Review
Veterinary Sciences
Robert W. Elwood
Summary: Studies suggest that pain responses in fish and decapod crustaceans go beyond mere nociceptive reflex, involving central processing and the possibility of pain experience, although not proven. The research recommends further consideration and welfare measures for both groups.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Psychology, Multidisciplinary
Di Yang, Xiong Li, Yinya Zhang, Zuoshan Li, Jing Meng
Summary: This study found that empathic responses may be influenced by characteristics other than race, such as skin color and attractiveness.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Medicinal
Qianqian Liang, Zhen Qiao, Qiqi Zhou, Dengqi Xue, KeWei Wang, Liming Shao
Summary: This study reports the synthesis of N-indazole-4-aryl piperazine carboxamide analogues as TRPV1 modulators. Compound 28 is identified as a potent and selective TRPV1 agonist, relieving inflammatory and thermal pain by desensitizing the native TRPV1 current in mice. The study also reveals an important hydrogen interaction between Arg557 and the indazole of compound 28.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Psychology, Multidisciplinary
Wen Li, Yue Lv, Xu Duan, Guo Cheng, Senbang Yao, Sheng Yu, Lingxue Tang, Huaidong Cheng
Summary: This study found that breast cancer patients undergoing chemotherapy showed impairment in pain empathy, which may be correlated with changes in N1 and P2 components in ERP.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Richard B. Lipton, Agustin Melo-Carrillo, Mark Severs, Michael Reed, Sait Ashina, Timothy Houle, Rami Burstein
Summary: This real-world study suggests that treatment with narrow band green light during migraine attacks can relieve pain and photophobia, reduce anxiety, and improve sleep.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alberto Hernandez-Leon, Gabriel Fernando Moreno-Perez, Martha Martinez-Gordillo, Eva Aguirre-Hernandez, Maria Guadalupe Valle-Dorado, Maria Irene Diaz-Reval, Maria Eva Gonzalez-Trujano, Francisco Pellicer
Summary: The study explores the potential of Mexican genera of Lamiaceae as a source of secondary metabolites responsible for analgesic and anti-inflammatory properties. Bioactive constituents mainly include terpenes and phenolic compounds, with scarce information reported on the biological activities of certain subgenera. Further preclinical and clinical studies are needed to evaluate the therapeutic potential of these natural products for pain relief and inflammation. Due to the high endemism of Lamiaceae species in Mexico, conservation efforts and investigation of their health benefits are crucial.
Review
Chemistry, Analytical
Badrinathan Sridharan, Alok Kumar Sharma, Hae Gyun Lim
Summary: Ultrasound imaging and focused ultrasound therapy play crucial roles in cancer diagnosis, pain reduction, surgical resection guidance, and chemotherapy effectiveness. This study conducted a bibliometric analysis to examine the growth trend and future prospects in the research field encompassing ultrasound, cancer management, pain, and related challenges. Using data from the Web of Science, a total of 3248 documents from 1100 journal sources were analyzed, with 390 articles published in 2022, demonstrating an almost 100% growth rate compared to previous years. Network analysis suggests that continuous research in this domain will significantly improve patient care for various diseases, including cancer and its co-morbidities.
Article
Multidisciplinary Sciences
Mario A. Acuna, Fernando Kasanetz, Paolo De Luna, Marta Falkowska, Thomas Nevian
Summary: The perception of pain is a complex experience and understanding how the brain distinguishes pain from other sensory stimuli has been a challenge. In this study, researchers used calcium imaging in mice to investigate the coding of pain in the anterior cingulate cortex. They found that population activity, rather than single-cell responses, allowed the discrimination of painful stimuli. Additionally, they discovered that chronic neuropathic pain led to changes in sensory processing, which were restored by analgesic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Xiaomin Huang, Junxiao Yin, Xinli Liu, Wenwei Tan, Mengting Lao, Xianglong Wang, Sishi Liu, Qiling Ou, Danzhe Tang, Wen Wu
Summary: Research suggests that individuals with high pain sensitivity are more likely to experience fear generalization related to pain, possibly due to their heightened sensitivity towards the threat of pain and allocation of more attention resources to pain-related threatening stimuli.
Review
Neurosciences
Francesco Ferrini, Chiara Salio, Elena M. Boggio, Adalberto Merighi
Summary: This review summarizes the role of BDNF and GDNF as modulators of synaptic transmission in the mature CNS, with a focus on their interaction in the regulation of nociceptive neurotransmission. BDNF is identified as a key player in pain modulation, whereas the full role of GDNF remains to be elucidated. These neurotrophic factors hold potential as targets for investigating and addressing chronic pain.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Romuald A. Janik, Igor T. Podolak, Lukasz Struski, Anna Ceglarek, Koryna Lewandowska, Barbara Sikora-Wachowicz, Tadeusz Marek, Magdalena Fafrowicz
Summary: This study analyzes the dynamics of information processing in a visual short-term memory task from the perspective of neural responses, conflict level, and correctness/erroneous. The results suggest that information processing varies depending on correct or false recognition, with prolonged processing for stimuli inducing high cognitive conflict and erroneous responses.
