Article
Computer Science, Interdisciplinary Applications
Subhas Khajanchi, Sovan Bera, Tapan Kumar Roy
Summary: This study investigates a mathematical model for the CD8+ T-cell response to HTLV-I infection, revealing three biologically feasible equilibria and showing that the local and global dynamics are determined by the threshold parameters R-0 and R1. The model predicts different outcomes for HTLV-I response and infection based on the values of R-0 and R1, highlighting the importance of these parameters in understanding the dynamics of CTL response to HTLV-I infections in vivo.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2021)
Article
Biochemistry & Molecular Biology
Marcia Bellon, Izabela Bialuk, Veronica Galli, Xue-Tao Bai, Lourdes Farre, Achilea Bittencourt, Ambroise Marcais, Michael N. Petrus, Lee Ratner, Thomas A. Waldmann, Vahid Asnafi, Antoine Gessain, Masao Matsuoka, Genoveffa Franchini, Olivier Hermine, Toshiki Watanabe, Christophe Nicot
Summary: The epigenetic alteration of FHIT was found to be specifically present in chronic and acute ATL patients, while absent in asymptomatic HTLV-I carriers and TSP/HAM patients. The extent of FHIT methylation in ATL patients was quantitatively comparable in virus-infected and non-infected cells. Results suggest that germinal epigenetic mutation of FHIT may predispose individuals to the development of ATL diseases.
Article
Immunology
Mariele Guerra, Natalia B. Carvalho, Silvane Santos, Mauricio T. T. Nascimento, Renata Sa, Augusto M. M. Carvalho, Edgar M. M. Carvalho, Lucas P. P. Carvalho
Summary: This study found that HTLV-1 infected individuals, especially those with HAM/TSP, have higher levels of MMP-9 production. MMP-9 levels are positively correlated with viral load and TNF levels. These findings suggest an association between MMP-9 production and the proinflammatory state associated with HTLV-1 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tatiane Assone, Soraya Maria Menezes, Fernanda de Toledo Goncalves, Victor Angelo Folgosi, Gabriela da Silva Prates, Tim Dierckx, Marcos Braz, Jerusa Smid, Michel E. Haziot, Rosa M. N. Marcusso, Flavia E. Dahy, Evelien Vanderlinden, Sandra Claes, Dominique Schols, Roberta Bruhn, Edward L. Murphy, Augusto Cesar Penalva de Oliveira, Dirk Daelemans, Jurgen Vercauteren, Jorge Casseb, Johan Van Weyenbergh
Summary: This study investigated potential biomarkers of immunopathogenesis and therapeutic response in HAM/TSP. The results showed that older age, female sex, and higher proviral load are risk factors for HAM/TSP. Systemic cytokine IL-6 and the chronic inflammatory marker GlycA displayed an "inflammaging" signature in asymptomatic individuals, but not in HAM/TSP patients. IFN-gamma and IL-17A were identified as biomarkers of untreated HAM/TSP, while pre-treatment GlycA and TNF levels predicted therapeutic response to prednisolone pulse therapy.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Eric A. Meyerowitz, Shibani S. Mukerji, G. Kyle Harrold, Rachel M. Erdil, Steven T. Chen, Emily A. Rudmann, Athe Tsibris, Nagagopal Venna, Gregory K. Robbins
Summary: Mogamulizumab shows potential for improving symptoms in patients with HAM/TSP, but more clinical trials are needed to confirm its effectiveness.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Tomoo Sato, Junji Yamauchi, Naoko Yagishita, Natsumi Araya, Naoki Takao, Yuki Ohta, Eisuke Inoue, Masaki Takahashi, Makoto Yamagishi, Yutaka Suzuki, Kaoru Uchimaru, Naoki Matsumoto, Yasuhiro Hasegawa, Yoshihisa Yamano
Summary: This study evaluated the long-term safety and efficacy of the anti-CCR4 antibody mogamulizumab in patients with HAM/TSP. The results showed that mogamulizumab had long-term safety and inhibitory effects on the progression of lower limb motor disability in HAM/TSP patients.
