Article
Clinical Neurology
Stephanie A. Chu, Taru M. Flagan, Adam M. Staffaroni, Lize C. Jiskoot, Jersey Deng, Salvatore Spina, Liwen Zhang, Virginia E. Sturm, Jennifer S. Yokoyama, William W. Seeley, Janne M. Papma, Dan H. Geschwind, Howard J. Rosen, Bradley F. Boeve, Adam L. Boxer, Hilary W. Heuer, Leah K. Forsberg, Danielle E. Brushaber, Murray Grossman, Giovanni Coppola, Bradford C. Dickerson, Yvette M. Bordelon, Kelley Faber, Howard H. Feldman, Julie A. Fields, Jamie C. Fong, Tatiana Foroud, Ralitza H. Gavrilova, Nupur Ghoshal, Neill R. Graff-Radford, Ging-Yuek Robin Hsiung, Edward D. Huey, David J. Irwin, Kejal Kantarci, Daniel I. Kaufer, Anna M. Karydas, David S. Knopman, John Kornak, Joel H. Kramer, Walter A. Kukull, Maria I. Lapid, Irene Litvan, Ian R. A. Mackenzie, Mario F. Mendez, Bruce L. Miller, Chiadi U. Onyike, Alexander Y. Pantelyat, Rosa Rademakers, Eliana Marisa Ramos, Erik D. Roberson, Maria Carmela Tartaglia, Nadine A. Tatton, Arthur W. Toga, Ashley Vetor, Sandra Weintraub, Bonnie Wong, Zbigniew K. Wszolek, John C. Van Swieten, Suzee E. Lee
Summary: This study found that a subset of presymptomatic MAPT mutation carriers exhibited low volumes in the mesial temporal lobe, a region commonly atrophied in all symptomatic carriers. With increasing age, a higher percentage of presymptomatic carriers showed low mesial temporal volume, suggesting early neurodegeneration.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Clinical Neurology
Roderick P. P. W. M. Maas, Sven Killaars, Bart P. C. van de Warrenburg, Dennis J. L. G. Schutter
Summary: The CCAS-S is effective in identifying cognitive deficits in SCA3 patients, showing a high discriminative ability and correlating with disease severity measures.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Samuel Shribman, Maggie Burrows, Rhian Convery, Martina Bocchetta, Carole H. Sudre, Julio Acosta-Cabronero, David L. Thomas, Godfrey T. Gillett, Emmanuel A. Tsochatzis, Oliver Bandmann, Jonathan D. Rohrer, Thomas T. Warner
Summary: Cognitive deficits are common in patients with Wilson's disease (WD). Patients with hepatic presentations, although seemingly without neurological symptoms, still exhibit cognitive impairments associated with diffuse cortical and white matter pathology.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Isha Puntambekar, Jennifer A. Foley
Summary: Visual hallucinations are common in Lewy Body Disease and are associated with cognitive impairment. This study investigates the cognitive deficits associated with different types of hallucinations in LBD patients, and suggests a pattern of cognitive dysfunction that may underlie the occurrence of visual hallucinations.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Flora Gossink, Annemiek Dols, Max L. Stek, Philip Scheltens, Bas Nijmeijer, Petra Cohn Hokke, Anke Dijkstra, Fred Van Ruissen, Cora Aalfs, Yolande A. L. Pijnenburg
Summary: This study explores the lifelong behavioral and personality characteristics in bvFTD patients with C9orf72(RE) gene mutation, and identifies distinctive features during the disease course, such as excessive buying and obsessive physical exercise. The findings suggest a lifelong neuropsychiatric vulnerability in carriers of the C9orf72(RE) gene, potentially linking neurodevelopmental and neurodegenerative diseases.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Sara Badesso, Paz Cartas-Cejudo, Maria Espelosin, Enrique Santamaria, Mar Cuadrado-Tejedor, Ana Garcia-Osta
Summary: DHA, as the most abundant polyunsaturated fatty acid in the brain, is essential for successful aging and may lower the risk for developing Alzheimer's disease. DHA enhances memory function through promoting synapse formation and has potential for dietary supplement for AD dementia prevention.
