Editorial Material
Hematology
Amy E. DeZern
Summary: The study provides a sophisticated description of patients with idiopathic cytopenia of undetermined significance (ICUS) and clonal cytopenia of undetermined significance (CCUS) by identifying three main predictive variables for outcomes. Clinical comparisons were made with overt MN patients and older control patients to better characterize the clonal metrics. The research aims to help clinicians advise cytopenic patients on their risk of transformation to overt MN based on their molecular mutational profile.
Article
Critical Care Medicine
Mark Z. Y. Tan
Summary: This article aims to broaden the understanding of resilience from individual and psychological resilience to organizational levels and calls for intensivists to actively foster resilience for their staff.
Article
Biology
Eduardo M. Arraut, Sean W. Walls, David W. Macdonald, Robert E. Kenward
Summary: The coexistence between humans, animals, and ecosystem services is complex and impacted by landscape change. Afforestation in Great Britain has increased in recent years, raising questions about the consequences for biodiversity. This study explored the impact of afforestation on the common buzzard population, predicting a nonlinear decrease in abundance with increasing woodland conversion. This approach could be useful for anticipating population patterns in changing landscapes and balancing economy, landscape change, and biodiversity.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
News Item
Multidisciplinary Sciences
Emma Marris
Summary: Lead attorney Julia Olson outlines the requirements for future victories.
Article
Astronomy & Astrophysics
Amedeo Balbi, Manasvi Lingam
Summary: The probability of abiogenesis, the spontaneous emergence of life in a suitable environment, remains unknown in astrobiology. The lack of a widely accepted theory for the origin of life and the presence of selection biases make it difficult to assess this probability. Asserting the typicality of Earth's history uncritically is problematic. In this paper, a Bayesian statistical approach is applied to establish lower bounds on the probability of abiogenesis based on current and future evidence. It is found that the prior probability assigned to the appearance of life on Earth strongly influences the final result. The existence of numerous habitable worlds does not necessarily imply a high probability of common life in the universe.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Article
Geography
Jessica Quinton, Lorien Nesbitt, James J. T. Connolly, Elvin Wyly
Summary: Green gentrification refers to the phenomenon where urban greening and sustainability measures lead to neighborhood upgrading and displacement of existing residents. A study found that green interventions frequently occur during and after gentrification in various cities in Canada. This implies the need for a broader understanding of the relationship between urban greening and gentrification.
Article
Oncology
Tanimola Martins, Gary Abel, Obioha C. Ukoumunne, Sarah Price, Georgios Lyratzopoulos, Frank Chinegwundoh, William Hamilton
Summary: This study examined the time to diagnosis among different ethnic groups in the UK for seven types of cancer. The results showed that ethnic minority groups experienced a longer time to diagnosis compared to the White group in five out of the seven cancers studied. However, these differences were small and unlikely to be the sole explanation for the disparities in cancer outcomes across ethnic groups.
Article
Public, Environmental & Occupational Health
Jeon Mi Lee, Hyun Jin Lee
Summary: This study investigated the effect of obstructive sleep apnea (OSA) on hearing ability and found that the presence of OSA minimally affected hearing level. Further research on the association between the duration of OSA and hearing loss is needed.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Clinical Neurology
Robert J. Fox
Summary: Active inflammation in patients with progressive multiple sclerosis is associated with improved efficacy of anti-inflammatory therapies, but the frequency of this inflammation in this patient population is unknown, prompting a new study to investigate further.
NATURE REVIEWS NEUROLOGY
(2021)
Review
Multidisciplinary Sciences
Sophia E. Fedorowicz, Robert C. Dempsey, Naomi Ellis, Elliott Phillips, Christopher Gidlow
Summary: This scoping review examined how suicide risk assessments are conducted and experienced by healthcare practitioners, patients, carers, relatives, and friends of people who have died by suicide in the UK. The study found considerable variation in the ways in which suicide risk assessments are conducted in practice, and highlighted the need for increased inclusion of patient perspectives and better training for healthcare staff. Further research is needed to understand how the process can be improved.