Review
Immunology
Antoine Gessain, Jill-Lea Ramassamy, Philippe V. Afonso, Olivier Cassar
Summary: The African continent has a high prevalence of the oncogenic retrovirus HTLV-1, with an estimated two to five million infected individuals. However, there is limited data on the epidemiological aspects, such as prevalence, risk factors, and geographical distribution. This is due to a lack of large-scale and representative studies, as well as the absence of confirmatory tests in many studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Apio Ricardo Nazareth Dias, Luiz Fabio Magno Falcao, Juarez Antonio Simoes Quaresma
Summary: Previous studies have shown that individuals infected with HTLV-1 develop pulmonary impairment. Complications such as alveolitis and bronchiectasis are caused by chronic inflammation. These patients have abnormal levels of lymphocytes, cytokines, inflammatory chemokines, and cell adhesion molecules in the lungs, resulting in chronic inflammation and lung injury. High-resolution computed tomography reveals centrilobular nodules, parenchymal bands, lung cysts, bronchiectasis, ground-glass opacity, mosaic attenuation, and pleural thickening. Recent studies suggest a causal relationship between HTLV-1 and pulmonary diseases, with progressive decline in lung function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Roberto S. Accolla
Summary: This review discusses the expression of HTLV-1 basic leucine-zipper factor HBZ during HTLV-1 infection, providing a deeper understanding of HTLV-1 infection and oncogenesis mechanisms, and suggesting new directions for further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Michi Miura, Tadasuke Naito, Mineki Saito
Summary: Human T-cell leukemia virus type 1 (HTLV-1) is a replication-competent human retrovirus that is associated with two types of diseases, adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although most infected individuals remain asymptomatic, a subpopulation develops these diseases. The complex virus-host interactions and the host immune response may regulate the development of HTLV-1-associated diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Marina Penova, Shuji Kawaguchi, Jun-ichirou Yasunaga, Takahisa Kawaguchi, Tomoo Sato, Meiko Takahashi, Masakazu Shimizu, Mineki Saito, Kunihiro Tsukasaki, Masanori Nakagawa, Norihiro Takenouchi, Hideo Hara, Eiji Matsuura, Satoshi Nozuma, Hiroshi Takashima, Shuji Izumo, Toshiki Watanabe, Kaoru Uchimaru, Masako Iwanaga, Atae Utsunomiya, Yasuharu Tabara, Richard Paul, Yoshihisa Yamano, Masao Matsuoka, Fumihiko Matsuda
Summary: This study identified strong associations in HLA class I and class II loci with HAM/TSP, with specific alleles like HLAC*07:02, HLA-B*07:02, HLA-DRB1*01:01, and HLA-DQB1*05:01 related to disease risk. Conversely, alleles like HLA-B*40:06, HLA-DRB1*15:01, and HLA-DQB1*06:02 were found to be protective. The amino acid residue DRB1-GB-7-Leu was identified as a genetic risk factor for HAM/TSP development independently of proviral load, serving as a specific marker for disease risk.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Asami Yamada, Jun-ichirou Yasunaga, Lihan Liang, Wenyi Zhang, Junya Sunagawa, Shinji Nakaoka, Shingo Iwami, Yasunori Kogure, Yuta Ito, Keisuke Kataoka, Masanori Nakagawa, Masako Iwanaga, Atae Utsunomiya, Ki-Ryang Koh, Toshiki Watanabe, Kisato Nosaka, Masao Matsuoka
Summary: This study demonstrates that profiling the humoral immunity to HTLV-1 antigens and measuring proviral load can be used to classify disease status and predict the development of HTLV-1-associated diseases. The study also highlights the importance of anti-Gag proteins in disease prognosis.
Article
Microbiology
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Satoshi Nozuma, Eiji Matsuura, Hiroshi Takashima, Shuji Izumo, Ryuji Kubota
Summary: The study compared the performance of different detection methods in the CSF of HAM/TSP patients and HTLV-1 carriers, demonstrating that CLIA was closer to PA in performance, while CLEIA had lower sensitivity.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Lorena Abreu Fernandes, Augusto Cesar Penalva de Oliveira, Youko Nukui, Jorge Casseb, Fernando Roberto Machado Cunha, Luiz Henrique da Silva Nali, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study found that IgG obtained from HAM/TSP and ATLL patients can differentially modulate the cytokine production by human T and B cells, and elicit distinct effects on target populations.
