Article
Biology
Somin Lee, Sarita S. Deshpande, Edward M. Merricks, Emily Schlafly, Robert Goodman, Guy M. McKhann, Emad N. Eskandar, Joseph R. Madsen, Sydney S. Cash, Michel J. A. M. van Putten, Catherine A. Schevon, Wim van Drongelen
Summary: This study investigates the relationship between the fast action potentials of individual neurons and the slower fluctuations of the local field potential by adding a spatial component. The theoretical derivation and real-world observations using microelectrode array recordings demonstrate a consistent pattern. The findings suggest that in some cases, the temporal pattern of neural activity can predict the underlying spatial pattern.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Simon Henin, Anita Shankar, Helen Borges, Adeen Flinker, Werner Doyle, Daniel Friedman, Orrin Devinsky, Gyorgy Buzsaki, Anli Liu
Summary: The spatiotemporal characteristics of cortical high-gamma activity, hippocampal ripple activity, and interictal epileptiform discharges have a significant impact on memory performance during an associative memory task, particularly in the hippocampal region. Interictal epileptiform discharges may impair associative memory by disrupting physiological activity, making them a promising therapeutic target for memory remediation in patients with epilepsy.
Article
Chemistry, Physical
Tarpan Maiti, Pushpita Ghosh
Summary: Designing and predicting self-organized pattern formation in out-of-equilibrium chemical and biochemical reactions is of fundamental significance. This study investigates the effects of photo-illumination and circularly polarized electric field on the spatiotemporal dynamics of a reaction-diffusion system, revealing various interesting pattern instabilities. The interplay between these two external influences leads to the emergence of distinct superlattice patterns with hexagonal and square-based symmetry.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Clinical Neurology
Sana Hannan, John Thomas, Kassem Jaber, Charbel El Kosseifi, Alyssa Ho, Chifaou Abdallah, Tamir Avigdor, Jean Gotman, Birgit Frauscher
Summary: Objective sleep has significant influences on focal interictal epileptiform discharges (IEDs), with increased rates and spatial extent in non-rapid eye movement (NREM) sleep. However, the effects of sleep on seizures are unclear, and its impact on seizure topography is poorly documented. This study evaluates the influences of NREM sleep on ictal spatiotemporal dynamics, finding that NREM sleep does not significantly affect these dynamics.
ANNALS OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Njikem Asong-Fontem, Arnau Panisello-Rosello, Mylene Sebagh, Mathilde Gonin, Joan Rosello-Catafau, Rene Adam
Summary: The scarcity of livers for transplantation is a growing concern and researchers are exploring new strategies to expand the donor pool. A study found that IGL-2 preservation solution demonstrated a protective role for fatty livers by preserving endothelial glycocalyx, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Eros Quarta, Alessandro Scaglione, Jessica Lucchesi, Leonardo Sacconi, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone
Summary: This study used wide-field calcium imaging in mice to investigate the neocortical dynamics during reach-to-grasp movements. The researchers found that beyond motor regions, other areas such as the visual and retrosplenial cortices also increased their activity levels during successful reach-to-grasp movements. Functional connectivity among neocortical areas increased transiently around movement onset and decreased during movement. However, neural activity levels correlated with kinematics measures of successful reach-to-grasp movements only in sensorimotor areas.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Physics, Multidisciplinary
F. Baldassi, F. D'Amico, A. Malizia, P. Gaudio
Summary: The novel coronavirus has rapidly spread globally, with only a few vaccines approved and no definitive treatments identified. Social distancing measures like quarantine are crucial in limiting virus transmission during an outbreak. Predictive epidemiological tools are essential for better managing emergencies like this and understanding the effectiveness of containment measures.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
Article
Physics, Multidisciplinary
A. Molavi Tabrizi, A. Mesgarnejad, M. Bazzi, S. Luther, J. Christoph, A. Karma
Summary: Research has found that rotating excitation waves during ventricular fibrillation (VF) are associated with rotating waves of mechanical deformation. There are two types of mechanical phase singularities: paired singularities that are colocalized with electrical phase singularities, and unpaired singularities that can form independently. The formation of unpaired singularities is influenced by the anisotropy of the active force field generated by fiber anisotropy and the nonlocality of elastic interactions. These insights can potentially be used to locate electrical rotor cores from mechanical measurements.
