Article
Physiology
Junqing Sun, Shiyue Pan, Emma Karey, Yi-Je Chen, Kent E. Pinkerton, Christopher G. Wilson, Chao-Yin Chen
Summary: Exposure to secondhand smoke reduces excitability of cardiac vagal neurons, alters action potential characteristics, and impacts small conductance calcium-activated potassium channel activity, potentially leading to changes in regulatory cardiac vagal signaling and cardiovascular consequences associated with exposure to secondhand smoke.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Avin Veerakumar, Andrea R. Yung, Yin Liu, Mark A. Krasnow
Summary: This study provides insights into the molecular and functional diversity of cardiac parasympathetic control circuit in mice, revealing two distinct subtypes of neurons that control cardiac function and coordinate cardiac and pulmonary function. These findings have implications for the treatment of cardiac and pulmonary diseases and the understanding of control and coordination circuits of other organs.
Article
Neurosciences
Anna K. Kamitakahara, Ramin Ali Marandi Ghoddousi, Alexandra L. Lanjewar, Valerie M. Magalong, Hsiao-Huei Wu, Pat Levitt
Summary: MET plays a crucial role in vocalization by affecting the survival of nAmb motor neurons. Deletion of MET can result in vocal deficits in both early postnatal life and adulthood. Some mice are able to recover vocal capacity, indicating heterogeneity in circuit restitution. Conditional deletion of MET leads to a decrease in the number of nAmb motor neurons and axonal loss in the recurrent laryngeal nerve.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Monica Garcia-Domingo, Jose Angel Garcia-Pedraza, Juan Francisco Fernandez-Gonzalez, Cristina Lopez, Maria Luisa Martin, Asuncion Moran
Summary: Comorbid diabetes and depression is a major health issue that worsens cardiovascular diseases. The impact of fluoxetine on cardiac diabetic complications is still unclear. This study found that fluoxetine treatment reduces cardiac vagal input and alters the modulation of bradycardic responses by serotonin in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Clara Leung, Shaina Robbins, Alison Moss, Maci Heal, Mahyar Osanlouy, Richard Christie, Navid Farahani, Corey Monteith, Jin Chen, Peter Hunter, Susan Tappan, Rajanikanth Vadigepalli, Zixi (Jack) Cheng, James S. Schwaber
Summary: The study developed and analyzed a single-cell scale anatomical map of the rat intrinsic cardiac nervous system (ICNS) across male and female hearts, revealing a reliable structural organization plan and providing a foundation for further analysis in cardiac function and disease. The distribution and clustering of ICNS neurons were highly conserved across all male and female rat hearts with distinct clusters consistently localized, though female hearts had fewer neurons and slightly reduced distribution. The anatomical data from each heart were registered to a geometric scaffold for standardization of common anatomical planes, allowing integration and comparison of multiple experimental results and data types.
Article
Cell Biology
Daniel Dautan, Adrienn Kovacs, Tsogbadrakh Bayasgalan, Miguel A. Diaz-Acevedo, Balazs Pal, Juan Mena-Segovia
Summary: CnF and PPN neurons in the MLR demonstrate distinct physiological properties and connectivity patterns, contributing to short-lasting muscle activation and long-lasting muscle tone increase in motor behavior, respectively.
Review
Neurosciences
Valerie Y. H. van Weperen, Marmar Vaseghi
Summary: The control of cardiac sympathetic and parasympathetic tone plays a crucial role in regulating cardiac function. This control relies on sensory information transmitted from the heart to the central nervous system. The vagus nerve, which contains vagal cardiac afferent fibers, carries this sensory information to the brainstem. While vagal afferent signaling has been shown to increase parasympathetic response, it appears to change after cardiac injury, with many unknowns remaining. This review aims to summarize the current understanding of cardiac vagal afferent signaling in health and cardiovascular disease, particularly after myocardial infarction, and highlight remaining knowledge gaps.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yan Zhao, Juan Wang, Muhan Li, Tingting Ma, Xingyue Zhang, Xin Xu, Min Zeng, Yuming Peng
Summary: This retrospective case-control study analyzed patients undergoing cerebellopontine angle surgery between October 1, 2015, and September 30, 2020. It found that 2.78% of patients experienced trige-minocardiac reflex (TCR) episodes, with 2 cases developing severe cardiac complications. The prevalence of adverse cardiovascular events was significantly higher in the TCR group compared to the control group. Tumor compression of the brainstem was identified as an independent risk factor for TCR episodes.
