Review
Clinical Neurology
Jordan N. Alves, Britta U. Westner, Andreas Hojlund, Rimona Sharon Weil, Sarang S. Dalal
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, leading to bradykinesia, rest tremor and rigidity. Visual disorders and retinal abnormalities are common in patients with Parkinson's disease, and can be detected through decreased visual acuity, abnormal spatial contrast sensitivity and difficulty in complex visual tasks. This review examines the retinal dysfunction in Parkinson's disease, highlighting the electrophysiological and structural changes observed. The findings suggest that retinal functional measures could serve as valuable and cost-effective tools for early evaluation of Parkinson's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Danika L. Paulo, Helen Qian, Deeptha Subramanian, Graham W. Johnson, Zixiang Zhao, Kilian Hett, Hakmook Kang, C. Chris Kao, Noah Roy, Jessica E. Summers, Daniel O. Claassen, Kaltra Dhima, Sarah K. Bick
Summary: Cognitive impairment in Parkinson's disease is related to deficits in cognitive functions such as working memory. The role of beta oscillations in cognitive impairment is not well understood. Decreased dopamine in motor CSTC circuits results in increased beta oscillatory power and motor symptoms. Similar changes in cognitive CSTC circuits involving the caudate and DLPFC may contribute to cognitive impairment in Parkinson's disease.
Review
Medicine, General & Internal
Yuqi Yang, Tong Zhang, Lixu Liu, Lei Shan, Xueyan Hu, Lingyu Yang, Fei Gao, Xiaoli Wu, Hanzhi Li
Summary: The efficacy and safety of botulinum toxin (BTX) for motor dysfunction in Parkinson's disease (PD) were evaluated through a systematic review and meta-analysis. The findings suggest that BTX treatment may not alleviate motor symptoms significantly, but it can benefit pain alleviation and functional mobility improvement.
Article
Clinical Neurology
San San Xu, Wee-Lih Lee, Thushara Perera, Nicholas C. Sinclair, Kristian J. Bulluss, Hugh J. McDermott, Wesley Thevathasan
Summary: This study found that evoked resonant neural activity (ERNA) showed better predictive performance in the selection of contacts for deep brain stimulation compared to anatomical location and beta oscillations, supporting the development of probability-based algorithms using neuronal signals and anatomical data to assist programming of deep brain stimulation.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Anand Tekriwal, Gidon Felsen, Steven G. Ojemann, Aviva Abosch, John A. Thompson
Summary: The severity of motor symptoms in Parkinson's disease (PD) is influenced by environmental conditions. This study investigates the neural mechanisms underlying context-dependent symptom attenuation in PD patients undergoing deep brain stimulation surgery. The results suggest that the substantia nigra pars reticulata (SNr) plays a role in motor planning and execution, and should be further studied in human sensorimotor integration and as a target for neuromodulatory therapies.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Lucia K. Feldmann, Roxanne Lofredi, Bassam Al-Fatly, Johannes L. Busch, Varvara Mathiopoulou, Jan Roediger, Patricia Krause, Gerd-Helge Schneider, Katharina Faust, Andreas Horn, Andrea A. Kuehn, Wolf-Julian Neumann
Summary: This study investigated the influence of Christmas on beta activity in patients with Parkinson's disease. The results showed a significant reduction in beta activity on Christmas Eve. The study suggests that circadian and holiday-related changes should be considered when tailoring adaptive deep brain stimulation algorithms.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Nicolas A. M. Zang, Marlieke Schneider, Daniel Weiss
Summary: The study aimed to explore the cortical neuronal mechanisms underlying movement recovery after freezing episodes in Parkinson's disease patients. The findings suggest that different cortical pathways are used when re-initiating movement after freezing or voluntary stops. These findings may facilitate the development of neuromodulation strategies to counteract freezing behavior.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Giorgio Leodori, Maria Ilenia De Bartolo, Andrea Fabbrini, Matteo Costanzo, Marco Mancuso, Daniele Belvisi, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli
Summary: This study found that tremor suppression in patients with Parkinson's disease may be related to the activity of the primary motor cortex, and there may be differences in tremor features between patients with and without tremor suppression.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Deborah Jacob, Lorena Guerrini, Federica Pescaglia, Simona Pierucci, Carmine Gelormini, Vincenzo Minutolo, Antonio Fratini, Giorgio Di Lorenzo, Hannes Petersen, Paolo Gargiulo
Summary: This study demonstrates the potential of using a complex postural control task to assess early-stage Parkinson's Disease patients by measuring the combined output of posturography, muscle activation, and cortical response.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Ashraf S. Gorgey, Refka E. Khalil, Malak Alrubaye, Ranjodh Gill, Jeannie Rivers, Lance L. Goetz, David X. Cifu, Teodoro Castillo, Deborah Caruso, Timothy D. Lavis, Edward J. Lesnefsky, Christopher C. Cardozo, Robert A. Adler
Summary: This study aims to investigate the effects of long pulse width stimulation (LPWS) and testosterone treatment (TT) on muscle size and metabolic health in individuals with spinal cord injury (SCI). Through various measurements and tests, the study hopes to determine if TT+LPWS can enhance protein synthesis, improve mitochondrial health, and ultimately lead to muscle growth and improved metabolic health.
