Article
Biochemistry & Molecular Biology
Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
Summary: Dopamine in the prefrontal cortex has opposing effects on social behavior depending on the duration of its activation. Sustained dopamine activation suppresses social behavior while acute activation enhances it. The duration of social interactions is positively correlated with transient dopamine release and negatively correlated with sustained dopamine increase in the prefrontal cortex. Dopamine levels also modulate neural calcium signaling and c-Fos induction triggered by social stimuli in prefrontal neurons.
Article
Biology
David S. Jacobs, Madeleine C. Allen, Junchol Park, Bita Moghaddam
Summary: This study developed a novel model for anxiety during motivated behavior and found that neuronal activity in the ventral tegmental area (VTA) and dorsomedial prefrontal cortex (dmPFC) represents the relationship between action and punishment risk. Additionally, the study suggests that diazepam may have anxiolytic properties.
Article
Neurosciences
Meiling Li, Louisa Dahmani, Catherine S. Hubbard, Yongbo Hu, Meiyun Wang, Danhong Wang, Hesheng Liu
Summary: The identification of reliable neuroimaging biomarkers for mental disorders is limited due to clinical heterogeneity and comorbidity. This study used personalized fMRI to identify meaningful and replicable imaging markers related to clinical domains across different disorders. The findings highlight the importance of personalized interventions and shed new light on the connectivity underpinnings of psychiatric symptoms.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biology
Zhenni Wang, Shihao Lou, Xiao Ma, Hui Guo, Yan Liu, Wenjing Chen, Dating Lin, Yupeng Yang
Summary: This study found that the medial prefrontal cortex (mPFC) plays a crucial role in both the training and maintenance processes of visual perceptual learning (VPL). By recording the calcium activity of mPFC pyramidal neurons, distinct ON and OFF neural ensembles were identified, which may encode different cognitive information. Additionally, the mPFC was found to recruit more reward-related components during VPL.
Article
Neurosciences
Michael M. Tranter, Samarth Aggarwal, Jared W. Young, Daniel G. Dillon, Samuel A. Barnes
Summary: The ability to update the value of actions is crucial for flexible decision making. This study investigated the effects of disrupting glutamate neurotransmission in early postnatal rats on decision making using the probabilistic reversal learning task. The results showed that the rats with disrupted glutamatergic transmission exhibited impaired decision making, and a deep neural network trained on their behavior could accurately predict the treatment group, suggesting the potential for using neural networks in schizophrenia diagnosis.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Cell Biology
Christian M. Wood, Laith Alexander, Johan Alsio, Andrea M. Santangelo, Lauren McIver, Gemma J. Cockcroft, Angela C. Roberts
Summary: Poor outcomes are common in anxiety and depression, thus understanding the neural circuits underlying symptoms and treatment responses is important. By using a chemogenetics strategy involving designer receptors and drugs, the scACC-25 neural circuits related to anhedonia and anxiety in marmosets were identified. Targeting these circuits with the fast-acting antidepressant ketamine may lead to new treatment strategies.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Behavioral Sciences
Daniela L. L. Uliana, Xiyu Zhu, Felipe V. V. Gomes, Anthony A. A. Grace
Summary: Animal models have been instrumental in studying psychiatric disorders and identifying therapeutic targets, but there is a recent shift towards focusing on circuits in normal subjects. This shift is driven by a lack of discovery of new effective targets and the failure of targets based on preclinical research to show efficacy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Julia Cox, Adelaide R. Minerva, Weston T. Fleming, Christopher A. Zimmerman, Cameron Hayes, Samuel Zorowitz, Akhil Bandi, Sharon Ornelas, Brenna McMannon, Nathan F. Parker, Ilana B. Witten
Summary: Emerging evidence suggests that there are sex differences in decision-making behavior, but the neural substrates underlying these differences are not well understood. This study demonstrates that in mice, the motivation to engage in a value-based decision-making task is modulated more strongly by action value in females than in males. The anterior cingulate cortex neurons projecting to the dorsomedial striatum contribute to this sex difference.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Robertas Guzulaitis, Luca Godenzini, Lucy Maree Palmer
Summary: The anterior lateral motor cortex plays an important role in influencing behavioral performance and impulsive behavior. Planning motor actions can improve performance, but it can also lead to premature actions.
NATURE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Claudia Sagheddu, Enzo Cancedda, Farshid Bagheri, Predrag Kalaba, Anna Lisa Muntoni, Jana Lubec, Gert Lubec, Fabrizio Sanna, Marco Pistis
Summary: CE-158 potentiates dopamine neurotransmission, promotes behavioral flexibility, and restores learning and memory in rats. Chronic administration of CE-158 does not induce abuse potential or pro-psychotic-like effects. These findings provide important evidence for the clinical application of CE-158.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
A. J. Culbreth, E. K. Schwartz, M. J. Frank, E. C. Brown, Z. Xu, S. Chen, J. M. Gold, J. A. Waltz
Summary: This study found that patients with schizophrenia show reduced reward-seeking behavior and a bias toward loss avoidance learning. However, there was no significant difference in exploratory behavior between patients and controls. Perceptions of relative uncertainty were associated with activity in the rostrolateral prefrontal cortex.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Justin M. Fine, David J. -N. Maisson, Seng Bum Michael Yoo, Tyler V. Cash-Padgett, Maya Zhe Wang, Jan Zimmermann, Benjamin Y. Hayden
Summary: An important question in neuroeconomics is how the brain represents the value of offers in a way that allows for comparison while preserving the details that influence value. This study examined neuronal responses in male macaques and found that there was no overlap in neural coding between risky and safe options, even when the options had identical subjective values. However, these regions were linked through a linear transform of their encodings, allowing for comparison of different types of options.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Adam J. Culbreth, Zuzana Kasanova, Thomas J. Ross, Betty J. Salmeron, James M. Gold, Elliot A. Stein, James A. Waltz
Summary: The study found that brain responses to different forms of salience were detected, and there were no significant differences in salient event activation between SZ patients and controls in several regions, but there was a significant correlation between the magnitudes of salience contrasts and positive symptoms in SZ patients.
