Article
Neurosciences
Yuan Chang-Halabi, Jose Cordero, Xander Sarabia, Daniela Villalobos, Nelson P. Barrera
Summary: This review discusses the mechanism of interaction between P2X and 5-HT3 receptors, providing current evidence supporting this crosstalk at the structural to the transduction pathway level. We expect this work to guide the design of further experiments to obtain a comprehensive view of the neuropharmacological role of these interacting receptors.
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Psychiatry
Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-Koenig, Deborah Janowitz, Hans J. Grabe
Summary: Previous studies have suggested a connection between childhood trauma, serotonergic neurotransmission, and alexithymia. The study found that childhood trauma and the rs6295 polymorphism have a significant interaction effect on alexithymia in male subjects.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Psychology, Multidisciplinary
Chunhua Ju, Geyao Li, Fuguang Bao, Ting Gao, Yiling Zhu
Summary: This study aims to improve the accuracy of link prediction in directed social networks by proposing a four-dimensional link prediction model that integrates personality link preference and asymmetric interaction. Comparative experiments confirm the higher accuracy of the proposed model compared to the model based solely on similarity.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Magdalena Janc, Mariola Sliwinska-Kowalska, Magdalena Jozefowicz-Korczynska, Pawel Marciniak, Oskar Rosiak, Rafal Kotas, Zuzanna Szmytke, Joanna Grodecka, Ewa Zamyslowska-Szmytke
Summary: This study found that the performance of the MediPost sensor in balance testing is significantly better than the force plate in patients with unilateral vestibular dysfunction and healthy individuals. The sensitivity and specificity of the MediPost sensor were best in all conditions, indicating its potential for use in clinical balance assessments.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Ecology
Matthew J. Silk, Robbie A. McDonald, Richard J. Delahay, Daniel Padfield, David J. Hodgson
Summary: Long-term capture-mark-recapture data can provide valuable information on individual movements and social structures in populations. The CMRnet package introduced in this study generates social and movement networks from spatially explicit capture-mark-recapture data, with important applications in wildlife management and conservation.
METHODS IN ECOLOGY AND EVOLUTION
(2021)
Article
Food Science & Technology
Ben Wei, Huiping Xiao, Baocai Xu, Kamil Kuca, Zihui Qin, Xinyi Guo, Wenda Wu, Qinghua Wu
Summary: Type B trichothecenes, including DON and four congeners, cause emetic reactions in human and animal due to food contamination. PYY and 5-HT play key roles in the emetic reactions induced by these mycotoxins.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiaojiao Hua, Zhengyi Yang, Tianzi Jiang, Shan Yu
Summary: The complexity of the human brain is determined by the orchestrated expression of thousands of genes, while pairwise interactions between genes are sufficient to predict the transcriptional pattern of the brain. This quadratic complexity of transcriptional patterns in the human brain, as revealed by the study, highlights the importance of gene-gene interactions in the functional and structural richness of the brain.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Liza J. Severs, Nicholas E. Bush, Lely A. Quina, Skyler Hidalgo-Andrade, Nicholas J. Burgraff, Tatiana Dashevskiy, Andy Y. Shih, Nathan A. Baertsch, Jan-Marino Ramirez
Summary: Sighs play important roles in lung function, emotional expression and arousal. The preBotzinger complex (preBotC) is involved in the generation of spontaneous and hypoxia-induced sighs. Purinergic signaling is necessary for the generation of sighs and increasing astrocytic calcium levels can enhance sigh frequency.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Elise C. Wilcox, Elazer R. Edelman
Summary: Endothelial cells interact with and regulate the immune system, modulating immune cell function through the expression of various molecules and influencing immune recognition outcomes. Cell-substratum interactions impact endothelial cell phenotype and subsequently affect the immune response to transplanted cells. Endothelial cells grown on different substrata exhibit distinct basal expression levels and responsiveness to inflammatory stimuli. Understanding the relationship between endothelial cell substratum and allorecognition is crucial for predicting and modifying the outcome of endothelial cell-immune interactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiaqi Jin, Fan Xu, Yi Zhang, Jing Guan, Xiurui Liang, Yuxin Zhang, Ansheng Yuan, Runkun Liu, Jihua Fu
Summary: This study investigated the relationship between RIRI and the activation of the renal 5-HT degradation system, revealing that inhibiting 5-HT2AR and 5-HT synthases can alleviate RIRI-induced damage, highlighting the involvement of 5-HT2AR in this process.
