Article
Neurosciences
Marieclaire Overton, Benjamin Sjogren, Solve Elmstahl, Aldana Rosso
Summary: This study compared the diagnostic stability and prediction of dementia using the Petersen criteria and the Neuropsychological criteria in patients with mild cognitive impairment (MCI), and found that the reversion rates were similar for both criteria. Moreover, factors such as multiple domain MCI, cohabitation, and alcohol consumption played important roles in predicting the trajectory of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Natalia Roberto, Maria J. Portella, Marta Marquie, Montserrat Alegret, Isabel Hernandez, Ana Mauleon, Maitee Rosende-Roca, Carla Abdelnour, Ester Esteban de Antonio, Silvia Gil, Juan P. Tartari, Liliana Vargas, Ana Espinosa, Gemma Ortega, Alba Perez-Cordon, Angela Sanabria, Adelina Orellana, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Emilio Alarcon-Martin, Agustin Ruiz, Lluis Tarraga, Merce Boada, Sergi Valero
Summary: Neuropsychiatric symptoms (NPS) have been identified as risk factors for conversion to Alzheimer's disease (AD) and other dementia types in patients with Mild Cognitive Impairment (MCI). Four NPS profiles emerged based on prominent symptoms in MCI patients, with Irritability and Apathy being predictors of dementia conversion. The findings suggest that NPS can be used as early diagnosis facilitators and to identify different illness trajectories in MCI progression.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Yi-Hua Huang, Wei-Yu Chen, Yao-Hong Liu, Ting-Ying Li, Ching-Po Lin, Pou-Leng Cheong, Yi-Min Wang, Jiann-Shing Jeng, Chia-Wei Sun, Chau-Chung Wu
Summary: This study explores the potential of using fNIRS and the WCST to detect MCI patients. The results show that individuals with lower cognitive scores have greater changes in blood oxygenation during the WCST. This noninvasive approach combined with cognitive assessments may effectively detect MCI, offering hope for proactive dementia prevention.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Mark Sanderson-Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen
Summary: Cognitive practice effects (PEs) can impact the diagnosis and progression prediction of MCI, increasing prevalence, reducing reversion rates, and increasing the risk of dementia. Accounting for PEs can improve diagnostic accuracy and the prediction ability of dementia in MCI diagnoses.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Farooq Kamal, Cassandra Morrison, Josefina Maranzano, Yashar Zeighami, Mahsa Dadar
Summary: This study aimed to investigate the association between the change in white matter hyperintensities (WMH) burden and conversion to dementia in individuals with mild cognitive impairment (MCI) who are either amyloid-positive (A & beta;+) or amyloid-negative (A & beta;-). The results showed that individuals with A & beta;+ had the highest increase in WMH burden and steepest accumulation over time compared to individuals with A & beta;-.
Article
Clinical Neurology
Soeren Mattke, Hankyung Jun, Emily Chen, Ying Liu, Andrew Becker, Christopher Wallick
Summary: This study aimed to compare the actual diagnosis rates of mild cognitive impairment (MCI) and dementia in the full Medicare population with the predicted diagnosis rates. The study found that the detection rate for MCI was low, especially among Black and Hispanic beneficiaries. Dementia was diagnosed more frequently, particularly in non-Hispanic White beneficiaries.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Review
Psychiatry
Maria Casagrande, Giulia Marselli, Francesca Agostini, Giuseppe Forte, Francesca Favieri, Angela Guarino
Summary: Mild cognitive impairment (MCI) is characterized by a decline in cognitive performance that can predict the development of dementia. Understanding the prevalence and diagnostic criteria of MCI is crucial for dementia prevention and treatment. However, current research shows significant heterogeneity, making it difficult to draw definite conclusions about MCI prevalence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Kang Min Park, Chang Min Heo, Dong Ah Lee, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Bong Soo Park
Summary: This study aimed to investigate the effect of hemodialysis on functional brain connectivity in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS). The study found significant changes in functional brain connectivity measures between the pre- and post-hemodialysis periods, but no changes between the pre- and mid-hemodialysis periods or between the mid- and post-hemodialysis periods. These findings suggest that hemodialysis has a significant effect on functional brain connectivity in patients with ESRD.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Jui-Hung Hsu, Chien-Cheng Liu, I-Wen Chen, Jheng-Yan Wu, Po-Yu Huang, Ting-Hui Liu, Kuo-Chuan Hung
Summary: The visual cognitive assessment test (VCAT) is a language-neutral screening tool for detecting MCI/mild dementia. This meta-analysis showed that VCAT demonstrated acceptable diagnostic accuracy in distinguishing MCI/mild dementia in cognitively normal older adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Xiao-Yan Ge, Kai Cui, Long Liu, Yao Qin, Jing Cui, Hong-Juan Han, Yan-Hong Luo, Hong-Mei Yu