Article
Multidisciplinary Sciences
Keisuke Shimada, Soojin Park, Haruhiko Miyata, Zhifeng Yu, Akane Morohoshi, Seiya Oura, Martin M. Matzuk, Masahito Ikawa
Summary: The study revealed the crucial role of ARMC12 in sperm mitochondrial sheath formation, with its absence leading to reduced sperm motility and male sterility. ARMC12, a mitochondrial peripheral membrane protein, functions by interacting with mitochondrial membrane proteins VDAC2 and VDAC3 to form the mitochondrial sheath.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Fernando Hernandez-Sanchez, Leonardo Peraza-Reyes
Summary: Eukaryotic cell development involves precise regulation of organelles to adapt to changing requirements. Meiotic development involves the formation and dynamics of distinct intracellular membrane compartments, and plays important roles in organelle segregation, quality control, and cell rejuvenation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physics, Applied
Abderzak el Farsy, Essaid Chakib Tighidet, Charles Ballage, Tiberiu Minea
Summary: Electron powder bed fusion (E-PBF) is an additive manufacturing technology used to produce parts layer-wise. Precise control over the energy transferred to the powder is crucial for process improvements. This study used tunable diode laser absorption spectroscopy to characterize the evaporated titanium atoms and investigate the effects of the energy transferred by the electron beam.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Biology
Jesse R. Holt, Wei-Zheng Zeng, Elizabeth L. Evans, Seung-Hyun Woo, Shang Ma, Hamid Abuwarda, Meaghan Loud, Ardem Patapoutian, Medha M. Pathak
Summary: Mechanically activated ion channel PIEZO1 regulates keratinocyte migration and wound healing, with Piezo1 knockout mice exhibiting faster wound closure and gain-of-function mice displaying slower wound closure. The spatiotemporal dynamics of PIEZO1 channels play a key role in controlling tissue-scale events beyond wound healing.
Article
Medicine, General & Internal
Miao Zhang, Qikai Qin, Shuning Zhang, Wei Liu, Hongping Meng, Mengyang Xu, Xinyun Huang, Xiaozhu Lin, Mu Lin, Peter Herman, Fahmeed Hyder, Raymond C. Stevens, Zheng Wang, Biao Li, Garth J. Thompson
Summary: For patients with temporal lobe epilepsy, OGI imaging during inter-ictal period shows higher values on the same side as the epileptic focus compared to the opposite side. OGI results agree with invasive electrophysiology, providing promising insights into metabolic changes in epilepsy.
Article
Immunology
Nguyen Thi Tam, Nguyen To Anh, Trinh Son Tung, Pham Ngoc Thach, Nguyen Thanh Dung, Van Dinh Trang, Le Manh Hung, Trinh Cong Dien, Nghiem My Ngoc, Le Van Duyet, Phan Manh Cuong, Hoang Vu Mai Phuong, Pham Quang Thai, Nguyen Le Nhu Tung, Dinh Nguyen Huy Man, Nguyen Thanh Phong, Vo Minh Quang, Pham Thi Ngoc Thoa, Nguyen Thanh Truong, Tran Nguyen Phuong Thao, Dao Phuong Linh, Ngo Tan Tai, Ho The Bao, Vo Trong Vuong, Huynh Thi Kim Nhung, Phan Nu Dieu Hong, Le Thi Phuoc Hanh, Le Thanh Chung, Nguyen Thi Thanh Nhan, Ton That Thanh, Do Thai Hung, Huynh Kim Mai, Trinh Hoang Long, Nguyen Thu Trang, Nguyen Thi Hong Thuong, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Nguyen Thi Han Ny, Cao Thu Thuy, Le Kim Thanh, Lam Anh Nguyet, Le Thi Quynh Mai, Tang Chi Thuong, Le Hong Nga, Tran Tan Thanh, Guy Thwaites, H. Rogier Van Doorn, Nguyen Van Vinh Chau, Thomas Kesteman, Le Van Tan
Summary: We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam and identified the Alpha and Delta variants as the main drivers of a large-scale COVID-19 outbreak in 2021. The Delta variant, specific to the AY.57 lineage, resulted in over 1.7 million infections and more than 32,000 deaths. Nonpharmaceutical interventions had a significant impact on viral transmission.
EMERGING INFECTIOUS DISEASES
(2023)