Article
Biochemistry & Molecular Biology
Dennis Dik-Long Chau, Wen Li, Wai Wa Ray Chan, Jacquelyne Ka-Li Sun, Yuqi Zhai, Hei-Man Chow, Kwok-Fai Lau
Summary: Neurite outgrowth, a fundamental process in neurons, is linked to insulin through the PKCl/lambda-mediated phosphorylation of FE65 and its interaction with ARF6-Rac1.
Article
Biochemistry & Molecular Biology
Sara Zocher, Rupert W. Overall, Gabriel Berdugo-Vega, Nicole Rund, Anne Karasinsky, Vijay S. Adusumilli, Christina Steinhauer, Sina Scheibenstock, Kristian Handler, Joachim L. Schultze, Federico Calegari, Gerd Kempermann
Summary: Newborn DNA methylation during adult neurogenesis is crucial for the maturation and integration of functional neurons in the hippocampus, facilitating transcriptional up-regulation of neuronal genes and affecting activation patterns in the hippocampal circuitry.
Article
Biology
Soo Jeong Kim, Youngsik Woo, Hyun Jin Kim, Bon Seong Goo, Truong Thi My Nhung, Seol-Ae Lee, Bo Kyoung Suh, Dong Jin Mun, Joung-Hun Kim, Sang Ki Park
Summary: This study identifies the role of the protein Rai14 in the regulation of dendritic spine dynamics and its association with stress-induced depressive-like behaviors. Rai14-deficient neurons exhibit reduced dendritic spine density and impaired synaptic activity. Rai14 forms a complex with Tara, preventing its degradation and accumulating in the dendritic spine neck, enhancing spine maintenance. Rai14 deficiency also alters gene expression relevant to depression and increases depressive-like behaviors.
Article
Neurosciences
Omri David Gilday, Adi Mizrahi
Summary: Sensory cortices, even of primary regions, show various forms of multisensory interactions. Learning and experience result in the combination of seemingly disparate sensory information, impacting perception, cognition, and action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Masato Uemura, Stefan Blankvoort, Sean Shui Liang Tok, Li Yuan, Luis Fernando Cobar, Kwok Keung Lit, Ayumu Tashiro
Summary: The distribution of neurogenesis in the dentate gyrus is positionally associated with active excitatory neurons and dissociated from a type of interneuron with high-burst tendency. This suggests that behaviorally relevant activity of excitatory-inhibitory neuronal circuits can define a microenvironment stimulating/inhibiting neurogenesis, contributing to strategic recruitment of new neurons for modification of functionally relevant neural circuits.
Article
Biochemistry & Molecular Biology
Dong Kyu Kim, Hyobin Jeong, Jingi Bae, Moon-Yong Cha, Moonkyung Kang, Dongjin Shin, Shinwon Ha, Seung Jae Hyeon, Hokeun Kim, Kyujin Suh, Mi-Sun Choi, Hoon Ryu, Seong-Woon Yu, Jong-Il Kim, Yeon-Soo Kim, Sang-Won Lee, Daehee Hwang, Inhee Mook-Jung
Summary: This study reveals the crucial role of mitochondria in neural progenitors and their association with the protein amyloid-beta, which is linked to Alzheimer's disease. Mitochondrial dysfunction inhibits neuronal differentiation, leading to deficits in adult hippocampal neurogenesis and cognitive function. The research suggests that lysine demethylase 5A epigenetically suppresses differentiation in response to mitochondrial damage.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Jae Ryong Lim, Chang Woo Chae, Ji Yong Park, Young Hyun Jung, Jee Hyeon Yoon, Min Jeong Kim, Hyun Jik Lee, Gee Euhn Choi, Ho Jae Han
Summary: Heavy alcohol consumption leads to neuronal cell death and cognitive impairment. The production of ceramide, a sphingolipid metabolite, may be responsible for the neuronal cell death induced by ethanol. However, the molecular mechanisms underlying this process have not been fully understood.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Michal Magott, Klaudia Plonka, Barbara Sieklucka, Katarzyna Dziedzic-Kocurek, Wataru Kosaka, Hitoshi Miyasaka, Dawid Pinkowicz
Summary: In this study, the tunability of spin state in iron(ii) spin cross-over (SCO) compounds and the manipulation of properties in breathing cyanido-bridged porous coordination polymers (PCPs) were demonstrated. The efficient approach of post-synthetic guest-exchange using common gases was showcased.