Article
Psychology, Clinical
Hengyi Cao
Summary: Difficulty in cognitive adjustment after a conflict or error is a hallmark for many psychiatric disorders. A study found that altered dynamic interactions in the prefrontal-cerebellar circuit may underlie these disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
J. Titulaer, O. Radhe, K. Danielsson, S. Dutheil, M. M. Marcus, K. Jardemark, T. H. Svensson, G. L. Snyder, M. Ericson, R. E. Davis, A. Konradsson-Geuken
Summary: Lumateperone is a novel drug approved for the treatment of schizophrenia and depressive episodes associated with bipolar depression. It simultaneously modulates key neurotransmitters and improves symptoms while enhancing prosocial behavior. The drug affects dopamine and glutamate signaling, potentially contributing to its effectiveness in improving mood-related symptoms.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Nelson K. Totah, Nikos K. Logothetis, Oxana Eschenko
PSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Corina O. Bondi, Ameer Y. Taha, Jody L. Tock, Nelson K. B. Totah, Yewon Cheon, Gonzalo E. Torres, Stanley I. Rapoport, Bita Moghaddam
BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Nelson K. B. Totah, Mark E. Jackson, Bita Moghaddam
Article
Neurosciences
Aude Marzo, Nelson K. Totah, Ricardo M. Neves, Nikos K. Logothetis, Oxana Eschenko
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Neurosciences
Nelson K. Totah, Ricardo M. Neves, Stefano Panzeri, Nikos K. Logothetis, Oxana Eschenko
Article
Neurosciences
Alan L. Pehrson, Corina O. Bondi, Nelson K. B. Totah, Bita Moghaddam
PSYCHOPHARMACOLOGY
(2013)
Meeting Abstract
Psychiatry
Nelson K. Totah, Mark Jackson, Bita Moghaddam
SCHIZOPHRENIA RESEARCH
(2010)
Review
Neurosciences
Nelson K. B. Totah, Nikos K. Logothetis, Oxana Eschenko
Article
Neurosciences
Dan J. Chandler, Patricia Jensen, Jordan G. McCall, Anthony E. Pickering, Lindsay A. Schwarz, Nelson K. Totah
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Nelson K. Totah, Nikos K. Logothetis, Oxana Eschenko
Summary: The brainstem noradrenergic locus coeruleus (LC) and the prefrontal cortex (PFC) are reciprocally connected, allowing for mutual influence. Transient increases in PFC high y power may indicate changes in LC activity. Synchronized PFC neuronal spiking during high y transients may provide a new mode of top-down control over the LC.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Dmitrii Vasilev, Daniel Havel, Simone Liebscher, Silvia Slesiona-Kuenzel, Nikos K. Logothetis, Katja Schenke-Layland, Nelson K. Totah
Summary: This study found that rats resumed normal growth levels after one week of water restriction, and water restriction did not drive renal adaptation. However, intermittent water restriction was associated with an increase in the stress hormone CORT.
Article
Multidisciplinary Sciences
Shahryar Noei, Ioannis S. Zouridis, Nikos K. Logothetis, Stefano Panzeri, Nelson K. Totah
Summary: The noradrenergic locus coeruleus (LC) plays a crucial role in controlling brain and behavioral states. It has been found that different ensembles of spontaneously coactive LC neurons could lead to diverse cortical states, with some showing high-frequency power increase and others showing decreased high-frequency power.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Dmitrii Vasilev, Isabel Raposo, Nelson K. Totah
Summary: The mind affects the body through the central nervous system's control of the autonomous nervous system. It has been observed that illusions perceived as bright lead to pupil constriction in humans, but it was not known if this response also occurs in other animals. This study found that rats exhibit the same pupil response to the brightness illusion as humans, suggesting that the mind-body connection is not exclusive to humans and the primary visual cortex may play a role in this connection.
Article
Cell Biology
Roy Lycke, Robin Kim, Pavlo Zolotavin, Jon Montes, Yingchu Sun, Aron Koszeghy, Esra Altun, Brian Noble, Rongkang Yin, Fei He, Nelson Totah, Chong Xie, Lan Luan
Summary: Researchers have developed ultraflexible stim-nanoelectronic threads that enable low-threshold, high-resolution, and chronic stable intracortical microstimulation. They have demonstrated seamless integration with the nervous tissue, stable neuronal activation, and long-lasting behavioral responses without causing tissue damage or exacerbation of side effects.