Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Kaisa Maki, Taina Nybo, Marja Hietanen, Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Susanna Melkas
Summary: Perceived injustice is associated with self-reported symptoms in patients with mild traumatic brain injury (mTBI). Our results suggest that perceived injustice could be a relevant construct to consider in clinical management of patients with mTBI, and it could be a potential target for psychological interventions promoting recovery after mTBI.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Anesthesiology
Cayden Peixoto, Derrick Matthew Buchanan, Richard Nahas
Summary: Missed diagnosis of mTBI is common in patients presenting to the ED after MVC, and these patients are at risk of developing chronic pain syndromes. Better screening for mTBI is needed, especially in patients with loss of consciousness, altered mental state, posttraumatic amnesia, or postinjury headache, who are at increased risk of PCS.
Article
Psychology, Clinical
Josh W. Faulkner, Deborah L. Snell, Alice Theadom, Susan Mahon, Suzanne Barker-Collo
Summary: The study found that psychological flexibility significantly affects postconcussion symptoms and functional status in individuals with mTBI, serving as an important treatment target in mTBI interventions. Researchers suggest that psychological flexibility is a psychological mechanism that contributes to recovery outcomes in individuals with mTBI.
REHABILITATION PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Barry M. Miskin, Lee A. Fox, Hussam Abou-Al-Shaar, Othman Bin-Alamer, Aaron Goertz, Conner T. Lipin, Nicole Fertig, Nevada Cox
Summary: This study evaluated the safety and outcomes of hyperbaric oxygen therapy (HBOT) in managing the long-term sequelae of traumatic brain injury (TBI). The results showed that TBI patients who underwent 40 sessions of HBOT at 1.5 atmosphere absolute experienced significant improvements in cognitive and physical function, as well as increased cerebral blood flow and oxygen metabolism. HBOT was considered a safe and effective modality in the treatment of the long-term sequelae of TBI.
WORLD NEUROSURGERY
(2023)
Article
Multidisciplinary Sciences
Mohammed M. Alnawmasi, Sieu K. Khuu
Summary: This study investigated the impact of TBI on the allocation and maintenance of visual attention to multiple moving targets using a multiple object tracking task. The results showed that patients with mild TBI had greater deficits in maintaining visual attention and detecting targets, particularly when the tracking load and distraction increased.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jia-Wei Chung, Doresses Liu, Li Wei, Ya-Ting Wen, Hsin-Ying Lin, Huan-Chieh Chen, Hsiao-Yean Chiu
Summary: This study investigated the frequency and risk factors of postconcussion symptoms (PCSs) in older adults with mild traumatic brain injury (TBI), and examined their effects on quality of life. The results showed that PCSs were prevalent in older adults even in the chronic phase after a TBI, and significantly affected their quality of life.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Helene Audrit, Miriam H. Beauchamp, Simon Tinawi, Maude Lague-Beauvais, Rajeet Saluja, Elaine de Guise
Summary: This study aimed to assess the feasibility and treatment effects of a psychoeducative and counseling intervention program targeting 4 postconcussion symptoms. The experimental group receiving the SAAM intervention showed high rates of satisfaction, and preliminary results suggested that this intervention could potentially reduce postconcussion symptoms, depression symptoms, fatigue, and sleep difficulties. Further randomized controlled trials on a larger scale are needed to confirm these findings.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Bryce Geeraert, Xiangyu Long, Miriam H. Beauchamp, William Craig, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Roger Zemek, Catherine Lebel
Summary: Sophisticated network-based approaches such as structural connectomics may help detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children, finding that both mTBI and OI groups demonstrated reduced global and regional network efficiency and segregation compared to TD children. This suggests a general effect of childhood injury on brain structure that could reflect pre- and postinjury factors.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Zachary M. Weil, Kate Karelina, Bailey Whitehead, Ruth Velazquez-Cruz, Robin Oliverio, Mark Pinti, Divine C. Nwafor, Samuel Nicholson, Julie A. Fitzgerald, John Hollander, Candice M. Brown, Ning Zhang, A. Courtney DeVries
Summary: Recent studies have shown that traumatic brain injury (TBI) can worsen outcomes after stroke by affecting neuroimmune and neurometabolic functions. In a mouse model, TBI led to larger stroke infarcts, more severe functional deficits, and increased neuroinflammation. Treatment with the insulin sensitizing drug pioglitazone was able to prevent the exacerbation of ischemic outcomes caused by TBI, suggesting that metabolic dysfunction plays a role in these processes.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Summary: This study demonstrates altered cytokine profiles and endotoxin responses in children with traumatic brain injury (TBI), including mild TBI. Children with mild TBI showed decreased levels of IL-8, IL-10, IL-17A, and TNF-alpha compared to controls, along with increased levels of IFN-gamma. In severe TBI, there was no significant IL-6 response to endotoxin, but an increase in IL-17A. These findings suggest immune dysfunction following TBI, especially in mild cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