Article
Biochemistry & Molecular Biology
Marcos Francisco Perez, Mehrnaz Shamalnasab, Alejandro Mata-Cabana, Simona Della Valle, Maria Olmedo, Mirko Francesconi, Ben Lehner
Summary: Research shows that chemical pheromones in the social environment can be transmitted across generations through sensory neurons, significantly impacting the timing of offspring development.
Article
Pharmacology & Pharmacy
Trevor T. Towner, Devon T. Applegate, Elena Varlinskaya, David F. Werner
Summary: Adolescence is a sensitive developmental period during which alcohol use can lead to long-term social impairments, particularly in males. However, the neuronal underpinnings for this sex-specific effect are not well understood. This study aimed to investigate whether social anxiety-like alterations in adolescent male rats following intermittent ethanol exposure are accompanied by changes in neuronal activation in brain regions associated with social behavior. The results suggest that AIE produces sex-specific social impairments potentially driven by differential neuronal activation states in specific brain regions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chaofan Wang, Yue Gao, Changjiao Luan, Wentao Sun, Sumin Ge, Yaru Li, Lei Xu, Qiu Du, Weili Liu, Guotao Lu, Weijuan Gong, Xingjie Ma
Summary: Cellular senescence is a stable cell cycle arrest accompanied by a senescence-associated secretory phenotype (SASP), and calcium signaling has been identified as a key regulator in cellular senescence. This study reveals that the nuclear receptor RXRA inhibits the endoplasmic reticulum calcium release channel ITPR2 to control intracellular calcium signaling during cellular senescence. Additionally, the zinc finger protein ZBTB17 is found to interact with RXRA and play a role in regulating cellular senescence.
Article
Multidisciplinary Sciences
Ellen Tedford, Norhidayah Binti Badya, Conor Laing, Nozomi Asaoka, Shuji Kaneko, Beatrice Maria Filippi, Glenn Alan McConkey
Summary: Infection with Toxoplasma gondii alters norepinephrine levels by down-regulating dopamine ss-hydroxylase (DBH) gene expression. Intracerebral injection of TINEVs induces DBH down-regulation and disrupts catecholaminergic signalling. TINEV treatment also leads to hypermethylation upstream of the DBH gene and the presence of an antisense lncRNA to DBH in purified TINEV preparations.
SCIENTIFIC REPORTS
(2023)
Article
Toxicology
Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sa, Joao Paulo Capela, Felix Carvalho, Vera Marisa Costa
Summary: This study evaluated the neurotoxic pathways of mitoxantrone in the brain of adult mice and found that it caused significant damage in regions associated with memory and cognition.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu Wu
Summary: Chronic stress can induce depressive-like behavior and inhibit adult hippocampal neurogenesis. Chronic corticosterone treatment decreases the proliferation and survival of neural stem cells, impairs the migration of newborn neurons, and increases neuronal autophagy. Inhibiting hyperactive neuronal autophagy can reverse the decrease in neuronal brain-derived neurotrophic factor levels, rescue neurogenesis, and exert antidepressant effects.
Article
Multidisciplinary Sciences
Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano, Masabumi Minami
Summary: This study reveals the neuronal plasticity in the bed nucleus of the stria terminalis (BNST) induced by chronic pain, which contributes to maladaptive anxiety. The findings provide insights into the underlying mechanisms of psychiatric disorders induced by chronic pain.
Review
Biochemistry & Molecular Biology
Daniel R. Lathen, Collin B. Merrill, Adrian Rothenfluh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Behavioral Sciences
Maggie M. Chvilicek, Iris Titos, Adrian Rothenfluh
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Biology
Puskar Mishra, Shany E. Yang, Austin B. Montgomery, Addison R. Reed, Aylin R. Rodan, Adrian Rothenfluh
Summary: The study introduces a new assay, FLEA, to accurately measure incentive motivation in Drosophila by adjusting electrical current levels in each feeding well. It is found that external incentives and internal motivational state can drive flies to overcome higher currents for better food, and current perception is not discounted as the flies become more food-deprived. Additionally, it is demonstrated that neuropeptide F plays a role in sensory processing of electrical current in fruit flies.
