Article
Medicine, General & Internal
Marjolein van der Vlegel, Suzanne Polinder, Ana Mikolic, Rana Kaplan, Nicole von Steinbuechel, Anne Marie Plass, Marina Zeldovich, Dominique van Praag, Fabian Bockhop, Katrin Cunitz, Isabelle Mueller, Juanita A. Haagsma
Summary: Research has shown that patients with mild traumatic brain injury (mTBI) are at risk for post-concussion (PC) symptoms, with 26.1% experiencing them, and post-traumatic stress disorder (PTSD) symptoms, with 9.8% experiencing them, with the majority experiencing both PC and PTSD symptoms. Patients with PC and/or PTSD symptoms reported lower health-related quality of life (HRQoL), higher rates of rehabilitation, and lower return to work rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
V Ouellet, V Boucher, F. Beauchamp, X. Neveu, P. Archambault, S. Berthelot, J. M. Chauny, E. De Guise, M. Emond, J. Frenette, E. Lang, J. Lee, Mercier, L. Moore, M. C. Ouellet, J. Perry, N. Le Sage
Summary: The study found that patients with concomitant injuries are more likely to experience post-concussion symptoms and have a higher risk of not returning to their normal activities compared to patients without concomitant injuries.
Article
Medicine, General & Internal
Fabian Bockhop, Marina Zeldovich, Sven Greving, Ugne Krenz, Katrin Cunitz, Dagmar Timmermann, Elena M. Bonke, Michaela V. Bonfert, Inga K. Koerte, Matthias Kieslich, Maike Roediger, Michael Staebler, Steffen Berweck, Thomas Paul, Knut Brockmann, Philine Rojczyk, Anna Buchheim, Nicole von Steinbuechel
Summary: This study examines the applicability of self-report and proxy versions of the German RPQ in adolescents after TBI. The results indicate that both self-report and proxy assessment forms of the German RPQ are suitable for evaluation in adolescents after TBI. However, proxy ratings tend to underestimate post-concussion symptoms (PCS).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Silje Christine Reistad Fure, Emilie Isager Howe, Oystein Spjelkavik, Cecilie Roe, Per-Ola Rike, Alexander Olsen, Jennie Ponsford, Nada Andelic, Marianne Lovstad
Summary: The study investigated patients with persistent post-concussion symptoms following mild-to-moderate TBI, finding a high symptom burden and decreased quality of life in the overall sample. Patients with traumatic intracranial abnormalities showed worse memory function compared to those without abnormalities. Therefore, in planning rehabilitation services for PPCS patients, factors beyond injury severity and traumatic intracranial abnormalities should be considered.
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Marina Zeldovich, Fabian Bockhop, Amra Covic, Katrin Cunitz, Suzanne Polinder, Juanita A. Haagsma, Nicole von Steinbuechel
Summary: This study aimed to provide reference values for the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) in the United Kingdom, the Netherlands, and Italy. The study analyzed data from general population samples and compared them with corresponding traumatic brain injury (TBI) samples. The results provide reference values for the total score and three sub-dimensions, which can be used in clinical practice and research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Medicine, General & Internal
Diego Rivera, Sven Greving, Juan Carlos Arango-Lasprilla, Nicole von Steinbuechel, Marina Zeldovich
Summary: This study analyzed the long-term changes in RPQ symptoms from three to twelve months after TBI and identified factors related to these symptoms. The results showed that the three-factor structure of RPQ remains stable within one year after TBI. Sex, injury cause, and prior psychiatric problems were found to be related to both the factor structure and total score of RPQ.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Kelvin Sunday Obiano, Rajiv Singh, Jeremy Dawson
Summary: This study investigated the incidence of persistent post-concussion symptoms and identified potential predictors of long-term disability. The findings confirmed the high occurrence of post-concussion symptoms at 1 year and identified certain associated features that increase risk, allowing for targeted intervention.
Article
Rehabilitation
Toril Skandsen, Jonas Stenberg, Turid Follestad, Migle Karaliute, Simen B. Saksvik, Cathrine E. Einarsen, Hanna Lillehaug, Asta K. Haberg, Anne Vik, Alexander Olsen, Grant L. Iverson
Summary: Personal factors play an important role in predicting postconcussion symptoms in patients with mild traumatic brain injury (MTBI). Factors such as work status, preinjury health problems, and gender were found to be predictors of postconcussion symptoms. Intracranial abnormalities on CT scans were also identified as a risk factor for postconcussion symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Todd J. Schwedt
Summary: Post-traumatic headache is a common and persistent symptom following mild traumatic brain injury, with onset typically within 7 days post-injury. Pathophysiological mechanisms of post-traumatic headache involve structural, functional, metabolic, and neuroinflammatory factors. Effective therapy options are currently lacking, with future research priorities including optimizing diagnostic criteria and understanding pathophysiology.
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Article
Critical Care Medicine
Karen M. Barlow, Kartik Iyer, Tingting Yan, Alex Scurfield, Helen Carlson, Yang Wang
Summary: Persistent post-concussion symptoms (PPCS) following pediatric mild traumatic brain injury (mTBI) are associated with differential changes in cerebral blood flow (CBF). Our study found that CBF levels were higher in participants with poor recovery and decreased over time, with a greater decrease observed in those with good recovery. These changes in CBF levels predicted outcomes in 77% of children with PPCS, highlighting its potential as a useful predictive biomarker in this population.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Sara M. Lippa, Louis M. French, Tracey A. Brickell, Angela E. Driscoll, Megan E. Glazer, Corie E. Tippett, Jamie K. Sullivan, Rael T. Lange
Summary: This study found that PTSD symptoms were more strongly related to cognitive performance in individuals with a history of complicated mild/moderate TBI compared to those with severe/penetrating TBI. The impact of PTSD symptoms on cognition should be considered in individuals with complicated mild/moderate TBI.
JOURNAL OF NEUROTRAUMA
(2021)
