Article
Neurosciences
Georgios A. Keliris, Yibin Shao, Michael C. Schmid, Mark Augath, Nikos K. Logothetis, Stelios M. Smirnakis
Summary: In adult macaque monkeys, the higher order visual areas V2/V3 display significant capacity for topographic reorganization following retinal lesions, exceeding the corresponding capacity of area V1. Neurons inside the lesion projection zone (LPZ) reorganize by receiving input from either the fovea or the peripheral border of the LPZ.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Richard T. Ibitoye, Emma-Jane Mallas, Niall J. Bourke, Diego Kaski, Adolfo M. Bronstein, David J. Sharp
Summary: The study investigates the functional anatomy of OP2 and adjacent areas in the posterior peri-sylvian cortex, which is proposed to be the core human vestibular cortex. The results show that different functional subregions of OP2 exhibit strong connectivity to other vestibular areas and distinct responses to visual and caloric stimulation, suggesting a central role for vestibular function in health and disease.
Article
Clinical Neurology
Sinem Balta Beylergil, Angela M. Noecker, Mikkel Petersen, Palak Gupta, Sarah Ozinga, Mark F. Walker, Camilla Kilbane, Cameron C. McIntyre, Aasef G. Shaikh
Summary: The study revealed that patients with Parkinson's disease showed lower accuracy in vestibular perception compared to healthy controls, but significant improvement was observed after deep brain stimulation treatment. However, there were no significant differences in visual heading perception between patients and controls.
JOURNAL OF NEUROLOGY
(2022)
Review
Biology
Steven J. Jerjian, Devin R. Harsch, Christopher R. Fetsch
Summary: In order to navigate and guide adaptive behaviour in a dynamic environment, animals need to accurately estimate their own motion relative to the external world. This process involves the integration of visual, vestibular and kinesthetic inputs. Recent research has shown that time and certainty are crucial for self-motion perception and decision-making in navigation. By extending current models, researchers have been able to study confidence in heading discrimination and explore the connection between self-motion perception and navigation. Overall, this study offers promise for a deeper understanding of spatial perception and decision-making in behaving animals.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Wei Gao, Yipeng Lin, Jiangrong Shen, Jianing Han, Xiaoxiao Song, Yukun Lu, Huijia Zhan, Qianbing Li, Haoting Ge, Zheng Lin, Wenlei Shi, Jan Drugowitsch, Huajin Tang, Xiaodong Chen
Summary: Gaze changes can disrupt spatial reference frames encoding visual and vestibular signals in the brain, impacting heading discrimination. Through altering eye and head positions, the study examined the effects of gaze changes on heading discrimination using visual, vestibular, and combined stimuli. The results revealed that gaze changes led to biases in perceived heading, increased discrimination thresholds, and reaction time across all stimulus conditions. The effects differed for visual and vestibular stimuli, with visual gaze effects biasing heading perception in the opposite direction of gaze and vestibular gaze effects biasing heading perception in the same direction of gaze. Integration of visual and vestibular signals deviated from predictions of an optimal diffusion model. These findings highlight the diverse effects of gaze changes on heading discrimination and emphasize the importance of spatial reference frame transformation.
Article
Biology
Spencer Chin-Yu Chen, Giacomo Benvenuti, Yuzhi Chen, Satwant Kumar, Charu Ramakrishnan, Karl Deisseroth, Wilson S. Geisler, Eyal Seidemann
Summary: The study investigates whether direct stimulation of primate V1 can substitute for a visual stimulus and mimic its perceptual effect. The researchers developed an optical-genetic toolkit to 'read' and 'write' neural population responses in behaving macaques. The results show that low-power optogenetic stimulation in V1 can mimic the visual masking effect, and there is a sublinear interaction between visual and optogenetic-evoked V1 responses that accounts for this effect. These findings provide further insights into perceptual substitutions by direct stimulation of sensory cortex.
