Article
Medicine, Research & Experimental
Yunmei Zhang, Yuan Zhang, Zizhang Wang, Yufang Sun, Xinghong Jiang, Man Xue, Yafeng Yu, Jin Tao
Summary: This study reveals that gentamicin decreases the I-DR in VG neurons through JNK and PKA-mediated signaling pathways, leading to neuronal hyperexcitability. Blocking JNK signaling and I-DR can attenuate this effect.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemical Research Methods
Luisa Zupin, Egidio Barbi, Raffaella Sagredini, Giulia Ottaviani, Sergio Crovella, Fulvio Celsi
Summary: This study found that PBMT at 800 and 970 nm wavelengths has a positive effect on nociceptive sensory neuronal cell line by reducing capsaicin-induced calcium flow, increasing ATP, and MMP hyperpolarization. Additionally, the 800 nm wavelength also increased ROS and O-2(-) levels.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Multidisciplinary Sciences
Matthew Alsaloum, Julie I. R. Labau, Shujun Liu, Mark Estacion, Peng Zhao, Fadia Dib-Hajj, Stephen G. Waxman
Summary: This study investigated the effects of Na(V)1.8 and Na(V)1.9 currents on the excitability of sensory neurons using dynamic clamp electrophysiology. It found direct relationships between Na(V)1.8 current density and action potential parameters, as well as effects of Na(V)1.9 current density on neuronal membrane potential and rheobase. Additionally, the study explored the simultaneous interplay between Na(V)1.8 and Na(V)1.9 on neuronal excitability.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
He Liu, Ashutosh Rastogi, Priyam Narain, Qing Xu, Merima Sabanovic, Ayesha Darwish Alhammadi, Lihua Guo, Jun-Li Cao, Hongxing Zhang, Hala Aqel, Vongai Mlambo, Rachid Rezgui, Basma Radwan, Dipesh Chaudhury
Summary: The disruption of daily rhythms in patients with mood disorders may be attributed to the dysfunction of the lateral habenula and dorsal raphe nucleus. Stress-susceptibility in mice is associated with decreased firing rates in cells projecting from LHb to DRN, while stress-resilient mice show maintained daily rhythms in firing. This correlation between activity in this neural circuit and mood disorders highlights the importance of circadian timekeeping in regulating emotional well-being.
Article
Multidisciplinary Sciences
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Summary: Oral cancer patients experience sensitivity to spicy foods and liquids, but the mechanism behind this sensitivity is not yet understood. In a mouse model of oral cancer, researchers found increased expression of TRPV1 in trigeminal ganglion neurons, indicating an anatomical basis for chemosensitivity. They also discovered that PAR(2) plays a role in mediating the sensitivity induced by TRPV1 in tongue afferents in the oral cancer mouse model.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yi Cheng, Nan Song, Renkai Ge, Yue Dai
Summary: In this study, the biophysical and modulatory properties of persistent inward currents (PICs) in serotonergic neurons in the medulla were investigated using patch-clamp technique. The study revealed that different components of PICs contribute to the upregulation of excitability in these neurons, and serotonin enhances this effect, leading to facilitated repetitive firing in serotonergic neurons. The findings shed light on the channel mechanisms responsible for serotonergic modulation of serotonergic neurons in the brainstem.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Hongsheng Wang, Wenbing Chen, Zhaoqi Dong, Guanglin Xing, Wanpeng Cui, Lingling Yao, Wen-Jun Zou, Heath L. Robinson, Yaoyao Bian, Zhipeng Liu, Kai Zhao, Bin Luo, Nannan Gao, Hongsheng Zhang, Xiao Ren, Zheng Yu, James Meixiong, Wen-Cheng Xiong, Lin Mei
Summary: A study has identified ErBB4 as a marker for heat-sensitive spinal neurons in mice, which receive inputs from nociceptors and form excitatory synapses onto target neurons. Activation of these neurons enhances heat response, while inhibition reduces it. NRG1 regulates this process by promoting glutamatergic transmission through the dynamic activity of the tyrosine kinase. This research reveals the spinal neuron connection and regulatory mechanism of heat sensation involving the NRG1-ErBB4 signaling.
