Article
Clinical Neurology
Jing Lin, Min Zhu, Xiaocheng Mao, Zeqing Jin, Meihong Zhou, Daojun Hong
Summary: Anti-DPPX encephalitis is a rare autoimmune encephalitis with a wide range of clinical symptoms, which may also include mild manifestations. The case report describes a patient who achieved complete recovery through immunoglobulin and corticosteroid therapy.
Article
Clinical Neurology
Ailiang Miao, Yongwei Shi, Xiaoshan Wang, Jianqing Ge, Chuanyong Yu
Summary: Anti-DPPX encephalitis mainly presents as neuropsychiatric symptoms. Most patients show marked improvement after immunotherapy, and brain magnetic resonance imaging is usually normal, while EEG shows diffuse slowing.
FRONTIERS IN NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Xiaoqing Yang, Yi Zhu, Qin Shi, Xinxin Zhao, Yan Huang, Feng Yao, Yuquan Zhang, Zhiwei Wang
Summary: DPPIV enhances tumor properties in EC through IL-6 and STAT3 signaling pathways. IL-6 triggers a positive feedback loop that increases DPPIV expression, while a DPPIV inhibitor reduces STAT3 expression and inhibits EC cell growth.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Food Science & Technology
Haixi You, Yu Zhang, Tianliang Wu, Juanrui Li, Liying Wang, Zhipeng Yu, Jingbo Liu, Xuebo Liu, Long Ding
Summary: This study aimed to investigate the DPP-IV inhibitory peptides from rapeseed proteins. The results showed that rapeseed protein hydrolysates had DPP-IV inhibitory activities. In silico approach was used to select potential DPP-IV inhibitory peptides and 12 of them were determined to have inhibitory activities. Four peptides (IPK, LPR, VPHL, and IPNQT) were identified from rapeseed protein hydrolysate, with IPK exhibiting the highest inhibitory activity. IPK acted as a competitive inhibitor and interacted with specific residues in the S1 and S2 pockets of DPP-IV. These findings suggest that rapeseed proteins are a valuable source of DPP-IV inhibitory peptides for the management of type 2 diabetes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Simon Nicot, Ghislain Gillard, Hathaichanok Impheng, Ewa Joachimiak, Serge Urbach, Kazufumi Mochizuki, Dorota Wloga, Francois Juge, Krzysztof Rogowski
Summary: Tubulin posttranslational modifications play a critical role in regulating microtubule functions. This study identifies and characterizes a family of tubulin-modifying enzymes, TMCP1 and TMCP2, which are involved in the processing of alpha- and beta-tubulin C-terminal tails and deglutamylation. TMCP1 acts as an alpha-tubulin detyrosinase and alpha Delta 2-tubulin catalyzer, while TMCP2 modifies beta I-tubulin and removes three amino acids from its C terminus, generating a previously unknown beta I Delta 3 modification.
Article
Nutrition & Dietetics
Yuki Shimizu, Hiroshi Hara, Tohru Hira
Summary: Although glucose is the most well-known nutrient to stimulate GLP-1 secretion, dietary peptides also play a significant role in stimulating GLP-1 secretion and inhibiting DPP-4 activity. Whey protein administration resulted in less degradation of GLP-1 compared to other nutrients, indicating a potential protective effect of dietary peptides on GLP-1.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Neurosciences
Yutaro Komuro, Ludovic Galas, Yury M. Morozov, Jennifer K. Fahrion, Emilie Raoult, Alexis Lebon, Amanda K. Tilot, Shin Kikuchi, Nobuhiko Ohno, David Vaudry, Pasko Rakic, Hitoshi Komuro
Summary: The study reveals that galanin plays a role in accelerating neuronal cell migration during normal brain development by altering signaling pathways, and its levels are affected by brain injury which in turn influences granule cell migration. This suggests that manipulating galanin signaling could be a potential therapeutic target for acute brain injuries during development.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Mona Mashayekhi, Jessica R. Wilson, Scott Jafarian-Kerman, Hui Nian, Chang Yu, Megan M. Shuey, James M. Luther, Nancy J. Brown
Summary: Genetic variation in the gene encoding the GLP-1 receptor may affect the metabolic response to DPP-4 inhibitors. The rs6923761 variant was associated with decreased postprandial glucose excursion in individuals with type 2 diabetes and hypertension. The study suggests a potential role of GLP1R rs6923761 genotype in modulating GLP-1 signaling in response to treatment.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Julio Rosenstock, Ahmed A. Kolkailah, Darren K. McGuire, Mark A. Espeland, Michaela Mattheus, Egon Pfarr, Soren S. Lund, Nikolaus Marx
Summary: The CAROLINA trial showed the non-inferiority of linagliptin compared to glimepiride in terms of major adverse cardiovascular events in patients with early type 2 diabetes and increased cardiovascular risk. The study also demonstrated that linagliptin significantly reduced the hypoglycaemic burden across all categories, including severe episodes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Sara Matic, Ivana Kekez, Marko Tomin, Ferenc Bogar, Filip Supljika, Sasa Kazazic, Maja Hanic, Shalinee Jha, Hrvoje Brkic, Benjamin Bourgeois, Tobias Madl, Karl Gruber, Peter Macheroux, Dubravka Matkovic-Calogovic, Mihaela Matovina, Sanja Tomic
Summary: This study highlights the synergy between theory and experiment in elucidating the binding mechanism between DPP III and KEAP1, shedding light on the significance of the NRF2-KEAP1 signaling pathway in antioxidant stress response.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Endocrinology & Metabolism
Yunyun Wu, Yun Li, Miao Sun, Fangliu Yu, Hui Liu, Jingyun Xu, Xingli Tang
Summary: This study demonstrates that FAP deficiency protects mice against diet-induced obesity and related metabolic dysfunction. This protective effect is probably mediated through the promotion of WAT beiging and suppression of inflammation.