FRONTIERS IN MEDICINE
(2023)
Article
Orthopedics
Eiji Matsuura, Satoshi Nozuma, Ayano Shigehisa, Mika Dozono, Tomonori Nakamura, Masakazu Tanaka, Ryuji Kubota, Akihiro Hashiguchi, Hiroshi Takashima
Summary: This case report describes a rare association between HTLV-1 infection and sporadic late onset nemaline myopathy (SLONM). Further studies are needed to understand the relationship between retroviruses and muscle diseases.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Clinical Neurology
Hui Qin Xing, Yu Zhang, Kimiko Izumo, Shiho Arishima, Ryuji Kubota, Xiang Ye, Qiping Xu, Kazuyasu Mori, Shuji Izumo
Article
Microbiology
Madoka Kuramitsu, Tsuyoshi Sekizuka, Tadanori Yamochi, Sanaz Firouzi, Tomoo Sato, Kazumi Umeki, Daisuke Sasaki, Hiroo Hasegawa, Ryuji Kubota, Rieko Sobata, Chieko Matsumoto, Noriaki Kaneko, Haruka Momose, Kumiko Araki, Masumichi Saito, Kisato Nosaka, Atae Utsunomiya, Ki-Ryang Koh, Masao Ogata, Kaoru Uchimaru, Masako Iwanaga, Yasuko Sagara, Yoshihisa Yamano, Akihiko Okayama, Kiyonori Miura, Masahiro Satake, Shigeru Saito, Kazuo Itabashi, Kazunari Yamaguchi, Makoto Kuroda, Toshiki Watanabe, Kazu Okuma, Isao Hamaguchi
JOURNAL OF CLINICAL MICROBIOLOGY
(2017)
Article
Infectious Diseases
Hongzhi Gao, Xiang Ye, Ruowei Cai, Qiping Xu, Liping Liang, Shuji Izumo, Hui Qin Xing, Ryuji Kubota
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Madoka Kuramitsu, Kazu Okuma, Makoto Nakashima, Tomoo Sato, Daisuke Sasaki, Hiroo Hasegawa, Kazumi Umeki, Ryuji Kubota, Keiko Sasada, Rieko Sobata, Chieko Matsumoto, Noriaki Kaneko, Kenta Tezuka, Sahoko Matsuoka, Atae Utsunomiya, Ki-Ryang Koh, Masao Ogata, Kenji Ishitsuka, Mai Taki, Kisato Nosaka, Kaoru Uchimaru, Masako Iwanaga, Yasuko Sagara, Yoshihisa Yamano, Akihiko Okayama, Kiyonori Miura, Masahiro Satake, Shigeru Saito, Toshiki Watanabe, Isao Hamaguchi
MICROBIOLOGY AND IMMUNOLOGY
(2018)
Article
Neurosciences
Norihiro Takenouchi, Masakazu Tanaka, Teruaki Sato, Jinchun Yao, Jun-ichi Fujisawa, Shuji Izumo, Ryuji Kubota, Eiji Matsuura
JOURNAL OF NEUROVIROLOGY
(2020)
Review
Neurosciences
Satoshi Nozuma, Ryuji Kubota, Steven Jacobson
JOURNAL OF NEUROVIROLOGY
(2020)
Article
Infectious Diseases
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Kimiko Izumo, Nobuaki Nakano, Eiji Matsuura, Mineki Saito, Masahiro Nagai, Masahisa Horiuchi, Atae Utsunomiya, Hiroshi Takashima, Ryuji Kubota, Shuji Izumo
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Virology
Kazu Okuma, Madoka Kuramitsu, Toshihiro Niwa, Tomokuni Taniguchi, Yumiko Masaki, Gohzoh Ueda, Chieko Matsumoto, Rieko Sobata, Yasuko Sagara, Hitomi Nakamura, Masahiro Satake, Kiyonori Miura, Naoki Fuchi, Hideaki Masuzaki, Akihiko Okayama, Kazumi Umeki, Yoshihisa Yamano, Tomoo Sato, Masako Iwanaga, Kaoru Uchimaru, Makoto Nakashima, Atae Utsunomiya, Ryuji Kubota, Kenji Ishitsuka, Hiroo Hasegawa, Daisuke Sasaki, Ki-Ryang Koh, Mai Taki, Kisato Nosaka, Masao Ogata, Isao Naruse, Noriaki Kaneko, Sara Okajima, Kenta Tezuka, Emi Ikebe, Sahoko Matsuoka, Kazuo Itabashi, Shigeru Saito, Toshiki Watanabe, Isao Hamaguchi
Article
Microbiology
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Satoshi Nozuma, Eiji Matsuura, Hiroshi Takashima, Shuji Izumo, Ryuji Kubota
Summary: The study compared the performance of different detection methods in the CSF of HAM/TSP patients and HTLV-1 carriers, demonstrating that CLIA was closer to PA in performance, while CLEIA had lower sensitivity.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Immunology
Yuichi Tashiro, Eiji Matsuura, Yasuko Sagara, Satoshi Nozuma, Daisuke Kodama, Masakazu Tanaka, Chihaya Koriyama, Ryuji Kubota, Hiroshi Takashima