SCIENTIFIC REPORTS
(2022)
Review
Behavioral Sciences
Anne Margarette S. Maallo, Eric A. Moulton, Christine B. Sieberg, Donald B. Giddon, David Borsook, Scott A. Holmes
Summary: This study examines the association between pain and depression, highlighting overlapping neural substrates; it suggests monitoring left-sided pain symptoms in individuals diagnosed with depression; and recommends psychological evaluation as part of standard practice in pain treatment for patients with pain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Sydney Trask, Shane E. Pullins, Nicole C. Ferrara, Fred J. Helmstetter
Summary: Recent studies have indicated that there are different impacts on memory formation when either the anterior or posterior region of the retrosplenial cortex (RSC) is damaged in rats. Inhibition of neural activity in the anterior RSC selectively impacted behavior evoked by the auditory CS, while inhibition of the posterior RSC selectively impaired memory for the context in which training was conducted. These findings highlight distinct roles of subregions of the RSC in learning and memory.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Manorot Borirakarawin, Yunyong Punsawad
Summary: In this study, an auditory stimulus pattern was developed for improving control and communication in quadriplegia with visual impairment, utilizing EEG channels to observe ERP responses and classification efficiency. The proposed auditory stimulus pattern showed higher accuracy, and multi-loudspeaker patterns provided increased accuracy.
Article
Statistics & Probability
Simon Lunagomez, Sofia C. Olhede, Patrick J. Wolfe
Summary: This article introduces a new class of models for multiple networks, parameterizing a distribution on labeled graphs and controlling concentration using a parameter. The hierarchical Bayesian approach and sampling strategies are provided, demonstrating efficacy through simulation studies and data analysis examples from systems biology and neuroscience.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2021)
Article
Clinical Neurology
Anastasis Georgoulas, Laura Jones, Maria Pureza Laudiano-Dray, Judith Meek, Lorenzo Fabrizi, Kimberley Whitehead
Summary: In this study of 175 infants, unique regulation of sleep-wake states was observed, with particularly long durations of active sleep. Stress and nociception were found to impact sleep durations, especially in preterm infants, highlighting the importance of environmental interventions in promoting healthy sleep patterns.
Review
Pediatrics
Christopher Eccleston, Emma Fisher, Richard F. Howard, Rebeccah Slater, Paula Forgeron, Tonya M. Palermo, Kathryn A. Birnie, Brian J. Anderson, Christine T. Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B. Sieberg, Dick Tibboel, Suellen M. Walker, Dominic Wilkinson, Chantal Wood
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Letter
Anesthesiology
Caroline Hartley, Luke Baxter, Fiona Moultrie, Ryan Purdy, Aomesh Bhatt, Richard Rogers, Chetan Patel, Eleri Adams, Rebeccah Slater
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Multidisciplinary Sciences
Luke Baxter, Fiona Moultrie, Sean Fitzgibbon, Marianne Aspbury, Roshni Mansfield, Matteo Bastiani, Richard Rogers, Saad Jbabdi, Eugene Duff, Rebeccah Slater
Summary: Studying the neurophysiology of neonatal responses to noxious stimulation can predict brain responses and their associations with white matter structure. The research shows that brain activity evoked by noxious stimulation in healthy neonates is linked to resting-state activity and white matter microstructure, providing valuable insights for early life pain management.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Maria M. Cobo, Caroline Hartley, Deniz Gursul, Foteini Andritsou, Marianne van der Vaart, Gabriela Schmidt Mellado, Luke Baxter, Eugene P. Duff, Miranda Buckle, Ria Evans Fry, Gabrielle Green, Amy Hoskin, Richard Rogers, Eleri Adams, Fiona Moultrie, Rebeccah Slater
Summary: Despite the high burden of pain in hospitalised neonates, few analgesics have proven efficacy. Testing analgesics in neonates comes with challenges, both experimentally and ethically; however, EEG-derived measures of noxious-evoked brain activity can help assess efficacy. A new experimental paradigm accounting for individual differences in noxious-evoked baseline sensitivity was developed and tested across four studies, providing evidence of the efficacy of gentle brushing and paracetamol in neonates. This work represents an important step towards safe and cost-effective clinical trials of analgesics in neonates.