Article
Neurosciences
Makiko Kashio, Makoto Tominaga
Summary: This article focuses on thermo-transient receptor potential ion channels (thermo-TRPs) expressed in somatosensory neurons and their role in temperature sensation.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mehmet Sxerif Aydin, Sadik Bay, Esra Nur Yigit, Cemil Ozgul, Elif Kaval Oguz, Elcin Yenidunya Konuk, Nesxe Aysxit, Nureddin Cengiz, Ender Erdogan, Aydin Him, Mehmet Kocak, Emrah Eroglu, Gurkan Ozturk
Summary: This study demonstrates that axotomy triggers actomyosin contraction and calpain activity in neurons, causing them to shrink and force water out through aquaporin channels to prevent swelling and bursting. Inhibiting this cellular response increases the likelihood of neuronal cell death. These findings provide new insights into the pathophysiological processes in the nervous system.
Article
Physiology
Korynne S. Rollins, Alec L. E. Butenas, Auni C. Williams, Steven W. Copp
Summary: The mechanoreflex is exaggerated in patients with peripheral artery disease and in rat models of simulated PAD. In rats with a ligated femoral artery, blocking TxA2 receptors on sensory endings of thin fiber muscle afferents reduces the pressor response to muscle stretch. Additionally, IP3 receptors play a role in the exaggerated response to mechanoreflex activation in rats with ligated arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Oncology
Noemi Bencze, Csaba Schvarcz, Gabor Kriszta, Lea Danics, Eva Szoke, Peter Balogh, Arpad Szallasi, Peter Hamar, Zsuzsanna Helyes, Balint Botz
Summary: The study assessed the role of capsaicin-sensitive nerve terminals in breast cancer growth, demonstrating their beneficial antitumoral properties and inhibitory effect on tumor vascular bed disruption. The levels of intratumoral neuropeptides did not differ significantly between RTX-pretreated and non-pretreated animals, indicating potential non-neural sources contributing to their expression.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Zhidong Liao, Muhammad Umar, Xingyun Huang, Ling Qin, Guozhi Xiao, Yan Chen, Liping Tong, Di Chen
Summary: This study aims to determine the molecular mechanisms and analgesic effects of TRPV1 in the treatments of osteoarthritis and rheumatoid arthritis. The study found that TRPV1 plays a crucial role in regulating cellular function and homeostasis, especially in chondrocytes, synovial fibroblasts, macrophages, and osteoclasts. Additionally, TRPV1 is involved in nerve sensitization and sensitization in the occurrence of pain in these conditions. The study suggests that TRPV1 may be a promising therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Olga Kopach, Yulia Dobropolska, Pavel Belan, Nana Voitenko
Summary: The dorsal horn (DH) neurons of the spinal cord play a critical role in processing nociceptive input in the central nervous system. The hyperexcitability of DH neurons has been linked to Ca2+-permeable AMPA receptors (AMPARs) and contributes to nociceptive hypersensitivity. Inflammatory pain conditions result in changes in action potential (AP) parameters in DH neurons, and selective inhibition of Ca2+-permeable AMPARs can alleviate nociceptive hypersensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Giorgia Guarneri, Simone Pifferi, Michele Dibattista, Johannes Reisert, Anna Menini
Summary: The Ca2+-activated Cl over bar channel TMEM16B plays a crucial role in olfactory sensory neurons by controlling the transduction current and the length of action potentials. Knockout of TMEM16B in mice resulted in larger EOG responses, faster kinetics, and altered adaptation to repeated stimulation. This paradoxical effect may be due to the removal of clamping and/or shunting action of Ca2+-activated Cl over bar currents.
Article
Multidisciplinary Sciences
Toyoshi Umezu, Tomoharu Sano, Junko Hayashi
Summary: The study found that subcutaneous administration of l-menthol increased the number of c-Fos-like immunoreactive nuclei in the dorsal striatum of mice and elevated dopamine levels, thereby promoting motor activity.