Article
Multidisciplinary Sciences
Chen Fang, Xingya Cai, Haidong D. Lu
Summary: In mammals, there is a higher number of neurons in the V1 area dedicated to cardinal orientations than to oblique orientations. However, studies on macaque monkeys have produced conflicting results regarding the orientation distribution in their visual cortex. It has also been unclear whether different visual areas in the cortex exhibit different orientation anisotropies. This study analyzed optical imaging data and found that both V1 and V4 exhibit significant orientation anisotropies, but with different overrepresented orientations. These findings suggest that different cortical areas have evolved to prioritize different features for their functional purposes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Ken-ichi Okada, Ryuji Takeya, Masaki Tanaka
Summary: This study investigated the response properties of cerebellar cells in macaques performing synchronized saccades and identified three groups of cerebellar neurons with distinct response profiles. One-third of the neurons were active regardless of saccade direction and showed greater activity for synchronized saccades. The activity of these neurons corresponded to the internal rhythmic structure rather than specific motor commands.
NATURE COMMUNICATIONS
(2022)
Review
Neurosciences
Ming Li, Niansheng Ju, Rundong Jiang, Fang Liu, Hongfei Jiang, Stephen Macknik, Susana Martinez-Conde, Shiming Tang
Summary: This study found that the three primary dimensions of human color perception (hue, lightness, and chroma) are determined in the earliest cortical stages, based on cortical color responses in macaques.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biology
Ying Zhang, Kenneth E. Schriver, Jia Ming Hu, Anna Wang Roe
Summary: Spatial frequency is an important attribute in the visual scene and how it is encoded in extrastriate areas of primate visual cortex remains unclear. This study used optical imaging to investigate the relationship between spatial frequency maps and visual topography, color, and orientation maps. The findings suggest a population-based spatial frequency organization that is related to color and orientation in different cortical areas.
Article
Neurosciences
Valerie Nunez, James Gordon, Robert Shapley
Summary: In this study, the chromatic visual evoked potential (cVEP) was used to investigate the responses in human visual cortex to equiluminant color stimuli. The results showed that there were distinct dynamic differences in cVEP responses to single-opponent and double-opponent stimuli, supporting the hypothesis that the single-opponent signals in the cVEP come from a specific population of cells that receive subtractive inputs from L and M cones.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Thomas Decramer, Elsie Premereur, Qi Zhu, Wim Van Paesschen, Johannes van Loon, Wim Vanduffel, Jessica Taubert, Peter Janssen, Tom Theys
Summary: The study showed that single neurons in the human visual cortex exhibit selective activity for faces, suggesting the importance of neural mechanisms in human face recognition. This provides crucial experimental evidence linking imaging studies in humans and invasive studies in animal models.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biology
Zhao Zeng, Ce Zhang, Yong Gu
Summary: Multi-sensory decision making (MSDM) is crucial for making accurate decisions in complex environments. Recent research in computational theory, psychophysical behavior, and neurophysiology has made significant progress in understanding MSDM. By studying a visuo-vestibular heading model system, researchers have uncovered the complex temporal dynamics of vestibular signals in various brain regions, challenging the brain's ability to integrate cues across time and sensory modalities. Moreover, new evidence from higher-level decision-related areas has revised our understanding of how signals from different sensory modalities are processed and accumulated to form a unified perceptual decision.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Grace A. A. Gabriel, Laurence R. R. Harris, Denise Y. P. Henriques, Maryam Pandi, Jennifer L. L. Campos
Summary: The study aimed to improve self-motion heading perception in older adults and younger adults through providing feedback, demonstrating that visual heading perception can be enhanced through multisensory training. Older adults showed better integration throughout the study, while younger adults only exhibited optimal integration post-training.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sinem Balta Beylergil, Mikkel Petersen, Palak Gupta, Mohamed Elkasaby, Camilla Kilbane, Aasef G. Shaikh
