Article
Audiology & Speech-Language Pathology
Zeeshan Haqqee, Roberto Valdizon-Rodriguez, Paul A. Faure
Summary: The study investigates the response properties of single neurons in the inferior colliculus of big brown bats to onset ITDs in high frequency pure tones. It found that neurons show sensitivity to onset ITD cues, with an average change of 36% of its maximal response within a behaviorally relevant range of ITDs. Additionally, there is a consistent average time-intensity trading ratio of 30 mu s/dB in the sensitivity of the ITD response function to changing ILDs, indicating the potential use of onset ITD cues for azimuthal sound localization in echolocating bats.
Article
Audiology & Speech-Language Pathology
Alexander C. Thompson, Dexter R. F. Irvine, James B. Fallon
Summary: Custom ITD-aware sound processing strategies can enhance ITD sensitivity in the clinical population, as shown by studies using a cat model of neonatal deafness.
Article
Audiology & Speech-Language Pathology
Carol A. Sammeth, Andrew D. Brown, Nathaniel T. Greene, Daniel J. Tollin
Summary: The binaural interaction component (BIC) of the auditory brainstem response (ABR) is a biomarker of binaural processing abilities. This study examined the effect of interaural frequency mismatch (IFM) on BIC and behavioral interaural time difference (ITD) sensitivity in normal adult human subjects. Results showed that IFM had significant effects on BIC amplitudes and elevated ITD discrimination thresholds. The study also found that combinations of ITD, IFM, and sound level were bound by the empirically-measured BIC.
Article
Multidisciplinary Sciences
Yan Wang, Yue Gong, Shenming Huang, Xuechao Xing, Ziyu Lv, Junjie Wang, Jia-Qin Yang, Guohua Zhang, Ye Zhou, Su-Ting Han
Summary: The study developed an artificial LGMD visual neuron using light-mediated threshold switching memristor to mimic the escape response of LGMD neuron. Additionally, robot navigation with obstacle avoidance capability and biomimetic compound eyes with wide field-of-view detection capability were demonstrated.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Multidisciplinary
Alexandra Annemarie Ludwig, Sylvia Meuret, Rolf-Dieter Battmer, Marc Schoenwiesner, Michael Fuchs, Arne Ernst
Summary: Spatial hearing is crucial in real life but deteriorates in participants with severe sensorineural hearing loss or single-sided deafness. This study investigated sound localization ability in participants with single-sided deafness using a unilateral cochlear implant (CI). Results showed that CI can largely restore sound localization ability in participants, with some difficulties remaining at frontal locations and on the CI side. Improved speech understanding in noise was observed with CI, particularly when sound localization was also enhanced.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Joerg Encke, Mathias Dietz
Summary: This study introduces a new method to obtain binaural statistics of tones, which can be used to study masking effects in binaural hearing more directly.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Rei Yamada, Hiroshi Kuba
Summary: Clustering of synapses at distal dendritic branches strengthens sublinear integration within a dendritic tree and enables integration of signals from different trees, maintaining the dynamic range of binaural computation. This clustering differs based on dendritic length and frequency tuning of neurons, being most prominent for long dendrites and low-frequency tuning, ensuring binaural spatial hearing for wide intensity and frequency ranges.
Article
Audiology & Speech-Language Pathology
Kongyan Li, Vani G. Rajendran, Ambika Prasad Mishra, Chloe H. K. Chan, Jan W. H. Schnupp
Summary: The study found that neural d' values show similar trends with behavioral performance under different conditions, and neural d' correlates better with behavioral performance compared to mutual information (MI). Additionally, when ITD values are encoded as left or right ear leading, results from neural d' and MI are highly correlated.
Article
Neurosciences
Jianzhi Zeng, Xuelin Li, Renzimo Zhang, Mingyue Lv, Yipan Wang, Ke Tan, Xiju Xia, Jinxia Wan, Miao Jing, Xiuning Zhang, Yu Li, Yang Yang, Liang Wang, Jun Chu, Yan Li, Yulong Li
Summary: This study found that dopamine bi-directionally regulates the temporal window of olfactory learning in Drosophila and affects the synaptic plasticity of Kenyon cells in the mushroom body. The release of acetylcholine by KCs activates the serotonergic DPM neuron, which provides inhibitory feedback to KCs. The study also discovered that 5-HT signals have spatial heterogeneity in the mushroom body and can proportionally gate the coincidence time windows of different compartments.
Article
Neurosciences
Maike Klingel, Bernhard Laback
Summary: The study explores the impact of visual reinforcement training on ITD cues for CI listeners, showing a slight increase in perceptual contribution of ITDs for 100-pps stimuli but limited impact for 300-pps stimuli. Additionally, adding azimuth-dependent ITDs to stimuli containing ILDs increased the extent of lateralization across both stimulus types. These findings suggest that training and incorporating robustly encoded low-rate ITD cues may enhance sound localization with future CI systems.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
William O. Gray, Paul G. Mayo, Matthew J. Goupell, Andrew D. Brown
Summary: Empirical measurements of binaural cue transmission via bilateral cochlear implants (BiCIs) revealed that asymmetric spectral peak-picking may degrade binaural cues, particularly envelope ITD cues, for source locations away from the midline. Additionally, pulse amplitude saturation due to nonlinear level mapping resulted in smaller ILDs at higher presentation levels. Furthermore, variation in transmitted envelope ITDs due to independent left and right processor clocks was observed, suggesting potential avenues for improvement of BiCI technology.
