against maternal changes in BDNF levels.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Ateaque, Spyros Merkouris, Sean Wyatt, Nicholas D. Allen, Jia Xie, Peter S. DiStefano, Ronald M. Lindsay, Yves-Alain Barde
Summary: In the central nervous system, both NT3 and TrkC have unique roles in the assembly of neuronal circuits. NT3 activates TrkC at lower concentrations, but at high concentrations, it can also activate TrkB and down-regulate TrkC. These findings are important for understanding neurodevelopment and the pathogenesis of neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Neurosciences
Alfredo Llorca, Ruben Deogracias
Summary: This review describes the diversity of interneurons that make up local circuits in the neocortex and summarizes the mechanisms underlying their development and assembly into functional networks.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Erin Wosnitzka, Xinsheng Nan, Jeff Nan, Pedro Chacon-Fernandez, Lothar Kussmaul, Michael Schuler, Bastian Hengerer, Yves-Alain Barde
Article
Neurosciences
Yvonne Naegelin, Hayley Dingsdale, Katharina Sauberli, Sabine Schadelin, Ludwig Kappos, Yves-Alain Barde