Article
Neurosciences
María Valles-Salgado, María Nieves Cabrera-Martín, Rosie E. Curiel-Cid, Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, María José Gil-Moreno, Jorge Matías-Guiu, David A. Loewenstein, Jordi A. Matias-Guiu
Summary: This study examines the cognitive and neural basis of failure to recover from proactive and retroactive semantic interference, using the neuropsychological test LASSI-L. The results suggest that dysfunction in episodic memory and the involvement of the medial temporal lobe, precuneus, and posterior cingulate contribute to this failure.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Han Soo Yoo, Hyeokjin Kwon, Seok Jong Chung, Young H. Sohn, Jong-Min Lee, Phil Hyu Lee
Summary: This study investigated the neural correlates of impaired self-awareness of cognitive deficits in non-demented patients with Parkinson's disease. The results showed that patients with impaired self-awareness had poorer white matter integrity, particularly in the genu of the corpus callosum and anterior limb of the internal capsule. However, there were no significant differences in cortical thickness or striatal DAT availability based on the presence of impaired self-awareness.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Kalpana M. Merchant, Tanya Simuni, Janel Fedler, Chelsea Caspell-Garcia, Michael Brumm, Kelly N. H. Nudelman, Elizabeth Tengstrandt, Frank Hsieh, Roy N. Alcalay, Christopher Coffey, Lana Chahine, Tatiana Foroud, Andrew Singleton, Daniel Weintraub, Samantha Hutten, Todd Sherer, Brit Mollenhauer, Andrew Siderowf, Caroline Tanner, Ken Marek
Summary: We quantified concentrations of three isoforms of BMP in different cohorts of Parkinson's disease patients and found that LRRK2 and GBA1 gene mutations were associated with elevated BMP levels. However, BMP is not a prognostic or disease progression biomarker.
NPJ PARKINSONS DISEASE
(2023)
Article
Behavioral Sciences
Carmen Garcia-Sanchez, Marco Calabria, Nicholas Grunden, Catalina Pons, Juan Antonio Arroyo, Beatriz Gomez-Anson, Alberto Lleo, Daniel Alcolea, Roberto Belvis, Noemi Morollon, Isabel Mur, Virginia Pomar, Pere Domingo
Summary: Subjective cognitive complaints are reported in COVID-19 patients across different disease severities. This study found that attention abilities were widely affected in post-COVID patients with subjective complaints, and were associated with deficits in executive functions, learning, and long-term memory. These cognitive deficits were largely unrelated to clinical factors such as hospitalization and disease duration.
BRAIN AND BEHAVIOR
(2022)
Article
Nutrition & Dietetics
Ignacio Lucas, Romina Miranda-Olivos, Giulia Testa, Roser Granero, Isabel Sanchez, Jessica Sanchez-Gonzalez, Susana Jimenez-Murcia, Fernando Fernandez-Aranda
Summary: This study examined the relationship between treatment outcomes and decision-making learning abilities in patients with eating disorders using the Iowa Gambling Task. The results indicated that learning performance in decision-making tasks could predict future therapy outcomes.
Article
Clinical Neurology
Benedetta Vai, Silvia Cazzetta, Rosalia Scalisi, Alessia Donati, Margherita Bechi, Sara Poletti, Laura Sforzini, Raffaele Visintini, Cesare Maffei, Francesco Benedetti
Summary: The study revealed deficits in verbal memory, working memory, attention, information processing speed, and psychomotor speed and coordination in BPD patients, with the impairment in psychomotor abilities remaining significant after controlling for medication load. A multiple regression analysis confirmed the impact of psychomotor abilities on the severity of BPD symptoms. The study suggests a potential clinical benefit of cognitive remediation programs in BPD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S. Baskar, Kelvin Kwan, David J. Margolis, Peng Jiang, Alexander W. Kusnecov, Qian Cai
Summary: This study reveals that mitochondrial distribution deficits and Parkin-mediated mitophagy are key factors in early tauopathy-related synaptic pathogenesis. Enhancing synaptic mitochondrial supply can protect against synaptic damage and cognitive impairment in tauopathy mouse models.
Article
Psychiatry
Sowmya Selvaraj, Venkataram Shivakumar, Paranthaman V. Kavya, Thrinath Mullapudi, Gaurav Bhalerao, Vanteemar S. Sreeraj, Satish Suhas, Damodharan Dinakaran, Rujuta Parlikar, Harleen Chhabra, Janardhanan C. Narayanaswamy, Monojit Debnath, Naren P. Rao, Kesavan Muralidharan, Ganesan Venkatasubramanian
Summary: The study found a significant positive association between BDNF gene expression and DLPFC activation during the working memory task. In addition, BDNF gene expression negatively correlated with negative symptom scores and left DLPFC fMRI activation.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Marco Canevelli, Lindsay M. K. Wallace, Giuseppe Bruno, Matteo Cesari, Kenneth Rockwood, David D. Ward
Summary: Frailty is associated with cognitive expression of neuropsychological deficits in older adults, as found in the analysis of data from three large cohort studies. Among participants with higher frailty levels, there was a stronger negative association between neuropsychological deficits and cognitive performance.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
