Article
Immunology
Donghyun Kim, Ye Jin Jeong, Yerin Lee, Jihoon Choi, Young Min Park, Oh Chan Kwon, Yong Woo Ji, Sung Jun Ahn, Hyung Keun Lee, Min-Chan Park, Jae-Yol Lim
Summary: Recent studies have shown that the oral microbiome in patients with Sjogren's syndrome (SS) differs significantly from that in healthy individuals. The composition and diversity of the oral microbiome are correlated with clinical features of SS, especially ductal structures and salivary flow, suggesting that the oral microbiome may serve as a potential diagnostic biomarker for SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Takuya Nakagawa, Jessica Santos, Chanond A. Nasamran, Prakriti Sen, Sayed Sadat, Abdula Monther, Joseph Bendik, Koji Ebisumoto, Jingjing Hu, Sebastian Preissl, Theresa Guo, Vera Vavinskaya, Kathleen M. Fisch, Joseph A. Califano
Summary: The gene expression profiles of salivary gland cells are associated with the occurrence of salivary gland cancers, indicating the existence of specific cell of origin in certain types of salivary gland cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Neurosciences
Joshua D. Sammons, Caroline E. Bass, Jonathan D. Victor, Patricia M. Di Lorenzo
Summary: This study investigated how GABA-derived inhibitory activity in the nucleus tractus solitarius affects the balance of taste- and lick-driven neuronal activity. Results showed that enhancing GABAergic tone can increase lick coherence, better distinguish basic taste qualities and different salts, as well as amplify the amount of information that discriminates palatable versus unpalatable tastants.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Yusuke Amano, Kentaro Tsuji, Atshushi Kihara, Daisuke Matsubara, Noriyoshi Fukushima, Hiroshi Nishino, Toshiro Niki
Summary: Salivary duct carcinoma (SDC) is a rare and aggressive cancer with potential for early metastasis. This case report describes successful surgical treatment of SDC metastasis from the parotid gland to the adrenal gland, suggesting that surgical resection of solitary metastatic lesions may provide survival benefits for patients with metastatic SDC.
Article
Engineering, Biomedical
Fangyuan Cao, Jingjing Zhang, Dapeng Li, Mengke Wang, Chunhao Lai, Tianqi Xu, Ayache Bouakaz, Pengyu Ren, Mingxi Wan, Jie Han, Siyuan Zhang
Summary: By applying noninvasive ultrasound (US) neuromodulation to stimulate the solitary tract nucleus (NTS) of spontaneously hypertensive rats (SHRs), blood pressure (BP) can be regulated effectively. After two months of US stimulation, systolic blood pressure decreased significantly. US stimulation inhibited the pathological process of target organs, enhanced neuronal activities in relevant brain regions, and did not cause brain tissue damage. This study demonstrates the potential of using US stimulation of NTS as a therapeutic intervention for lowering BP in SHRs.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Physiology
Lukasz Chrobok, Michal Wojcik, Jasmin Daniela Klich, Kamil Pradel, Marian Henryk Lewandowski, Hugh David Piggins
Summary: The study explored the phasic neuronal activity in the rodent NTS using multi-electrode array recordings ex vivo, revealing a characteristic phasic pattern displayed by a subset of neurons in the dorsomedial NTS. It found that mice exhibit higher phasic frequency and firing rate compared to rats, peaking at the middle of the night. Additionally, the phasic cells were shown to be sensitive to alpha(2) adrenergic receptors activation and responsive to electrical stimulation of the area postrema, potentially identifying them as downstream targets of the AP noradrenergic system.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Mei Feng, Qingping Yin, Jing Ren, Fei Wu, Mei Lan, He Wang, Min Wang, Lu Li, Xiaojian Chen, Jinyi Lang
Summary: The study investigated the changes in three-dimensional apparent diffusion coefficient (3D-ADC) of parotid glands in head and neck cancer patients during radiotherapy, and found correlations with radiation dose, volume reduction, and salivary secretary function. Results showed that the mean 3D-ADC increased and was negatively correlated with salivary function and volume reduction, but positively correlated with radiation dose. These dynamic 3D-ADC changes could serve as an early indicator for predicting and evaluating parotid gland function during radiotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ken Karipidis, Rohan Mate, Masoumeh Sanagou, Chris Brzozek, David Urban, Mark Elwood
Summary: The study findings suggest that mobile phone use did not increase the incidence of parotid or other salivary gland cancers. The increase in parotid gland cancer in females since 2006 may be attributed to other possible risk factors specific to this gender.