Summary: Japan is a highly endemic area for HTLV-1, and the infection rate increases with age. This study estimated the number and rate of HTLV-1 infection in Kagoshima using preoperative screening data. The results showed a high infection rate among the elderly, suggesting that the infection risk may have been present since infancy.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2022)
Article
Clinical Neurology
Satoshi Nozuma, Eiji Matsuura, Yuichi Tashiro, Ryusei Nagata, Masahiro Ando, Yu Hiramatsu, Yujiro Higuchi, Yusuke Sakiyama, Akihiro Hashiguchi, Kumiko Michizono, Keiko Higashi, Toshio Matsuzaki, Daisuke Kodama, Masakazu Tanaka, Yoshihisa Yamano, Takashi Moritoyo, Ryuji Kubota, Hiroshi Takashima
Summary: This study evaluated the efficacy and safety of l-arginine in patients with HAM/TSP. The results showed that l-arginine therapy improved motor function and reduced inflammatory markers in the cerebrospinal fluid. Therefore, l-arginine may be a promising therapeutic option for patients with HAM/TSP.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Orthopedics
Eiji Matsuura, Satoshi Nozuma, Ayano Shigehisa, Mika Dozono, Tomonori Nakamura, Masakazu Tanaka, Ryuji Kubota, Akihiro Hashiguchi, Hiroshi Takashima
Summary: This case report describes a rare association between HTLV-1 infection and sporadic late onset nemaline myopathy (SLONM). Further studies are needed to understand the relationship between retroviruses and muscle diseases.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Clinical Neurology
Ryusei Nagata, Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Yutaka Noguchi, Masahiro Ando, Yu Hiramatsu, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Munekazu Yamakuchi, Yujiro Higuchi, Yusuke Sakiyama, Hitoshi Arata, Keiko Higashi, Teruto Hashiguchi, Shunya Nakane, Hiroshi Takashima
Summary: This study investigated the correlation between the presence of serum anti-ganglionic acetylcholine receptor (gAChR) antibodies and autonomic symptoms in patients with functional neurological symptom disorder/conversion disorder (FNSD/CD). The results showed that among the 59 FNSD/CD patients, 88.1% exhibited autonomic disturbances and 27.1% were positive for serum anti-gAChR antibodies. Patients positive for anti-gAChR antibodies had a higher prevalence of cardiovascular autonomic dysfunction but a lower prevalence of involuntary movements compared to antibody-negative patients. The findings suggest that an autoimmune mechanism mediated by anti-gAChR antibodies may be involved in the etiology of FNSD/CD in a subgroup of patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Satoshi Nozuma, Eiji Matsuura, Masakazu Tanaka, Daisuke Kodama, Toshio Matsuzaki, Akiko Yoshimura, Yusuke Sakiyama, Shingo Nakahata, Kazuhiro Morishita, Yoshimi Enose-Akahata, Steven Jacoboson, Ryuji Kubota, Hiroshi Takashima
Summary: This study demonstrates that analyzing TCR repertoires of HTLV-1-infected cells can provide insights into the clonal dynamics and potential pathogenic clones expanded in the CNS of HAM/TSP patients. The TCR beta repertoire analysis reveals a higher clonal expansion in HTLV-1-infected cells compared to noninfected cells, and the TCR sequences of infected cells remain stable over time. Furthermore, highly expanded infected clones are found in the cerebrospinal fluid of HAM/TSP patients.
Article
Microbiology
Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Hiroshi Takashima
Summary: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurological disease caused by HTLV-1 infection. The most common clinical manifestations of HAM/TSP include weakness of the proximal muscles of the lower extremities and atrophy of the paraspinal muscles, with the upper extremities being mostly unaffected. This study aimed to identify the muscle involvement pattern in HAM/TSP to aid diagnosis, rehabilitation and understanding of its pathogenesis.
