Article
Clinical Neurology
Joshua S. Catapano, Kavelin Rumalla, Visish M. Srinivasan, Dimitri Benner, Ethan A. Winkler, Peter M. Lawrence, Kristen Larson Keil, Michael T. Lawton
Summary: This study proposes a novel taxonomic system for deep thalamic CMs based on clinical presentation and anatomical location, which can guide the selection of surgical approach and improve patient outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Neurosciences
Norihiro Takakuwa, Kaoru Isa, Hirotaka Onoe, Jun Takahashi, Tadashi Isa
Summary: Blindsight is a phenomenon where some patients can respond to visual stimuli in their lesion-affected visual field even after damage to the primary visual cortex (V1). The study used pharmacological inactivation of the pulvinar and LGN to clarify their roles in a simple visually guided saccades task, finding that both regions play key roles in performing the task after V1 lesioning.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Zhichao Xia, Cheng Wang, Roeland Hancock, Maaike Vandermosten, Fumiko Hoeft
Summary: The study found a significant association between paternal age at childbirth and offspring's reading ability, potentially affecting the development of offspring's brain structure and mediated by volumetric maturation of specific brain regions. These findings provide new insights into the impact of paternal age on reading acquisition and suggest promising areas for future research.
HUMAN BRAIN MAPPING
(2021)
Article
Biology
Vinod Jangir Kumar, Christian F. Beckmann, Klaus Scheffler, Wolfgang Grodd
Summary: Nearly all processing in the cortex depends strongly on interactions with the thalamus, but the functional interactions between the human thalamus nuclei and the cerebral cortex are still not fully understood. This study examines the connectivity and mapping of different thalamic nuclei with cortical networks, revealing intertwined functional associations and suggesting that relay-specific thalamic nuclei are involved in higher-order functions as well. The findings contribute to our understanding of the interactions between cortical networks and the thalamus, which may be of interest to researchers in neuroscience and clinical fields.
COMMUNICATIONS BIOLOGY
(2022)
Article
Behavioral Sciences
Elena Borra, Marianna Rizzo, Giuseppe Luppino
Summary: The lateral prefrontal cortex (LPF) in the primate brain plays a critical role in cognitive control of behavior. This study investigates the thalamic projections to the LPF and finds that the topography of these projections is mainly organized according to functional criteria, rather than simple topological rules.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Jessica M. Phillips, Niranjan A. Kambi, Michelle J. Redinbaugh, Sounak Mohanta, Yuri B. Saalmann
Summary: The prefrontal cortex has a complex relationship with the thalamus, where thalamocortical neurons in several nuclei are modulated by affective and cognitive signals. This modulation contributes to all aspects of cognitive control, including internal states processing, attentional allocation, and goal-directed behavior. Thalamic modulation of cortical gain and cortico-cortical functional connectivity play important roles in these processes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Lukasz Chrobok, Kamil Pradel, Marcelina Elzbieta Janik, Anna Magdalena Sanetra, Monika Bubka, Jihwan Myung, Amalia Ridla Rahim, Jasmin Daniela Klich, Jagoda Stanislawa Jeczmien-Lazur, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski
Summary: This study demonstrates the intrinsic clock properties of the lateral geniculate nucleus (LGN) in male rats and mice, suggesting it may function as a light-entrainable oscillator with autonomous timekeeping mechanisms. The research identifies specific nuclei within the LGN showing core clock gene expression and circadian variation in neuronal activity, implying a more complex circadian timekeeping system beyond the central brain clock.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Jie Li, Mark L. Baccei
Summary: In a subset of glutamatergic interneurons in the neonatal spinal superficial dorsal horn (SDH), there is intrinsic burst-firing activity regulated by persistent Na+ channels and inward-rectifying K+ channels, which decreases during postnatal development. While ascending lamina I projection neurons targeting the parabrachial nucleus (PB) or periaqueductal gray (PAG) can also display pacemaker activity in early life, the mechanisms driving this activity and its conservation across cell types in the spinal dorsal horn remain unclear. Our study demonstrates that adolescent projection neurons retain the ability to generate pacemaker activity, with differences in membrane properties compared to adjacent neurons lacking intrinsic burst-firing. Further research is needed to understand the mechanisms governing pacemaker activity in the major output neurons of the SDH network.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Prudhvi Raj Rayi, Hanoch Kaphzan
Summary: Angelman syndrome is a neurogenetic disorder characterized by developmental delay, speech impairment, and other symptoms. Studies have shown that hippocampal deficits in AS mice may be related to altered calcium dynamics and increased alpha 1-Na/K-ATPase expression levels. However, the causal link between hippocampal deficits and major behavioral phenotypes in AS is still unclear.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Yi Ning Leow, Blake Zhou, Heather A. Sullivan, Alexandria R. Barlowe, Ian R. Wickersham, Mriganka Sur
Summary: The rodent homolog of the primate pulvinar, the lateral posterior thalamus, is interconnected with multiple cortical areas, particularly the anterior cingulate cortex (ACC). The ACC and lateral posterior thalamus receive inputs from various cortical and subcortical regions, playing a role in sensory processing, attentional regulation, and visuomotor functions. This study provides insights into the reciprocal interactions and information integration between ACC and lateral posterior thalamus.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Megan A. Kirchgessner, Alexis D. Franklin, Edward M. Callaway
Summary: The study demonstrates different functional influences of layer 5 and layer 6 corticothalamic pathways on the higher-order thalamus (HO), with layer 5 projections driving visual responses in the pulvinar. Additionally, it shows that inputs from cortical layer 5 and subcortical structures both contribute to visual thalamus activity in awake mice.