CANCER EPIDEMIOLOGY
(2021)
Article
Mathematical & Computational Biology
Francisco Gomez-Garcia, Jose-Angel Diaz-Madrid, Pia Lopez-Jornet, Juan L. G. Guirao, Yolanda Guerrero-Sanchez
Summary: Oral dryness can lead to oral health problems. This study proposes a saliva stimulation device using vibrotactile stimuli, which significantly stimulates saliva secretion and has the advantages of low cost, ease of use, and safety.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Cell Biology
Diaa Massoud, Attalla F. El-kott, Fayez Shaldoum
Summary: The study investigated the histochemical and stereological properties of the parotid gland and sublingual gland in Caucasian squirrels, revealing unique morphological features and distinct cell reactions in different acini. The ductal systems also showed variations between the two glands, with acini and striated ducts contributing significantly to the total volume in both glands. Overall, the PG and SLG in Caucasian squirrels exhibit structural properties different from other rodent and mammalian species.
Article
Neurosciences
Yadong Ji, Chimdiya Onwukwe, Jesse Smith, Hanna Laub, Luca Posa, Asaf Keller, Radi Masri, Nathan Cramer
Summary: Noxious stimuli activate catecholaminergic input and increase the activity of PB neurons, leading to amplified responses to sensory stimuli. This mechanism may be related to prolonged catecholaminergic transients.
Article
Neurosciences
Coty M. Cooper, Ariana Q. Farrand, Michael C. Andresen, Eric Beaumont
Summary: This study suggests that in VNS therapy, a mid-collicular knife cut (KC) reduces the basal spontaneous activity of second-order NTS neurons receiving myelinated vagal input, and acute VNS increases activity in these neurons. Furthermore, the KC interrupts VNS activation of higher order NTS neurons and second-order NTS neurons receiving unmyelinated vagal input, indicating the importance of supramedullary descending projections to NTS in amplifying the peripheral neuronal signal from VNS.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Nutrition & Dietetics
Olga D. Escanilla, Andras Hajnal, Krzysztof Czaja, Patricia M. Di Lorenzo
Summary: Previous studies have shown that taste responses in the nucleus tractus solitarius (NTS) are impaired in rats with diet-induced obesity (DIO), and this impairment can be partially reversed by Roux-en-Y gastric bypass (RYGB) surgery.
Article
Anatomy & Morphology
Nader Goodarzi, Alireza Kahrizi
Summary: The present study aimed to investigate the histochemical and immunohistochemical features of the parotid and submandibular salivary glands in the porcupine. The findings showed that the parotid gland secretes acidic and sulfated mucous, while the submandibular gland secretes non-acidic and non-sulfated saliva. S100 protein was extensively expressed in the myoepithelial cells of the parotid gland, but rarely expressed in the submandibular gland. These findings have important implications for understanding the histophysiology of the digestive system in zoo animals.
Article
Pharmacology & Pharmacy
Siqin Zhang, Jiarui Li, Xiaolin Nong, Yuxiang Zhan, Jiazhi Xu, Danni Zhao, Chubin Ma, Yuchen Wang, Yixing Li, Zhan Li, Jiaquan Li
Summary: This study demonstrated that artesunate or metformin alone, as well as the combination of the two, can alleviate a range of symptoms in diabetic rats and mitigate hyposalivation by improving damage to the central SSN and salivary glands under hyperglycemic conditions. These treatments regulate the PI3K/Akt pathway to inhibit apoptosis and autophagy, while also preserving parasympathetic innervation to alleviate diabetes-induced hyposalivation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Rika Yahagi, Kazuhisa Okuda-Akabane, Hideyuki Fukami, Norio Matsumoto, Yasuyuki Kitada
NEUROSCIENCE LETTERS
(2008)
Article
Geriatrics & Gerontology
T. Kobayashi, H. Fukami, E. Ishikawa, K. Shibata, M. Kubota, H. Kondo, Y. Sahara
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Neurosciences
Kazuhisa Okuda-Akabane, Hideyuki Fukami, Kinya Narita, Yasuyuki Kitada
Article
Neurosciences
A Yoshida, M Yamamoto, M Moritani, H Fukami, YC Bae, Z Chang, S Sugiyo, M Takemura, KP Park, Y Shigenaga
Article
Neurosciences
H Fukami, RM Bradley
JOURNAL OF NEUROPHYSIOLOGY
(2005)
Article
Neurosciences
M Moritani, H Kida, Y Nagase, H Fukami, S Honma, M Takemura, Y Masuda, YC Bae, Y Shigenaga, A Yoshida
EXPERIMENTAL BRAIN RESEARCH
(2003)
Article
Neurosciences
YC Bae, BJ Choi, MG Lee, HJ Lee, KP Park, LF Zhang, S Honma, H Fukami, A Yoshida, OP Ottersen, Y Shigenaga
JOURNAL OF COMPARATIVE NEUROLOGY
(2002)
Article
Neurosciences
A Yoshida, H Fukami, Y Nagase, K Appenteng, S Honma, LF Zhang, YC Bae, Y Shigenaga
JOURNAL OF NEUROSCIENCE
(2001)
Review
Neurosciences
Y Shigenaga, Y Hirose, A Yoshida, H Fukami, S Honma, YC Bae
JOURNAL OF COMPARATIVE NEUROLOGY
(2000)