Article
Acoustics
Monica L. Folkerts, Erin M. Picou, G. Christopher Stecker
Summary: Spectral weighting of sound localization cues in the presence of competing noise was measured. The results showed that the perceptual weight was highest for components within the interaural time difference (ITD) dominance region, with a shift towards lower-frequency components in all competing noise conditions. These findings contradict previous studies suggesting a shift towards higher frequencies, but support the idea that low-frequency ITD cues are least disrupted by competing noise.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Biology
Tom P. Franken, Brian J. Bondy, David B. Haimes, Joshua H. Goldwyn, Nace L. Golding, Philip H. Smith, Philip X. Joris
Summary: The study found that Lateral Superior Olive (LSO) neurons exhibit exquisite sensitivity to interaural time differences (ITDs) and can accurately process transient sound information. Inhibition in LSO neurons can block excitation over an extremely short window, achieved through inhibitory synapses on the axon initial segment.
Article
Multidisciplinary Sciences
James B. Isbister, Vicente Reyes-Puerta, Jyh-Jang Sun, Illia Horenko, Heiko J. Luhmann
Summary: The study investigates how information is encoded in the nervous system through patterns of action potentials, specifically focusing on multi-neuron patterns of single spikes during stimulus-evoked responses. It is found that spike time patterns between neurons are influenced by trial-to-trial changes in shared excitability, leading to time-warped differences that explain the lack of fixed spike time patterns and noise correlations reported. Additionally, the study suggests the potential of spike time pattern modulation by population-wide trial-to-trial changes in excitability, introducing the concept of state-dependent coding and proposing an improved encoding capacity.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Woongsang Sunwoo
Summary: This study examined the effect of neonatal deafness on the processing of interaural time differences (ITDs) in cochlear-implant stimuli. Animal studies have shown differences in neural ITD sensitivity based on the intracochlear location of stimulating electrodes. The results suggest that neonatal deafness significantly impacts ITD sensitivity and tuning patterns in the inferior colliculus.
Article
Neurosciences
Catherine E. Carr, Sahil Shah, Thomas McColgan, Go Ashida, Paula T. Kuokkanen, Sandra Brill, Richard Kempter, Hermann Wagner
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Multidisciplinary Sciences
Go Ashida, Kazuo Funabiki, Jutta Kretzberg
Article
Neurosciences
Stefan N. Oline, Go Ashida, R. Michael Burger
JOURNAL OF NEUROSCIENCE
(2016)
Article
Acoustics
Amin Saremi, Rainer Beutelmann, Mathias Dietz, Go Ashida, Jutta Kretzberg, Sarah Verhulst
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2016)
Article
Biochemical Research Methods
Go Ashida, Jutta Kretzberg, Daniel J. Tollin
PLOS COMPUTATIONAL BIOLOGY
(2016)
Article
Biochemical Research Methods
Go Ashida, Daniel J. Tolling, Jutta Kretzberg
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Neurosciences
Paula T. Kuokkanen, Go Ashida, Anna Kraemer, Thomas McColgan, Kazuo Funabiki, Hermann Wagner, Christine Koeppl, Catherine E. Carr, Richard Kempter
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Paula T. Kuokkanen, Go Ashida, Catherine E. Carr, Hermann Wagner, Richard Kempter
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Mathematical & Computational Biology
Go Ashida, Kazuo Funabiki, Catherine E. Carr
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2013)
Article
Neurosciences
Amarins N. Heeringa, Lichun Zhang, Go Ashida, Rainer Beutelmann, Friederike Steenken, Christine Koeppl
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemical Research Methods
Go Ashida, Helen T. Heinermann, Jutta Kretzberg
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Biochemical Research Methods
Go Ashida, Daniel J. Tollin, Jutta Kretzberg
Summary: Sound localization heavily relies on precise timing and intensity differences in sound inputs to both ears. While aging leads to a loss of inhibitory synaptic transmission in the auditory system, activity-dependent plasticity may help neurons maintain their binaural tuning function. Computational modeling suggests that compensatory mechanisms, such as adjusting the strength of remaining inhibitory inputs, can mitigate the negative effects of inhibition loss on sound localization.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Amarins N. Heeringa, Fiona Teske, Go Ashida, Christine Koeppl
Summary: Aging and cochlear degeneration lead to functional changes in auditory nerve fibers (ANFs). This study found that ANFs in aged gerbils had lower spontaneous rates (SRs) for low-frequency signals and a loss of low-SR fibers for high-frequency signals. The distribution of rate-level function (RLF) types also changed in aged ANFs. A physiologically based cochlear model was used to simulate these effects, revealing that the changes in SR and RLF types were due to both striatal degeneration and reduced basilar membrane gain.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Lena Koepcke, Go Ashida, Jutta Kretzberg
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2016)
Review
Acoustics
Go Ashida
ACOUSTICAL SCIENCE AND TECHNOLOGY
(2015)