Article
Medicine, General & Internal
Christoph Wohlmuth, Iris Wohlmuth-Wieser
Summary: This study assessed the incidence and prognostic indicators of gynecologic malignancies in pediatric population, finding ovarian tumors to be the most common. Sarcomas were the predominant type of malignancies in vagina, cervix, uterus, and vulva.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Daniela Esposito, Oskar Ragnarsson, Gudmundur Johannsson, Daniel S. Olsson
Summary: The risk of malignancies is slightly increased in acromegaly patients, especially for colorectal and anal cancer, and renal and ureteral cancer. Meanwhile, the incidence of benign tumors has more than doubled in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Alasdair D. D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. H. Smith, Joseph Hayes, Kathryn E. E. Mansfield, Sinead M. Langan
Summary: This study found that people with eczema and psoriasis have an increased risk of common mental disorders (anxiety, depression), and sleep quality may be an important factor leading to anxiety and depression in eczema patients.
Article
Psychology, Clinical
Daphne Kounali, Katherine S. Button, Gemma Lewis, Simon Gilbody, David Kessler, Ricardo Araya, Larisa Duffy, Paul Lanham, Tim J. Peters, Nicola Wiles, Glyn Lewis
Summary: This study examined the Minimum Clinically Important Difference (MCID) for the Patient Health Questionnaire (PHQ-9), the Beck Depression Inventory (BDI-II), and the Generalised Anxiety Disorder Assessment (GAD-7). The findings suggest that for patients with moderate baseline severity, a reduction of 20% in scores represents an MCID. Patients with milder symptoms require larger improvements to notice a benefit.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Applied
Hyun-Soo Woo, John P. Berns, Pol Solanelles
Summary: This article examines the challenges faced by logit and probit models when studying binary dependent variables in strategic management research. It finds that the appropriateness and effectiveness of these models are compromised when the event rate of the dependent variable is rare or common. The study highlights issues such as biased coefficients, standard error inflation, low statistical power, and model convergence failure. It also emphasizes the amplification of these issues with small sample sizes. The findings provide step-by-step guidance for strategy researchers in dealing with extreme event rates and small sample sizes.
ORGANIZATIONAL RESEARCH METHODS
(2023)
Letter
Clinical Neurology
Massimiliano Di Filippo, Cinzia Cordioli, Simona Malucchi, Pietro Annovazzi, Paola Cavalla, Valentina Torri Clerici, Paolo Ragonese, Viviana Nociti, Marta Radaelli, Alice Laroni, Fabio Buttari, Lorena Lorefice, Diana Ferraro, Alberto Gajofatto, Luca Prosperini, Roberta Fantozzi, Laura Boffa, Roberta Lanzillo, Marcello Moccia, Marinella Clerico, Giovanna De Luca, Valentina Tomassini, Massimiliano Calabrese, Angela Borrelli, Damiano Paolicelli, Giorgia Teresa Maniscalco, Paola Gazzola, Antonio Gallo, Claudio Solaro, Eleonora Cocco, Claudio Gasperini, Carla Tortorella
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Afagh Garjani, Rachael Hunter, Graham R. Law, Rodden M. Middleton, Katherine A. Tuite-Dalton, Ruth Dobson, David Ford, Stella Hughes, Owen R. Pearson, David Rog, Emma C. Tallantyre, Richard Nicholas, Richard Morriss, Nikos Evangelou, Roshan das Nair
Summary: The study found that during the first wave of the outbreak in the United Kingdom, people with MS were more likely to experience anxiety, depression, loneliness, worse social support, and worsened exercise habits compared to the general population.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Emma C. Tallantyre, Nicola Vickaryous, Valerie Anderson, Aliye Nazli Asardag, David Baker, Jonathan Bestwick, Kath Bramhall, Randy Chance, Nikos Evangelou, Katila George, Gavin Giovannoni, Andrew Godkin, Leanne Grant, Katharine E. Harding, Aimee Hibbert, Gillian Ingram, Meleri Jones, Angray S. Kang, Samantha Loveless, Stuart J. Moat, Neil P. Robertson, Klaus Schmierer, Martin J. Scurr, Sita Navin Shah, Jessica Simmons, Matthew Upcott, Mark Willis, Stephen Jolles, Ruth Dobson
Summary: The study found that some disease modifying therapies are associated with attenuated serological responses to SARS-CoV-2 vaccination in people with multiple sclerosis, including anti-CD20 monoclonal antibodies and fingolimod treatment. Additionally, vaccine type and treatment duration also impact vaccine response.