Article
Plant Sciences
Erica Hawkins, Jiawen Chen, Alexander Watson-Lazowski, Jennifer Ahn-Jarvis, J. Elaine Barclay, Brendan Fahy, Matthew Hartley, Frederick J. Warren, David Seung
Summary: The role of SS4 in wheat grain development was investigated through TILLING mutants, which showed severe alterations in starch granule morphology. SS4 deficiency results in compound granule formation, similar to mutants deficient in BGC1. Both SS4 and BGC1 are required for proper control of granule initiation during early grain development, leading to the formation of a single A-type granule per amyloplast.
Article
Medicine, Research & Experimental
Cristina Bouzas, Rosario Pastor, Silvia Garcia, Margalida Monserrat-Mesquida, Miguel Angel Martinez-Gonzalez., Jordi Salas-Salvado, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Olga Fernandez-Barcelo, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majema, Blanca Riquelme-Gallegop, Vicente Martin-Sanchez, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia, Josep Vidal, Jersy-Jair Cardenas-Salas, Lidia Daimiel, Emilio Ros, Estefania Toledo, Josep M. Manzanares, Inmaculada Gonzalez-Monge, Miguel-Angel Munoz, Diego Martinez-Urbistondo, Lucas Tojal-Sierra, Carlos Munoz-Bravoaf, Salvador Miralles-Gisbert, Marian Martin, Antonio Garcia-Rios, Sara Castro-Barquero, Jose Carlos Fernandez-Garcia, Jose Manuel Santos-Lozano, F. Javier Basterra-Gortari, Liliana Gutierrez-Carrasquilla, Patricia Guillem-Saiz, Alba Satorres, Itziar Abete, Carolina Sorto-Sanchez, Javier Diez-Espino, Nancy Babio, Montse Fito, Josep A. Tur
Summary: In a one-year study involving 6881 patients with MetS, it was found that those treated with GLP-1RA and DPP-4I had better glycemic profiles, but improvements in weight and waist circumference were modest.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Analytical
Yibo Zhou, Xiaofei Ma, Shan Hu, Sheng Yang, Jingru Guo, Junbin Li, Yue-Fei Zhang, Juewen Liu, Zhihe Qing, Ronghua Yang
Summary: In this study, a signaling manner called ATP-specific polyvalent hydrogen binding (APHB) was discovered, which mimics the ATP/aptamer binding process but avoids interference from biomolecules. An ATP-specific binding-lighted fluorophore (ABF) was successfully obtained and used for amplification biosensing of fibroblast activation protein (FAP) in activated hepatic stellate cells. The ATP-powered amplification enabled sensitive detection and imaging of FAP, revealing the potential relationship between hepatocyte differentiation and FAP concentration, highlighting the great potential of APHB-mediated signaling for intracellular sensing.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Ting-Hao Chen, Chen-Cheng Yang, Kuei-Hau Luo, Chia-Yen Dai, Yao-Chung Chuang, Hung-Yi Chuang
Summary: This study utilized whole genomic genotypes from the Taiwan Biobank to explore the association between Al concentrations in plasma and renal function, identifying a link between DPP6 SNPs, plasma Al concentrations, and eGFR. Further longitudinal studies and research on mechanism are needed to validate these findings. This analysis represents the first study to investigate the impact of DPP6, SNPs, and Al in plasma on eGFR.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)