Article
Neurosciences
Marianne van der Vaart, Caroline Hartley, Luke Baxter, Gabriela Schmidt Mellado, Foteini Andritsou, Maria M. Cobo, Ria Evans Fry, Eleri Adams, Sean Fitzgibbon, Rebeccah Slater
Summary: The study found that heart rate responses increase with age, and noxious-evoked brain activity undergoes three developmental stages, including a previously unreported transitory stage. Additionally, infant responses to noxious and nonnoxious stimuli are discriminable in prematurity.
Article
Neuroimaging
Gabriela Schmidt Mellado, Kirubin Pillay, Eleri Adams, Ana Alarcon, Foteini Andritsou, Maria M. Cobo, Ria Evans Fry, Sean Fitzgibbon, Fiona Moultrie, Luke Baxter, Rebeccah Slater
Summary: This study investigates the impact of prematurity on neurodevelopment in infants, finding that premature birth may accelerate maturation of the visual and tactile sensory systems. By analyzing evoked responses in infants using EEG and comparing different groups of infants, it was observed that visual and tactile response template magnitudes differ between premature and late preterm infants.
NEUROIMAGE-CLINICAL
(2022)
Article
Biology
Laura Jones, Madeleine Verriotis, Robert J. Cooper, Maria Pureza Laudiano-Dray, Mohammed Rupawala, Judith Meek, Lorenzo Fabrizi, Maria Fitzgerald
Summary: Topographic cortical maps are crucial for spatial localization of sensory stimulation and generation of appropriate motor responses. In adult somatosensory (S1) cortex, somatosensation and nociception are finely mapped and aligned. However, in infancy, when pain behavior is disorganized and poorly directed, nociceptive maps may be less refined.
Article
Multidisciplinary Sciences
Maria M. Cobo, Gabrielle Green, Foteini Andritsou, Luke Baxter, Ria Evans Fry, Annika Grabbe, Deniz Gursul, Amy Hoskin, Gabriela Schmidt Mellado, Marianne van der Vaart, Eleri Adams, Aomesh Bhatt, Franziska Denk, Caroline Hartley, Rebeccah Slater
Summary: The relationship between immune function, pain sensitivity, and early life inflammation is not well understood in humans. This study found that neonatal inflammation is associated with increased spinal cord excitability and evoked brain activity following tactile and noxious stimulation. These findings suggest that hyperalgesia may persist post-inflammation, supporting previous research on immune dysfunction and pain sensitivity in adults.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Pishan Chang, Lorenzo Fabrizi, Maria Fitzgerald
Summary: Early life pain experience alters adult pain behavior and hypersensitivity, affecting functional brain connectivity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shaun Warrington, Elinor Thompson, Matteo Bastiani, Jessica Dubois, Luke Baxter, Rebeccah Slater, Saad Jbabdi, Rogier B. Mars, Stamatios N. Sotiropoulos
Summary: This study proposes a novel framework that integrates structural connectivity maps from humans and nonhuman primates onto a common space, allowing the study of divergences and similarities in connectivity over evolutionary and developmental scales to reveal brain maturation trajectories.
Article
Biochemistry & Molecular Biology
Mohammed Rupawala, Oana Bucsea, Maria Pureza Laudiano-Dray, Kimberley Whitehead, Judith Meek, Maria Fitzgerald, Sofia Olhede, Laura Jones, Lorenzo Fabrizi
Summary: Habituation to recurrent non-threatening or unavoidable noxious stimuli is an important aspect of adaptation to pain. Neonates, especially if preterm, are exposed to repeated noxious procedures during their clinical care. This study investigated changes in cortical microstates following repeated heel lances in term and preterm infants, and found that term infants showed habituation while preterm infants did not. However, both groups engaged different longer-latency cortical microstates with repeated stimulation.
Article
Computer Science, Information Systems
Tuomas A. Rajala, Sofia C. Olhede, Jake P. Grainger, David J. Murrell
Summary: This paper determines how to define a discretely implemented Fourier transform when analyzing an observed spatial point process. To develop this transform, the authors answer four questions: the natural definition of a Fourier transform and its spectral moments, calculate fourth-order moments of the Fourier transform using Campbell's theorem, determine how to implement tapering for spectral analysis of other stochastic processes, and produce an isotropic representation of the Fourier transform of the process. This determines the basic spectral properties of an observed spatial point process.
IEEE TRANSACTIONS ON INFORMATION THEORY
(2023)
Article
Physics, Fluids & Plasmas
Anatol E. Wegner, Sofia Olhede
Summary: The study introduces random graph models that generate graphs with extensive numbers of triangles and other network motifs, by connecting larger subsets of vertices with small atomic subgraphs. The models can be parametrized in terms of basic building blocks and their distributions, including random hypergraphs, bipartite models, and stochastic block models. The entropy for all these models can be derived from a single expression characterized by the symmetry groups of atomic subgraphs.