ANNALS OF NEUROLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Valeria Pozzilli, Eleonora Agata Grasso, Valentina Tomassini
Summary: Multiple sclerosis (MS) and type 1 diabetes (T1D) are chronic conditions stemming from immune system dysfunction, with differences in genetic susceptibility, age of onset, and treatment approaches.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Correction
Clinical Neurology
Antonio Riccardo Buonomo, Giulio Viceconte, Massimiliano Calabrese, Giovanna De Luca, Valentina Tomassini, Paola Cavalla, Giorgia Teresa Maniscalco, Diana Ferraro, Viviana Nociti, Marta Radaelli, Maria Chiara Buscarinu, Damiano Paolicelli, Alberto Gajofatto, Pietro Annovazzi, Federica Pinardi, Massimiliano Di Filippo, Cinzia Cordioli, Emanuela Zappulo, Riccardo Scotto, Ivan Gentile, Antonio Luca Spiezia, Martina Petruzzo, Marcello De Angelis, Vincenzo Brescia Morra, Claudio Solaro, Claudio Gasperini, Eleonora Cocco, Marcello Moccia, Roberta Lanzillo
JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Clinical Neurology
Emma C. Tallantyre
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Clinical Neurology
Afagh Garjani, Brandon Jun-Yu Liu, Christopher Martin Allen, Douglas David Gunzler, Stephen William Gerry, Sarah Marie Planchon, Roshan das Nair, Jeremy Chataway, Emma C. Tallantyre, Daniel Ontaneda, Nikos Evangelou
Summary: Randomised controlled trials (RCTs) play a crucial role in MS research and decentralised clinical trials (DCTs) have emerged as a new approach, utilizing digital and mobile technologies for flexible and convenient participation. However, there are still gaps in knowledge regarding the design and conduct of DCTs in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Emma C. Tallantyre, Martin J. Scurr, Nicola Vickaryous, Aidan Richards, Valerie Anderson, David Baker, Randy Chance, Nikos Evangelou, Katila George, Gavin Giovannoni, Katharine E. Harding, Aimee Hibbert, Gillian Ingram, Stephen Jolles, Meleri Jones, Angray S. Kang, Samantha Loveless, Stuart J. Moat, Neil P. Robertson, Francesca Rios, Klaus Schmierer, Mark Willis, Andrew Godkin, Ruth Dobson
Summary: This study investigated the immune response of multiple sclerosis patients after receiving COVID-19 vaccines. The results showed that approximately one third of the patients seroconverted after receiving the third vaccine, indicating the benefit of boosters in this group. Nearly 80% of the patients had a measurable immune response after the third vaccine.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Endocrinology & Metabolism
Hannah L. Chandler, Rachael C. Stickland, Eleonora Patitucci, Michael Germuska, Antonio M. Chiarelli, Catherine Foster, Shona Bhome-Dhaliwal, Thomas M. Lancaster, Neeraj Saxena, Sharmila Khot, Valentina Tomassini, Richard G. Wise
Summary: By using dual-calibrated functional magnetic resonance imaging (dc-fMRI), we found that cerebral blood flow, oxygen consumption, and oxygen diffusivity were significantly reduced in patients with multiple sclerosis (MS), while mitochondrial oxygen pressure was increased. These findings may indicate reduced oxygen demand or utilization in the MS brain and mitochondrial dysfunction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Katharine Elizabeth Harding, Gillian Ingram, Emma Clare Tallantyre, Fady Joseph, Mark Wardle, Trevor P. Pickersgill, Mark D. Willis, Valentina Tomassini, Owen Rhys Pearson, Neil P. Robertson