Article
Medicine, General & Internal
Akiyoshi Matsugi, Hiroyuki Ohtsuka, Kyota Bando, Yuki Kondo, Yutaka Kikuchi
Summary: Currently, there is no curative treatment available for degenerative cerebellar ataxia (DCA), which results in unmet medical and rehabilitation needs for patients. Non-invasive brain stimulation techniques have been suggested as a possible intervention to improve cerebellar ataxia. This study aims to systematically evaluate the clinical effects of these techniques on DCA patients.
Article
Biochemical Research Methods
Miguel Cesar Merino Ruiz, Rayanne Poletti Guimaraes, Marcia Renata Mortari
Summary: This review discusses the pathogenesis of Parkinson's disease, the principles of deep brain stimulation (DBS), and the role and limitations of rodent models in DBS research. Rodent models have replaced non-human primate models and played an important role in guiding the evolution of treatment methods in scientific research.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Clinical Neurology
Danika L. Paulo, Graham W. Johnson, Derek J. Doss, Jackson H. Allen, Hernan F. J. Gonzalez, Robert Shults, Rui Li, Tyler J. Ball, Sarah K. Bick, Travis J. Hassell, Pierre-Francois D'Haese, Peter E. Konrad, Benoit M. Dawant, Saramati Narasimhan, Dario J. Englot
Summary: This study aims to demonstrate the value of intraoperative neurophysiological testing paired with image-based data in optimizing final electrode positioning in deep brain stimulation surgery. The results show that this approach can lead to improved patient outcomes.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Editorial Material
Multidisciplinary Sciences
Zak Doric, Ken Nakamura
Summary: By disrupting mitochondria in vulnerable neuronal cells, mice provide a new model of Parkinson's disease that challenges long-held ideas about the disease's motor symptoms.
Article
Clinical Neurology
Yo-Ichi Suzuki, Kazumoto Shibuya, Sonoko Misawa, Tomoki Suichi, Atsuko Tsuneyama, Yuta Kojima, Keigo Nakamura, Hiroki Kano, Mario Prado, Yuya Aotsuka, Ryo Otani, Marie Morooka, Satoshi Kuwabara
Summary: Patients with ALS show hyperexcitability in both the motor cortex and peripheral motor axons. The results suggest that cortical excitability remains high regardless of the extent of peripheral burden, while peripheral hyperexcitability is associated with the extent of peripheral burden and disease evolution speed. Alterations of ion channel function may play an important role in ALS pathophysiology.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Letter
Clinical Neurology
Irene Litvan, Anthony E. Lang, Melissa Armstrong
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alessandra Fanciulli, Fabian Leys, Magdalena Krbot Skoric, Diogo Reis Carneiro, Giovanna Calandra-Buonaura, Jennifer Camaradou, Giacomo Chiaro, Pietro Cortelli, Cristian Falup-Pecurariu, Roberta Granata, Pietro Guaraldi, Raimund J. Helbok, Max Hilz, Valeria Iodice, Jens Jordan, Evert C. A. Kaal, Anita Kamondi, Anne Pavy Le Traon, Isabel Rocha, Johann Sellner, Jean Michel Senard, Astrid K. Terkelsen, Gregor Wenning, Elena Moro, Thomas D. Berger, Roland Thijs, Walter Struhal, Mario Habek
Summary: This study investigated the impact of the COVID-19 pandemic on European clinical autonomic practice. The results showed a significant decrease in the number of autonomic tests and visits during the first year of the pandemic. COVID-19 infection was associated with the development or worsening of cardiovascular autonomic disorders, while the association with COVID-19 vaccines was deemed unlikely.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Francesco Cavallieri, Annalisa Gessani, Andrea Merlo, Isabella Campanini, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Valerie Fraix, Sara Meoni, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Serge Pinto, Elena Moro, Franco Valzania
Summary: This study evaluates correlations between speech and gait parameters in advanced Parkinson's disease patients under different medication and subthalamic nucleus deep brain stimulation conditions. The results show that patients who spoke louder had greater trunk acceleration during gait, and patients with poorer voice quality performed worse in the sit to stand and gait phases of the iTUG. Conversely, patients with higher speech rate performed well in the turning and walking phases of the iTUG.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Jessica Rossi, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Sara Meoni, Valerie Fraix, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Andrea Merlo, Elena Moro, Franco Valzania
Summary: This study assessed the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on gait in advanced Parkinson's Disease (PD) patients. The results showed that in the long-term after surgery, STN-DBS can contribute to gait and postural control improvement when used together with dopamine replacement therapy.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Antigony Rigas, Tina Mainka, Tamara Pringsheim, Alexander Muenchau, Irene Malaty, Yulia Worbe, Andrea E. Cavanna, Andrew John Lees, Anthony E. Lang, Davide Martino, Christos Ganos