Article
Neurosciences
Rafael Barrientos, Alberto Alatorre, Aldo Oviedo-Chavez, Alfonso Delgado, Nielsine Nielsen, Enrique Querejeta
Summary: The study found that the discharge of serotonin through activation of 5-HT1A receptors in the reticular thalamic nucleus (RTn) increases burst firing index and simultaneously decreases the basal spiking frequency.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Deepak Kumbhare, Md Ali Azam, Ravi Hadimani, Jamie Toms, George Weistroffer, Jayasimha Atulasimha, Mark S. Baron
Summary: This study used computational simulations to investigate the influence of the basal ganglia on thalamic firing modes. By inputting different combinations of healthy and pathological neuronal recordings into a computational model, the study found that the basal ganglia act as firing mode selectors for thalamic motor relay neurons. The timing and extent of opening thalamic calcium channels are determined by the basal ganglia, allowing for precise orchestration of thalamocortical burst motor signaling.
Article
Neurosciences
Yoonsub Kim, Sooyun Kim, Won-Kyung Ho, Suk-Ho Lee
Summary: High frequency burst firing plays a crucial role in dendritic membrane potential depolarization. The physiological significance of burst firings in hippocampal dentate granule cells (GCs) remains unclear. This study found that GCs can be categorized into regular-spiking (RS) and burst-spiking (BS) cells based on their initial firing frequency (F-init) and investigated their differences in long-term potentiation (LTP) induced by high-frequency inputs. The results showed that Hebbian LTP at lateral perforant pathway (LPP) synapses required burst firing, which was dependent on persistent Na+ current and larger in BS cells. Calcium channels also played a role in LTP, with L-type channels involved in LPP synapses and T-type channels in medial perforant pathway (PP) synapses.
Article
Neurosciences
Kevin R. Duffy, Nathan A. Crowder, Arnold J. Heynen, Mark F. Bear
Summary: During a critical period after birth, monocular deprivation (MD) reduces the size of neurons in the dorsal lateral geniculate nucleus (dLGN) connected to the deprived eye and shifts cortical ocular dominance in favor of the non-deprived eye. Temporary inactivation of the non-deprived eye, known as monocular inactivation (MI), can promote better recovery from long-term MD effects compared to conventional occlusion therapy. MI has a significant impact on neuron size in the dLGN, especially when applied during the peak of the critical period. Unlike MD, MI induces structural plasticity in both the binocular and monocular segments of the dLGN. The effectiveness of MI decreases with age but still produces significant effects even beyond the critical period, showing double the magnitude and efficacy compared to MD. The effects of MI can be fully remedied with a short period of binocular experience, leading to full recovery of vision in the previously inactivated eye. These findings highlight the potential of MI to modify the visual pathway and its ability to ameliorate visual system disorders like amblyopia.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Pathology
Patricia M. Kralik, Yunshi Long, Ye Song, Lu Yang, Haiyang Wei, Susan Coventry, Shirong Zheng, Paul N. Epstein
AMERICAN JOURNAL OF PATHOLOGY
(2009)
Article
Neurosciences
Ranida D. Chomsung, Haiyang Wei, Jonathan D. Day-Brown, Heywood M. Petry, Martha E. Bickford
Review
Neurosciences
Martha E. Bickford, Haiyang Wei, Michael A. Eisenback, Ranida D. Chomsung, Arkadiusz S. Slusarczyk, Aygul B. Dankowsi
JOURNAL OF COMPARATIVE NEUROLOGY
(2008)
Article
Neurosciences
Mary K. L. Baldwin, Haiyang Wei, Jamie L. Reed, Martha E. Bickford, Heywood M. Petry, Jon H. Kaas
JOURNAL OF COMPARATIVE NEUROLOGY
(2013)
Article
Biochemical Research Methods
John D. Graef, Haiyang Wei, Patrick M. Lippiello, Merouane Bencherif, Nikolai Fedorov
JOURNAL OF NEUROSCIENCE METHODS
(2013)
Editorial Material
Neurosciences
Christopher M. Whitaker, Haiyang Wei
JOURNAL OF PHYSIOLOGY-LONDON
(2009)
Article
Multidisciplinary Sciences
Haiyang Wei, Sean P. Masterson, Heywood M. Petry, Martha E. Bickford
Article
Anatomy & Morphology
Jonathan D. Day-Brown, Haiyang Wei, Ranida D. Chomsung, Heywood M. Petry, Martha E. Bickford
FRONTIERS IN NEUROANATOMY
(2010)
Article
Biochemical Research Methods
John D. Graef, Lisa C. Benson, Serguei S. Sidach, Haiyang Wei, Patrick M. Lippiello, Merouane Bencherif, Nikolai B. Fedorov
JOURNAL OF BIOMOLECULAR SCREENING
(2013)
Article
Neurosciences
Hao Wang, Haiyang Wei, Bo Chen, Yifeng Zhou
NEUROSCIENCE LETTERS
(2006)
Article
Neurosciences
F Jia, HY Wei, XR Li, XQ Xie, YF Zhou
NEUROSCIENCE LETTERS
(2006)