Summary: The study found that Parkinson's disease affects motion perception in both the visual and vestibular domains, with a more severe impact on vestibular perception compared to visual perception, depending on the severity of the disease.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Reuben H. Fan, Sheng Liu, Gregory C. DeAngelis, Dora E. Angelaki
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Xaq Pitkow, Sheng Liu, Dora E. Angelaki, Gregory C. DeAngelis, Alexandre Pouget
Article
Neurosciences
Xiaoxiu Tie, Shuo Li, Yilin Feng, Biqin Lai, Sheng Liu, Bin Jiang
Article
Neurosciences
Sheng Liu, J. David Dickman, Dora E. Angelaki
Article
Neurosciences
Sheng Liu, Tatyana Yakusheva, Gregory C. DeAngelis, Dora E. Angelaki
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. DeAngelis, Dora E. Angelaki
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Sheng Liu, Yong Gu, Gregory C. DeAngelis, Dora E. Angelaki
NATURE NEUROSCIENCE
(2013)
Article
Neurosciences
Yong Gu, Sheng Liu, Christopher R. Fetsch, Yun Yang, Sam Fok, Adhira Sunkara, Gregory C. DeAngelis, Dora E. Angelaki
Article
Multidisciplinary Sciences
Sheng Liu, J. David Dickman, Shawn D. Newlands, Gregory C. DeAngelis, Dora E. Angelaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Cell Biology
Dongchang Xiao, Kangxin Jin, Suo Qiu, Qiannan Lei, Wanjing Huang, Haiqiao Chen, Jing Su, Qiang Xu, Zihui Xu, Bin Gou, Xiaoxiu Tie, Feng Liu, Sheng Liu, Yizhi Liu, Mengqing Xiang
Summary: This study demonstrates that a combination of transcription factors Math5 and Brn3b can reprogram mature mouse Muller glia cells into retinal ganglion cells (RGCs), which show proper axon projections and improve visual responses in mouse models with RGC loss. This discovery suggests a promising new therapeutic approach for restoring vision in patients with glaucoma and other optic neuropathies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Zhao-Zhe Hao, Jia-Ru Wei, Dongchang Xiao, Ruifeng Liu, Nana Xu, Lei Tang, Mengyao Huang, Yuhui Shen, Changsheng Xing, Wanjing Huang, Xialin Liu, Mengqing Xiang, Yizhi Liu, Zhichao Miao, Sheng Liu
Summary: The study used single-cell RNA sequencing and culturing techniques to investigate adult neurogenesis in the macaque hippocampus. The analysis revealed the presence of various neural precursor cell populations and the processes involved in adult neurogenesis. This study provides a comprehensive atlas of adult neurogenesis in primates.
NATURE NEUROSCIENCE
(2022)
Article
Cell Biology
Wanjing Huang, Qiang Xu, Jing Su, Lei Tang, Zhao-zhe Hao, Chuan Xu, Ruifeng Liu, Yuhui Shen, Xuan Sang, Nana Xu, Xiaoxiu Tie, Zhichao Miao, Xialin Liu, Ying Xu, Feng Liu, Yizhi Liu, Sheng Liu
Summary: In this study, we characterized the transcriptomic, morphological, and functional features of 472 high-quality RGCs using Patch-seq. The findings provide functional and morphological annotation for different transcriptomic-defined cell types in a previously established RGC atlas. The research highlights the convergence of different modalities in defining RGC identity and identifies differentially expressed genes among RGC subtypes, which could serve as candidate marker genes for functional studies.
Article
Multidisciplinary Sciences
Jia-Ru Wei, Zhao-Zhe Hao, Chuan Xu, Mengyao Huang, Lei Tang, Nana Xu, Ruifeng Liu, Yuhui Shen, Sarah A. Teichmann, Zhichao Miao, Sheng Liu
Summary: The study describes a single-cell RNA sequencing dataset of macaque V1 cortex cells, revealing similarities and specific markers compared to human cortex. Differences in gene expression profiles and neuron diversity across species were found, providing insights into cognitive functions.
NATURE COMMUNICATIONS
(2022)
Article
Ophthalmology
Wanjing Huang, Qiang Xu, Feng Liu, Jing Su, Dongchang Xiao, Lei Tang, Zhao-Zhe Hao, Ruifeng Liu, Kangjian Xiang, Yalan Bi, Zhichao Miao, Xialin Liu, Yizhi Liu, Sheng Liu
Summary: This study identified GABAergic amacrine cells expressing trophoblast glycoprotein (TPBG) in the retina of DAT-tdTomato transgenic mice, using experimental techniques such as immunostaining and patch-sequencing.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biology
Jean Laurens, Sheng Liu, Xiong-Jie Yu, Raymond Chan, David Dickman, Gregory C. DeAngelis, Dora E. Angelaki