Article
Urology & Nephrology
Laith Farah Al-Rabadi, Tiffany Caza, Claire Trivin-Avillach, Aylin R. Rodan, Nicole Andeen, Norifumi Hayashi, Brandi Williams, Monica P. Revelo, Fred Clayton, Jo Abraham, Edwin Lin, Willisa Liou, Chang-Jiang Zou, Nirupama Ramkumar, Tim Cummins, Daniel W. Wilkey, Issa Kawalit, Christian Herzog, Aaron Storey, Rick Edmondson, Ronald Sjoberg, Tianxin Yang, Jeremy Chien, Michael Merchant, John Arthur, Jon Klein, Chris Larsen, Laurence H. Beck
Summary: The study identified serine protease HTRA1 as a novel podocyte antigen in primary membranous nephropathy (MN) patients. Anti-HTRA1 antibodies in patients with HTRA1-associated MN were predominantly IgG4 and seemed to correlate with clinical disease activity. Screening of 118 quadruple-negative patients revealed a 4.2% prevalence of HTRA1-associated MN.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Iris Titos, Adrian Rothenfluh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Sima Jonusaite, Aylin R. Rodan
Summary: The paper discusses the molecular mechanisms involved in the development and maintenance of the Malpighian tubules, with a focus on the roles of smooth septate junction (sSJ) proteins and GATAe transcription factor in Drosophila. It also compares the functions of sSJ proteins in the fly midgut versus the Malpighian tubule, emphasizing the importance of cellular context for protein functions.
CURRENT OPINION IN INSECT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Travis James Philyaw, Adrian Rothenfluh, Iris Titos
Summary: This article introduces Drosophila as a translational model organism for studying the effects of psychostimulant drugs and discusses its efficiency and cost-effectiveness in discovering novel candidate genes and molecular mechanisms involved in behavioral responses.
Article
Physiology
Kelly A. Hyndman, Elena Isaeva, Oleg Palygin, Luciano D. Mendoza, Aylin R. Rodan, Alexander Staruschenko, Jennifer S. Pollock
Summary: The enzyme NOS1 beta plays a critical role in sodium homeostasis and blood pressure control. Knockout of NOS1 beta leads to decreased activity of K(ir)4.1/K(ir)5.1 channels, affecting the regulation of Na+ and K+ by the kidney.
PHYSIOLOGICAL REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Collin B. Merrill, Austin B. Montgomery, Miguel A. Pabon, Andrey A. Shabalin, Aylin R. Rodan, Adrian Rothenfluh
Summary: This study applied ATAC-seq and RNA-seq to investigate chromatin regions and gene expression changes in response to insulin signaling pathway in Drosophila cells. The results showed correlations between accessible chromatin regions and gene expression, especially for enhancer regions. Cloning of candidate enhancer regions demonstrated the potential of insulin-inducible reporter gene expression.
Article
Biochemistry & Molecular Biology
Jeffrey N. Schellinger, Qifei Sun, John M. Pleinis, Sung-Wan An, Jianrui Hu, Gaelle Mercenne, Iris Titos, Chou-Long Huang, Adrian Rothenfluh, Aylin R. Rodan
Summary: The intracellular chloride concentration in the small ventral lateral (sLN(v)) pacemaker neurons of fruit flies can regulate the length of the circadian period by influencing the activation of the WNK-Fray signaling pathway and the activation of an inwardly rectifying potassium channel. This finding helps us understand the regulatory mechanism of circadian rhythms.
Article
Urology & Nephrology
Titilayo O. Ilori, Jing Liu, Aylin R. Rodan, Ashish Verma, Katherine T. Mills, Jiang He, Cheryl A. Winkler, Josee Dupuis, Cheryl A. M. Anderson, Sushrut S. Waikar
Summary: The APOL1 genotypes can modify the association between dietary potassium and CKD progression. Higher urinary potassium excretion is associated with lower risk of CKD progression in individuals with high-risk APOL1 genotypes, and higher risk of CKD progression in individuals with low-risk APOL1 genotypes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Aylin R. Rodan
Summary: This article discusses the regulatory role of potassium ions on WNK kinase and the importance of WNK in maintaining ion balance in the body. In the nephron, changes in extracellular ion concentrations affect intracellular ion concentrations, thereby regulating WNK activity and downstream transporters and channels.
Article
Multidisciplinary Sciences
Collin B. Merrill, Miguel A. Pabon, Austin B. Montgomery, Aylin R. Rodan, Adrian Rothenfluh
Summary: ATAC-seq is a powerful method for studying gene regulation that is now being optimized for use in Drosophila, taking advantage of the unique features of this model system. The optimized protocol accounts for various complicating factors in flies and successfully generates high-quality libraries, paving the way for extensive studies on chromatin-mediated gene regulation in Drosophila.
SCIENTIFIC REPORTS
(2022)
