Journal
JOURNAL OF NEUROSCIENCE
Volume 31, Issue 17, Pages 6379-6391Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0129-11.2011
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [TA-310-2, SFB592-A21, SPP1109]
- Inserm [R05245DS]
- NeRF/Region de l'Ile-de-France
- Fondation de France
- Association pour la Recherche sur la Sclerose en Plaques
Ask authors/readers for more resources
Neural crest stem cells (NCSCs) give rise to the neurons and glia of the peripheral nervous system (PNS). NCSC-like cells can be isolated from multiple peripheral organs and maintained in neurosphere culture. Combining in vitro culture and transplantation, we show that expanded embryonic NCSC-like cells lose PNS traits and are reprogrammed to generate CNS cell types. When transplanted into the embryonic or adult mouse CNS, they differentiate predominantly into cells of the oligodendrocyte lineage without any signs of tumor formation. NCSC-derived oligodendrocytes generate CNS myelin and contribute to the repair of the myelin deficiency in shiverer mice. These results demonstrate a reprogramming of PNS progenitors to CNS fates without genetic modification and imply that PNS cells could be a potential source for cell-based CNS therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available