Article
Neurosciences
[Anonymous]
Article
Neurosciences
Thomas H. Miller, Katie Clements, Sungwoo Ahn, Choongseok Park, Eoon Hye Ji, Fadi A. Issa
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Choongseok Park, Katie N. Clements, Fadi A. Issa, Sungwoo Ahn
FRONTIERS IN NEURAL CIRCUITS
(2018)
Article
Biology
Katie N. Clements, Thomas H. Miller, Jared M. Keever, Amanda M. Hall, Fadi A. Issa
BIOLOGICAL BULLETIN
(2018)
Article
Cell Biology
Fadi A. Issa, Allan F. Mock, Alvaro Sagasti, Diane M. Papazian
DISEASE MODELS & MECHANISMS
(2012)
Article
Biology
Fadi A. Issa, Georgeann O'Brien, Petronella Kettunen, Alvaro Sagasti, David L. Glanzman, Diane M. Papazian
JOURNAL OF EXPERIMENTAL BIOLOGY
(2011)
Article
Neurosciences
Julien Bacque-Cazenave, Fadi A. Issa, Donald H. Edwards, Daniel Cattaert
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
Fadi A. Issa, Christopher Mazzochi, Allan F. Mock, Diane M. Papazian
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Fadi A. Issa, Joanne Drummond, Daniel Cattaert, Donald H. Edwards
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Jui-Yi Hsieh, Brittany Ulrich, Fadi A. Issa, Jijun Wan, Diane M. Papazian
FRONTIERS IN NEURAL CIRCUITS
(2014)
Article
Physiology
Julien Bacque-Cazenave, Pascal Fossat, Fadi A. Issa, Donald H. Edwards, Jean Paul Delbecque, Daniel Cattaert
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Biology
Jui-Yi Hsieh, Brittany N. Ulrich, Fadi A. Issa, Meng-chin A. Lin, Brandon Brown, Diane M. Papazian
Article
Behavioral Sciences
Stephen A. Orr, Sungwoo Ahn, Choongseok Park, Thomas H. Miller, Miki Kassai, Fadi A. Issa
Summary: This study investigates the impact of social status on neural circuits regulation of motor behavior through the endocannabinoid system (ECS) in dominants and subordinates, suggesting that ECS plays a role in mediating swimming activity patterns and startle escape response sensitivity. The findings demonstrate that social factors influence nervous system function by regulating the ECS to optimize motor output, revealing the balance in synaptic strength between excitatory and inhibitory inputs controlled by social status.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Jonathan J. Carver, Skyler C. Carrell, Matthew W. Chilton, Julia N. Brown, Lengxob Yong, Yong Zhu, Fadi A. Issa
Summary: Aggression is a fundamental behavior in animal species, but excessive or insufficient aggression can have negative consequences for individuals and group members. Research has shown the importance of nuclear steroid hormone receptors in regulating aggressive behaviors in male zebrafish.
HORMONES AND BEHAVIOR
(2021)
Article
Biology
Fadi A. Issa, M. Kristen Hall, Cody J. Hatchett, Douglas A. Weidner, Alexandria C. Fiorenza, Ruth A. Schwalbe
Summary: This study investigates the role of N-glycans in modulating potassium channel function in highly repetitive firing neurons, showing that N-glycosylation processing of Kv3.1b regulates neuronal development and excitability, thereby controlling motor activity. The replacement of complex N-glycans with oligomannose on Kv3.1b results in slowed opening and closing rates of Kv3 channels, suggesting a reduction in intrinsic dynamics of the Kv3.1b alpha-subunit.