Summary: This study revealed that the diagnostic distinction between primary and functional tics is often difficult, even for expert clinicians, in the absence of clinical information.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Kai -Hsiang Stanley Chen, Tzu-Kang Hung, Rupesh Kumar Chikara, Yu-Ting Kuo, Yi-Ping Liu, Yan-Siou Dong, Yih-Ru Wu, Li -Wei Ko, Ying-Zu Huang, Robert Chen
Summary: Based on the theory of coordinated reset (CR) stimulation, the noninvasive coordinated multifocal burst stimulation (COMBS) was developed to modulate the target frequency in the primary motor cortex. The results showed an increase in a-band power and low I3-band power during the finger-tapping task, and a reduction in low I3-band event-related desynchronization after COMBS. However, there were no significant changes in cortical excitability measured by various parameters.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Letter
Clinical Neurology
Timour Vitte, Anna Castrioto, Emmanuelle Schmitt, Elena Moro, Sina R. Potel
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Talyta Grippe, Alfonso Fasano, Robert Chen
Summary: This article describes an unusual case involving a combination of slow orthostatic tremor, orthostatic myoclonus, and parkinsonism. The case highlights the importance of utilizing electrophysiology for precise characterization of physical findings in order to establish a diagnosis.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Behavioral Sciences
Sara Grisanti, Alessandro Fraternali, Francesco Cavallieri, Valentina Fioravanti, Massimiliano Casali, Giulia Toschi, Laura Ferri, Rossella Sabadini, Marialuisa Zedde, Gaetano Salomone, Manuela Napoli, Rosario Pascarella, Valeria Ferrari, Maria Scarano, Giuseppe Biagini, Augusto Scaglioni, Elena Moro, Annibale Versari, Franco Valzania
Summary: This study compared the differences between GBA-PD and I-PD patients and found that GBA-PD patients had lower SBR values in the most affected anterior putamen and left caudate. However, these differences were no longer significant after Bonferroni multiple comparisons correction, highlighting the need for larger, longitudinal studies.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Brice Passera, Sylvain Harquel, Alan Chauvin, Pauline Gerard, Lisa Lai, Elena Moro, Sara Meoni, Valerie Fraix, Olivier David, Estelle Raffin
Summary: This study proposes a multi-dimensional TMS mapping approach that combines TMS-EMG and TMS-EEG methods to investigate the mechanisms of deep brain stimulation (DBS) in Parkinson's disease patients. The results show that DBS can induce rapid changes in motor cortex representations and enhance corticospinal excitability, as well as increase activity in inhibitory circuits. These findings have important implications for understanding the therapeutic effects of DBS and the neural activity mechanisms in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yazan Shamli Oghli, Talyta Grippe, Tarun Arora, Tasnuva Hoque, Ghazaleh Darmani, Robert Chen
Summary: In this study, the mechanisms of transcranial ultrasound stimulation (TUS) in human primary motor cortex were investigated by administering different drugs to healthy subjects. The results showed that all study drugs reduced the plasticity effects of tbTUS on motor cortex excitability. The conclusion is that tbTUS may induce NMDA-dependent synaptic plasticity and is influenced by increased GABAA receptor activity and blockers of voltage-gated Na+ and Ca2+ channels.
Article
Clinical Neurology
Stephanie Tran, Calaina Brooke, Young Joon Kim, Stephen D. Perry, Jean-Francois Nankoo, Cricia Rinchon, Tarun Arora, Luc Tremblay, Robert Chen
Summary: People with Parkinson's disease show impaired visual and vestibular perception, but relatively preserved visual-vestibular integration during gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Talyta Grippe, Robert Chen
Summary: Many studies have shown that botulinum toxin (BoNT) can be an effective option for treating both motor and non-motor symptoms in Parkinson's disease (PD) and parkinsonian syndromes. BoNT has advantages over oral medications as it has localized action and a low incidence of systemic side effects, which is crucial in treating neurodegenerative diseases. However, most of the evidence for the use of BoNT in parkinsonism is based on open-label studies and there is a lack of randomized, controlled trials. Further research is needed to provide more evidence of its efficacy and determine the optimal injection protocols for different symptoms.
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Anthony E. Lang, Zahra Azad, Seyed Amir Hassan Habibi, Afagh Alavi, Gholamali Shahidi, Maziar Emamikhah, Ahmad Chitsaz
Summary: Among 122 genetically confirmed NBIA patients, KRS had the best survival and longest preservation of ambulation ability, while classical PKAN and MPAN patients showed similar progression patterns in loss of ambulation ability, with MPAN patients having a slower progression to death. Spasticity was identified as the most significant factor associated with death.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
