Article
Biochemistry & Molecular Biology
Juliana Gurgel-Giannetti, Lucas Santos Souza, Guilherme L. Yamamoto, Marina Belisario, Monize Lazar, Wilson Campos, Rita de Cassia M. Pavanello, Mayana Zatz, Umbertina Reed, Edmar Zanoteli, Acary Bulle Oliveira, Vilma-Lotta Lehtokari, Erasmo B. Casella, Marcela C. Machado-Costa, Carina Wallgren-Pettersson, Nigel G. Laing, Vincenzo Nigro, Mariz Vainzof
Summary: Nemaline myopathy in Brazilian patients shows significant clinical and genetic heterogeneity, with a high frequency of NEB gene mutations. There is noticeable variability in clinical presentation and MRI patterns, with respiratory involvement often being severe.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Clinical Neurology
Shaia Bierman-Chow, Steven M. Holland, Amy P. Hsu, Cindy Palmer, John Lynch, Yair Mina, HyunJoo (Sophie) Cho
Summary: This study characterized the clinical, laboratory, and imaging findings of 10 patients with GATA2 deficiency who presented with early-onset ischemic stroke. The results suggest a link between GATA2 deficiency and stroke, emphasizing the need for further research to understand this unique vulnerability within this patient population.
Article
Immunology
Simin Almasi, Azadeh Rashidi, Manizhe Ataee Kachuee, Bentolhoda Mohammad Shirazi, Shirin Izadi, Sara Ghaffarpour, Mehdi Azimi, Mohammad Mehdi Naghizadeh, Mahin Jamshidi Makiani, Mitra Ranjbar, Manizheh Goudarzi, Neda Rahimian, Tooba Ghazanfari
Summary: This study found that the administration of tofacitinib combined with other treatments is not effective in treating severe COVID-19 patients, and the use of this medication should be considered before the disease deterioration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Wandong Hong, Qin Chen, Songzan Qian, Zarrin Basharat, Vincent Zimmer, Yumin Wang, Maddalena Zippi, Jingye Pan
Summary: This study investigated clinical features and laboratory findings between critically ill and non-critically ill COVID-19 pneumonia patients. It was found that older patients with higher interleukin-6 levels were more likely to develop critical illness. Interleukin-6 was identified as a superior predictor of disease severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Dianwu Li, Huaying Liang, Yiqun Zhu, Qinyu Chang, Pinhua Pan, Yan Zhang
Summary: This study retrospectively analyzed the clinical features and prognosis of patients with Talaromyces marneffei (TM) infection, comparing HIV-positive and negative patients. The results showed that HIV-positive patients were more likely to develop disseminated TM, resulting in higher mortality rates. Patients without HIV but with immunocompromised conditions had similar hospital mortality rates compared to immunocompetent patients, but required longer hospitalization for recovery.
FRONTIERS IN MEDICINE
(2022)
Article
Veterinary Sciences
Saskia Neubert, Christina Puff, Sven Kleinschmidt, Patricia Kammeyer, Alexandra von Altrock, Michael Wendt, Matthias Gerhard Wagener
Summary: Gastric ulcers are common in South American camelids and are difficult to diagnose clinically or by laboratory investigations. These ulcers are often chronic processes involving other organ systems, so regular monitoring of the animals' nutritional status and early detection of disease symptoms may help prevent gastric ulcers.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Elie Naddaf, Pritikanta Paul, Omar F. AbouEzzeddine
Summary: Long-term exposure to CQ and HCQ can lead to myopathy with a wide range of clinical presentations, affecting swallowing, respiratory, and cardiac muscles. Discontinuation of the medication can result in improvement in most patients, but often with residual weakness.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Xiao-jing Wei, Hui Sun, Jing Miao, Ru-qing Qiu, Zong-zhi Jiang, Zhen-wei Ma, Wei Sun, Xue-fan Yu
Summary: This study assessed 36 Chinese patients with rimmed vacuolar myopathies (RVMs) and found that muscle MRI is a valuable tool for disease identification and differential diagnosis. The study identified the most prevalent form of RVMs as GNE myopathy and highlighted the role of MRI in identifying causative genes and confirming pathogenicity of novel mutations.