Summary: This study proposed a two-stage screening frame for high-risk MCI subjects, finding that ADAS-13 was more sensitive for filtering out high-risk individuals. The optimal model included a change rate of clinical assessments and three neuroimaging measurements, significantly associated with a net reclassification improvement (NRI) of 0.246 and integrated discrimination improvement (IDI) of 0.090. The ADAS-13 longitudinal models had the best discrimination performance.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Lindsay White, Bailey Ingraham, Eric Larson, Paul Fishman, Sungchul Park, Norma B. Coe
Summary: Timely diagnosis of cognitive impairment is a key goal of the National Plan to Address Alzheimer's Disease, but studies on factors contributing to timely diagnosis are limited. This retrospective observational study found that only 26% of respondents with incident dementia and 11.4% with incident MCI received a timely diagnosis. Non-Hispanic Black and individuals with lower educational attainment were less likely to receive timely diagnosis of dementia or MCI compared to Non-Hispanic White respondents or those with a college degree.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Priya Palta, Michelle C. Carlson, Rosa M. Crum, Elizabeth Colantuoni, A. Richey Sharrett, Sevil Yasar, Richard L. Nahin, Steven T. DeKosky, Beth Snitz, Oscar Lopez, Jeff D. Williamson, Curt D. Furberg, Stephen R. Rapp, Sherita Hill Golden
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Article
Clinical Neurology
David A. Loewenstein, Rosie E. Curiel, Steven DeKosky, Russell M. Bauer, Monica Rosselli, Salvador M. Guinjoan, Malek Adjouadi, Ailyn Penate, William W. Barker, Sindy Goenaga, Todd Golde, Maria T. Greig-Custo, Kevin S. Hanson, Chunfei Li, Gabriel Lizarraga, Michael Marsiske, Ranjan Duara
Article
Clinical Neurology
Catherine W. Striley, Sadaf A. Milani, Evan Kwiatkowski, Steven T. DeKosky, Linda B. Cottler
ALZHEIMERS & DEMENTIA
(2019)
Article
Anesthesiology
L. Evered, B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, G. Crosby, M. Berger, R. G. Eckenhoff
ANESTHESIA AND ANALGESIA
(2018)
Article
Anesthesiology
L. Evered, B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, G. Crosby, M. Berger, R. G. Eckenhoff
Article
Anesthesiology
L. Evered, B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, G. Crosby, M. Berger, R. G. Eckenhoff
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2018)
Article
Neurosciences
Yat-Fung Shea, Warren Barker, Maria T. Greig-Gusto, David A. Loewenstein, Steven T. DeKosky, Ranjan Duara
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Neurosciences
L. Evered, B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, G. Crosby, M. Berger, R. G. Eckenhoff
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Geriatrics & Gerontology
Melissa J. Armstrong, Slande Alliance, Pamela Corsentino, Steven T. DeKosky, Angela Taylor
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2019)
Article
Clinical Neurology
Breton M. Asken, Russell M. Bauer, Steven T. DeKosky, Zachary M. Houck, Charles C. Moreno, Michael S. Jaffee, Arthur G. Weber, James R. Clugston
Article
Neurosciences
Adrian M. Svingos, Breton M. Asken, Russell M. Bauer, Steven T. DeKosky, Gabrielle A. Hromas, Michael S. Jaffee, Ronald L. Hayes, James R. Clugston
Editorial Material
Clinical Neurology
Steven T. DeKosky, John B. Williamson
Article
Clinical Neurology
Sean A. P. Clouston, Charles B. Hall, Minos Kritikos, David A. Bennett, Steven DeKosky, Jerri Edwards, Caleb Finch, William C. Kreisl, Michelle Mielke, Elaine R. Peskind, Murray Raskind, Marcus Richards, Richard P. Sloan, Avron Spiro, Neil Vasdev, Robert Brackbill, Mark Farfel, Megan Horton, Sandra Lowe, Roberto G. Lucchini, David Prezant, Joan Reibman, Rebecca Rosen, Kacie Sell, Rachel Zeig-Owens, Yael Deri, Erica D. Diminich, Bernadette A. Fausto, Sam Gandy, Mary Sano, Evelyn J. Bromet, Benjamin J. Luft
Summary: The terrorist attacks on the World Trade Center on September 11, 2001 have had long-lasting impacts, with individuals affected facing significant psychological and physical stressors. Research indicates that some of these individuals are experiencing neurocognitive and motor dysfunctions resembling neurodegenerative diseases in midlife, as well as cortical atrophy. Moreover, chronic exposure to the events at the WTC is associated with post-traumatic stress disorder and neurocognitive symptoms.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Clinical Neurology
Michael Grundman, Roger Morgan, Jason D. Lickliter, Lon S. Schneider, Steven DeKosky, Nicholas J. Izzo, Robert Guttendorf, Michelle Higgin, Julie Pribyl, Kelsie Mozzoni, Hank Safferstein, Susan M. Catalano
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2019)
Review
Neuroimaging
Breton Michael Asken, Steven T. DeKosky, James R. Clugston, Michael S. Jaffee, Russell M. Bauer
BRAIN IMAGING AND BEHAVIOR
(2018)