WORLD NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Nima Khalighinejad, Sanjay Manohar, Masud Husain, Matthew F. S. Rushworth
Summary: Decision-making involves choosing actions, as well as determining when and whether to initiate them. Different brain regions, such as DRN, BF, and ACC, contribute to different stages of decision-making, with 5-HT and ACh playing complementary roles.
Article
Neurosciences
Mengyu Liu, Dong-Wook Kim, Hongkui Zeng, David J. Anderson
Summary: This study identifies two distinct subtypes of estrogen receptor-1-positive neurons in the ventrolateral subdivision of the female ventromedial hypothalamus (VMHvl) that control sexual receptivity and aggressiveness in virgins and lactating mothers, respectively. The results also show that aggression-specific cells acquire an increased responsiveness to social cues during the transition from virginity to maternity, while the responsiveness of the mating-specific population appears unchanged.
Review
Psychology, Biological
John M. Karemaker
Summary: This paper reviews the various functions of the vagus nerve and explores their interactions in daily life, as well as the potential therapeutic applications of electrical stimulation. The study focuses on the physiological mechanisms behind heart rate variability and discusses the role of the vagus nerve in limiting inflammation. It also highlights the challenges in using whole vagus nerve stimulation due to the lack of specificity.
BIOLOGICAL PSYCHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Asokan Devarajan, Ke Wang, Kassandra Shannon, Yujuan Su, Jamie Verheyden, Xin Sun, Marmar Vaseghi
Summary: Significant cardiorespiratory coordination is required for maintaining physiological function, and the sensory neuronal cross-talk between the heart and the lungs is mediated by sensory neural pathways in the autonomic ganglia. The presence of cardiorespiratory neurons in the vagal ganglia suggests a pre-existing neuronal substrate for cardiorespiratory neurotransmission, which may play an important role in cardiopulmonary diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Behavioral Sciences
Kenji Doya, Kayoko W. Miyazaki, Katsuhiko Miyazaki
Summary: Recent advances in molecular tools have provided detailed data on serotonergic neuromodulation, showing substantial differences in signaling and effects depending on projection targets. It is conjectured that the evolution of serotonergic neuromodulation originated from signaling the time and resource available for action, learning, and development.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2021)
Article
Medicine, General & Internal
Xu Zhang, Bin Sun, Chen Pac-Soo, Daqing Ma, Liwei Wang
Summary: Cardiac arrest caused by trigeminocardiac reflex after endoscopic nasal surgery is rare. Venous-arterial extracorporeal membrane oxygenation can help healthcare providers identify the cause and initiate treatment.
Article
Biochemistry & Molecular Biology
Chloe Berland, Julien Castel, Romano Terrasi, Enrica Montalban, Ewout Foppen, Claire Martin, Giulio G. Muccioli, Serge Luquet, Giuseppe Gangarossa
Summary: This study explores the functional connection between the gut-brain axis and the reward and homeostatic brain structures using a physiologically relevant binge eating (BE) mouse model and multiscale in vivo approaches. The results reveal that compensatory adaptations in response to BE require the gut-to-brain axis, which relies on the permissive actions of peripheral endocannabinoids (eCBs) signaling through the vagus nerve. Inhibition of peripheral CB1 receptors increases hypothalamic activity, modulates metabolic efficiency, and dampens mesolimbic dopamine circuit activity, suppressing palatable eating. This study provides compelling evidence for a yet unappreciated physiological integrative mechanism involving peripheral eCBs and the vagus nerve in regulating homeostatic and reward-driven feeding.
MOLECULAR PSYCHIATRY
(2022)