FRONTIERS IN NEUROLOGY
(2023)
Review
Allergy
Angelo Valerio Marzano, Carlo Alberto Maronese, Giovanni Genovese, Silvia Ferrucci, Chiara Moltrasio, Riccardo Asero, Massimo Cugno
Summary: Urticarial vasculitis (UV) is a rare skin disease characterized by recurrent episodes of wheal-like lesions, lasting for a long period of time, and with specific histopathological features. The pathogenesis of UV is mainly related to immune complexes and the complement cascade. It can be divided into two types, one of which is associated with antibodies and may have systemic symptoms. This article summarizes the clinical features, pathophysiological mechanisms, and other similar diseases of UV.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Marcus Pinto, Ruple S. Laughlin, Christopher J. Klein, Jay Mandrekar, Elie Naddaf
Summary: Dysphagia was the main clinical feature of IBM correlating with endomysial inflammation. Otherwise, inclusion body myositis clinical measures had limited correlation with histopathological features in this study. The shortness of MUP duration correlated with all clinical measures.
Article
Clinical Neurology
Kye Hee Cho, Eun Young Han, Ji Cheol Shin, Min Cheol Ha, Kwang Ho Ahn, Su Hyun Cho, Sang Hee Im
Summary: This study investigated neurophysiologic changes in patients with chemotherapy-induced peripheral neuropathy (CIPN) and compared them with symptom severity. The results showed a positive correlation between nerve conduction study results and symptom severity. Serial nerve conduction studies can help assess the degree of chemotherapy-induced nerve damage and monitor the progression of CIPN.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Daniel T. Corp, Christopher J. Greenwood, Jordan Morrison-Ham, Jaakko Pullinen, Georgia M. McDowall, Ellen F. P. Younger, Hyder A. Jinnah, Michael D. Fox, Juho Joutsa
Summary: This study identified cases of lesion-induced dystonia from published literature and classified patients into subgroups based on lesion location and body regions affected by dystonia. Significant differences were found between these subgroups on a range of dystonia symptoms.
Review
Biochemistry & Molecular Biology
Giulia Maria Camerino, Nancy Tarantino, Ileana Canfora, Michela De Bellis, Olimpia Musumeci, Sabata Pierno
Summary: Statins are effective drugs for treating cardiovascular diseases, but can lead to skeletal muscle toxicity which needs risk assessment and study of new biomarkers. Identifying a marker of toxicity is important to prevent or to cure statin induced myopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Sajid Hameed, Ayisha Farooq Khan, Sara Khan
Summary: Neurological manifestations in COVID-19 patients vary, with myopathic EMG changes commonly seen, especially in intubated patients, and also found in non-intubated patients, with one case presenting Guillain-Barre syndrome.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Immunology
James T. Lee, Elisabeth M. Hesse, Heather N. Paulin, Deblina Datta, Lee S. Katz, Amish Talwar, Gregory Chang, Romeo R. Galang, Jennifer L. Harcourt, Azaibi Tamin, Natalie J. Thornburg, Karen K. Wong, Valerie Stevens, Kaylee Kim, Suxiang Tong, Bin Zhou, Krista Queen, Jan Drobeniuc, Jennifer M. Folster, D. Joseph Sexton, Sumathi Ramachandran, Hannah Browne, John Iskander, Kiren Mitruka
Summary: The investigation on potential SARS-CoV-2 reinfection cases in the United States from May to July 2020 did not confirm any cases within 90 days of the initial infection. The findings support current CDC guidance on quarantine and testing for patients who have recovered from COVID-19.
CLINICAL INFECTIOUS DISEASES
(2021)