Summary: This study provides a detailed contemporary model of disability outcomes in a representative population-based MS cohort. The results support a trend of increasing time to disability milestones compared with historical reference populations, and document disability variation with the use of transitional matrices. This study has important implications for patient counseling, clinical trial design, and assessment of therapeutic interventions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Antonio Maria Chiarelli, Alessandro Villani, Daniele Mascali, Nikolaos Petsas, Emma Biondetti, Alessandra Caporale, Anna Digiovanni, Eleonora Agata Grasso, Paola Ajdinaj, Maria D'Apolito, Marianna Gabriella Rispoli, Stefano Sensi, Kevin Murphy, Carlo Pozzilli, Richard G. Wise, Valentina Tomassini
Summary: This study investigated the relationship between cerebrovascular reactivity (CVR) and neuroinflammation in patients with multiple sclerosis (MS). The findings showed lower CVR in patients before treatment compared to healthy controls and a negative correlation between pre-treatment CVR and grey matter volume. During treatment, CVR increased and was negatively correlated with pre-treatment CVR. Reduction in enhancing lesions was associated with increased CVR. The resolution of inflammation may restore altered cerebrovascular function in MS.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Karim L. Kreft, Emeka Uzochukwu, Sam Loveless, Mark Willis, Ray Wynford-Thomas, Katharine E. Harding, Peter Holmans, Michael Lawton, Emma C. Tallantyre, Neil P. Robertson
Summary: This study aimed to determine if the recent significant single-nucleotide variant (rs10191329A) and other genetic loci associated with overall disability outcomes in multiple sclerosis (MS) can influence individual patient management. The results showed no association between rs10191329A and various clinically relevant outcomes. However, two other suggestive SNVs (rs7289446G and rs868824C) were found to be associated with the development of fixed disability, and the HLA-DRB1*1501 locus was associated with age at onset.
ANNALS OF NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Gogem Topcu, Laura Smith, Jacqueline R. Mhizha-Murira, Nia Goulden, Zoe Hoare, Avril Drummond, Deborah Fitzsimmons, Nikos Evangelou, Klaus Schmierer, Emma C. Tallantyre, Paul Leighton, Kimberley Allen-Philbey, Andrea Stennett, Paul Bradley, Clare Bale, James Turton, Roshan das Nair
Summary: This study aims to develop a cognitive screening and management pathway for people with multiple sclerosis (MS) and evaluate its feasibility. Through observational study, a feasibility randomized controlled trial, and semi-structured interviews, researchers will assess the clinical and cost-effectiveness of the intervention as well as its potential impact on the management of cognitive problems in MS patients.
PILOT AND FEASIBILITY STUDIES
(2022)
Article
Neuroimaging
Danka Jandric, Geoff J. M. Parker, Hamied Haroon, Valentina Tomassini, Nils Muhlert, Ilona Lipp
Summary: Understanding the brain changes underlying cognitive dysfunction in multiple sclerosis (MS) is crucial for improving monitoring and treatment. This study explored the relationship between changes in white matter and cognitive symptoms, using a tractometry approach. The findings revealed a main covariance pattern that explained the most variance in microstructure across all white matter tracts. This covariance pattern contributed to explaining a moderate degree of variance in one cognitive domain in MS. These findings emphasize the importance of investigating the relationship between normal appearing white matter and cognitive impairment in MS.
NEUROIMAGE-CLINICAL
(2022)